DrLLPS - Data resource of LLPS

LLPS-Sus-a908
CDH2

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Uncharacterized protein
Gene Name:	CDH2
Ensembl Gene:	ENSSSCG00000003722.4
Ensembl Protein:	ENSSSCP00000004030.3
Organism:	Sus scrofa
Taxa ID:	9823
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-a924	P19022	Client	Postsynaptic density	98.01	0.0	1826
Mus musculus	LLPS-Mum-a909	P15116	Client	Postsynaptic density	96.80	0.0	1796

▼ FUNCTION

Cadherins are calcium-dependent cell adhesion proteins.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSSSCT00000004122.3	ENSSSCP00000004030.3
UniProt		F1SAM3, F1SAM3_PIG
GeneBank	AEMK02000045
RefSeq	XM_013996117.1	XP_013851571.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MCRILGAPRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSQDVL EGQPLLNVKF 60 61 SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHS KFLIYAQDKE TQEKWQVAVK 120 121 LSLKPTLPED SMKESREIEE IVFPRQVTKH SGYLQRQKRD WVIPPINLPE NSRGPFPQEL 180 181 VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240 241 DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 300 301 NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360 361 GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAVY 420 421 RISGGDPTGR FAIQTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480 481 TATVSVTVID VNENPYFAPN PKIIRQEEGL HTGTMLTTFT AQDPDRYMQQ NIRYTKLSDP 540 541 ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600 601 NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR NWTITRLNGD 660 661 FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720 721 GTGAIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780 781 EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840 841 KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 900 901 YGGGDD 906
Nucleotide CDS Sequence (FASTA)
1 AATATGTGTC ATCGCTTTCT TCCTTTAAAC ATTTATTCCA AAATTTATGA AAGAGAAGGT 60 61 TTGCAAGGAA AGAGAAGGAA CAAAGTGAAG TTCAGCAATT GCAATGGGAA AAGAAAAGTA 120 121 CAATATGAAA GCAGCGAACC AGCAGATTTT AAGGTAGATG AAGATGGCAT GGTGTATGCT 180 181 GTGAGAAGTT TTCCCCTGTC CTCTGAGCAC TCAAAGTTCC TGATATATGC TCAAGACAAA 240 241 GAGACTCAGG AAAAATGGCA AGTAGCAGTA AAATTGAGCC TCAAGCCAAC CTTACCTGAG 300 301 GATTCCATGA AGGAATCACG AGAAATTGAA GAAATAGTAT TCCCAAGACA AGTGACCAAG 360 361 CACAGTGGCT ACCTACAAAG GCAGAAGAGA GACTGGGTTA TCCCTCCAAT CAACTTGCCA 420 421 GAAAACTCCA GAGGGCCTTT TCCTCAAGAG CTTGTCAGGA TCAGGTCCGA TAGAGATAAA 480 481 AACCTTTCTC TGCGGTACAG CGTAACTGGG CCAGGAGCTG ACCAGCCTCC AACTGGTATC 540 541 TTCATTATCA ACCCCATCTC AGGTCAGCTG TCCGTGACCA AGCCTCTGGA CCGCGAGCTG 600 601 ATAGCCCGGT TTCATTTGAG GGCACATGCC GTGGATATTA ATGGGAATCA AGTGGAAAAC 660 661 CCCATTGACA TCGTCATCAA TGTTATTGAC ATGAATGATA ACAGACCTGA GTTCCTACAC 720 721 CAGGTGTGGA ATGGCACGGT TCCCGAGGGA TCCAAGCCTG GAACATATGT GATGACGGTC 780 781 ACTGCTATTG ATGCTGACGA TCCAAACGCC CTCAATGGGA TGTTGAGGTA CAGAATCCTG 840 841 TCCCAGGCTC CAAGCACCCC CTCGCCCAAC ATGTTTACAA TCAACAATGA GACTGGTGAC 900 901 ATTATCACAG TGGCCGCCGG ACTTGATAGA GAAAAAGTGC AGCAGTATAC GTTAATAATT 960 961 CAAGCCACAG ATATGGAAGG CAATCCCACG TATGGCCTTT CCAACACAGC CACGGCTGTC 1020 1021 ATCACGGTGA CAGATGTCAA TGACAATCCT CCAGAGTTTA CTGCCATGAC ATTCTACGGC 1080 1081 GAGGTCCCTG AAAACAGGGT GGATGTCATA GTAGCTAATC TGACAGTGAC AGATAAGGAC 1140 1141 CAGCCCCATA CACCGGCCTG GAACGCGGTC TACAGAATCA GCGGTGGGGA TCCCACTGGC 1200 1201 CGGTTTGCCA TTCAGACCGA CCCCAACAGC AACGACGGCT TAGTCACCGT AGTAAAACCA 1260 1261 ATCGACTTTG AAACAAATAG GATGTTTGTC CTTACTGTTG CTGCAGAAAA TCAAGTGCCA 1320 1321 TTAGCCAAGG GTATTCAGCA CCCACCTCAG TCAACTGCAA CTGTGTCTGT CACAGTTATT 1380 1381 GATGTGAATG AAAACCCTTA TTTTGCCCCA AATCCTAAGA TCATCCGCCA AGAAGAAGGC 1440 1441 CTTCACACTG GTACCATGTT AACAACGTTC ACTGCTCAGG ACCCAGATCG ATATATGCAG 1500 1501 CAAAATATTA GGTACACAAA ATTATCCGAT CCAGCCAACT GGCTAAAAAT AGATCCTGTG 1560 1561 AATGGACAGA TAACTACCAT TGCCGTTTTG GACAGAGAAT CACCAAATGT GAAAAACAAT 1620 1621 ATATATAATG CTACTTTCCT TGCTTCTGAC AATGGTATGA AATCCTTCTA TGAGTGGAAC 1680 1681 GGGACCCTGC AGATCTATTT ACTGAAAATA ACGCATGCCC CGCAGGTGTT ACTTAAGGAG 1740 1741 GGGGAAAATT TGGAAACTCC GGACCCCAGC AATTACTATA GAAGCCTGAG CATTTTTTAC 1800 1801 TTCCTGTGTG GAGACTACTT TGACTATAAT TTGAAACCTG CATGCTATAC TAATAATCCA 1860 1861 CTTGCTAGAT TTAGCCCTAG AACAATGGTA AATGAGATCA TGTATCTGGC TTTAAAAGGA 1920 1921 GATTTTAGAG AGAATGCATT CCTAGATGTG CACTTAGGGA TATGTTTCAC TTTCAACCTT 1980 1981 ACCAAGAAAG ACTTAGATCT GATGGATTGT GATGTCCACT CAGTGAGTTC ACAGGGTATC 2040 2041 AATTTCTTGA CACGAACCCT AGTGCTCTGG GCCTCTGCTT TGTCTTGTTT CTCGTCATGT 2100 2101 GAGGCCAAAA CCTTAGTCCT TGTTCTCATG TTTGTGGTAT GGATGAAGCG CCGAGATAAA 2160 2161 GAACGCCAGG CCAAGCAACT TTTAATTGAT CCAGAAGATG ATGTAAGAGA TAATATTTTA 2220 2221 AAATATGATG AAGAAGGTGG AGGAGAAGAA GACCAGGACT ATGACTTGAG CCAGCTCCAG 2280 2281 CAGCCTGATA CTGTGGAACC AGATGCCATC AAGCCTGTTG GAATCCGACG GTTGGATGAG 2340 2341 AGACCCATCC ATGCTGAGCC CCAGTACCCG GTTCGATCTG CAGCCCCTCA CCCTGGGGAC 2400 2401 ATCGGGGACT TCATTAATGA GGGTCTTAAA GCTGCTGACA ATGATCCCAC AGCTCCGCCA 2460 2461 TATGACTCCC TTCTAGTCTT TGACTATGAA GGCAGTGGCT CTACCGCTGG GTCCTTGAGC 2520 2521 TCCCTTAATT CCTCCAGTAG TGGAGGTGAG CAGGACTATG ATTACCTGAA CGATTGGGGG 2580 2581 CCACGTTTCA AGAAGCTCGC TGACATGTAC GGTGGAGGTG ATGACTGA 2628

Nucleotide Sequence

>LLPS-Sus-a908|ENSSSCG00000003722.4
AATATGTGTCATCGCTTTCTTCCTTTAAACATTTATTCCAAAATTTATGAAAGAGAAGGTTTGCAAGGAAAGAGAAGGAACAAAGTGAAGTTCAGCAATTGCAATGGGAAAAGAAAAGTACAATATGAAAGCAGCGAACCAGCAGATTTTAAGGTAGATGAAGATGGCATGGTGTATGCTGTGAGAAGTTTTCCCCTGTCCTCTGAGCACTCAAAGTTCCTGATATATGCTCAAGACAAAGAGACTCAGGAAAAATGGCAAGTAGCAGTAAAATTGAGCCTCAAGCCAACCTTACCTGAGGATTCCATGAAGGAATCACGAGAAATTGAAGAAATAGTATTCCCAAGACAAGTGACCAAGCACAGTGGCTACCTACAAAGGCAGAAGAGAGACTGGGTTATCCCTCCAATCAACTTGCCAGAAAACTCCAGAGGGCCTTTTCCTCAAGAGCTTGTCAGGATCAGGTCCGATAGAGATAAAAACCTTTCTCTGCGGTACAGCGTAACTGGGCCAGGAGCTGACCAGCCTCCAACTGGTATCTTCATTATCAACCCCATCTCAGGTCAGCTGTCCGTGACCAAGCCTCTGGACCGCGAGCTGATAGCCCGGTTTCATTTGAGGGCACATGCCGTGGATATTAATGGGAATCAAGTGGAAAACCCCATTGACATCGTCATCAATGTTATTGACATGAATGATAACAGACCTGAGTTCCTACACCAGGTGTGGAATGGCACGGTTCCCGAGGGATCCAAGCCTGGAACATATGTGATGACGGTCACTGCTATTGATGCTGACGATCCAAACGCCCTCAATGGGATGTTGAGGTACAGAATCCTGTCCCAGGCTCCAAGCACCCCCTCGCCCAACATGTTTACAATCAACAATGAGACTGGTGACATTATCACAGTGGCCGCCGGACTTGATAGAGAAAAAGTGCAGCAGTATACGTTAATAATTCAAGCCACAGATATGGAAGGCAATCCCACGTATGGCCTTTCCAACACAGCCACGGCTGTCATCACGGTGACAGATGTCAATGACAATCCTCCAGAGTTTACTGCCATGACATTCTACGGCGAGGTCCCTGAAAACAGGGTGGATGTCATAGTAGCTAATCTGACAGTGACAGATAAGGACCAGCCCCATACACCGGCCTGGAACGCGGTCTACAGAATCAGCGGTGGGGATCCCACTGGCCGGTTTGCCATTCAGACCGACCCCAACAGCAACGACGGCTTAGTCACCGTAGTAAAACCAATCGACTTTGAAACAAATAGGATGTTTGTCCTTACTGTTGCTGCAGAAAATCAAGTGCCATTAGCCAAGGGTATTCAGCACCCACCTCAGTCAACTGCAACTGTGTCTGTCACAGTTATTGATGTGAATGAAAACCCTTATTTTGCCCCAAATCCTAAGATCATCCGCCAAGAAGAAGGCCTTCACACTGGTACCATGTTAACAACGTTCACTGCTCAGGACCCAGATCGATATATGCAGCAAAATATTAGGTACACAAAATTATCCGATCCAGCCAACTGGCTAAAAATAGATCCTGTGAATGGACAGATAACTACCATTGCCGTTTTGGACAGAGAATCACCAAATGTGAAAAACAATATATATAATGCTACTTTCCTTGCTTCTGACAATGGTATGAAATCCTTCTATGAGTGGAACGGGACCCTGCAGATCTATTTACTGAAAATAACGCATGCCCCGCAGGTGTTACTTAAGGAGGGGGAAAATTTGGAAACTCCGGACCCCAGCAATTACTATAGAAGCCTGAGCATTTTTTACTTCCTGTGTGGAGACTACTTTGACTATAATTTGAAACCTGCATGCTATACTAATAATCCACTTGCTAGATTTAGCCCTAGAACAATGGTAAATGAGATCATGTATCTGGCTTTAAAAGGAGATTTTAGAGAGAATGCATTCCTAGATGTGCACTTAGGGATATGTTTCACTTTCAACCTTACCAAGAAAGACTTAGATCTGATGGATTGTGATGTCCACTCAGTGAGTTCACAGGGTATCAATTTCTTGACACGAACCCTAGTGCTCTGGGCCTCTGCTTTGTCTTGTTTCTCGTCATGTGAGGCCAAAACCTTAGTCCTTGTTCTCATGTTTGTGGTATGGATGAAGCGCCGAGATAAAGAACGCCAGGCCAAGCAACTTTTAATTGATCCAGAAGATGATGTAAGAGATAATATTTTAAAATATGATGAAGAAGGTGGAGGAGAAGAAGACCAGGACTATGACTTGAGCCAGCTCCAGCAGCCTGATACTGTGGAACCAGATGCCATCAAGCCTGTTGGAATCCGACGGTTGGATGAGAGACCCATCCATGCTGAGCCCCAGTACCCGGTTCGATCTGCAGCCCCTCACCCTGGGGACATCGGGGACTTCATTAATGAGGGTCTTAAAGCTGCTGACAATGATCCCACAGCTCCGCCATATGACTCCCTTCTAGTCTTTGACTATGAAGGCAGTGGCTCTACCGCTGGGTCCTTGAGCTCCCTTAATTCCTCCAGTAGTGGAGGTGAGCAGGACTATGATTACCTGAACGATTGGGGGCCACGTTTCAAGAAGCTCGCTGACATGTACGGTGGAGGTGATGACTGA

▼ KEYWORD

ID	Family
KW-0106	Calcium
KW-0130	Cell adhesion
KW-1003	Cell membrane
KW-0181	Complete proteome
KW-0472	Membrane
KW-1267	Proteomics identification
KW-1185	Reference proteome
KW-0677	Repeat
KW-0732	Signal
KW-0812	Transmembrane
KW-1133	Transmembrane helix

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0045177	Cellular Component	Apical part of cell
GO:0016324	Cellular Component	Apical plasma membrane
GO:0016323	Cellular Component	Basolateral plasma membrane
GO:0016342	Cellular Component	Catenin complex
GO:0009986	Cellular Component	Cell surface
GO:0005913	Cellular Component	Cell-cell adherens junction
GO:0030864	Cellular Component	Cortical actin cytoskeleton
GO:0005737	Cellular Component	Cytoplasm
GO:0005916	Cellular Component	Fascia adherens
GO:0099060	Cellular Component	Integral component of postsynaptic specialization membrane
GO:0099059	Cellular Component	Integral component of presynaptic active zone membrane
GO:0014704	Cellular Component	Intercalated disc
GO:0030027	Cellular Component	Lamellipodium
GO:0043005	Cellular Component	Neuron projection
GO:0005886	Cellular Component	Plasma membrane
GO:0044853	Cellular Component	Plasma membrane raft
GO:0014069	Cellular Component	Postsynaptic density
GO:0042383	Cellular Component	Sarcolemma
GO:0045202	Cellular Component	Synapse
GO:0045294	Molecular Function	Alpha-catenin binding
GO:0008013	Molecular Function	Beta-catenin binding
GO:0045296	Molecular Function	Cadherin binding
GO:0005509	Molecular Function	Calcium ion binding
GO:0008092	Molecular Function	Cytoskeletal protein binding
GO:0045295	Molecular Function	Gamma-catenin binding
GO:0042803	Molecular Function	Protein homodimerization activity
GO:0019901	Molecular Function	Protein kinase binding
GO:0019903	Molecular Function	Protein phosphatase binding
GO:0034332	Biological Process	Adherens junction organization
GO:0048514	Biological Process	Blood vessel morphogenesis
GO:0048854	Biological Process	Brain morphogenesis
GO:0016339	Biological Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016477	Biological Process	Cell migration
GO:0000902	Biological Process	Cell morphogenesis
GO:0098609	Biological Process	Cell-cell adhesion
GO:0044331	Biological Process	Cell-cell adhesion mediated by cadherin
GO:0007043	Biological Process	Cell-cell junction assembly
GO:0021987	Biological Process	Cerebral cortex development
GO:0007157	Biological Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0048872	Biological Process	Homeostasis of number of cells
GO:0007156	Biological Process	Homophilic cell adhesion via plasma membrane adhesion molecules
GO:0090090	Biological Process	Negative regulation of canonical Wnt signaling pathway
GO:0060563	Biological Process	Neuroepithelial cell differentiation
GO:0097118	Biological Process	Neuroligin clustering involved in postsynaptic membrane assembly
GO:0097150	Biological Process	Neuronal stem cell population maintenance
GO:0043410	Biological Process	Positive regulation of MAPK cascade
GO:2000809	Biological Process	Positive regulation of synaptic vesicle clustering
GO:0072659	Biological Process	Protein localization to plasma membrane
GO:0060019	Biological Process	Radial glial cell differentiation
GO:0050770	Biological Process	Regulation of axonogenesis
GO:0070445	Biological Process	Regulation of oligodendrocyte progenitor proliferation
GO:1902897	Biological Process	Regulation of postsynaptic density protein 95 clustering
GO:0051966	Biological Process	Regulation of synaptic transmission, glutamatergic
GO:0051146	Biological Process	Striated muscle cell differentiation
GO:0007416	Biological Process	Synapse assembly

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Hos-a924	Homo sapiens	0.0	1826	undefined
LLPS-Mum-a909	Mus musculus	0.0	1796	undefined

LLPS-Sus-a908CDH2

Protein Sequence

Nucleotide Sequence

LLPS-Sus-a908
CDH2