• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Sus-2886
CALR

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Calreticulin; CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP
Gene Name: CALR
Ensembl Gene: ENSSSCG00000013746.3
Ensembl Protein: ENSSSCP00000042930.1
Organism: Sus scrofa
Taxa ID: 9823
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLLPVPLLLG  LVGLAAAEPT  IYFKEQFLDG  DGWTDRWIES  KHKPDFGRFV  LSSGKFYGDQ  60
61    EKDKGLQTSQ  DARFYALSAR  FEPFSNKGQT  LVVQFTVKHE  QNIDCGGGYV  KLFPDGLDQT  120
121   DMHGDSEYNI  MFGPDICGPG  TKKVHVIFNY  KGKNVLINKD  IRCKDDEFTH  LYTLIVRPDN  180
181   TYEVKIDNSQ  VESGSLEDDW  DFLPPKKIKD  PDAVKPEDWD  ERAKIDDPTD  SKPEDWDKPE  240
241   HIPDPDAKKP  EDWDEEMDGE  WEPPVIQNPE  YKGEWKPRQI  DNPDYKGTWI  HPEIDNPEYS  300
301   PDSNIYAYEN  FAVLGLDLWQ  VKSGTIFDNF  LITNDEAYAE  EFGNETWGVT  KAAEKQMKDK  360
361   QDEEQRLKEE  EEEKKRKEEE  EVDKEDEEDK  DEDEEEEDEK  EEEEEEDAAA  GQAKDEL  417
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCTCC  CAGTCCCACT  ACTGCTCGGC  CTTGTCGGCC  TGGCCGCCGC  TGAACCCACT  60
61    ATTTACTTCA  AGGAGCAATT  TCTGGACGGA  GACGGGTGGA  CTGATCGCTG  GATTGAATCC  120
121   AAACACAAAC  CGGATTTTGG  CAGATTCGTT  CTCAGTTCCG  GCAAATTCTA  CGGTGACCAG  180
181   GAGAAAGATA  AAGGGCTACA  GACAAGCCAG  GATGCCCGGT  TTTACGCTCT  GTCGGCCAGA  240
241   TTTGAGCCCT  TCAGCAACAA  GGGTCAGACG  CTGGTAGTGC  AGTTCACGGT  GAAACACGAA  300
301   CAGAACATCG  ACTGTGGGGG  TGGATACGTG  AAGCTGTTTC  CAGATGGTTT  GGACCAGACA  360
361   GACATGCATG  GAGACTCCGA  ATACAACATC  ATGTTTGGCC  CGGACATCTG  TGGCCCTGGC  420
421   ACCAAGAAAG  TTCATGTCAT  CTTCAACTAC  AAGGGCAAGA  ACGTGCTCAT  CAATAAGGAT  480
481   ATCCGTTGCA  AGGATGATGA  ATTCACACAC  CTGTACACAC  TGATTGTGCG  GCCCGATAAT  540
541   ACTTATGAGG  TGAAGATTGA  CAACAGTCAG  GTGGAGTCAG  GCTCCTTGGA  GGACGATTGG  600
601   GACTTCTTGC  CGCCTAAGAA  GATAAAGGAT  CCTGATGCTG  TGAAGCCTGA  AGACTGGGAC  660
661   GAGCGAGCCA  AAATTGATGA  CCCTACAGAC  TCCAAACCTG  AGGACTGGGA  CAAGCCTGAA  720
721   CACATTCCTG  ACCCTGATGC  TAAGAAGCCC  GAAGACTGGG  ATGAAGAGAT  GGATGGAGAG  780
781   TGGGAACCGC  CAGTGATACA  GAACCCAGAG  TACAAGGGTG  AGTGGAAGCC  CAGGCAGATT  840
841   GACAACCCCG  ATTACAAGGG  CACTTGGATC  CACCCAGAAA  TAGACAACCC  TGAGTACTCC  900
901   CCTGATAGCA  ACATCTATGC  CTATGAAAAC  TTTGCTGTGC  TGGGCCTGGA  TCTCTGGCAG  960
961   GTCAAGTCTG  GTACCATCTT  TGACAACTTC  CTCATTACCA  ACGATGAGGC  CTACGCTGAG  1020
1021  GAGTTTGGCA  ACGAGACATG  GGGTGTTACA  AAGGCAGCAG  AAAAGCAAAT  GAAAGACAAG  1080
1081  CAGGATGAAG  AGCAGAGGCT  AAAGGAGGAG  GAGGAGGAGA  AGAAGCGCAA  GGAAGAGGAG  1140
1141  GAGGTAGACA  AGGAAGACGA  GGAGGACAAG  GATGAGGATG  AGGAGGAGGA  GGATGAGAAG  1200
1201  GAGGAAGAGG  AGGAGGAAGA  TGCTGCCGCT  GGCCAGGCCA  AGGATGAGCT  GTAG  1254

▼ KEYWORD

ID
Family
Acetylation
Calcium
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Lectin
Membrane
Metal-binding
Reference proteome
Repeat
Sarcoplasmic reticulum
Signal
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Endoplasmic reticulum quality control compartment
Cellular Component
External side of plasma membrane
Cellular Component
Extracellular space
Cellular Component
MHC class I peptide loading complex
Cellular Component
Nuclear envelope
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Polysome
Cellular Component
Sarcoplasmic reticulum lumen
Molecular Function
Androgen receptor binding
Molecular Function
Calcium ion binding
Molecular Function
Carbohydrate binding
Molecular Function
Integrin binding
Molecular Function
MRNA binding
Molecular Function
Ubiquitin protein ligase binding
Molecular Function
Unfolded protein binding
Biological Process
Cellular senescence
Biological Process
Cortical actin cytoskeleton organization
Biological Process
Negative regulation of cell cycle arrest
Biological Process
Negative regulation of intracellular steroid hormone receptor signaling pathway
Biological Process
Negative regulation of neuron differentiation
Biological Process
Negative regulation of retinoic acid receptor signaling pathway
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Negative regulation of translation
Biological Process
Negative regulation of trophoblast cell migration
Biological Process
Peptide antigen assembly with MHC class I protein complex
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of dendritic cell chemotaxis
Biological Process
Positive regulation of endothelial cell migration
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of NIK/NF-kappaB signaling
Biological Process
Positive regulation of phagocytosis
Biological Process
Positive regulation of substrate adhesion-dependent cell spreading
Biological Process
Protein export from nucleus
Biological Process
Protein folding
Biological Process
Protein localization to nucleus
Biological Process
Protein stabilization
Biological Process
Regulation of meiotic nuclear division

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-4044Ursus maritimus98.830.0 660
LLPS-Fec-3684Felis catus98.540.0 661
LLPS-Caf-4180Canis familiaris98.540.0 657
LLPS-Mup-1597Mustela putorius furo98.540.0 659
LLPS-Aim-4110Ailuropoda melanoleuca97.960.0 655
LLPS-Tut-0738Tursiops truncatus97.950.0 657
LLPS-Ova-2673Ovis aries97.380.0 654
LLPS-Mea-0602Mesocricetus auratus97.321e-141 413
LLPS-Eqc-2783Equus caballus96.790.0 650
LLPS-Bot-2863Bos taurus96.790.0 649
LLPS-Myl-0215Myotis lucifugus96.780.0 647
LLPS-Cas-1485Carlito syrichta96.50.0 648
LLPS-Dio-4136Dipodomys ordii96.210.0 643
LLPS-Otg-2094Otolemur garnettii96.180.0 642
LLPS-Caj-4835Callithrix jacchus96.180.0 637
LLPS-Ran-4630Rattus norvegicus96.180.0 640
LLPS-Hos-1238Homo sapiens95.880.0 637
LLPS-Man-1854Macaca nemestrina95.880.0 637
LLPS-Poa-0977Pongo abelii95.880.0 637
LLPS-Maf-1648Macaca fascicularis95.880.0 637
LLPS-Chs-2437Chlorocebus sabaeus95.880.0 637
LLPS-Paa-4374Papio anubis95.880.0 637
LLPS-Mal-4327Mandrillus leucophaeus95.880.0 637
LLPS-Fud-1577Fukomys damarensis95.630.0 646
LLPS-Pat-4442Pan troglodytes95.590.0 635
LLPS-Nol-2865Nomascus leucogenys95.590.0 636
LLPS-Gog-3579Gorilla gorilla95.590.0 636
LLPS-Mum-3677Mus musculus95.590.0 637
LLPS-Cea-2369Cercocebus atys95.390.0 565
LLPS-Rhb-0947Rhinopithecus bieti95.340.0 641
LLPS-Loa-1826Loxodonta africana95.340.0 642
LLPS-Pap-1781Pan paniscus95.290.0 634
LLPS-Ict-3404Ictidomys tridecemlineatus94.750.0 635
LLPS-Cap-2643Cavia porcellus94.170.0 637
LLPS-Meg-0522Meleagris gallopavo92.616e-141 409
LLPS-Aon-0719Aotus nancymaae90.490.0 598
LLPS-Fia-3396Ficedula albicollis89.414e-108 323
LLPS-Ora-3165Ornithorhynchus anatinus88.820.0 600
LLPS-Sah-0721Sarcophilus harrisii88.50.0 598
LLPS-Tag-0660Taeniopygia guttata87.224e-82 255
LLPS-Gaga-0929Gallus gallus86.590.0 594
LLPS-Anc-3830Anolis carolinensis86.130.0 578
LLPS-Pes-1324Pelodiscus sinensis86.060.0 555
LLPS-Mod-2787Monodelphis domestica84.750.0 561
LLPS-Mam-1719Macaca mulatta84.270.0 602
LLPS-Leo-2021Lepisosteus oculatus82.650.0 567
LLPS-Xet-3672Xenopus tropicalis81.630.0 558
LLPS-Orn-0489Oreochromis niloticus80.940.0 547
LLPS-Pof-0146Poecilia formosa79.770.0 539
LLPS-Xim-3989Xiphophorus maculatus79.770.0 539
LLPS-Asm-0473Astyanax mexicanus79.590.0 544
LLPS-Scf-2358Scleropages formosus79.590.0 545
LLPS-Dar-1558Danio rerio79.530.0 541
LLPS-Icp-2424Ictalurus punctatus79.530.0 540
LLPS-Tar-3182Takifugu rubripes78.890.0 538
LLPS-Gaa-3996Gasterosteus aculeatus78.530.0 530
LLPS-Ten-0338Tetraodon nigroviridis78.30.0 538
LLPS-Lac-2406Latimeria chalumnae77.980.0 523
LLPS-Orl-3057Oryzias latipes77.450.0 526
LLPS-Scm-0892Scophthalmus maximus76.020.0 519
LLPS-Cis-0021Ciona savignyi74.059e-171 492
LLPS-Drm-1968Drosophila melanogaster71.37e-156 454
LLPS-Cii-0397Ciona intestinalis70.553e-165 478
LLPS-Orc-1158Oryctolagus cuniculus69.021e-154 451
LLPS-Cae-1140Caenorhabditis elegans67.63e-144 424
LLPS-Anp-0190Anas platyrhynchos65.387e-156 454
LLPS-Sei-1794Setaria italica59.037e-114 345
LLPS-Mua-1018Musa acuminata58.74e-121 365
LLPS-Zem-1909Zea mays57.651e-118 359
LLPS-Org-0056Oryza glaberrima57.524e-118 358
LLPS-Orr-1331Oryza rufipogon57.524e-118 358
LLPS-Orm-1707Oryza meridionalis57.523e-118 358
LLPS-Orni-0306Oryza nivara57.522e-118 358
LLPS-Orb-1974Oryza barthii57.524e-118 358
LLPS-Ori-1778Oryza indica57.524e-118 358
LLPS-Orgl-0038Oryza glumaepatula57.522e-118 359
LLPS-Orbr-1887Oryza brachyantha57.453e-115 351
LLPS-Sob-2383Sorghum bicolor57.392e-121 366
LLPS-Ors-1766Oryza sativa57.232e-117 356
LLPS-Amt-0811Amborella trichopoda57.142e-117 355
LLPS-Chr-1666Chlamydomonas reinhardtii57.144e-117 355
LLPS-Lep-0997Leersia perrieri56.931e-116 354
LLPS-Orp-1300Oryza punctata56.812e-118 359
LLPS-Mae-1451Manihot esculenta56.82e-115 351
LLPS-Prp-1180Prunus persica56.641e-117 357
LLPS-Brr-1869Brassica rapa56.527e-117 362
LLPS-Hov-1606Hordeum vulgare56.517e-116 353
LLPS-Via-1549Vigna angularis56.424e-116 353
LLPS-Tru-1845Triticum urartu56.342e-117 356
LLPS-Tra-2056Triticum aestivum56.341e-117 356
LLPS-Nia-0107Nicotiana attenuata56.32e-117 356
LLPS-Viv-1381Vitis vinifera56.232e-118 358
LLPS-Dac-0811Daucus carota56.052e-113 345
LLPS-Phv-1504Phaseolus vulgaris55.988e-116 352
LLPS-Abg-1270Absidia glauca55.862e-113 347
LLPS-Glm-2470Glycine max55.757e-115 350
LLPS-Art-1224Arabidopsis thaliana55.653e-117 356
LLPS-Bro-1656Brassica oleracea55.652e-117 357
LLPS-Brn-0366Brassica napus55.653e-117 356
LLPS-Arl-1715Arabidopsis lyrata55.651e-116 354
LLPS-Gor-1407Gossypium raimondii55.563e-116 353
LLPS-Coc-0502Corchorus capsularis55.435e-116 353
LLPS-Sol-0457Solanum lycopersicum55.439e-116 351
LLPS-Hea-0883Helianthus annuus55.397e-117 354
LLPS-Met-0455Medicago truncatula55.169e-115 349
LLPS-Brd-1769Brachypodium distachyon55.162e-114 349
LLPS-Pot-2516Populus trichocarpa55.138e-117 354
LLPS-Sot-0588Solanum tuberosum55.135e-114 347
LLPS-Thc-1979Theobroma cacao54.554e-115 350
LLPS-Php-1378Physcomitrella patens54.477e-115 348
LLPS-Sem-1207Selaginella moellendorffii53.241e-116 353
LLPS-Cus-1705Cucumis sativus52.173e-108 332
LLPS-Vir-0308Vigna radiata46.063e-86 275
LLPS-Tum-1593Tuber melanosporum37.192e-53 192