LLPS-Scp-1520
eaf6
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Chromatin modification-related protein eaf6 |
| Gene Name: | eaf6, SPAC6F6.09 |
| Ensembl Gene: | SPAC6F6.09 |
| Ensembl Protein: | SPAC6F6.09.1 |
| Organism: | Schizosaccharomyces pombe |
| Taxa ID: | 284812 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | SPAC6F6.09.1 | SPAC6F6.09.1 |
| UniProt | O14240, EAF6_SCHPO | |
| GeneBank | CU329670 | CAB11732.1 |
| RefSeq | NM_001019332.2 | NP_593902.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSTPNSTPSE PPVNVSYYEQ CKKELHEMIE KRQLLETSLI GLEDSIYRLE GSYLEKTSGT 60 61 GNIIRGFEGL LKNNASNLRR RADYSESDRL FSLSSLSSPH TRSPAYDLDD STETSRRRKR 120 121 KNESDSHEGR RRSSFREL 138 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGACTC CCAATTCGAC GCCTAGCGAG CCACCCGTGA ATGTTTCCTA TTATGAACAG 60 61 TGCAAAAAGG AGCTTCATGA AATGATTGAA AAGCGACAAT TGTTGGAAAC TTCGTTAATA 120 121 GGTCTCGAGG ACTCTATCTA TAGGCTGGAA GGCAGTTACT TAGAAAAAAC ATCGGGTACT 180 181 GGCAACATTA TTCGTGGATT CGAAGGTCTT TTAAAAAACA ATGCATCAAA CCTCCGCCGT 240 241 CGTGCAGACT ATTCGGAATC AGACAGACTG TTTTCTCTTT CTTCCCTGTC GAGTCCCCAT 300 301 ACACGTAGTC CAGCTTATGA CCTCGACGAC TCGACAGAAA CTAGTCGAAG AAGAAAACGA 360 361 AAAAATGAAT CTGATAGTCA CGAAGGAAGA AGACGTTCTT CTTTTCGAGA ACTATAA 417 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | H4/H2A histone acetyltransferase complex | |
Cellular Component | MOZ/MORF histone acetyltransferase complex | |
Cellular Component | Mst2 histone acetyltransferase complex | |
Cellular Component | NuA3a histone acetyltransferase complex | |
Cellular Component | NuA3b histone acetyltransferase complex | |
Cellular Component | NuA4 histone acetyltransferase complex | |
Cellular Component | Nuclear chromatin | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Biological Process | Chromatin remodeling | |
Biological Process | DNA repair | |
Biological Process | Histone acetylation | |
Biological Process | Histone H2A acetylation | |
Biological Process | Histone H3-K14 acetylation | |
Biological Process | Histone H3-K23 acetylation | |
Biological Process | Histone H4-K12 acetylation | |
Biological Process | Histone H4-K5 acetylation | |
Biological Process | Histone H4-K8 acetylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scc-1353 | Schizosaccharomyces cryophilus | 69.34 | 3e-49 | 161 |
| LLPS-Aon-2110 | Aotus nancymaae | 50.0 | 6e-07 | 50.1 |
| LLPS-Drm-2295 | Drosophila melanogaster | 49.02 | 3e-06 | 48.5 |
| LLPS-Scj-0134 | Schizosaccharomyces japonicus | 48.97 | 3e-29 | 109 |
| LLPS-Orl-0666 | Oryzias latipes | 48.08 | 1e-08 | 55.5 |
| LLPS-Asm-3380 | Astyanax mexicanus | 48.08 | 2e-08 | 55.1 |
| LLPS-Abg-1582 | Absidia glauca | 47.83 | 2e-13 | 68.2 |
| LLPS-Xim-4144 | Xiphophorus maculatus | 47.17 | 7e-09 | 55.5 |
| LLPS-Gaa-0651 | Gasterosteus aculeatus | 47.17 | 6e-09 | 55.5 |
| LLPS-Icp-0497 | Ictalurus punctatus | 47.17 | 9e-09 | 55.1 |
| LLPS-Dar-2161 | Danio rerio | 47.17 | 8e-09 | 55.1 |
| LLPS-Pof-0901 | Poecilia formosa | 47.17 | 7e-09 | 55.5 |
| LLPS-Scm-0303 | Scophthalmus maximus | 47.17 | 6e-09 | 55.5 |
| LLPS-Orn-2484 | Oreochromis niloticus | 47.17 | 6e-09 | 55.8 |
| LLPS-Ast-1471 | Aspergillus terreus | 46.43 | 4e-11 | 61.6 |
| LLPS-Bot-0399 | Bos taurus | 46.03 | 3e-08 | 53.9 |
| LLPS-Mam-4204 | Macaca mulatta | 46.03 | 2e-08 | 54.3 |
| LLPS-Mod-0696 | Monodelphis domestica | 46.03 | 3e-07 | 52.8 |
| LLPS-Dos-1620 | Dothistroma septosporum | 45.61 | 5e-11 | 61.2 |
| LLPS-Dio-4382 | Dipodomys ordii | 45.31 | 2e-08 | 54.3 |
| LLPS-Scf-0460 | Scleropages formosus | 45.31 | 4e-08 | 53.5 |
| LLPS-Ran-2770 | Rattus norvegicus | 45.31 | 1e-08 | 54.7 |
| LLPS-Paa-2586 | Papio anubis | 45.31 | 1e-08 | 54.7 |
| LLPS-Maf-3938 | Macaca fascicularis | 45.31 | 1e-08 | 54.7 |
| LLPS-Mum-4732 | Mus musculus | 45.31 | 2e-08 | 54.3 |
| LLPS-Ora-1036 | Ornithorhynchus anatinus | 45.31 | 1e-08 | 54.7 |
| LLPS-Chs-0943 | Chlorocebus sabaeus | 45.31 | 1e-08 | 54.7 |
| LLPS-Sus-3398 | Sus scrofa | 45.31 | 3e-08 | 53.9 |
| LLPS-Leo-3274 | Lepisosteus oculatus | 45.31 | 2e-08 | 54.3 |
| LLPS-Cea-0089 | Cercocebus atys | 45.31 | 1e-08 | 54.7 |
| LLPS-Sah-2035 | Sarcophilus harrisii | 45.31 | 1e-08 | 54.7 |
| LLPS-Caj-2202 | Callithrix jacchus | 45.31 | 1e-08 | 54.7 |
| LLPS-Poa-3461 | Pongo abelii | 45.31 | 1e-08 | 54.7 |
| LLPS-Eqc-0987 | Equus caballus | 45.31 | 2e-08 | 54.3 |
| LLPS-Xet-2280 | Xenopus tropicalis | 45.31 | 4e-08 | 53.5 |
| LLPS-Gaga-3085 | Gallus gallus | 45.31 | 2e-08 | 54.3 |
| LLPS-Hos-1829 | Homo sapiens | 45.31 | 1e-08 | 54.7 |
| LLPS-Pat-2104 | Pan troglodytes | 45.31 | 1e-08 | 54.7 |
| LLPS-Fec-2520 | Felis catus | 45.31 | 1e-08 | 54.7 |
| LLPS-Lac-4040 | Latimeria chalumnae | 45.31 | 2e-08 | 53.9 |
| LLPS-Man-1036 | Macaca nemestrina | 45.31 | 1e-08 | 54.7 |
| LLPS-Otg-3971 | Otolemur garnettii | 45.31 | 1e-08 | 54.7 |
| LLPS-Asf-0324 | Aspergillus flavus | 44.83 | 2e-11 | 62.8 |
| LLPS-Cii-0473 | Ciona intestinalis | 44.44 | 6e-07 | 50.1 |
| LLPS-Asfu-0798 | Aspergillus fumigatus | 43.55 | 2e-11 | 63.2 |
| LLPS-Crn-0888 | Cryptococcus neoformans | 43.4 | 3e-08 | 52.8 |
| LLPS-Nef-0580 | Neosartorya fischeri | 43.33 | 4e-11 | 62.4 |
| LLPS-Nia-2001 | Nicotiana attenuata | 42.62 | 3e-06 | 47.8 |
| LLPS-Tar-0364 | Takifugu rubripes | 41.1 | 4e-09 | 57.0 |
| LLPS-Gag-0847 | Gaeumannomyces graminis | 41.1 | 6e-08 | 52.8 |
| LLPS-Ten-0260 | Tetraodon nigroviridis | 41.1 | 1e-09 | 57.4 |
| LLPS-Hea-0319 | Helianthus annuus | 40.98 | 1e-06 | 48.5 |
| LLPS-Asn-1361 | Aspergillus nidulans | 40.62 | 5e-11 | 62.0 |
| LLPS-Asc-1152 | Aspergillus clavatus | 40.54 | 5e-12 | 64.7 |
| LLPS-Map-1108 | Magnaporthe poae | 40.26 | 3e-09 | 56.2 |
| LLPS-Tum-0322 | Tuber melanosporum | 40.0 | 8e-08 | 52.4 |
| LLPS-Cis-1837 | Ciona savignyi | 39.06 | 4e-07 | 50.4 |
| LLPS-Coc-0423 | Corchorus capsularis | 37.93 | 9e-06 | 46.2 |
| LLPS-Viv-0391 | Vitis vinifera | 37.93 | 5e-06 | 47.0 |
| LLPS-Kop-1349 | Komagataella pastoris | 37.88 | 4e-10 | 58.5 |
| LLPS-Amt-1922 | Amborella trichopoda | 37.74 | 3e-06 | 45.8 |