• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Scp-1053
pol3

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA polymerase delta catalytic subunit; DNA polymerase III
Gene Name: pol3, pold, SPBC336.04
Ensembl Gene: SPBC336.04
Ensembl Protein: SPBC336.04.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MTDRSSNEGV  VLNKENYPFP  RRNGSIHGEI  TDVKRRRLSE  RNGYGDKKGS  SSKEKTSSFE  60
61    DELAEYASQL  DQDEIKSSKD  QQWQRPALPA  INPEKDDIYF  QQIDSEEFTE  GSVPSIRLFG  120
121   VTDNGNSILV  HVVGFLPYFY  VKAPVGFRPE  MLERFTQDLD  ATCNGGVIDH  CIIEMKENLY  180
181   GFQGNEKSPF  IKIFTTNPRI  LSRARNVFER  GEFNFEELFP  VGVGVTTFES  NTQYLLRFMI  240
241   DCDVVGMNWI  HLPASKYQFR  YQNRVSNCQI  EAWINYKDLI  SLPAEGQWSK  MAPLRIMSFD  300
301   IECAGRKGVF  PDPSIDPVIQ  IASIVTQYGD  STPFVRNVFC  VDTCSQIVGT  QVYEFQNQAE  360
361   MLSSWSKFVR  DVDPDVLIGY  NICNFDIPYL  LDRAKSLRIH  NFPLLGRIHN  FFSVAKETTF  420
421   SSKAYGTRES  KTTSIPGRLQ  LDMLQVMQRD  FKLRSYSLNA  VCSQFLGEQK  EDVHYSIITD  480
481   LQNGTADSRR  RLAIYCLKDA  YLPQRLMDKL  MCFVNYTEMA  RVTGVPFNFL  LARGQQIKVI  540
541   SQLFRKALQH  DLVVPNIRVN  GTDEQYEGAT  VIEPIKGYYD  TPIATLDFSS  LYPSIMQAHN  600
601   LCYTTLLDSN  TAELLKLKQD  VDYSVTPNGD  YFVKPHVRKG  LLPIILADLL  NARKKAKADL  660
661   KKETDPFKKA  VLDGRQLALK  VSANSVYGFT  GATNGRLPCL  AISSSVTSYG  RQMIEKTKDV  720
721   VEKRYRIENG  YSHDAVVIYG  DTDSVMVKFG  VKTLPEAMKL  GEEAANYVSD  QFPNPIKLEF  780
781   EKVYFPYLLI  SKKRYAGLFW  TRTDTYDKMD  SKGIETVRRD  NCPLVSYVID  TALRKMLIDQ  840
841   DVEGAQLFTK  KVISDLLQNK  IDMSQLVITK  ALSKTDYAAK  MAHVELAERM  RKRDAGSAPA  900
901   IGDRVAYVII  KGAQGDQFYM  RSEDPIYVLE  NNIPIDAKYY  LENQLSKPLL  RIFEPILGEK  960
961   ASSLLHGDHT  RTISMAAPSV  GGIMKFAVKV  ETCLGCKAPI  KKGKTALCEN  CLNRSAELYQ  1020
1021  RQVAQVNDLE  VRFARLWTQC  QRCQGSMHQD  VICTSRDCPI  FYMRIAEHKK  LQQSVDLLKR  1080
1081  FDEMSW  1086
Nucleotide CDS Sequence (FASTA)
1     ATGACAGATA  GGTCTTCAAA  TGAGGGCGTC  GTGTTAAATA  AAGAAAACTA  TCCATTTCCC  60
61    CGAAGAAATG  GTTCAATTCA  TGGCGAAATT  ACAGATGTCA  AACGGCGACG  TTTAAGCGAA  120
121   AGAAATGGAT  ATGGTGATAA  AAAGGGCTCA  TCCTCAAAAG  AAAAAACTTC  ATCTTTTGAG  180
181   GATGAGCTGG  CTGAATACGC  TTCACAATTG  GACCAAGATG  AAATAAAATC  TTCAAAAGAT  240
241   CAGCAGTGGC  AACGACCAGC  TTTACCTGCA  ATAAATCCTG  AGAAGGATGA  TATTTATTTT  300
301   CAGCAAATCG  ATAGTGAGGA  GTTCACAGAA  GGATCTGTAC  CTTCAATTCG  TTTGTTTGGT  360
361   GTTACTGACA  ATGGAAACAG  CATCCTTGTT  CATGTTGTGG  GATTCCTTCC  GTACTTTTAT  420
421   GTTAAAGCCC  CGGTTGGATT  TCGACCTGAG  ATGCTAGAAC  GTTTCACACA  AGATTTAGAT  480
481   GCTACTTGTA  ATGGGGGTGT  GATCGATCAT  TGCATTATAG  AGATGAAGGA  AAATTTATAT  540
541   GGATTTCAGG  GAAATGAAAA  ATCTCCATTC  ATTAAAATCT  TTACTACTAA  CCCTCGTATA  600
601   TTATCTCGAG  CACGAAATGT  ATTTGAAAGA  GGAGAATTCA  ACTTCGAAGA  GCTTTTCCCT  660
661   GTTGGTGTCG  GTGTCACTAC  TTTTGAGAGC  AATACGCAAT  ATCTTCTTAG  ATTCATGATT  720
721   GACTGTGATG  TTGTTGGTAT  GAATTGGATT  CATCTTCCTG  CTTCAAAATA  TCAATTTCGT  780
781   TACCAGAATC  GAGTTTCTAA  TTGTCAAATT  GAAGCTTGGA  TTAATTACAA  AGACTTGATC  840
841   AGTCTTCCAG  CTGAAGGCCA  GTGGTCTAAA  ATGGCCCCAC  TGAGGATCAT  GAGCTTTGAT  900
901   ATTGAATGCG  CAGGTCGCAA  AGGCGTTTTT  CCTGATCCCT  CTATTGACCC  TGTAATTCAA  960
961   ATTGCAAGTA  TAGTAACGCA  GTATGGAGAC  TCCACTCCTT  TTGTTCGTAA  TGTCTTTTGT  1020
1021  GTTGATACAT  GCTCACAAAT  CGTTGGAACA  CAAGTATATG  AATTTCAAAA  TCAGGCTGAA  1080
1081  ATGCTTTCAA  GTTGGTCAAA  ATTTGTTCGT  GATGTTGACC  CAGATGTTTT  AATTGGGTAC  1140
1141  AACATCTGCA  ACTTTGATAT  CCCTTACCTC  TTGGATCGAG  CAAAAAGCTT  ACGCATTCAC  1200
1201  AATTTCCCAT  TACTTGGCCG  TATTCATAAT  TTTTTTTCTG  TCGCAAAGGA  AACCACGTTT  1260
1261  TCAAGTAAAG  CATATGGTAC  TCGTGAAAGC  AAAACCACTA  GTATTCCTGG  GCGTTTGCAG  1320
1321  CTTGATATGT  TACAAGTAAT  GCAGCGTGAT  TTTAAGCTTC  GATCTTACTC  TTTAAATGCA  1380
1381  GTCTGCTCTC  AGTTTCTAGG  CGAGCAAAAA  GAAGATGTAC  ACTATTCTAT  CATCACTGAC  1440
1441  TTGCAAAATG  GCACTGCCGA  TTCTAGAAGA  CGTTTAGCTA  TTTATTGTCT  GAAAGATGCA  1500
1501  TATTTACCCC  AACGCTTAAT  GGACAAATTA  ATGTGTTTTG  TTAACTATAC  TGAAATGGCA  1560
1561  AGAGTAACAG  GTGTACCGTT  TAATTTTCTT  CTTGCTAGAG  GCCAACAGAT  TAAAGTTATT  1620
1621  TCTCAATTGT  TTCGCAAAGC  TCTTCAACAT  GACCTAGTTG  TTCCAAATAT  ACGTGTAAAT  1680
1681  GGAACAGATG  AGCAATATGA  AGGTGCTACA  GTCATTGAAC  CGATTAAAGG  ATACTATGAT  1740
1741  ACCCCTATTG  CAACACTGGA  TTTTAGTTCA  CTTTATCCTT  CGATTATGCA  AGCCCATAAT  1800
1801  TTATGCTATA  CGACATTACT  TGACTCAAAT  ACTGCAGAAT  TATTAAAACT  TAAGCAAGAT  1860
1861  GTTGACTACT  CAGTGACTCC  GAACGGAGAT  TATTTCGTTA  AACCACATGT  TCGTAAAGGA  1920
1921  CTACTCCCTA  TTATCTTAGC  TGATTTACTT  AATGCACGTA  AGAAAGCAAA  AGCAGATCTA  1980
1981  AAAAAGGAAA  CGGACCCATT  CAAAAAGGCT  GTTTTGGATG  GTAGACAGCT  AGCTTTAAAA  2040
2041  GTAAGTGCTA  ATTCAGTATA  TGGATTTACT  GGTGCTACCA  ACGGACGTTT  GCCGTGTTTA  2100
2101  GCAATTTCTT  CTTCTGTTAC  CTCTTATGGT  CGACAAATGA  TTGAAAAAAC  CAAGGATGTT  2160
2161  GTAGAAAAGA  GATACAGAAT  TGAGAATGGA  TACTCTCACG  ATGCAGTTGT  AATCTATGGT  2220
2221  GACACTGATT  CTGTTATGGT  TAAGTTTGGC  GTTAAAACGT  TACCTGAAGC  CATGAAATTA  2280
2281  GGAGAGGAAG  CAGCTAATTA  TGTTTCAGAC  CAGTTTCCGA  ATCCTATTAA  ACTGGAGTTT  2340
2341  GAGAAAGTGT  ACTTTCCATA  TCTTTTAATT  TCCAAAAAAC  GTTATGCAGG  ATTATTTTGG  2400
2401  ACTCGTACAG  ATACTTATGA  TAAAATGGAC  TCTAAAGGAA  TAGAAACTGT  CAGAAGAGAT  2460
2461  AACTGTCCTC  TAGTATCTTA  TGTGATTGAC  ACAGCTTTGA  GAAAAATGTT  AATTGATCAG  2520
2521  GATGTAGAGG  GTGCACAGTT  GTTTACAAAA  AAAGTTATTT  CCGATTTGTT  ACAAAACAAA  2580
2581  ATTGATATGT  CACAACTTGT  AATCACAAAG  GCATTATCAA  AAACTGATTA  TGCTGCCAAA  2640
2641  ATGGCACACG  TTGAATTGGC  TGAGCGAATG  CGTAAACGAG  ATGCTGGCTC  CGCCCCAGCC  2700
2701  ATAGGAGATC  GCGTTGCATA  CGTTATTATT  AAAGGTGCAC  AAGGTGATCA  ATTTTATATG  2760
2761  AGGTCGGAGG  ACCCTATATA  TGTATTGGAA  AATAACATTC  CTATTGATGC  AAAATATTAT  2820
2821  TTGGAAAATC  AACTCTCCAA  ACCTTTGCTT  AGAATTTTTG  AGCCTATTCT  TGGTGAAAAA  2880
2881  GCTAGCTCTT  TACTTCATGG  TGACCATACT  CGGACGATTT  CCATGGCAGC  CCCCAGTGTT  2940
2941  GGAGGAATAA  TGAAATTCGC  AGTAAAGGTT  GAGACCTGTC  TTGGATGCAA  AGCTCCCATA  3000
3001  AAAAAAGGTA  AAACTGCTTT  ATGTGAGAAT  TGTCTAAATA  GATCGGCGGA  ACTGTATCAA  3060
3061  CGTCAGGTTG  CTCAAGTGAA  TGATTTAGAA  GTTCGTTTTG  CTCGCTTATG  GACTCAATGT  3120
3121  CAGCGATGCC  AAGGAAGTAT  GCATCAAGAC  GTCATTTGTA  CCAGTAGAGA  CTGCCCCATA  3180
3181  TTTTATATGC  GAATTGCAGA  ACACAAGAAA  CTTCAGCAAT  CTGTTGACTT  ACTGAAAAGA  3240
3241  TTTGATGAAA  TGTCCTGGTG  A  3261

▼ KEYWORD


ID
Family
4Fe-4S
Complete proteome
DNA replication
DNA-binding
DNA-directed DNA polymerase
Exonuclease
Hydrolase
Iron
Iron-sulfur
Metal-binding
Nuclease
Nucleotidyltransferase
Nucleus
Reference proteome
Transferase
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Delta DNA polymerase complex
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nucleus
Molecular Function
3'-5' exonuclease activity
Molecular Function
3'-5'-exodeoxyribonuclease activity
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
DNA binding
Molecular Function
DNA-directed DNA polymerase activity
Molecular Function
Metal ion binding
Molecular Function
Nucleotide binding
Biological Process
Base-excision repair, gap-filling
Biological Process
DNA replication proofreading
Biological Process
DNA strand elongation involved in DNA replication
Biological Process
DNA synthesis involved in UV-damage excision repair
Biological Process
DNA-dependent DNA replication
Biological Process
Mitotic DNA replication lagging strand elongation
Biological Process
Nucleotide-excision repair, DNA gap filling

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-0094Schizosaccharomyces cryophilus85.70.01929
LLPS-Scj-0155Schizosaccharomyces japonicus77.390.01749
LLPS-Ora-0864Ornithorhynchus anatinus66.672e-118 373
LLPS-Miv-0571Microbotryum violaceum65.650.01401
LLPS-Ast-0800Aspergillus terreus65.190.01372
LLPS-Crn-0187Cryptococcus neoformans64.380.01391
LLPS-Mua-0168Musa acuminata64.371e-144 471
LLPS-Cogr-0618Colletotrichum graminicola64.350.01360
LLPS-Nia-0189Nicotiana attenuata64.350.0 750
LLPS-Asfu-1029Aspergillus fumigatus64.330.01355
LLPS-Asni-0117Aspergillus niger64.330.01361
LLPS-Asc-0091Aspergillus clavatus64.130.01352
LLPS-Nef-0527Neosartorya fischeri64.040.01350
LLPS-Cog-0330Colletotrichum gloeosporioides63.80.01341
LLPS-Ved-0423Verticillium dahliae63.710.01344
LLPS-Coo-0272Colletotrichum orbiculare63.670.01346
LLPS-Pug-0538Puccinia graminis63.650.01364
LLPS-Asf-0022Aspergillus flavus63.290.01358
LLPS-Aso-0280Aspergillus oryzae63.290.01358
LLPS-Zyt-0694Zymoseptoria tritici63.270.01349
LLPS-Nec-0263Neurospora crassa63.250.01350
LLPS-Via-1190Vigna angularis63.160.0 676
LLPS-Yal-0007Yarrowia lipolytica63.10.01356
LLPS-Lem-0136Leptosphaeria maculans63.070.01326
LLPS-Usm-0336Ustilago maydis63.020.01332
LLPS-Map-0709Magnaporthe poae62.870.01320
LLPS-Spr-1122Sporisorium reilianum62.850.01343
LLPS-Blg-0442Blumeria graminis62.720.01333
LLPS-Dos-0685Dothistroma septosporum62.710.01343
LLPS-Phn-0148Phaeosphaeria nodorum62.490.01317
LLPS-Mel-0056Melampsora laricipopulina62.460.01350
LLPS-Gag-0415Gaeumannomyces graminis62.440.01322
LLPS-Trr-0713Trichoderma reesei62.420.01342
LLPS-Mao-0819Magnaporthe oryzae62.420.01315
LLPS-Tum-0473Tuber melanosporum62.340.01296
LLPS-Pyt-0243Pyrenophora teres62.220.01314
LLPS-Fus-0768Fusarium solani62.190.01346
LLPS-Trv-0854Trichoderma virens62.130.01337
LLPS-Beb-0763Beauveria bassiana62.10.01321
LLPS-Fuo-0473Fusarium oxysporum61.90.01318
LLPS-Fuv-0387Fusarium verticillioides61.80.01306
LLPS-Kop-0648Komagataella pastoris61.220.01301
LLPS-Pytr-0264Pyrenophora triticirepentis61.070.01309
LLPS-Asn-0568Aspergillus nidulans60.480.01219
LLPS-Put-0295Puccinia triticina59.840.0 633
LLPS-Xim-1026Xiphophorus maculatus58.920.01214
LLPS-Sem-0516Selaginella moellendorffii58.920.01167
LLPS-Orl-0641Oryzias latipes58.810.01217
LLPS-Abg-0900Absidia glauca58.750.01244
LLPS-Pof-2148Poecilia formosa58.540.01202
LLPS-Dar-1681Danio rerio58.440.01215
LLPS-Tar-0496Takifugu rubripes58.440.01208
LLPS-Ten-1421Tetraodon nigroviridis58.360.01195
LLPS-Asm-1882Astyanax mexicanus58.340.01226
LLPS-Scm-1450Scophthalmus maximus57.960.01207
LLPS-Gaa-1244Gasterosteus aculeatus57.750.01185
LLPS-Org-0532Oryza glaberrima57.50.01192
LLPS-Lep-1228Leersia perrieri57.250.01192
LLPS-Sei-0080Setaria italica57.180.01197
LLPS-Tra-0944Triticum aestivum57.120.01198
LLPS-Xet-0839Xenopus tropicalis57.10.01164
LLPS-Orn-0766Oreochromis niloticus57.060.01207
LLPS-Amt-1119Amborella trichopoda57.050.01194
LLPS-Sob-0031Sorghum bicolor57.050.01201
LLPS-Ors-0109Oryza sativa57.050.01198
LLPS-Osl-0118Ostreococcus lucimarinus57.040.01118
LLPS-Zem-0106Zea mays56.950.01196
LLPS-Caj-0246Callithrix jacchus56.882e-50 198
LLPS-Orbr-1252Oryza brachyantha56.80.01187
LLPS-Pot-0140Populus trichocarpa56.750.01186
LLPS-Arl-0203Arabidopsis lyrata56.730.01157
LLPS-Ori-0391Oryza indica56.730.01185
LLPS-Vir-0057Vigna radiata56.70.01091
LLPS-Gor-0112Gossypium raimondii56.690.01170
LLPS-Brd-0428Brachypodium distachyon56.670.01195
LLPS-Orb-0937Oryza barthii56.630.01161
LLPS-Orp-0166Oryza punctata56.570.01187
LLPS-Anc-0202Anolis carolinensis56.560.01220
LLPS-Php-0115Physcomitrella patens56.520.01167
LLPS-Mae-0843Manihot esculenta56.50.01171
LLPS-Orr-1108Oryza rufipogon56.250.01167
LLPS-Hea-0073Helianthus annuus56.20.01174
LLPS-Orm-0919Oryza meridionalis56.190.01169
LLPS-Orni-0335Oryza nivara56.190.01168
LLPS-Met-0378Medicago truncatula56.150.01184
LLPS-Thc-0081Theobroma cacao56.110.01174
LLPS-Glm-0055Glycine max56.060.01169
LLPS-Prp-1494Prunus persica56.050.01179
LLPS-Sac-0181Saccharomyces cerevisiae56.040.01191
LLPS-Coc-0166Corchorus capsularis56.020.01170
LLPS-Hov-0106Hordeum vulgare55.830.01175
LLPS-Scf-1086Scleropages formosus55.750.01217
LLPS-Ict-2022Ictidomys tridecemlineatus55.570.01190
LLPS-Cii-1221Ciona intestinalis55.560.01142
LLPS-Brn-1163Brassica napus55.510.01156
LLPS-Art-0286Arabidopsis thaliana55.470.01147
LLPS-Dac-1751Daucus carota55.440.01149
LLPS-Bro-0119Brassica oleracea55.420.01156
LLPS-Lac-0293Latimeria chalumnae55.410.01151
LLPS-Pat-0946Pan troglodytes55.310.01192
LLPS-Cis-0402Ciona savignyi55.30.01121
LLPS-Bot-0877Bos taurus55.280.01185
LLPS-Paa-1806Papio anubis55.210.01192
LLPS-Cea-2281Cercocebus atys55.210.01191
LLPS-Maf-1890Macaca fascicularis55.210.01191
LLPS-Mea-0115Mesocricetus auratus55.210.01174
LLPS-Sol-0384Solanum lycopersicum55.180.01163
LLPS-Cus-0224Cucumis sativus55.150.01043
LLPS-Ran-0322Rattus norvegicus55.120.01171
LLPS-Mum-2118Mus musculus55.120.01177
LLPS-Caf-0691Canis familiaris55.110.01082
LLPS-Phv-0602Phaseolus vulgaris55.110.01164
LLPS-Otg-1380Otolemur garnettii55.110.01184
LLPS-Urm-0424Ursus maritimus55.02e-47 189
LLPS-Fec-1799Felis catus54.990.01180
LLPS-Mup-2489Mustela putorius furo54.990.01180
LLPS-Orgl-0533Oryza glumaepatula54.760.01118
LLPS-Sus-1896Sus scrofa54.610.01148
LLPS-Aim-0819Ailuropoda melanoleuca54.60.01164
LLPS-Asg-0013Ashbya gossypii54.520.01166
LLPS-Chs-0679Chlorocebus sabaeus54.470.01168
LLPS-Eqc-0017Equus caballus54.440.01156
LLPS-Man-1210Macaca nemestrina54.310.01182
LLPS-Mam-1464Macaca mulatta54.060.01150
LLPS-Rhb-0793Rhinopithecus bieti54.040.01163
LLPS-Mal-1206Mandrillus leucophaeus53.810.01177
LLPS-Hos-0835Homo sapiens53.770.01176
LLPS-Nol-0886Nomascus leucogenys53.750.01125
LLPS-Pap-2358Pan paniscus53.670.01156
LLPS-Drm-1484Drosophila melanogaster53.460.01156
LLPS-Dio-2554Dipodomys ordii53.450.01157
LLPS-Cap-0452Cavia porcellus53.390.01157
LLPS-Icp-0984Ictalurus punctatus53.210.01140
LLPS-Chr-0694Chlamydomonas reinhardtii52.590.01058
LLPS-Poa-2659Pongo abelii52.440.01120
LLPS-Brr-1176Brassica rapa52.340.01128
LLPS-Chc-0290Chondrus crispus52.280.01004
LLPS-Gog-0732Gorilla gorilla52.210.0 849
LLPS-Cym-0142Cyanidioschyzon merolae51.790.0 994
LLPS-Cas-0038Carlito syrichta51.010.01037
LLPS-Gas-0140Galdieria sulphuraria49.90.01021
LLPS-Cae-0981Caenorhabditis elegans49.90.0 996
LLPS-Aon-3379Aotus nancymaae49.670.01028
LLPS-Fud-1573Fukomys damarensis49.660.0 994
LLPS-Ova-0954Ovis aries46.210.0 897
LLPS-Loa-2782Loxodonta africana38.440.0 659
LLPS-Gaga-3493Gallus gallus29.523e-0759.7
LLPS-Leo-1952Lepisosteus oculatus28.413e-83 304
LLPS-Anp-0774Anas platyrhynchos28.16e-87 315
LLPS-Tag-2136Taeniopygia guttata28.093e-83 304
LLPS-Orc-2813Oryctolagus cuniculus27.42e-86 314
LLPS-Mod-3809Monodelphis domestica27.385e-84 306
LLPS-Myl-3092Myotis lucifugus26.921e-84 308