DrLLPS - Data resource of LLPS

LLPS-Scp-0996
phf1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	SWM histone demethylase complex subunit phf1; PHD finger domain-containing protein phf1
Gene Name:	phf1, saf50, swp1, SPCC4G3.07c
Ensembl Gene:	SPCC4G3.07c
Ensembl Protein:	SPCC4G3.07c.1
Organism:	Schizosaccharomyces pombe
Taxa ID:	284812
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Chromatin, Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-1576	Q02395	Client	Chromatin, Nucleolus	42.59	2e-08	61.2

▼ FUNCTION

Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	SPCC4G3.07c.1	SPCC4G3.07c.1
UniProt		P87233, PHF1_SCHPO
GeneBank	CU329672	CAB09774.1
RefSeq	NM_001022824.2	NP_587831.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSQKNFFDEG KSYGVNDYAG FHFENGADSS LPQVSAQGVV RETDSSNFDA SPVASGSGIS 60 61 DVGPFGADFH QLQQHVQTPY GGMTMPASSS SGATSVPPEQ DPSLSVSFNR LPKSASTKTK 120 121 NGRIRSSRRE DDNRIPFYDL DVAEGAEDDL QEDFHVEGMK TKSGRKIQRP VAYNPNATAL 180 181 KRKSRKVDMV TLCSVCQRGH SPLSNRIVFC DGCNSPYHQL CHHPPIDDAT VQDVDAEWFC 240 241 MKCQYRRAKQ PLETGMTAQD LGLSESDKKM YLSSLPTPHL ADLILFCEKS YPSLPIYNPR 300 301 TRELLGEIRH QLLVSSERQQ ISLQERLHAK QDEAPSDEPA PVPYTASYVA NSGTLYDYPT 360 361 LIRLAIRNTL SPSKDEIFNW LAQNVPLLPT FHDSASEAIR WMVNKGQLVR SGSIYQIATV 420 421 EEYPHLQPSL LPTFQRNRKV PKLVPVSFPT DDPQNLCATV L 461
Nucleotide CDS Sequence (FASTA)
1 ATGTCTCAAA AGAATTTTTT CGACGAAGGA AAGAGCTATG GTGTAAATGA CTATGCCGGT 60 61 TTCCATTTTG AAAATGGTGC TGATTCATCC CTTCCTCAGG TATCGGCTCA AGGTGTAGTT 120 121 AGAGAAACGG ACAGCTCGAA TTTTGATGCT TCCCCTGTCG CATCGGGTTC TGGAATTTCC 180 181 GATGTTGGAC CATTTGGCGC TGATTTCCAT CAACTGCAGC AGCATGTACA GACACCGTAT 240 241 GGCGGTATGA CTATGCCTGC ATCTTCCTCT TCAGGCGCTA CTTCAGTACC ACCGGAGCAA 300 301 GATCCTTCTT TGTCTGTATC ATTCAATCGC TTGCCCAAGT CTGCATCAAC CAAGACTAAG 360 361 AATGGACGCA TTCGATCGTC TCGTCGGGAA GACGATAATC GTATACCATT TTACGATCTC 420 421 GATGTTGCAG AAGGTGCCGA GGATGATTTA CAGGAAGACT TTCACGTGGA AGGAATGAAA 480 481 ACAAAATCGG GTAGAAAGAT TCAGCGGCCA GTCGCATACA ATCCTAATGC CACCGCATTG 540 541 AAACGGAAAA GTCGCAAGGT CGATATGGTC ACCTTGTGTA GCGTCTGTCA ACGAGGACAT 600 601 TCTCCTTTAT CTAATCGAAT CGTATTTTGT GATGGATGCA ATTCTCCATA TCATCAGCTT 660 661 TGCCATCACC CTCCGATTGA CGATGCAACC GTTCAGGATG TGGATGCTGA ATGGTTTTGT 720 721 ATGAAATGCC AGTACAGGCG TGCCAAGCAA CCTTTAGAAA CGGGAATGAC GGCACAAGAT 780 781 CTTGGGTTAA GTGAATCAGA CAAAAAAATG TATCTATCAA GTTTACCTAC TCCTCATCTC 840 841 GCAGATCTTA TTCTTTTTTG TGAAAAGTCT TATCCATCTC TTCCCATATA CAACCCACGT 900 901 ACTCGGGAGT TGTTGGGTGA GATTCGGCAT CAACTACTTG TTAGTTCTGA ACGCCAACAA 960 961 ATATCTTTAC AAGAGCGACT TCATGCTAAA CAAGATGAAG CTCCCTCTGA TGAGCCTGCA 1020 1021 CCTGTCCCCT ATACCGCAAG TTATGTTGCG AATTCTGGAA CCTTATACGA CTATCCAACG 1080 1081 TTAATACGGT TAGCTATTCG TAACACCCTC TCACCTTCCA AAGATGAAAT ATTTAACTGG 1140 1141 CTTGCTCAAA ACGTACCATT GTTACCAACT TTTCACGACA GCGCTTCCGA GGCCATTCGT 1200 1201 TGGATGGTAA ATAAAGGTCA ACTGGTCCGT TCCGGTAGCA TCTATCAAAT AGCAACAGTC 1260 1261 GAAGAATACC CTCACCTCCA ACCCTCTTTA CTTCCTACTT TTCAACGAAA CCGTAAGGTA 1320 1321 CCTAAATTGG TGCCTGTCTC TTTCCCCACC GATGATCCTC AAAATTTATG TGCTACTGTT 1380 1381 TTATGA 1386

▼ KEYWORD

ID	Family
KW-0156	Chromatin regulator
KW-0181	Complete proteome
KW-0479	Metal-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0804	Transcription
KW-0805	Transcription regulation
KW-0862	Zinc
KW-0863	Zinc-finger

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0033193	Cellular Component	Lsd1/2 complex
GO:0005634	Cellular Component	Nucleus
GO:0046872	Molecular Function	Metal ion binding
GO:0035064	Molecular Function	Methylated histone binding
GO:0043565	Molecular Function	Sequence-specific DNA binding
GO:0061659	Molecular Function	Ubiquitin-like protein ligase activity
GO:0033169	Biological Process	Histone H3-K9 demethylation
GO:0045893	Biological Process	Positive regulation of transcription, DNA-templated
GO:0070647	Biological Process	Protein modification by small protein conjugation or removal

▼ KEGG

spo:SPCC4G3.07c

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Tar-3075	Takifugu rubripes	50.94	1e-08	61.6
LLPS-Scm-3949	Scophthalmus maximus	50.94	2e-08	60.5
LLPS-Orl-3269	Oryzias latipes	50.0	7e-09	62.4
LLPS-Xim-0509	Xiphophorus maculatus	49.06	6e-08	59.3
LLPS-Pof-1205	Poecilia formosa	49.06	6e-08	59.3
LLPS-Icp-3660	Ictalurus punctatus	48.15	7e-08	58.9
LLPS-Dar-3858	Danio rerio	48.15	9e-09	62.0
LLPS-Orn-2934	Oreochromis niloticus	47.17	2e-07	57.4
LLPS-Xet-0494	Xenopus tropicalis	46.3	1e-08	61.2
LLPS-Cis-1242	Ciona savignyi	45.76	7e-08	58.2
LLPS-Scf-1286	Scleropages formosus	44.44	7e-08	58.9
LLPS-Anc-3705	Anolis carolinensis	44.44	7e-09	62.0
LLPS-Gog-1210	Gorilla gorilla	42.59	1e-08	61.2
LLPS-Fud-3178	Fukomys damarensis	42.59	1e-08	61.2
LLPS-Caj-1973	Callithrix jacchus	42.59	1e-08	61.2
LLPS-Mum-1576	Mus musculus	42.59	1e-08	61.2
LLPS-Maf-2609	Macaca fascicularis	42.59	1e-08	61.2
LLPS-Mea-1929	Mesocricetus auratus	42.59	1e-08	61.2
LLPS-Chs-1075	Chlorocebus sabaeus	42.59	1e-08	61.2
LLPS-Sus-2718	Sus scrofa	42.59	1e-08	61.2
LLPS-Leo-0491	Lepisosteus oculatus	42.59	1e-07	58.5
LLPS-Cea-3790	Cercocebus atys	42.59	2e-08	60.8
LLPS-Sah-2897	Sarcophilus harrisii	42.59	8e-09	59.7
LLPS-Ran-2734	Rattus norvegicus	42.59	1e-08	61.2
LLPS-Paa-0092	Papio anubis	42.59	1e-08	61.2
LLPS-Mal-3850	Mandrillus leucophaeus	42.59	2e-08	60.8
LLPS-Ova-1403	Ovis aries	42.59	1e-08	61.2
LLPS-Myl-3234	Myotis lucifugus	42.59	1e-08	61.2
LLPS-Aim-0249	Ailuropoda melanoleuca	42.59	1e-08	61.2
LLPS-Mup-0378	Mustela putorius furo	42.59	1e-08	61.6
LLPS-Dio-2914	Dipodomys ordii	42.59	6e-09	62.4
LLPS-Bot-2574	Bos taurus	42.59	1e-08	61.2
LLPS-Pes-1997	Pelodiscus sinensis	42.59	2e-08	60.8
LLPS-Orc-2756	Oryctolagus cuniculus	42.59	2e-08	60.8
LLPS-Rhb-2655	Rhinopithecus bieti	42.59	3e-08	60.5
LLPS-Hos-3798	Homo sapiens	42.59	1e-08	61.2
LLPS-Meg-1139	Meleagris gallopavo	42.59	2e-08	60.8
LLPS-Urm-4081	Ursus maritimus	42.59	1e-08	61.2
LLPS-Pat-0779	Pan troglodytes	42.59	1e-08	61.2
LLPS-Mod-3191	Monodelphis domestica	42.59	1e-08	60.8
LLPS-Fec-0050	Felis catus	42.59	2e-08	60.8
LLPS-Lac-3866	Latimeria chalumnae	42.59	4e-08	59.7
LLPS-Man-2195	Macaca nemestrina	42.59	1e-08	61.2
LLPS-Loa-0648	Loxodonta africana	42.59	1e-08	61.2
LLPS-Anp-0828	Anas platyrhynchos	42.59	2e-08	60.8
LLPS-Cas-0909	Carlito syrichta	42.59	1e-08	61.2
LLPS-Gaga-2406	Gallus gallus	42.59	2e-08	60.8
LLPS-Nol-0393	Nomascus leucogenys	42.59	1e-08	61.2
LLPS-Ict-1581	Ictidomys tridecemlineatus	42.59	1e-08	61.2
LLPS-Caf-3160	Canis familiaris	42.59	1e-08	61.2
LLPS-Poa-1384	Pongo abelii	42.59	1e-08	61.2
LLPS-Eqc-0332	Equus caballus	42.59	1e-08	61.2
LLPS-Mam-0699	Macaca mulatta	42.59	1e-08	61.2
LLPS-Zyt-0948	Zymoseptoria tritici	41.72	2e-25	114
LLPS-Asm-2988	Astyanax mexicanus	40.74	2e-06	54.3
LLPS-Tag-0611	Taeniopygia guttata	40.74	4e-08	59.7
LLPS-Pap-0787	Pan paniscus	40.68	1e-08	61.2
LLPS-Gaa-3579	Gasterosteus aculeatus	36.27	1e-08	61.2
LLPS-Yal-0595	Yarrowia lipolytica	36.24	2e-36	143
LLPS-Blg-0493	Blumeria graminis	35.82	8e-30	124
LLPS-Gag-0633	Gaeumannomyces graminis	35.5	2e-20	97.8
LLPS-Ora-0984	Ornithorhynchus anatinus	34.85	5e-06	52.0
LLPS-Otg-1985	Otolemur garnettii	34.85	1e-06	54.7
LLPS-Fia-2472	Ficedula albicollis	34.85	1e-06	54.7
LLPS-Ten-3289	Tetraodon nigroviridis	34.85	8e-07	55.5
LLPS-Cap-3142	Cavia porcellus	34.85	2e-06	54.3
LLPS-Vir-0581	Vigna radiata	32.91	7e-06	52.0
LLPS-Via-2310	Vigna angularis	32.91	4e-06	52.8
LLPS-Asfu-0957	Aspergillus fumigatus	31.58	4e-21	100
LLPS-Miv-0149	Microbotryum violaceum	31.25	6e-17	87.8
LLPS-Nec-0906	Neurospora crassa	29.94	1e-16	86.7
LLPS-Asn-0126	Aspergillus nidulans	28.8	2e-15	82.8
LLPS-Asf-1046	Aspergillus flavus	28.26	1e-20	98.6
LLPS-Aso-1358	Aspergillus oryzae	28.26	4e-20	97.1
LLPS-Cog-0931	Colletotrichum gloeosporioides	24.11	9e-07	55.5

LLPS-Scp-0996phf1

Protein Sequence

Nucleotide Sequence

LLPS-Scp-0996
phf1