• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scp-0992
kap104

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Importin subunit beta-2; Importin-104; Karyopherin subunit beta-2; Karyopherin-104; Transportin; TRN
Gene Name: kap104, SPAC2F3.06c
Ensembl Gene: SPAC2F3.06c
Ensembl Protein: SPAC2F3.06c.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Droplet, Nuclear pore complex, Nucleolus, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblSPAC2F3.06c.1SPAC2F3.06c.1
UniProtO14089, IMB2_SCHPO
GeneBankCU329670CAB16272.1
RefSeqNM_001019806.2NP_594385.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGDNPWVLQE  QVLVELSEVI  KNSLSENSQT  RNAALNLLEK  AKDIPDLNNY  LTCILINATE  60
61    LSVSIRSAAG  LLLKNNVRVS  SLESGSGLQS  LDYTKSTVIR  GLCDPEQLIR  GISGNVITTI  120
121   ISRWGISTWP  EVLPQLMEML  SSPASTTQEG  AFSALTKICE  DSAQELDRDF  NGTRPLDFMI  180
181   PRFIELARHE  NPKIRTDALF  CLNQFVLIQS  QSLYAHIDTF  LETCYALATD  VSPNVRKNVC  240
241   QALVYLLDVR  PDKIAPSLGS  IVEYMLYSTQ  DSDQNVALEA  CEFWLAIAEQ  PDLCSALGPY  300
301   LDKIVPMLLQ  GMVYSDMDLL  LLGNDADDYD  VEDREEDIRP  QHAKGKSRIT  LNTQGPITQQ  360
361   GSSNADADEL  EDEDEDDDEF  DEDDDAFMDW  NLRKCSAAAL  DVLSSFWKQR  LLEIILPHLK  420
421   QSLTSEDWKV  QEAGVLAVGA  IAEGCMDGMV  QYLPELYPYF  LSLLDSKKPL  VRTITCWTLG  480
481   RYSKWASCLE  SEEDRQKYFV  PLLQGLLRMV  VDNNKKVQEA  GCSAFAILEE  QAGPSLVPYL  540
541   EPILTNLAFA  FQKYQRKNVL  ILYDAVQTLA  DYVGSALNDK  RYIELLITPL  LQKWSMIPDD  600
601   DPNLFPLFEC  LSSVAVALRD  GFAPFAAETY  ARTFRILRNT  LYLITTAQND  PTVDVPDRDF  660
661   LVTTLDLVSG  IIQALGSQVS  PLLAQADPPL  GQIIGICAKD  EVPEVRQSAY  ALLGDMCMYC  720
721   FDQIRPYCDA  LLVDMLPQMQ  LPLLHVSASN  NAIWSAGEMA  LQLGKDMQQW  VKPLLERLIC  780
781   ILKSKKSNTT  VLENVAITIG  RLGVYNPELV  APHLELFYQP  WFEIIKTVGE  NEEKDSAFRG  840
841   FCNILACNPQ  ALSYLLPMFV  LCVAEYENPS  AELRDMFQKI  LQGSVELFNG  KASWQASPEV  900
901   LAQIQAQYGV  910
Nucleotide CDS Sequence (FASTA)
1     ATGGGGGACA  ATCCTTGGGT  TCTCCAGGAA  CAAGTCCTCG  TAGAACTTTC  AGAAGTGATA  60
61    AAGAATTCAC  TCTCCGAAAA  CTCTCAGACT  AGGAATGCTG  CTTTAAATTT  GCTTGAGAAA  120
121   GCAAAGGATA  TACCAGATCT  AAATAATTAC  CTTACTTGCA  TTCTCATCAA  CGCTACGGAG  180
181   CTTAGTGTTT  CAATTAGATC  TGCTGCTGGT  CTTTTGTTGA  AGAACAATGT  TCGTGTTTCA  240
241   AGCTTAGAGT  CTGGTTCAGG  TTTGCAGAGC  CTCGATTACA  CAAAGTCAAC  AGTTATTCGC  300
301   GGTTTGTGTG  ACCCTGAACA  ACTCATTCGA  GGCATATCTG  GTAATGTGAT  CACTACAATC  360
361   ATTAGTCGTT  GGGGAATTAG  TACTTGGCCT  GAAGTATTGC  CACAATTAAT  GGAAATGCTT  420
421   TCTAGCCCTG  CTTCTACCAC  TCAAGAAGGA  GCATTCAGCG  CCTTAACTAA  AATATGTGAG  480
481   GATTCGGCTC  AAGAGTTAGA  TCGTGATTTC  AATGGTACTC  GTCCCTTGGA  TTTTATGATA  540
541   CCCCGGTTTA  TTGAACTTGC  TCGACACGAG  AACCCAAAAA  TTCGTACGGA  CGCCCTTTTC  600
601   TGTCTGAACC  AGTTTGTTCT  AATTCAAAGT  CAATCTCTCT  ATGCCCATAT  TGATACATTC  660
661   CTTGAAACAT  GCTACGCCTT  AGCAACAGAC  GTTTCTCCAA  ATGTGCGTAA  AAATGTCTGT  720
721   CAAGCTCTTG  TTTACCTGCT  CGATGTCCGT  CCTGATAAAA  TTGCACCCTC  CTTGGGAAGC  780
781   ATTGTCGAAT  ACATGTTGTA  CTCTACTCAA  GATTCTGATC  AGAATGTCGC  ATTAGAAGCT  840
841   TGTGAGTTTT  GGCTTGCAAT  TGCTGAACAA  CCCGATCTTT  GCTCTGCTTT  AGGTCCTTAT  900
901   TTGGATAAAA  TAGTCCCCAT  GCTTCTCCAA  GGGATGGTTT  ATTCAGACAT  GGACTTGCTG  960
961   TTACTTGGTA  ATGATGCTGA  CGACTATGAT  GTTGAAGATA  GAGAAGAGGA  TATTCGTCCT  1020
1021  CAGCATGCAA  AGGGTAAATC  GAGGATTACC  TTGAATACCC  AGGGACCAAT  TACTCAACAA  1080
1081  GGTTCTTCCA  ACGCCGATGC  TGATGAATTG  GAAGATGAAG  ACGAGGATGA  TGATGAATTT  1140
1141  GACGAGGATG  ATGACGCTTT  CATGGATTGG  AATTTGCGAA  AGTGCTCGGC  TGCTGCACTG  1200
1201  GATGTTTTAT  CATCGTTTTG  GAAGCAAAGG  TTACTTGAAA  TCATTCTTCC  TCATCTGAAG  1260
1261  CAAAGTCTTA  CGAGTGAAGA  TTGGAAAGTT  CAAGAAGCCG  GTGTTTTGGC  CGTTGGTGCC  1320
1321  ATTGCAGAAG  GTTGTATGGA  TGGAATGGTT  CAATATTTAC  CAGAATTATA  CCCTTACTTT  1380
1381  CTTTCGCTTT  TAGATAGTAA  AAAGCCACTG  GTCCGTACGA  TTACATGTTG  GACCCTTGGT  1440
1441  CGATACTCCA  AGTGGGCTTC  GTGTTTGGAG  TCCGAGGAGG  ATCGTCAAAA  GTACTTTGTC  1500
1501  CCACTTTTGC  AAGGATTGCT  TCGCATGGTG  GTTGATAATA  ACAAAAAAGT  GCAAGAGGCT  1560
1561  GGTTGCTCGG  CTTTTGCAAT  TCTGGAAGAG  CAAGCTGGCC  CTTCGTTAGT  TCCTTATCTA  1620
1621  GAACCGATCC  TTACCAACCT  TGCTTTTGCA  TTCCAAAAGT  ACCAACGCAA  GAATGTGCTC  1680
1681  ATTCTGTACG  ACGCAGTTCA  GACCCTCGCT  GATTATGTAG  GATCTGCTTT  GAATGATAAA  1740
1741  CGGTATATCG  AACTATTGAT  TACCCCATTA  CTTCAAAAAT  GGTCCATGAT  TCCTGATGAT  1800
1801  GATCCTAATC  TTTTCCCTCT  ATTTGAGTGT  CTTTCATCTG  TTGCAGTGGC  TTTGCGTGAC  1860
1861  GGATTTGCGC  CATTTGCAGC  TGAAACGTAT  GCACGCACGT  TCCGAATTCT  TCGCAACACC  1920
1921  TTATACCTAA  TCACTACTGC  ACAAAATGAT  CCTACAGTTG  ACGTTCCAGA  TAGGGATTTC  1980
1981  CTTGTTACTA  CATTGGATTT  GGTTAGTGGA  ATTATACAAG  CTTTGGGTAG  TCAAGTTAGT  2040
2041  CCTTTGCTTG  CGCAAGCTGA  CCCACCACTC  GGTCAAATCA  TTGGCATTTG  TGCCAAGGAT  2100
2101  GAGGTGCCGG  AAGTTCGTCA  ATCTGCTTAT  GCTTTGTTGG  GAGATATGTG  TATGTACTGC  2160
2161  TTTGACCAAA  TACGCCCGTA  TTGTGATGCT  TTATTGGTGG  ATATGCTTCC  CCAAATGCAA  2220
2221  CTTCCTTTGT  TACATGTGAG  TGCATCGAAC  AACGCTATTT  GGTCAGCTGG  CGAAATGGCT  2280
2281  TTGCAATTAG  GAAAAGACAT  GCAACAATGG  GTAAAGCCGT  TATTGGAGAG  ATTGATCTGT  2340
2341  ATCCTCAAAT  CTAAAAAATC  GAACACTACA  GTACTTGAGA  ATGTTGCGAT  CACGATAGGC  2400
2401  AGATTGGGTG  TTTATAACCC  GGAGCTCGTT  GCCCCTCACC  TAGAGTTGTT  TTATCAACCT  2460
2461  TGGTTTGAAA  TCATCAAAAC  GGTGGGTGAG  AATGAAGAGA  AAGATTCCGC  GTTTAGGGGA  2520
2521  TTCTGCAACA  TATTGGCGTG  CAATCCACAA  GCACTTTCAT  ACTTGTTGCC  AATGTTTGTC  2580
2581  CTTTGTGTGG  CCGAATATGA  AAATCCTTCA  GCCGAACTTC  GTGATATGTT  TCAAAAGATT  2640
2641  TTACAAGGAT  CTGTGGAGTT  GTTTAATGGT  AAGGCATCCT  GGCAAGCGAG  TCCTGAAGTG  2700
2701  CTCGCACAGA  TTCAGGCACA  GTATGGTGTC  TAA  2733

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
mRNA transport
Nucleus
Protein transport
Reference proteome
Repeat
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Mitotic spindle midzone
Cellular Component
Nuclear envelope
Cellular Component
Nuclear membrane
Cellular Component
Nuclear periphery
Cellular Component
Nuclear pore
Cellular Component
Nucleus
Molecular Function
GTP binding
Molecular Function
Nuclear import signal receptor activity
Molecular Function
Nuclear localization sequence binding
Molecular Function
Protein transporter activity
Biological Process
MRNA transport
Biological Process
NLS-bearing protein import into nucleus
Biological Process
Protein import into nucleus
Biological Process
Ribosomal protein import into nucleus

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-0155Schizosaccharomyces cryophilus84.260.01580
LLPS-Scj-0071Schizosaccharomyces japonicus74.180.01373
LLPS-Cap-3126Cavia porcellus47.10.0 695
LLPS-Anp-0487Anas platyrhynchos47.042e-83 276
LLPS-Dio-0988Dipodomys ordii46.290.0 715
LLPS-Otg-2192Otolemur garnettii46.010.0 659
LLPS-Loa-0006Loxodonta africana45.960.0 729
LLPS-Caf-0589Canis familiaris45.840.0 724
LLPS-Sah-0272Sarcophilus harrisii45.840.0 728
LLPS-Scm-2883Scophthalmus maximus45.750.0 703
LLPS-Tar-1950Takifugu rubripes45.680.0 707
LLPS-Ora-1410Ornithorhynchus anatinus45.570.0 721
LLPS-Cas-0997Carlito syrichta45.480.0 712
LLPS-Pof-1953Poecilia formosa45.450.0 711
LLPS-Asm-0042Astyanax mexicanus45.450.0 702
LLPS-Fia-0859Ficedula albicollis45.410.0 733
LLPS-Gaa-0915Gasterosteus aculeatus45.340.0 720
LLPS-Anc-0577Anolis carolinensis45.30.0 731
LLPS-Ova-0573Ovis aries45.30.0 731
LLPS-Usm-0506Ustilago maydis45.230.0 782
LLPS-Gaga-0998Gallus gallus45.190.0 728
LLPS-Pes-2989Pelodiscus sinensis45.190.0 732
LLPS-Urm-0740Ursus maritimus45.190.0 732
LLPS-Sus-0168Sus scrofa45.190.0 731
LLPS-Mam-0922Macaca mulatta45.070.0 731
LLPS-Rhb-0544Rhinopithecus bieti45.070.0 731
LLPS-Orc-0408Oryctolagus cuniculus45.075e-162 504
LLPS-Fec-0730Felis catus45.070.0 731
LLPS-Pat-2309Pan troglodytes45.070.0 731
LLPS-Pap-0134Pan paniscus45.070.0 731
LLPS-Hos-1144Homo sapiens45.070.0 731
LLPS-Man-1056Macaca nemestrina45.070.0 731
LLPS-Ran-0484Rattus norvegicus45.070.0 727
LLPS-Mup-0925Mustela putorius furo45.070.0 732
LLPS-Paa-2621Papio anubis45.070.0 731
LLPS-Mal-0402Mandrillus leucophaeus45.070.0 731
LLPS-Bot-1259Bos taurus45.070.0 731
LLPS-Gog-1353Gorilla gorilla45.070.0 731
LLPS-Fud-0841Fukomys damarensis45.070.0 733
LLPS-Chs-0610Chlorocebus sabaeus45.070.0 731
LLPS-Maf-2665Macaca fascicularis45.070.0 731
LLPS-Cea-0234Cercocebus atys45.070.0 731
LLPS-Orn-0823Oreochromis niloticus45.030.0 714
LLPS-Spr-1047Sporisorium reilianum45.010.0 782
LLPS-Xim-0808Xiphophorus maculatus45.00.0 706
LLPS-Myl-0315Myotis lucifugus44.980.0 730
LLPS-Eqc-0301Equus caballus44.960.0 731
LLPS-Poa-0371Pongo abelii44.960.0 725
LLPS-Mea-1024Mesocricetus auratus44.960.0 726
LLPS-Caj-2165Callithrix jacchus44.850.0 728
LLPS-Mum-0039Mus musculus44.850.0 726
LLPS-Aon-0364Aotus nancymaae44.850.0 728
LLPS-Aim-1029Ailuropoda melanoleuca44.780.0 711
LLPS-Nol-0455Nomascus leucogenys44.770.0 726
LLPS-Xet-1298Xenopus tropicalis44.720.0 733
LLPS-Leo-0209Lepisosteus oculatus44.610.0 711
LLPS-Scf-1403Scleropages formosus44.590.0 712
LLPS-Dar-0234Danio rerio44.30.0 706
LLPS-Icp-0875Ictalurus punctatus43.780.0 706
LLPS-Ict-1741Ictidomys tridecemlineatus43.60.0 694
LLPS-Tut-2125Tursiops truncatus43.60.0 694
LLPS-Ten-3232Tetraodon nigroviridis43.420.0 702
LLPS-Lac-1110Latimeria chalumnae43.420.0 685
LLPS-Mod-2901Monodelphis domestica43.280.0 697
LLPS-Cii-0857Ciona intestinalis43.120.0 619
LLPS-Scs-0080Sclerotinia sclerotiorum42.969e-93 312
LLPS-Put-0422Puccinia triticina42.955e-60 225
LLPS-Miv-1150Microbotryum violaceum42.550.0 737
LLPS-Tum-1330Tuber melanosporum42.540.0 708
LLPS-Abg-0833Absidia glauca42.510.0 685
LLPS-Drm-0638Drosophila melanogaster42.50.0 725
LLPS-Crn-0547Cryptococcus neoformans42.330.0 708
LLPS-Trr-0515Trichoderma reesei41.650.0 630
LLPS-Dac-1131Daucus carota40.933e-45 180
LLPS-Trv-0568Trichoderma virens40.920.0 627
LLPS-Mel-0222Melampsora laricipopulina40.920.0 634
LLPS-Ved-0443Verticillium dahliae40.620.0 609
LLPS-Fuo-0132Fusarium oxysporum40.420.0 619
LLPS-Blg-0147Blumeria graminis40.420.0 669
LLPS-Mao-0311Magnaporthe oryzae40.090.0 638
LLPS-Fus-0096Fusarium solani39.980.0 606
LLPS-Fuv-0140Fusarium verticillioides39.980.0 615
LLPS-Cog-0028Colletotrichum gloeosporioides39.890.0 616
LLPS-Pug-0086Puccinia graminis39.890.0 598
LLPS-Coo-0081Colletotrichum orbiculare39.820.0 614
LLPS-Nec-0491Neurospora crassa39.80.0 600
LLPS-Cogr-0501Colletotrichum graminicola39.690.0 610
LLPS-Asf-0480Aspergillus flavus39.663e-159 492
LLPS-Php-1161Physcomitrella patens39.650.0 572
LLPS-Zyt-0645Zymoseptoria tritici39.550.0 568
LLPS-Cis-0772Ciona savignyi39.450.0 672
LLPS-Prp-0790Prunus persica39.172e-178 547
LLPS-Phn-0910Phaeosphaeria nodorum39.00.0 633
LLPS-Pytr-0152Pyrenophora triticirepentis39.00.0 586
LLPS-Gag-0728Gaeumannomyces graminis38.920.0 609
LLPS-Dos-0221Dothistroma septosporum38.80.0 566
LLPS-Map-0713Magnaporthe poae38.770.0 611
LLPS-Mae-2256Manihot esculenta38.755e-180 551
LLPS-Beb-0605Beauveria bassiana38.60.0 577
LLPS-Pyt-0488Pyrenophora teres38.570.0 590
LLPS-Lem-0554Leptosphaeria maculans38.560.0 615
LLPS-Sol-1387Solanum lycopersicum38.360.0 554
LLPS-Cae-1012Caenorhabditis elegans38.340.0 587
LLPS-Ors-0347Oryza sativa38.312e-150 470
LLPS-Thc-0242Theobroma cacao38.212e-179 549
LLPS-Yal-0063Yarrowia lipolytica38.150.0 619
LLPS-Sem-1088Selaginella moellendorffii38.10.0 566
LLPS-Orni-0037Oryza nivara38.09e-174 541
LLPS-Sob-1364Sorghum bicolor37.990.0 573
LLPS-Coc-0460Corchorus capsularis37.980.0 555
LLPS-Org-0225Oryza glaberrima37.741e-168 527
LLPS-Tra-1585Triticum aestivum37.740.0 559
LLPS-Orbr-0421Oryza brachyantha37.727e-165 509
LLPS-Amt-1132Amborella trichopoda37.682e-81 279
LLPS-Orp-0956Oryza punctata37.615e-178 548
LLPS-Hov-0151Hordeum vulgare37.611e-179 550
LLPS-Zem-0153Zea mays37.550.0 568
LLPS-Aso-0296Aspergillus oryzae37.530.0 581
LLPS-Nia-1181Nicotiana attenuata37.50.0 580
LLPS-Sei-0167Setaria italica37.498e-176 540
LLPS-Nef-0753Neosartorya fischeri37.470.0 597
LLPS-Ast-0125Aspergillus terreus37.470.0 579
LLPS-Hea-2197Helianthus annuus37.440.0 570
LLPS-Gor-0710Gossypium raimondii37.390.0 554
LLPS-Ori-1273Oryza indica37.382e-175 539
LLPS-Asn-0625Aspergillus nidulans37.370.0 590
LLPS-Asfu-0001Aspergillus fumigatus37.330.0 595
LLPS-Orr-1659Oryza rufipogon37.283e-170 532
LLPS-Orgl-0573Oryza glumaepatula37.286e-170 531
LLPS-Orb-0069Oryza barthii37.282e-170 532
LLPS-Lep-0012Leersia perrieri37.277e-178 545
LLPS-Asc-1158Aspergillus clavatus37.190.0 597
LLPS-Tru-0737Triticum urartu37.12e-179 550
LLPS-Brr-1190Brassica rapa36.996e-170 524
LLPS-Asni-0452Aspergillus niger36.990.0 565
LLPS-Brd-0666Brachypodium distachyon36.987e-178 545
LLPS-Bro-2097Brassica oleracea36.912e-177 544
LLPS-Kop-0000Komagataella pastoris36.760.0 594
LLPS-Brn-1548Brassica napus36.765e-171 527
LLPS-Phv-0630Phaseolus vulgaris36.714e-173 533
LLPS-Pot-0630Populus trichocarpa36.672e-176 541
LLPS-Mua-0517Musa acuminata36.560.0 568
LLPS-Viv-0806Vitis vinifera36.48e-175 538
LLPS-Art-0416Arabidopsis thaliana36.376e-176 540
LLPS-Arl-0149Arabidopsis lyrata36.315e-176 540
LLPS-Glm-1712Glycine max36.221e-173 535
LLPS-Met-0927Medicago truncatula36.081e-175 540
LLPS-Chc-0651Chondrus crispus35.991e-85 294
LLPS-Via-1484Vigna angularis35.081e-158 494
LLPS-Sac-0061Saccharomyces cerevisiae33.711e-134 433
LLPS-Tag-2724Taeniopygia guttata32.824e-23 105
LLPS-Osl-0411Ostreococcus lucimarinus32.641e-144 459
LLPS-Vir-0380Vigna radiata32.532e-147 468
LLPS-Asg-0992Ashbya gossypii32.089e-116 382
LLPS-Chr-0924Chlamydomonas reinhardtii31.064e-115 382