• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Scp-0981
cdc28

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28; Pre-mRNA-processing protein 8
Gene Name: cdc28, prp8, SPBC19C2.01, SPBC21B10.01c, SPBC874.01
Ensembl Gene: SPBC19C2.01
Ensembl Protein: SPBC19C2.01.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, NucleolusPredicted from orthologs(View)

▼ FUNCTION


Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing (By similarity).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MSLEQYVSDK  AISLLGMSEP  SVVEYLIAEA  KGSSSSNNLY  QKLVSFGMDG  DDPAVKEFAH  60
61    TLYARIPREG  SRPKENYNAR  KKKEQGILQM  ERLNSSYDLL  IEPQSHETPG  KPLKKKSRSK  120
121   TPKREIARRQ  RDEDEWESDE  YEEVVDGSAS  HPIEEDSVST  DFQNHDYEKS  SDPETERLND  180
181   LREREEFEER  LRRKDLEAAT  NEFVEDYSSK  FSSEELALRK  LADDPESWRK  LASELRKKSR  240
241   QQYLKPRAQQ  QLEILRREIR  DEEQLFAGEK  LTQAEIRELE  KKKELLRIAE  ERQRLEKQAT  300
301   EYQMPEDYFT  EQGKLDRKRK  EEVLYQRYKD  SNEGEQNEVT  MGAAEQQRWE  AQQINKALLF  360
361   DQNEWLPPGE  KQFDFVFDES  QQIDFLLDTK  LSAENPVDTD  KMTDVKVEKS  LESSRKSLPV  420
421   YQYKDDLLKA  INEYQVLLIV  AETGSGKTTQ  LPQFLHEAGY  TKGNKKICCT  QPRRVAAMSV  480
481   AARVAKEMDV  RLGQEVGYSI  RFENATSEKT  VIKYLTDGML  LREFLTEPDL  ASYSVIIIDE  540
541   AHERTLHTDI  LFGLVKDIAR  FRPDLKVLIS  SATIDAEKFS  AYFDEAPVFY  VPGRRYPVDI  600
601   YYTPQPEANY  IQAAITTILQ  IHTTQPAGDI  LVFLTGQDEI  ELMSENMQEL  CRILGKRIPE  660
661   IILCPIYANL  PSELQAKIFD  PTPPGARKVV  LATNIAETSI  TIDGVNFVID  SGFVKQNMYN  720
721   PRTGMESLVS  VPCSRASADQ  RAGRAGRVGP  GKCFRLYTRR  TYNNELDMVT  SPEIQRTNLT  780
781   NIVLLLKSLG  INNLLDFDFM  DAPPPETLMR  SLELLYALGA  LNNRGELTKL  GRQMAEFPTD  840
841   PMLSKSLIAS  SKYGCVEEVL  SIVSMLGEAS  SLFYRPKDKI  MEADKARANF  TQPGGDHLTL  900
901   LHIWNEWVDT  DFSYNWAREN  FLQYKSLCRA  RDVRDQLANL  CERVEIELVT  NSSESLDPIK  960
961   KAITAGYFSN  AARLDRSGDS  YRTVKSNQTV  YIHPSSSVAE  KKPKVIIYFE  LVLTTKEYCR  1020
1021  QITEIQPEWL  LEISPHYFKP  ENIEELQKTQ  KRHKR  1055
Nucleotide CDS Sequence (FASTA)
1     ATGTCTTTAG  AGCAATATGT  GTCTGACAAA  GCGATTTCGC  TACTGGGAAT  GTCGGAACCT  60
61    TCCGTGGTAG  AATACCTAAT  TGCAGAAGCG  AAGGGCTCTT  CAAGTTCTAA  TAACCTGTAT  120
121   CAGAAACTCG  TCAGTTTTGG  TATGGATGGT  GATGATCCTG  CGGTTAAAGA  ATTTGCTCAT  180
181   ACGCTTTATG  CTAGAATACC  CAGAGAAGGC  TCAAGACCGA  AAGAAAACTA  CAATGCAAGA  240
241   AAGAAAAAAG  AACAGGGGAT  TTTACAAATG  GAGCGTTTGA  ATTCAAGTTA  TGATTTGTTG  300
301   ATAGAACCTC  AATCTCATGA  GACGCCTGGG  AAGCCTTTGA  AGAAAAAAAG  CCGTTCTAAA  360
361   ACTCCTAAGC  GAGAAATAGC  CAGGAGACAA  CGAGATGAGG  ATGAGTGGGA  GAGTGACGAG  420
421   TATGAGGAGG  TAGTGGATGG  AAGTGCTAGT  CATCCTATAG  AAGAAGATTC  AGTTTCTACC  480
481   GATTTTCAAA  ATCATGATTA  TGAAAAAAGC  TCAGATCCTG  AGACAGAAAG  ACTCAATGAT  540
541   TTACGTGAAA  GAGAAGAATT  TGAAGAGCGT  CTTAGACGTA  AAGACCTTGA  AGCCGCAACA  600
601   AATGAATTTG  TGGAGGATTA  TTCATCCAAA  TTTTCTTCGG  AAGAGCTAGC  TCTTAGAAAA  660
661   CTAGCAGATG  ATCCTGAATC  ATGGAGAAAA  CTTGCTTCTG  AACTTCGAAA  AAAATCGCGG  720
721   CAACAATATC  TTAAACCTAG  GGCTCAGCAA  CAGTTGGAAA  TCCTTCGCAG  AGAAATTCGA  780
781   GATGAGGAGC  AACTTTTTGC  AGGCGAGAAG  TTGACGCAAG  CAGAAATTAG  AGAGCTTGAA  840
841   AAGAAAAAAG  AACTACTTCG  AATTGCTGAA  GAACGTCAGA  GATTGGAAAA  ACAAGCCACT  900
901   GAATATCAAA  TGCCTGAAGA  CTATTTTACA  GAGCAAGGAA  AATTGGACAG  AAAACGAAAA  960
961   GAGGAGGTCT  TATATCAAAG  GTATAAGGAT  AGTAATGAAG  GTGAGCAAAA  CGAGGTTACG  1020
1021  ATGGGAGCTG  CCGAACAACA  GCGGTGGGAG  GCTCAACAAA  TAAATAAAGC  ATTACTTTTT  1080
1081  GATCAAAACG  AATGGCTTCC  TCCAGGAGAG  AAGCAATTTG  ATTTCGTATT  TGACGAATCG  1140
1141  CAACAGATTG  ATTTTTTACT  CGATACTAAG  CTTTCTGCGG  AGAATCCTGT  TGACACTGAC  1200
1201  AAGATGACTG  ATGTTAAAGT  TGAAAAATCA  TTAGAAAGTT  CTCGCAAAAG  TTTACCTGTT  1260
1261  TATCAATACA  AGGACGATCT  TTTGAAGGCA  ATAAATGAGT  ACCAAGTGTT  GCTTATTGTG  1320
1321  GCTGAGACCG  GATCTGGTAA  AACAACTCAA  CTTCCTCAAT  TTCTGCACGA  AGCTGGTTAT  1380
1381  ACTAAAGGAA  ATAAGAAAAT  TTGCTGCACC  CAACCAAGAA  GAGTTGCTGC  AATGTCTGTT  1440
1441  GCTGCTAGGG  TTGCCAAGGA  AATGGATGTA  CGGCTTGGAC  AGGAAGTTGG  GTACAGCATT  1500
1501  CGTTTTGAAA  ATGCTACTTC  TGAAAAAACT  GTCATAAAAT  ACTTGACTGA  TGGCATGCTT  1560
1561  CTCAGAGAAT  TTTTAACAGA  ACCTGACCTG  GCAAGCTATT  CTGTCATTAT  TATAGATGAA  1620
1621  GCCCATGAAA  GAACGCTTCA  TACAGACATT  TTATTTGGAC  TTGTAAAGGA  TATTGCTAGA  1680
1681  TTTCGTCCAG  ATTTAAAGGT  TCTAATTTCG  AGTGCTACTA  TAGATGCCGA  AAAATTTTCG  1740
1741  GCTTACTTTG  ATGAAGCTCC  AGTGTTCTAT  GTTCCTGGCA  GAAGATATCC  AGTCGATATT  1800
1801  TATTACACCC  CGCAACCTGA  AGCAAATTAT  ATACAAGCGG  CTATTACAAC  CATTCTTCAA  1860
1861  ATACATACTA  CCCAGCCTGC  TGGTGATATT  TTAGTTTTTT  TAACGGGCCA  AGATGAAATT  1920
1921  GAATTAATGT  CCGAAAACAT  GCAAGAACTT  TGTCGGATAC  TAGGAAAAAG  AATTCCGGAA  1980
1981  ATAATTTTAT  GTCCGATTTA  TGCCAATCTG  CCTTCTGAAT  TGCAAGCTAA  AATTTTTGAT  2040
2041  CCTACACCCC  CTGGTGCCCG  CAAAGTTGTA  TTAGCAACCA  ATATTGCTGA  AACTTCTATA  2100
2101  ACAATTGACG  GAGTGAATTT  TGTGATTGAT  TCTGGATTTG  TCAAACAAAA  CATGTATAAT  2160
2161  CCAAGGACTG  GTATGGAAAG  CTTAGTATCT  GTGCCTTGCT  CCCGTGCTTC  TGCTGATCAG  2220
2221  CGTGCCGGCC  GTGCTGGTCG  AGTAGGACCT  GGAAAGTGCT  TCCGTTTATA  TACGCGTCGG  2280
2281  ACATATAACA  ATGAACTGGA  TATGGTAACA  TCTCCTGAAA  TTCAAAGAAC  AAATTTGACA  2340
2341  AATATTGTTC  TCTTGCTTAA  ATCCCTAGGA  ATTAATAATC  TTTTAGATTT  CGACTTCATG  2400
2401  GATGCTCCAC  CACCTGAAAC  GTTGATGCGT  TCATTAGAGT  TATTGTATGC  GCTTGGTGCC  2460
2461  TTAAACAATA  GAGGAGAATT  GACTAAGCTC  GGCAGGCAGA  TGGCAGAGTT  TCCTACAGAT  2520
2521  CCTATGCTTT  CTAAATCTTT  GATTGCATCT  TCAAAGTATG  GATGTGTTGA  AGAAGTGTTA  2580
2581  TCAATTGTTT  CTATGTTAGG  GGAGGCTTCC  TCTTTATTCT  ATAGACCAAA  AGACAAAATA  2640
2641  ATGGAAGCGG  ATAAAGCTAG  AGCGAACTTT  ACCCAACCTG  GTGGTGATCA  TTTAACTCTT  2700
2701  CTTCATATTT  GGAATGAATG  GGTAGATACT  GACTTTTCGT  ACAATTGGGC  CCGTGAAAAC  2760
2761  TTTTTACAGT  ATAAGAGTTT  ATGTCGAGCT  CGAGATGTTC  GTGATCAACT  TGCCAATCTC  2820
2821  TGTGAACGGG  TGGAAATTGA  ATTGGTAACT  AATTCTTCAG  AGTCCCTTGA  TCCTATTAAG  2880
2881  AAAGCTATCA  CAGCTGGTTA  TTTTTCTAAT  GCTGCACGCT  TGGATCGTAG  TGGGGATTCT  2940
2941  TATCGCACTG  TTAAAAGTAA  TCAAACCGTT  TATATTCACC  CTAGTTCTTC  TGTAGCTGAG  3000
3001  AAAAAGCCAA  AAGTCATCAT  TTACTTTGAA  TTGGTTTTGA  CAACTAAGGA  GTATTGCAGA  3060
3061  CAAATTACTG  AAATACAACC  CGAGTGGCTC  TTGGAAATAA  GCCCCCATTA  TTTCAAGCCA  3120
3121  GAAAATATAG  AAGAATTGCA  AAAGACGCAA  AAACGACATA  AGCGGTAA  3168

▼ KEYWORD


ID
Family
ATP-binding
Complete proteome
Helicase
Hydrolase
mRNA processing
mRNA splicing
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Spliceosomal complex
Molecular Function
ATP binding
Molecular Function
ATP-dependent 3'-5' RNA helicase activity
Molecular Function
ATP-dependent RNA helicase activity
Molecular Function
RNA binding
Biological Process
Generation of catalytic spliceosome for first transesterification step

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-1322Schizosaccharomyces cryophilus77.870.01514
LLPS-Scj-0978Schizosaccharomyces japonicus76.310.01258
LLPS-Cii-0987Ciona intestinalis67.780.0 748
LLPS-Tum-0980Tuber melanosporum67.440.0 872
LLPS-Asfu-0907Aspergillus fumigatus63.520.01013
LLPS-Asf-0065Aspergillus flavus63.030.01008
LLPS-Aso-1402Aspergillus oryzae63.030.01008
LLPS-Ast-0804Aspergillus terreus62.210.01002
LLPS-Asc-0801Aspergillus clavatus62.150.01013
LLPS-Asn-0289Aspergillus nidulans62.050.0 993
LLPS-Pug-0719Puccinia graminis62.050.0 989
LLPS-Mel-0764Melampsora laricipopulina61.930.0 993
LLPS-Nef-0604Neosartorya fischeri61.820.01023
LLPS-Paa-3882Papio anubis61.80.0 679
LLPS-Trr-1132Trichoderma reesei61.60.0 954
LLPS-Miv-0028Microbotryum violaceum61.520.0 953
LLPS-Asni-1217Aspergillus niger61.430.01022
LLPS-Cogr-1068Colletotrichum graminicola61.360.0 969
LLPS-Coo-0712Colletotrichum orbiculare61.340.0 971
LLPS-Myl-4043Myotis lucifugus60.860.0 850
LLPS-Fus-0478Fusarium solani60.730.0 982
LLPS-Abg-0400Absidia glauca60.680.0 999
LLPS-Sei-2186Setaria italica60.560.0 886
LLPS-Trv-0937Trichoderma virens60.40.0 958
LLPS-Beb-1160Beauveria bassiana59.810.0 962
LLPS-Blg-1088Blumeria graminis59.70.0 967
LLPS-Orc-3053Oryctolagus cuniculus59.690.0 860
LLPS-Fuv-0236Fusarium verticillioides59.640.0 935
LLPS-Amt-2346Amborella trichopoda59.410.0 892
LLPS-Cog-0089Colletotrichum gloeosporioides59.350.0 922
LLPS-Map-0685Magnaporthe poae59.340.0 823
LLPS-Nia-0421Nicotiana attenuata59.30.0 863
LLPS-Ved-0424Verticillium dahliae59.280.0 920
LLPS-Mao-1507Magnaporthe oryzae59.190.0 967
LLPS-Fuo-1237Fusarium oxysporum59.130.0 956
LLPS-Sot-0781Solanum tuberosum59.00.0 852
LLPS-Pot-0828Populus trichocarpa59.00.0 875
LLPS-Cus-1297Cucumis sativus58.970.0 855
LLPS-Dac-1352Daucus carota58.830.0 889
LLPS-Art-0685Arabidopsis thaliana58.780.0 890
LLPS-Crn-0954Cryptococcus neoformans58.760.0 946
LLPS-Cis-0752Ciona savignyi58.720.0 899
LLPS-Prp-1328Prunus persica58.530.0 886
LLPS-Hea-1444Helianthus annuus58.520.0 883
LLPS-Glm-1497Glycine max58.420.0 876
LLPS-Gor-2406Gossypium raimondii58.420.0 882
LLPS-Scs-0957Sclerotinia sclerotiorum58.280.0 887
LLPS-Tra-0461Triticum aestivum58.280.0 908
LLPS-Phv-1128Phaseolus vulgaris58.140.0 869
LLPS-Met-1884Medicago truncatula57.990.0 875
LLPS-Viv-0941Vitis vinifera57.940.0 868
LLPS-Brd-0895Brachypodium distachyon57.810.0 903
LLPS-Sob-0862Sorghum bicolor57.80.0 913
LLPS-Thc-1160Theobroma cacao57.720.0 873
LLPS-Gag-0482Gaeumannomyces graminis57.660.0 947
LLPS-Mae-0717Manihot esculenta57.640.0 873
LLPS-Orbr-1446Oryza brachyantha57.610.0 900
LLPS-Orn-0587Oreochromis niloticus57.580.0 895
LLPS-Zem-0025Zea mays57.470.0 710
LLPS-Pof-3237Poecilia formosa57.240.0 884
LLPS-Ten-0833Tetraodon nigroviridis57.160.0 887
LLPS-Kop-1005Komagataella pastoris57.110.0 850
LLPS-Org-1487Oryza glaberrima57.030.0 902
LLPS-Orgl-1963Oryza glumaepatula56.970.0 753
LLPS-Lep-0808Leersia perrieri56.920.0 883
LLPS-Xim-2937Xiphophorus maculatus56.750.0 875
LLPS-Scf-3665Scleropages formosus56.720.0 886
LLPS-Scm-3807Scophthalmus maximus56.690.0 797
LLPS-Gas-0865Galdieria sulphuraria56.590.0 847
LLPS-Orp-1752Oryza punctata56.560.0 879
LLPS-Coc-1153Corchorus capsularis56.520.0 826
LLPS-Orm-1553Oryza meridionalis56.320.0 879
LLPS-Sem-1166Selaginella moellendorffii56.310.0 872
LLPS-Php-0092Physcomitrella patens56.110.0 837
LLPS-Asm-3370Astyanax mexicanus56.030.0 887
LLPS-Nec-0723Neurospora crassa55.980.0 863
LLPS-Orb-0361Oryza barthii55.930.0 874
LLPS-Ori-0826Oryza indica55.930.0 874
LLPS-Gaa-2648Gasterosteus aculeatus55.750.0 880
LLPS-Dar-0467Danio rerio55.710.0 891
LLPS-Osl-0141Ostreococcus lucimarinus55.690.0 829
LLPS-Mod-1292Monodelphis domestica55.680.0 864
LLPS-Icp-1314Ictalurus punctatus55.470.0 726
LLPS-Lac-0039Latimeria chalumnae55.470.0 723
LLPS-Cap-2906Cavia porcellus55.410.0 830
LLPS-Sah-1099Sarcophilus harrisii55.370.0 868
LLPS-Loa-1676Loxodonta africana55.370.0 865
LLPS-Sol-0480Solanum lycopersicum55.330.0 720
LLPS-Via-2191Vigna angularis55.330.0 722
LLPS-Gog-2467Gorilla gorilla55.320.0 721
LLPS-Caj-0739Callithrix jacchus55.320.0 721
LLPS-Maf-2200Macaca fascicularis55.320.0 721
LLPS-Mum-1655Mus musculus55.320.0 721
LLPS-Chs-0455Chlorocebus sabaeus55.320.0 720
LLPS-Sus-2794Sus scrofa55.320.0 721
LLPS-Cea-3455Cercocebus atys55.320.0 721
LLPS-Aon-0238Aotus nancymaae55.320.0 721
LLPS-Ran-1510Rattus norvegicus55.320.0 721
LLPS-Mup-3720Mustela putorius furo55.320.0 720
LLPS-Aim-2024Ailuropoda melanoleuca55.320.0 720
LLPS-Ova-0333Ovis aries55.320.0 720
LLPS-Bot-2925Bos taurus55.320.0 720
LLPS-Otg-0353Otolemur garnettii55.320.0 720
LLPS-Pes-2334Pelodiscus sinensis55.320.0 721
LLPS-Hos-0903Homo sapiens55.320.0 721
LLPS-Pat-2266Pan troglodytes55.320.0 721
LLPS-Urm-0423Ursus maritimus55.320.0 720
LLPS-Pap-0563Pan paniscus55.320.0 721
LLPS-Fec-2507Felis catus55.320.0 720
LLPS-Man-0858Macaca nemestrina55.320.0 721
LLPS-Cas-3884Carlito syrichta55.320.0 721
LLPS-Anc-0576Anolis carolinensis55.320.0 720
LLPS-Ict-1993Ictidomys tridecemlineatus55.320.0 721
LLPS-Poa-4028Pongo abelii55.320.0 721
LLPS-Caf-2788Canis familiaris55.320.0 720
LLPS-Eqc-1424Equus caballus55.320.0 720
LLPS-Mam-3332Macaca mulatta55.320.0 721
LLPS-Vir-1539Vigna radiata55.180.0 718
LLPS-Fud-1606Fukomys damarensis55.160.0 718
LLPS-Fia-0492Ficedula albicollis55.160.0 718
LLPS-Tag-2271Taeniopygia guttata55.160.0 718
LLPS-Orni-1875Oryza nivara55.110.0 712
LLPS-Orr-0026Oryza rufipogon55.110.0 712
LLPS-Mal-0451Mandrillus leucophaeus55.060.0 864
LLPS-Rhb-0340Rhinopithecus bieti55.060.0 865
LLPS-Orl-0562Oryzias latipes55.010.0 717
LLPS-Brn-1957Brassica napus54.870.0 693
LLPS-Brr-0131Brassica rapa54.870.0 696
LLPS-Tru-1263Triticum urartu54.830.0 823
LLPS-Dio-3840Dipodomys ordii54.820.0 863
LLPS-Hov-0308Hordeum vulgare54.80.0 716
LLPS-Drm-1045Drosophila melanogaster54.70.0 703
LLPS-Mua-1250Musa acuminata54.410.0 759
LLPS-Put-0979Puccinia triticina54.090.0 998
LLPS-Bro-0322Brassica oleracea53.940.0 693
LLPS-Nol-1134Nomascus leucogenys53.860.0 838
LLPS-Usm-0019Ustilago maydis53.780.01021
LLPS-Spr-1012Sporisorium reilianum53.490.01011
LLPS-Tar-1558Takifugu rubripes52.230.0 695
LLPS-Chc-0834Chondrus crispus51.870.0 761
LLPS-Xet-2219Xenopus tropicalis50.640.0 752
LLPS-Yal-0638Yarrowia lipolytica50.230.0 944
LLPS-Pytr-1258Pyrenophora triticirepentis49.730.0 687
LLPS-Mea-1657Mesocricetus auratus48.630.0 868
LLPS-Pyt-1334Pyrenophora teres48.170.0 697
LLPS-Ors-0351Oryza sativa47.950.0 881
LLPS-Cae-0860Caenorhabditis elegans47.00.0 867
LLPS-Arl-0222Arabidopsis lyrata46.030.0 760
LLPS-Phn-0025Phaeosphaeria nodorum45.620.0 686