• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Scp-0753
hcs1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA polymerase alpha-associated DNA helicase A
Gene Name: hcs1, SPCC737.07c
Ensembl Gene: SPCC737.07c
Ensembl Protein: SPCC737.07c.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION


DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblSPCC737.07c.1SPCC737.07c.1
UniProtO94247, HCS1_SCHPO
GeneBankCU329672CAA20863.1
RefSeqNM_001023360.2NP_588369.1

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSSSNEQICL  DEDWIQKFGD  REIEFVDEAQ  KSEVDETEKS  IKRFPLSVLQ  RKGLALINLR  60
61    IGVVKTGFGG  KTIIDFEKDP  AFSNGEELPA  NSFSPGDVVS  IRQDFQSSKK  KRPNETDISV  120
121   EGVVTRVHER  HISVALKSEE  DIPSSVTRLS  VVKLVNRVTY  ERMRHTMLEF  KRSIPEYRNS  180
181   LFYTLIGRKK  ADVSIDQKLI  GDIKYFNKEL  NASQKKAVKF  SIAVKELSLI  HGPPGTGKTH  240
241   TLVEIIQQLV  LRNKRILVCG  ASNLAVDNIV  DRLSSSGIPM  VRLGHPARLL  PSILDHSLDV  300
301   LSRTGDNGDV  IRGISEDIDV  CLSKITKTKN  GRERREIYKN  IRELRKDYRK  YEAKTVANIV  360
361   SASKVVFCTL  HGAGSRQLKG  QRFDAVIIDE  ASQALEPQCW  IPLLGMNKVI  LAGDHMQLSP  420
421   NVQSKRPYIS  MFERLVKSQG  DLVKCFLNIQ  YRMHELISKF  PSDTFYDSKL  VPAEEVKKRL  480
481   LMDLENVEET  ELTDSPIYFY  DTLGNYQEDD  RSEDMQNFYQ  DSKSNHWEAQ  IVSYHISGLL  540
541   EAGLEAKDIA  VVTPYNAQVA  LIRQLLKEKG  IEVEMGSVDK  VQGREKEAII  FSLVRSNDVR  600
601   EVGFLAEKRR  LNVAITRPKR  HLCVIGDSNT  VKWASEFFHQ  WVDFLEENAI  VMDIDATMFE  660
Nucleotide CDS Sequence (FASTA)
1     ATGTCTAGTT  CAAATGAACA  AATTTGTTTG  GACGAAGATT  GGATACAAAA  ATTTGGGGAT  60
61    AGGGAAATTG  AATTTGTGGA  TGAAGCTCAA  AAATCCGAAG  TTGATGAGAC  AGAAAAGTCT  120
121   ATAAAACGCT  TTCCGTTGTC  CGTATTACAA  AGAAAAGGAT  TAGCACTTAT  CAACCTTAGA  180
181   ATCGGAGTTG  TAAAAACTGG  ATTTGGTGGT  AAAACAATCA  TTGATTTTGA  AAAAGATCCA  240
241   GCGTTCTCCA  ATGGTGAAGA  ATTACCAGCA  AACTCTTTTT  CACCTGGTGA  TGTTGTCAGT  300
301   ATTCGACAGG  ATTTTCAATC  CTCCAAAAAA  AAACGTCCCA  ACGAAACAGA  TATCTCAGTG  360
361   GAGGGTGTGG  TTACCCGAGT  GCATGAAAGA  CATATATCTG  TTGCTTTAAA  GTCTGAAGAA  420
421   GATATTCCTT  CTTCCGTCAC  GCGTTTGTCA  GTCGTCAAAT  TGGTGAATCG  CGTTACGTAT  480
481   GAAAGAATGA  GACATACTAT  GTTGGAATTT  AAAAGAAGTA  TCCCGGAGTA  TCGAAACTCA  540
541   CTTTTTTACA  CCTTGATTGG  AAGGAAGAAG  GCAGATGTTT  CTATAGACCA  AAAATTAATC  600
601   GGTGACATTA  AATATTTCAA  CAAAGAATTA  AATGCAAGCC  AAAAGAAAGC  AGTTAAATTT  660
661   TCCATTGCGG  TCAAGGAATT  ATCACTAATT  CATGGTCCAC  CAGGAACCGG  TAAAACCCAC  720
721   ACCTTAGTTG  AAATCATACA  GCAGTTGGTT  TTAAGAAACA  AGCGTATTTT  GGTTTGCGGT  780
781   GCTTCCAATT  TGGCAGTTGA  CAACATAGTA  GATCGCCTAA  GCAGTTCTGG  GATTCCCATG  840
841   GTCCGCTTAG  GGCATCCTGC  TAGGCTCCTT  CCATCGATTT  TGGATCATTC  TTTGGATGTT  900
901   TTATCACGAA  CGGGTGATAA  TGGAGACGTA  ATCCGTGGAA  TAAGCGAAGA  CATAGATGTA  960
961   TGCTTAAGTA  AGATTACAAA  AACTAAAAAT  GGTAGAGAGC  GTCGTGAAAT  TTACAAAAAT  1020
1021  ATTCGGGAAC  TTCGCAAAGA  TTATCGAAAA  TACGAAGCTA  AGACGGTAGC  GAATATTGTT  1080
1081  TCGGCAAGTA  AGGTTGTGTT  TTGTACTCTT  CATGGTGCTG  GATCGAGGCA  GTTAAAAGGC  1140
1141  CAAAGATTTG  ATGCAGTGAT  AATTGATGAA  GCTTCACAAG  CGTTGGAACC  ACAATGTTGG  1200
1201  ATTCCTCTTT  TGGGAATGAA  TAAAGTGATC  CTGGCTGGCG  ATCATATGCA  ACTTTCACCA  1260
1261  AACGTACAAA  GCAAAAGGCC  TTATATATCT  ATGTTTGAAC  GATTGGTTAA  ATCTCAAGGA  1320
1321  GATTTGGTTA  AATGTTTTCT  AAATATACAA  TATCGAATGC  ATGAACTTAT  TAGTAAATTC  1380
1381  CCGTCTGATA  CATTTTACGA  TAGCAAATTA  GTTCCCGCTG  AAGAAGTAAA  AAAACGCTTA  1440
1441  CTTATGGATT  TAGAAAACGT  CGAAGAAACT  GAACTTACTG  ATTCACCAAT  TTACTTTTAC  1500
1501  GACACCCTGG  GGAATTACCA  AGAAGATGAT  CGATCAGAGG  ATATGCAAAA  TTTTTACCAA  1560
1561  GACAGTAAGA  GCAATCACTG  GGAAGCTCAG  ATTGTTAGCT  ATCATATATC  AGGACTACTA  1620
1621  GAAGCTGGAC  TTGAAGCTAA  GGACATAGCA  GTTGTTACTC  CCTATAACGC  ACAGGTAGCC  1680
1681  CTTATACGAC  AGTTATTAAA  GGAAAAGGGA  ATAGAGGTTG  AAATGGGCAG  CGTTGATAAA  1740
1741  GTGCAGGGCC  GCGAGAAAGA  GGCAATTATA  TTTTCTCTAG  TCAGAAGCAA  CGATGTTCGG  1800
1801  GAAGTAGGGT  TTTTGGCAGA  AAAGAGAAGA  CTCAATGTAG  CCATCACAAG  GCCTAAAAGG  1860
1861  CATCTTTGTG  TAATTGGGGA  TAGCAACACT  GTAAAGTGGG  CTAGTGAATT  CTTTCACCAA  1920
1921  TGGGTTGATT  TTTTGGAGGA  AAATGCCATT  GTGATGGATA  TTGATGCAAC  CATGTTTGAG  1980
1981  TAA  1983

▼ KEYWORD


ID
Family
ATP-binding
Complete proteome
Cytoplasm
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
DNA helicase A complex
Cellular Component
Nuclear replication fork
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
ATP-dependent 5'-3' DNA helicase activity
Biological Process
Mitotic DNA replication lagging strand elongation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-0244Schizosaccharomyces cryophilus66.210.0 930
LLPS-Gag-1266Gaeumannomyces graminis63.045e-26 118
LLPS-Scj-0268Schizosaccharomyces japonicus53.210.0 703
LLPS-Map-0473Magnaporthe poae49.83e-159 476
LLPS-Asni-0916Aspergillus niger49.257e-165 497
LLPS-Beb-0871Beauveria bassiana47.090.0 590
LLPS-Trv-0042Trichoderma virens46.650.0 566
LLPS-Blg-1146Blumeria graminis46.572e-117 365
LLPS-Scs-1055Sclerotinia sclerotiorum45.910.0 558
LLPS-Coo-0974Colletotrichum orbiculare45.890.0 551
LLPS-Trr-0049Trichoderma reesei45.72e-173 517
LLPS-Cogr-1435Colletotrichum graminicola45.630.0 546
LLPS-Cog-0686Colletotrichum gloeosporioides45.294e-179 532
LLPS-Fuv-1284Fusarium verticillioides44.760.0 549
LLPS-Aso-0227Aspergillus oryzae44.650.0 541
LLPS-Fuo-1544Fusarium oxysporum44.610.0 550
LLPS-Poa-3713Pongo abelii44.528e-65 232
LLPS-Zyt-1352Zymoseptoria tritici44.480.0 564
LLPS-Pyt-0754Pyrenophora teres44.313e-176 525
LLPS-Nec-0870Neurospora crassa44.013e-174 522
LLPS-Mao-1137Magnaporthe oryzae43.841e-176 527
LLPS-Ast-0201Aspergillus terreus43.716e-167 502
LLPS-Asfu-0285Aspergillus fumigatus43.671e-176 528
LLPS-Pytr-0817Pyrenophora triticirepentis43.442e-173 519
LLPS-Dos-0444Dothistroma septosporum43.230.0 555
LLPS-Tum-1235Tuber melanosporum42.962e-166 501
LLPS-Nef-0855Neosartorya fischeri42.795e-154 469
LLPS-Scf-3416Scleropages formosus42.734e-110 363
LLPS-Asn-0467Aspergillus nidulans42.665e-160 484
LLPS-Ved-1337Verticillium dahliae42.233e-173 516
LLPS-Orm-0143Oryza meridionalis42.073e-24 112
LLPS-Loa-1596Loxodonta africana42.071e-91 306
LLPS-Lem-1413Leptosphaeria maculans41.862e-148 451
LLPS-Abg-1245Absidia glauca41.523e-171 512
LLPS-Yal-1038Yarrowia lipolytica41.231e-149 456
LLPS-Pof-2510Poecilia formosa41.144e-135 428
LLPS-Orn-2716Oreochromis niloticus40.85e-133 422
LLPS-Asc-1221Aspergillus clavatus40.791e-167 506
LLPS-Tag-2336Taeniopygia guttata40.588e-132 418
LLPS-Phn-0566Phaeosphaeria nodorum40.533e-145 446
LLPS-Xim-1774Xiphophorus maculatus40.49e-133 421
LLPS-Mua-2027Musa acuminata40.341e-94 308
LLPS-Gaa-2641Gasterosteus aculeatus40.252e-129 413
LLPS-Pes-1702Pelodiscus sinensis40.191e-136 429
LLPS-Scm-2529Scophthalmus maximus40.194e-131 418
LLPS-Sei-0112Setaria italica40.123e-73 246
LLPS-Mod-1387Monodelphis domestica40.13e-129 416
LLPS-Mup-1272Mustela putorius furo39.872e-128 410
LLPS-Brd-1523Brachypodium distachyon39.872e-136 421
LLPS-Dar-3088Danio rerio39.774e-132 420
LLPS-Tar-2006Takifugu rubripes39.757e-132 419
LLPS-Urm-0008Ursus maritimus39.684e-127 407
LLPS-Lep-1542Leersia perrieri39.678e-135 417
LLPS-Glm-1445Glycine max39.643e-135 419
LLPS-Icp-3109Ictalurus punctatus39.499e-140 440
LLPS-Met-1142Medicago truncatula39.486e-135 417
LLPS-Pap-2076Pan paniscus39.364e-136 431
LLPS-Viv-1635Vitis vinifera39.354e-137 423
LLPS-Ten-1715Tetraodon nigroviridis39.335e-124 399
LLPS-Asm-0488Astyanax mexicanus39.333e-135 429
LLPS-Orl-1563Oryzias latipes39.326e-129 411
LLPS-Orp-0290Oryza punctata39.284e-134 416
LLPS-Pat-2537Pan troglodytes39.213e-135 429
LLPS-Hos-4389Homo sapiens39.067e-136 430
LLPS-Mal-3958Mandrillus leucophaeus39.061e-136 432
LLPS-Asg-0322Ashbya gossypii39.062e-145 445
LLPS-Aon-2074Aotus nancymaae39.065e-135 428
LLPS-Maf-2729Macaca fascicularis39.068e-137 432
LLPS-Anp-0243Anas platyrhynchos39.025e-125 400
LLPS-Chs-1215Chlorocebus sabaeus38.944e-135 428
LLPS-Caj-2008Callithrix jacchus38.912e-133 426
LLPS-Gog-3753Gorilla gorilla38.912e-134 427
LLPS-Tru-1613Triticum urartu38.794e-134 416
LLPS-Eqc-4606Equus caballus38.792e-133 423
LLPS-Tra-0775Triticum aestivum38.793e-134 416
LLPS-Orni-0296Oryza nivara38.772e-136 421
LLPS-Rhb-0404Rhinopithecus bieti38.759e-133 422
LLPS-Mum-1277Mus musculus38.753e-136 431
LLPS-Mea-0769Mesocricetus auratus38.732e-134 426
LLPS-Mae-0307Manihot esculenta38.674e-136 421
LLPS-Orr-1308Oryza rufipogon38.621e-135 419
LLPS-Ors-0568Oryza sativa38.628e-136 420
LLPS-Ori-1385Oryza indica38.628e-136 420
LLPS-Orb-1429Oryza barthii38.622e-135 419
LLPS-Ran-0201Rattus norvegicus38.616e-133 422
LLPS-Aim-2819Ailuropoda melanoleuca38.61e-133 424
LLPS-Xet-0828Xenopus tropicalis38.585e-110 360
LLPS-Gor-2410Gossypium raimondii38.521e-137 424
LLPS-Gaga-1722Gallus gallus38.512e-127 408
LLPS-Meg-0535Meleagris gallopavo38.512e-127 408
LLPS-Sob-0831Sorghum bicolor38.51e-134 417
LLPS-Art-0137Arabidopsis thaliana38.58e-138 425
LLPS-Orgl-0462Oryza glumaepatula38.462e-135 419
LLPS-Cap-1877Cavia porcellus38.453e-131 419
LLPS-Prp-1559Prunus persica38.42e-135 418
LLPS-Bot-2671Bos taurus38.379e-133 421
LLPS-Coc-1372Corchorus capsularis38.353e-128 400
LLPS-Hov-0253Hordeum vulgare38.341e-133 414
LLPS-Cis-0617Ciona savignyi38.311e-131 419
LLPS-Ict-2762Ictidomys tridecemlineatus38.31e-129 415
LLPS-Pot-0348Populus trichocarpa38.252e-133 414
LLPS-Thc-0650Theobroma cacao38.211e-132 412
LLPS-Cii-1566Ciona intestinalis38.129e-122 394
LLPS-Phv-0338Phaseolus vulgaris38.11e-135 419
LLPS-Fud-0172Fukomys damarensis38.092e-128 409
LLPS-Fec-0875Felis catus37.998e-130 414
LLPS-Php-1566Physcomitrella patens37.894e-137 424
LLPS-Cus-0814Cucumis sativus37.793e-134 416
LLPS-Via-0711Vigna angularis37.793e-135 418
LLPS-Man-3332Macaca nemestrina37.773e-124 399
LLPS-Nia-0131Nicotiana attenuata37.751e-134 417
LLPS-Hea-1837Helianthus annuus37.635e-134 415
LLPS-Amt-1331Amborella trichopoda37.61e-133 414
LLPS-Caf-0377Canis familiaris37.581e-131 419
LLPS-Mel-0945Melampsora laricipopulina37.571e-130 408
LLPS-Chc-0883Chondrus crispus37.464e-105 346
LLPS-Sus-3191Sus scrofa37.445e-121 389
LLPS-Brn-0975Brassica napus37.441e-134 416
LLPS-Dio-2759Dipodomys ordii37.385e-115 373
LLPS-Fia-2368Ficedula albicollis37.273e-120 388
LLPS-Cea-1877Cercocebus atys37.272e-112 367
LLPS-Lac-2744Latimeria chalumnae37.251e-118 385
LLPS-Crn-0067Cryptococcus neoformans37.235e-142 439
LLPS-Sem-0642Selaginella moellendorffii37.178e-131 407
LLPS-Bro-2074Brassica oleracea37.131e-132 412
LLPS-Osl-1411Ostreococcus lucimarinus37.087e-107 343
LLPS-Leo-2797Lepisosteus oculatus36.997e-120 387
LLPS-Brr-0742Brassica rapa36.988e-133 412
LLPS-Kop-0947Komagataella pastoris36.679e-130 407
LLPS-Vir-1392Vigna radiata36.462e-125 392
LLPS-Anc-2568Anolis carolinensis36.273e-111 365
LLPS-Nol-3404Nomascus leucogenys36.218e-113 369
LLPS-Sot-1163Solanum tuberosum36.179e-87 286
LLPS-Zem-0966Zea mays36.091e-125 394
LLPS-Sac-1393Saccharomyces cerevisiae35.854e-124 390
LLPS-Paa-2762Papio anubis35.719e-106 349
LLPS-Otg-0183Otolemur garnettii35.553e-115 375
LLPS-Sol-0425Solanum lycopersicum34.877e-123 387
LLPS-Dac-2336Daucus carota33.743e-109 350
LLPS-Asf-0739Aspergillus flavus33.211e-65 238
LLPS-Chr-0585Chlamydomonas reinhardtii32.911e-102 338
LLPS-Arl-1013Arabidopsis lyrata32.833e-62 230
LLPS-Spr-0648Sporisorium reilianum32.662e-64 235
LLPS-Usm-1250Ustilago maydis32.666e-65 236
LLPS-Org-1619Oryza glaberrima32.642e-63 233
LLPS-Orbr-0039Oryza brachyantha32.645e-64 233
LLPS-Gas-0028Galdieria sulphuraria32.317e-87 297
LLPS-Sah-3818Sarcophilus harrisii32.148e-61 224
LLPS-Ora-1328Ornithorhynchus anatinus32.147e-61 225
LLPS-Myl-0175Myotis lucifugus32.086e-61 225