LLPS-Scp-0634
ofd1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Prolyl 3,4-dihydroxylase ofd1; 2-oxoglutarate and Fe(II) dioxygenase domain-containing protein 1; PKHD-type hydroxylase ofd1; uS12 prolyl 3,4-dihydroxylase |
| Gene Name: | ofd1, SPBC6B1.08c |
| Ensembl Gene: | SPBC6B1.08c |
| Ensembl Protein: | SPBC6B1.08c.1 |
| Organism: | Schizosaccharomyces pombe |
| Taxa ID: | 284812 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | SPBC6B1.08c.1 | SPBC6B1.08c.1 |
| UniProt | Q11120, OFD1_SCHPO | |
| GeneBank | CU329671, D83659 | CAA17051.1, BAA12034.1 |
| RefSeq | NM_001022001.2 | NP_596087.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGDTQQPTVL DRFAPHALDT SEAERLSREY HKNGPYNHVV IRPLINDTLL RNVRKELMEN 60 61 IHFTEKVTDI YRVWQTGDLA NLDGLDKKEQ NMLKYLRQVR DALYSEEFRS HVQKITGCGP 120 121 LSASKKDLSV NVYSKGCHLM NHDDVIGTRC ISYILYLVEP DEGWKPEYGG ALRLFPTLQP 180 181 SFPAADFCHS IPPQWNQLSF FRVKPGHSFH DVEEVYVDKP RMAISGWFHY PQPGEPGYDA 240 241 NYCDNTVSTL QSLTMKQMDL ELPRFSYYPV VKPEPLSKQD TDILSNYINP LYLTPDGIEK 300 301 LSKRFFQDSV IVLVEFLNQE FANTLLKRII DAERQPTPMH SSEVSFPWKT AIPPHKHRYL 360 361 YLDHEEFGPD IILPMDLQRL PAFQRWIQLV SGLPLRSFHQ VGRRFRPGSD FTLATTNDTA 420 421 LLEATLCLSP GTGIANTDNG AYDIYMIGDE DPDVDAAVYR GDQQDDSILL SLPAAWNVFS 480 481 LVYRDEGVLQ FVKYVSRQAE SSRWDIYSQW NPVAE 515 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGGATA CTCAACAACC AACAGTGCTG GATAGATTTG CGCCTCATGC ATTAGATACC 60 61 AGTGAGGCAG AAAGACTTTC ACGGGAATAT CACAAAAATG GACCGTATAA TCATGTTGTG 120 121 ATTCGTCCTC TGATCAATGA TACACTTCTT CGAAATGTTC GTAAGGAACT TATGGAAAAC 180 181 ATACATTTTA CAGAGAAAGT AACTGATATT TACCGTGTTT GGCAAACTGG TGATCTAGCA 240 241 AACTTGGATG GATTAGACAA GAAAGAGCAA AACATGCTTA AGTATTTGCG TCAAGTTCGT 300 301 GATGCTCTTT ACTCTGAGGA ATTTCGCTCT CACGTTCAAA AGATTACCGG CTGTGGCCCT 360 361 TTATCGGCTA GCAAAAAAGA TTTGTCTGTT AATGTTTACT CAAAAGGATG CCATTTGATG 420 421 AATCATGACG ATGTTATTGG TACCAGGTGC ATTTCCTATA TCTTATACTT GGTAGAACCT 480 481 GACGAAGGTT GGAAACCCGA ATATGGAGGT GCACTCCGGT TGTTTCCTAC ATTACAACCA 540 541 TCCTTTCCTG CTGCTGATTT TTGTCACTCC ATTCCTCCTC AATGGAATCA ACTCTCTTTC 600 601 TTCCGAGTTA AGCCCGGACA TTCATTCCAT GATGTTGAAG AAGTTTATGT AGATAAACCT 660 661 CGAATGGCTA TTTCCGGCTG GTTTCATTAC CCTCAGCCTG GCGAACCTGG TTATGACGCT 720 721 AATTACTGCG ACAATACCGT TTCTACTTTG CAGTCTTTAA CAATGAAACA AATGGACTTA 780 781 GAACTTCCCC GGTTTTCATA CTACCCAGTT GTTAAGCCAG AACCTTTATC CAAACAGGAT 840 841 ACTGATATTT TAAGCAATTA TATTAATCCA CTTTACCTGA CACCTGATGG CATTGAAAAA 900 901 CTATCAAAAC GCTTTTTTCA AGATTCTGTT ATTGTTTTAG TAGAGTTTTT AAATCAGGAA 960 961 TTTGCAAACA CTCTCCTTAA GCGAATCATC GATGCTGAAA GGCAGCCCAC TCCTATGCAT 1020 1021 TCTTCCGAAG TGTCATTCCC TTGGAAAACT GCCATTCCTC CTCATAAGCA CAGGTACCTA 1080 1081 TATTTAGATC ATGAAGAGTT TGGCCCTGAT ATTATTTTGC CCATGGATTT GCAGCGCCTT 1140 1141 CCTGCGTTTC AGCGTTGGAT CCAACTTGTC AGTGGCTTAC CCCTTCGTTC CTTTCATCAA 1200 1201 GTTGGTCGAC GATTCCGCCC TGGTTCCGAT TTTACGCTTG CTACTACGAA TGACACAGCT 1260 1261 TTACTAGAAG CTACTCTTTG CTTATCTCCG GGGACAGGCA TTGCGAATAC TGACAATGGT 1320 1321 GCATATGATA TTTATATGAT TGGCGATGAA GATCCTGATG TAGATGCTGC TGTGTATAGG 1380 1381 GGTGATCAGC AAGATGACAG TATTTTGCTT TCTTTGCCAG CCGCTTGGAA TGTTTTTTCT 1440 1441 TTGGTTTATA GAGATGAAGG TGTCCTTCAA TTTGTCAAAT ATGTGTCGCG TCAAGCCGAA 1500 1501 TCTAGTCGCT GGGATATATA TTCACAATGG AATCCCGTTG CTGAGTAA 1548 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | Ribonucleoprotein complex | |
Molecular Function | Iron ion binding | |
Molecular Function | L-ascorbic acid binding | |
Molecular Function | Peptidyl-proline dioxygenase activity | |
Biological Process | Cellular response to hyperoxia | |
Biological Process | Negative regulation of cellular response to hypoxia | |
Biological Process | Negative regulation of DNA binding | |
Biological Process | Negative regulation of SREBP signaling pathway | |
Biological Process | Negative regulation of transcription by transcription factor catabolism | |
Biological Process | Peptidyl-proline di-hydroxylation | |
Biological Process | Peptidyl-proline hydroxylation | |
Biological Process | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | Regulation of translational termination |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scc-0363 | Schizosaccharomyces cryophilus | 80.58 | 0.0 | 890 |
| LLPS-Scj-0431 | Schizosaccharomyces japonicus | 76.89 | 0.0 | 857 |
| LLPS-Blg-0956 | Blumeria graminis | 55.07 | 4e-15 | 82.4 |
| LLPS-Mao-0136 | Magnaporthe oryzae | 52.05 | 5e-15 | 82.0 |
| LLPS-Scs-0758 | Sclerotinia sclerotiorum | 50.7 | 5e-16 | 85.1 |
| LLPS-Gag-1487 | Gaeumannomyces graminis | 49.33 | 4e-14 | 79.3 |
| LLPS-Cogr-0007 | Colletotrichum graminicola | 48.53 | 4e-08 | 60.1 |
| LLPS-Lem-0304 | Leptosphaeria maculans | 48.33 | 5e-09 | 62.8 |
| LLPS-Map-0056 | Magnaporthe poae | 48.0 | 2e-13 | 77.4 |
| LLPS-Yal-0285 | Yarrowia lipolytica | 44.81 | 1e-150 | 452 |
| LLPS-Asfu-0463 | Aspergillus fumigatus | 42.39 | 1e-119 | 370 |
| LLPS-Asg-0656 | Ashbya gossypii | 42.33 | 2e-133 | 407 |
| LLPS-Nef-0357 | Neosartorya fischeri | 41.8 | 2e-126 | 389 |
| LLPS-Mel-0552 | Melampsora laricipopulina | 41.1 | 2e-127 | 390 |
| LLPS-Sac-1368 | Saccharomyces cerevisiae | 40.92 | 3e-137 | 418 |
| LLPS-Abg-0107 | Absidia glauca | 40.83 | 2e-129 | 396 |
| LLPS-Trr-0911 | Trichoderma reesei | 40.79 | 1e-128 | 395 |
| LLPS-Asc-0698 | Aspergillus clavatus | 40.62 | 7e-125 | 386 |
| LLPS-Asni-1422 | Aspergillus niger | 40.54 | 1e-122 | 379 |
| LLPS-Nec-1331 | Neurospora crassa | 40.41 | 3e-123 | 383 |
| LLPS-Trv-0380 | Trichoderma virens | 40.35 | 1e-128 | 396 |
| LLPS-Cog-0442 | Colletotrichum gloeosporioides | 40.31 | 2e-127 | 393 |
| LLPS-Ast-1030 | Aspergillus terreus | 40.17 | 4e-122 | 379 |
| LLPS-Beb-1241 | Beauveria bassiana | 40.13 | 2e-121 | 378 |
| LLPS-Coo-0436 | Colletotrichum orbiculare | 40.1 | 7e-122 | 382 |
| LLPS-Pyt-0330 | Pyrenophora teres | 39.61 | 1e-118 | 370 |
| LLPS-Fus-1331 | Fusarium solani | 39.55 | 2e-120 | 375 |
| LLPS-Fuo-0609 | Fusarium oxysporum | 39.51 | 1e-121 | 378 |
| LLPS-Tum-0008 | Tuber melanosporum | 39.46 | 7e-126 | 389 |
| LLPS-Fuv-1390 | Fusarium verticillioides | 39.44 | 1e-119 | 372 |
| LLPS-Asn-1187 | Aspergillus nidulans | 39.33 | 7e-127 | 392 |
| LLPS-Phn-0994 | Phaeosphaeria nodorum | 39.31 | 1e-121 | 378 |
| LLPS-Pug-0118 | Puccinia graminis | 39.23 | 6e-115 | 359 |
| LLPS-Asf-0217 | Aspergillus flavus | 39.09 | 4e-130 | 400 |
| LLPS-Aso-0026 | Aspergillus oryzae | 39.09 | 4e-130 | 400 |
| LLPS-Spr-0628 | Sporisorium reilianum | 38.75 | 2e-95 | 310 |
| LLPS-Kop-0672 | Komagataella pastoris | 38.74 | 3e-128 | 394 |
| LLPS-Dos-0297 | Dothistroma septosporum | 38.42 | 1e-121 | 377 |
| LLPS-Put-0357 | Puccinia triticina | 38.25 | 2e-114 | 358 |
| LLPS-Zyt-1240 | Zymoseptoria tritici | 37.98 | 2e-112 | 353 |
| LLPS-Miv-0660 | Microbotryum violaceum | 36.32 | 3e-101 | 324 |
| LLPS-Cym-0257 | Cyanidioschyzon merolae | 35.66 | 1e-79 | 267 |
| LLPS-Crn-0305 | Cryptococcus neoformans | 35.52 | 3e-62 | 221 |
| LLPS-Usm-0311 | Ustilago maydis | 35.12 | 2e-108 | 344 |
| LLPS-Chr-0985 | Chlamydomonas reinhardtii | 35.02 | 4e-81 | 272 |
| LLPS-Osl-0730 | Ostreococcus lucimarinus | 34.54 | 7e-76 | 254 |
| LLPS-Hos-1501 | Homo sapiens | 34.03 | 2e-25 | 114 |
| LLPS-Myl-1597 | Myotis lucifugus | 32.64 | 4e-23 | 107 |
| LLPS-Sus-3472 | Sus scrofa | 32.29 | 1e-23 | 108 |
| LLPS-Tut-0932 | Tursiops truncatus | 32.29 | 1e-23 | 108 |
| LLPS-Eqc-1138 | Equus caballus | 32.29 | 1e-23 | 108 |
| LLPS-Ran-3498 | Rattus norvegicus | 31.49 | 6e-25 | 112 |
| LLPS-Aim-2633 | Ailuropoda melanoleuca | 31.32 | 6e-26 | 115 |
| LLPS-Otg-1397 | Otolemur garnettii | 31.32 | 8e-27 | 117 |
| LLPS-Pat-0502 | Pan troglodytes | 31.32 | 6e-26 | 115 |
| LLPS-Urm-2072 | Ursus maritimus | 31.32 | 5e-26 | 115 |
| LLPS-Man-1236 | Macaca nemestrina | 31.2 | 2e-20 | 98.6 |
| LLPS-Mam-2140 | Macaca mulatta | 31.2 | 1e-20 | 99.0 |
| LLPS-Sah-2707 | Sarcophilus harrisii | 31.04 | 5e-27 | 118 |
| LLPS-Caf-3481 | Canis familiaris | 31.04 | 4e-25 | 112 |
| LLPS-Mup-2183 | Mustela putorius furo | 30.96 | 3e-25 | 113 |
| LLPS-Cas-2844 | Carlito syrichta | 30.88 | 7e-24 | 109 |
| LLPS-Cea-3899 | Cercocebus atys | 30.85 | 1e-25 | 114 |
| LLPS-Cis-1519 | Ciona savignyi | 30.81 | 3e-11 | 68.2 |
| LLPS-Mea-1996 | Mesocricetus auratus | 30.77 | 1e-23 | 108 |
| LLPS-Bot-1740 | Bos taurus | 30.77 | 6e-26 | 115 |
| LLPS-Ova-1500 | Ovis aries | 30.68 | 7e-25 | 112 |
| LLPS-Dio-2367 | Dipodomys ordii | 30.68 | 1e-24 | 111 |
| LLPS-Paa-1136 | Papio anubis | 30.58 | 6e-25 | 112 |
| LLPS-Tar-3542 | Takifugu rubripes | 30.58 | 3e-22 | 103 |
| LLPS-Mum-0435 | Mus musculus | 30.25 | 1e-23 | 108 |
| LLPS-Poa-0061 | Pongo abelii | 30.24 | 6e-26 | 115 |
| LLPS-Caj-2911 | Callithrix jacchus | 30.22 | 5e-25 | 112 |
| LLPS-Fec-1223 | Felis catus | 30.22 | 7e-25 | 112 |
| LLPS-Rhb-2575 | Rhinopithecus bieti | 30.03 | 5e-25 | 112 |
| LLPS-Meg-2995 | Meleagris gallopavo | 29.96 | 7e-18 | 90.1 |
| LLPS-Ora-1384 | Ornithorhynchus anatinus | 29.67 | 2e-25 | 113 |
| LLPS-Fia-1269 | Ficedula albicollis | 29.63 | 1e-17 | 89.7 |
| LLPS-Fud-2279 | Fukomys damarensis | 29.4 | 2e-22 | 104 |
| LLPS-Tag-1318 | Taeniopygia guttata | 29.28 | 2e-19 | 95.1 |
| LLPS-Orc-3097 | Oryctolagus cuniculus | 29.25 | 7e-25 | 112 |
| LLPS-Xim-2468 | Xiphophorus maculatus | 29.2 | 1e-26 | 116 |
| LLPS-Gaa-2770 | Gasterosteus aculeatus | 28.95 | 6e-20 | 97.1 |
| LLPS-Nol-1396 | Nomascus leucogenys | 28.71 | 1e-25 | 114 |
| LLPS-Cap-1397 | Cavia porcellus | 28.64 | 3e-24 | 110 |
| LLPS-Aon-1195 | Aotus nancymaae | 28.57 | 7e-20 | 97.1 |
| LLPS-Maf-2072 | Macaca fascicularis | 28.54 | 5e-26 | 115 |
| LLPS-Chs-2346 | Chlorocebus sabaeus | 28.54 | 4e-26 | 115 |
| LLPS-Pap-2369 | Pan paniscus | 28.05 | 1e-25 | 114 |
| LLPS-Loa-1230 | Loxodonta africana | 27.98 | 1e-25 | 114 |
| LLPS-Ict-1548 | Ictidomys tridecemlineatus | 27.8 | 5e-27 | 118 |
| LLPS-Gog-3316 | Gorilla gorilla | 27.63 | 1e-25 | 114 |
| LLPS-Pes-1126 | Pelodiscus sinensis | 27.24 | 6e-28 | 120 |
| LLPS-Xet-0249 | Xenopus tropicalis | 27.18 | 3e-23 | 107 |
| LLPS-Scf-0070 | Scleropages formosus | 27.13 | 1e-24 | 111 |
| LLPS-Lac-3025 | Latimeria chalumnae | 26.91 | 1e-18 | 93.2 |
| LLPS-Scm-2615 | Scophthalmus maximus | 26.89 | 1e-27 | 119 |
| LLPS-Mal-3124 | Mandrillus leucophaeus | 26.64 | 3e-10 | 66.6 |
| LLPS-Gaga-0875 | Gallus gallus | 26.61 | 2e-19 | 95.9 |
| LLPS-Mod-1505 | Monodelphis domestica | 26.5 | 7e-27 | 118 |
| LLPS-Pof-2407 | Poecilia formosa | 26.14 | 2e-27 | 119 |
| LLPS-Anp-0645 | Anas platyrhynchos | 26.1 | 1e-18 | 92.0 |
| LLPS-Drm-1876 | Drosophila melanogaster | 26.05 | 2e-26 | 116 |
| LLPS-Orn-2702 | Oreochromis niloticus | 25.94 | 2e-24 | 110 |
| LLPS-Leo-0436 | Lepisosteus oculatus | 25.88 | 7e-25 | 112 |
| LLPS-Anc-0132 | Anolis carolinensis | 25.29 | 1e-27 | 120 |
| LLPS-Cii-0979 | Ciona intestinalis | 25.2 | 6e-22 | 102 |
| LLPS-Dar-0954 | Danio rerio | 25.14 | 3e-21 | 101 |
| LLPS-Orl-0792 | Oryzias latipes | 25.05 | 2e-22 | 105 |
| LLPS-Ten-0806 | Tetraodon nigroviridis | 23.58 | 1e-19 | 96.3 |
| LLPS-Cae-1891 | Caenorhabditis elegans | 22.9 | 2e-17 | 89.4 |