• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scp-0336
crb3

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pre-rRNA-processing protein crb3/ipi3
Gene Name: crb3, ipi3, SPAC13G7.08c
Ensembl Gene: SPAC13G7.08c
Ensembl Protein: SPAC13G7.08c.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Required for both pre-rRNA processing and heterochromatic gene silencing.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MELLLSGCEA  IEGEPSNVLC  HNLHTGTLVS  TFRQSSPAKN  ATCTTLNHLL  SAQHTRPQLN  60
61    IHNFGKEILD  QSIILPEILI  CVQSSPCGSW  LAAGTEKGNL  YIWSLKSGAL  IYFFRAHYQP  120
121   LTILKFSNDG  MVLFTASNDG  DVFAWLISTL  VDQNSTFETS  NSSVKAISHF  SGHKRSIVSM  180
181   EIGPGPIVSG  RLYTASEDNT  IRIWDVSTGN  LLTTIALPST  PSCMTVDPSE  RVVYVGNEKG  240
241   IIWIPLYTGS  STFSNNVKEK  KRVTSVDNTT  IPNAIGGMGR  VVDYNDSRES  SIISCQSPIT  300
301   TLTVSFDASL  LISGDKDGNV  LVWDSVSRQV  LRRLVQYYSP  VSFLQCKVDK  ISFYSNSSLS  360
361   FPVLKRMITN  EYLNSDVRIC  IQDDGVEQLM  QPENILKISS  DIVTQGSESS  WRAKAETSEM  420
421   QLKEAKRLFY  ELKQIHQALW  EKYLQK  446
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCTGC  TTCTTTCTGG  CTGTGAAGCT  ATTGAGGGTG  AACCAAGTAA  TGTTCTATGC  60
61    CACAATCTAC  ATACCGGTAC  CCTGGTGAGC  ACATTCCGTC  AAAGCTCACC  TGCTAAAAAC  120
121   GCGACATGTA  CTACTTTGAA  TCATTTGCTA  TCTGCTCAAC  ATACCCGTCC  ACAGCTGAAT  180
181   ATTCACAATT  TTGGAAAGGA  AATTTTGGAT  CAATCAATCA  TTTTACCTGA  AATACTTATT  240
241   TGTGTGCAAT  CGAGTCCTTG  TGGTTCTTGG  CTGGCAGCAG  GCACAGAAAA  AGGAAATTTG  300
301   TACATATGGT  CATTAAAATC  CGGTGCTCTT  ATTTATTTCT  TCAGAGCACA  CTACCAACCT  360
361   TTGACCATTT  TGAAATTTTC  CAATGATGGT  ATGGTTTTAT  TCACTGCTTC  CAACGATGGT  420
421   GATGTATTCG  CTTGGTTGAT  AAGCACTTTG  GTAGACCAAA  ACTCTACTTT  TGAAACAAGT  480
481   AATAGTTCAG  TTAAAGCGAT  TTCTCATTTC  TCTGGTCATA  AGCGTTCTAT  CGTGTCTATG  540
541   GAAATTGGCC  CTGGTCCCAT  CGTTAGTGGT  CGACTTTACA  CGGCTTCGGA  AGACAACACA  600
601   ATAAGGATTT  GGGATGTTTC  TACAGGAAAC  CTTTTGACAA  CGATTGCTCT  TCCCTCAACT  660
661   CCCAGTTGCA  TGACCGTGGA  TCCTTCCGAA  CGTGTTGTCT  ACGTTGGTAA  CGAAAAGGGA  720
721   ATAATATGGA  TTCCATTATA  CACAGGATCA  TCCACTTTTT  CTAACAACGT  TAAAGAGAAA  780
781   AAAAGAGTTA  CGTCTGTTGA  TAATACTACT  ATTCCAAACG  CCATCGGAGG  TATGGGTCGA  840
841   GTTGTAGATT  ATAACGACAG  TAGAGAATCA  AGTATTATAT  CGTGTCAATC  CCCAATAACC  900
901   ACGTTGACTG  TTTCCTTTGA  TGCTTCTCTA  CTCATTAGTG  GTGATAAGGA  TGGTAATGTT  960
961   TTGGTTTGGG  ATAGTGTTTC  TCGACAAGTT  TTGCGCCGCC  TCGTTCAGTA  TTATTCGCCG  1020
1021  GTCTCTTTTC  TTCAATGCAA  GGTCGACAAG  ATATCATTTT  ATTCAAACTC  TTCACTTTCT  1080
1081  TTTCCAGTTT  TAAAGCGCAT  GATTACAAAT  GAGTACTTAA  ATTCAGATGT  TCGAATTTGC  1140
1141  ATTCAAGATG  ATGGGGTAGA  GCAGCTGATG  CAACCGGAAA  ATATTCTCAA  AATCAGCTCT  1200
1201  GATATTGTCA  CACAAGGCTC  AGAGTCCAGT  TGGCGTGCCA  AAGCTGAAAC  CAGTGAAATG  1260
1261  CAGCTCAAGG  AAGCAAAAAG  ATTATTTTAT  GAATTAAAGC  AAATTCATCA  AGCGTTATGG  1320
1321  GAAAAATACC  TGCAAAAGTA  A  1341

▼ KEYWORD

ID
Family
Chromosome
Complete proteome
Nucleus
Reference proteome
Repeat
Ribosome biogenesis
rRNA processing
Transcription
Transcription regulation
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell division site
Cellular Component
Chromosome, centromeric region
Cellular Component
Cytosol
Cellular Component
Nuclear heterochromatin
Cellular Component
Nuclear pre-replicative complex
Cellular Component
Nucleus
Cellular Component
Rix1 complex
Biological Process
Chromatin silencing at centromere
Biological Process
Pre-replicative complex assembly involved in nuclear cell cycle DNA replication
Biological Process
Regulation of DNA-dependent DNA replication initiation
Biological Process
Ribosomal large subunit assembly
Biological Process
RRNA processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-0351Schizosaccharomyces cryophilus63.390.0 595
LLPS-Scj-0629Schizosaccharomyces japonicus52.911e-166 484
LLPS-Put-0570Puccinia triticina37.741e-1995.9
LLPS-Pug-0375Puccinia graminis37.572e-22 103
LLPS-Mel-0749Melampsora laricipopulina35.152e-21 100
LLPS-Ved-0568Verticillium dahliae32.034e-1066.2
LLPS-Mao-0010Magnaporthe oryzae32.031e-1067.8
LLPS-Yal-0604Yarrowia lipolytica31.529e-55 194
LLPS-Ast-0008Aspergillus terreus31.375e-0962.8
LLPS-Trr-0436Trichoderma reesei31.371e-0964.3
LLPS-Fus-0070Fusarium solani31.375e-1065.9
LLPS-Fuo-0073Fusarium oxysporum31.373e-1067.0
LLPS-Fuv-0379Fusarium verticillioides31.373e-1066.6
LLPS-Art-2179Arabidopsis thaliana31.334e-1065.9
LLPS-Gas-0529Galdieria sulphuraria30.952e-1890.9
LLPS-Beb-0664Beauveria bassiana30.722e-0964.3
LLPS-Cog-0579Colletotrichum gloeosporioides30.722e-0964.3
LLPS-Cogr-0323Colletotrichum graminicola30.722e-0964.3
LLPS-Coo-0256Colletotrichum orbiculare30.724e-0962.8
LLPS-Osl-0507Ostreococcus lucimarinus30.62e-0961.2
LLPS-Miv-0491Microbotryum violaceum30.21e-2098.6
LLPS-Abg-0934Absidia glauca30.053e-46 172
LLPS-Crn-0076Cryptococcus neoformans29.574e-34 137
LLPS-Kop-0142Komagataella pastoris29.37e-36 142
LLPS-Amt-0600Amborella trichopoda29.181e-23 106
LLPS-Tum-0005Tuber melanosporum29.05e-30 125
LLPS-Mua-1077Musa acuminata28.859e-22 101
LLPS-Cus-2080Cucumis sativus28.681e-0654.3
LLPS-Scs-0557Sclerotinia sclerotiorum28.611e-26 114
LLPS-Lac-1224Latimeria chalumnae28.571e-27 117
LLPS-Tru-0304Triticum urartu28.571e-21 100
LLPS-Hea-1495Helianthus annuus28.571e-0757.4
LLPS-Zyt-0348Zymoseptoria tritici28.521e-25 112
LLPS-Meg-1799Meleagris gallopavo28.421e-2199.8
LLPS-Pof-1473Poecilia formosa28.352e-27 117
LLPS-Orn-1794Oreochromis niloticus28.355e-27 115
LLPS-Tra-0817Triticum aestivum28.227e-29 121
LLPS-Scf-1685Scleropages formosus28.126e-28 118
LLPS-Asfu-1045Aspergillus fumigatus27.963e-26 115
LLPS-Rhb-1786Rhinopithecus bieti27.86e-1065.1
LLPS-Bot-0141Bos taurus27.747e-24 107
LLPS-Xim-1643Xiphophorus maculatus27.661e-27 117
LLPS-Gaga-1538Gallus gallus27.416e-24 107
LLPS-Ova-1324Ovis aries27.44e-2095.9
LLPS-Asc-0695Aspergillus clavatus27.382e-23 106
LLPS-Nef-1461Neosartorya fischeri27.362e-25 113
LLPS-Arl-0276Arabidopsis lyrata27.361e-26 114
LLPS-Asm-0651Astyanax mexicanus27.32e-25 111
LLPS-Leo-0144Lepisosteus oculatus27.271e-2097.8
LLPS-Ran-0263Rattus norvegicus27.224e-24 107
LLPS-Caf-0679Canis familiaris27.214e-2197.8
LLPS-Sob-0950Sorghum bicolor27.151e-25 112
LLPS-Mum-0337Mus musculus27.132e-23 105
LLPS-Viv-1466Vitis vinifera27.081e-26 115
LLPS-Mea-1333Mesocricetus auratus27.081e-2097.1
LLPS-Tag-1965Taeniopygia guttata27.056e-2094.7
LLPS-Sol-0097Solanum lycopersicum26.937e-29 121
LLPS-Sot-0392Solanum tuberosum26.935e-28 120
LLPS-Pat-2849Pan troglodytes26.926e-1065.5
LLPS-Pap-3047Pan paniscus26.926e-1065.5
LLPS-Hos-1971Homo sapiens26.927e-1065.5
LLPS-Loa-1995Loxodonta africana26.926e-1065.5
LLPS-Orc-1929Oryctolagus cuniculus26.927e-1065.5
LLPS-Eqc-4324Equus caballus26.926e-1065.5
LLPS-Cap-2306Cavia porcellus26.927e-1065.1
LLPS-Mam-4089Macaca mulatta26.926e-1065.5
LLPS-Maf-2964Macaca fascicularis26.927e-1065.5
LLPS-Chs-1788Chlorocebus sabaeus26.927e-1065.5
LLPS-Aon-1785Aotus nancymaae26.926e-1065.5
LLPS-Cea-4778Cercocebus atys26.926e-1065.5
LLPS-Gog-4076Gorilla gorilla26.926e-1065.5
LLPS-Dio-0610Dipodomys ordii26.926e-1065.5
LLPS-Paa-2698Papio anubis26.926e-1065.5
LLPS-Mup-1557Mustela putorius furo26.925e-1065.5
LLPS-Usm-0665Ustilago maydis26.92e-24 110
LLPS-Cis-0823Ciona savignyi26.874e-23 104
LLPS-Chr-0942Chlamydomonas reinhardtii26.874e-1684.7
LLPS-Tar-0640Takifugu rubripes26.834e-26 113
LLPS-Zem-1131Zea mays26.88e-26 112
LLPS-Sah-0822Sarcophilus harrisii26.691e-25 112
LLPS-Pytr-0267Pyrenophora triticirepentis26.644e-1272.8
LLPS-Pyt-0517Pyrenophora teres26.645e-1272.4
LLPS-Urm-0010Ursus maritimus26.594e-2198.2
LLPS-Met-0248Medicago truncatula26.592e-28 120
LLPS-Ten-1600Tetraodon nigroviridis26.541e-28 120
LLPS-Nia-0456Nicotiana attenuata26.535e-27 114
LLPS-Blg-0009Blumeria graminis26.458e-1271.6
LLPS-Orbr-1192Oryza brachyantha26.382e-1685.9
LLPS-Mal-0159Mandrillus leucophaeus26.326e-24 107
LLPS-Myl-0172Myotis lucifugus26.326e-23 103
LLPS-Map-1257Magnaporthe poae26.232e-1170.1
LLPS-Lem-0432Leptosphaeria maculans26.238e-1168.6
LLPS-Icp-2027Ictalurus punctatus26.22e-25 111
LLPS-Thc-1024Theobroma cacao26.057e-26 112
LLPS-Asf-1121Aspergillus flavus26.013e-23 106
LLPS-Dos-1142Dothistroma septosporum25.971e-26 115
LLPS-Sem-0314Selaginella moellendorffii25.978e-26 113
LLPS-Aso-0452Aspergillus oryzae25.972e-22 104
LLPS-Pot-0243Populus trichocarpa25.953e-24 108
LLPS-Phn-0016Phaeosphaeria nodorum25.841e-1170.9
LLPS-Asg-1096Ashbya gossypii25.838e-2199.0
LLPS-Aim-1528Ailuropoda melanoleuca25.814e-23 104
LLPS-Xet-3023Xenopus tropicalis25.81e-25 111
LLPS-Phv-1396Phaseolus vulgaris25.751e-28 121
LLPS-Poa-0756Pongo abelii25.686e-24 106
LLPS-Dar-0055Danio rerio25.674e-24 107
LLPS-Anp-2415Anas platyrhynchos25.661e-1067.8
LLPS-Spr-0277Sporisorium reilianum25.649e-24 107
LLPS-Orp-0118Oryza punctata25.544e-2199.4
LLPS-Prp-0051Prunus persica25.523e-26 113
LLPS-Nec-0288Neurospora crassa25.472e-1067.0
LLPS-Asni-0918Aspergillus niger25.451e-1067.8
LLPS-Man-0748Macaca nemestrina25.434e-24 107
LLPS-Sus-1480Sus scrofa25.435e-24 107
LLPS-Coc-2057Corchorus capsularis25.427e-1065.5
LLPS-Fec-3292Felis catus25.411e-2098.6
LLPS-Php-1193Physcomitrella patens25.394e-1994.0
LLPS-Sei-1120Setaria italica25.362e-26 114
LLPS-Brr-2105Brassica rapa25.326e-1168.9
LLPS-Bro-1649Brassica oleracea25.327e-1168.6
LLPS-Brn-3138Brassica napus25.324e-1169.3
LLPS-Scm-0600Scophthalmus maximus25.312e-23 105
LLPS-Ict-0482Ictidomys tridecemlineatus25.291e-24 108
LLPS-Hov-0868Hordeum vulgare25.277e-28 118
LLPS-Ors-0096Oryza sativa25.247e-28 118
LLPS-Cym-0796Cyanidioschyzon merolae25.219e-1167.0
LLPS-Via-1486Vigna angularis25.162e-28 120
LLPS-Nol-0762Nomascus leucogenys25.144e-22 101
LLPS-Orr-0146Oryza rufipogon25.072e-26 114
LLPS-Org-1382Oryza glaberrima25.073e-27 116
LLPS-Ori-0805Oryza indica25.074e-2197.8
LLPS-Brd-1300Brachypodium distachyon25.078e-24 106
LLPS-Fia-3556Ficedula albicollis25.01e-0964.7
LLPS-Orb-0196Oryza barthii25.01e-27 117
LLPS-Orni-0403Oryza nivara25.01e-27 117
LLPS-Orgl-1296Oryza glumaepatula25.01e-27 117
LLPS-Gag-0048Gaeumannomyces graminis24.921e-1171.2
LLPS-Tut-0573Tursiops truncatus24.811e-2097.4
LLPS-Glm-1519Glycine max24.731e-29 123
LLPS-Drm-0313Drosophila melanogaster24.71e-23 107
LLPS-Gor-1969Gossypium raimondii24.684e-1066.2
LLPS-Fud-1974Fukomys damarensis24.482e-25 111
LLPS-Orl-1623Oryzias latipes23.961e-28 120
LLPS-Asn-0116Aspergillus nidulans23.923e-21 100
LLPS-Orm-0515Oryza meridionalis23.92e-26 114
LLPS-Mae-0127Manihot esculenta23.792e-25 111
LLPS-Otg-0391Otolemur garnettii23.611e-24 108
LLPS-Gaa-2170Gasterosteus aculeatus23.613e-22 102
LLPS-Anc-3263Anolis carolinensis23.575e-1065.5
LLPS-Pes-0313Pelodiscus sinensis23.432e-1890.1
LLPS-Lep-0276Leersia perrieri23.421e-1789.0
LLPS-Trv-0056Trichoderma virens23.334e-1684.0
LLPS-Cae-0924Caenorhabditis elegans23.05e-1478.2
LLPS-Caj-1543Callithrix jacchus22.832e-1477.8
LLPS-Cas-2604Carlito syrichta22.757e-1065.5
LLPS-Dac-1287Daucus carota22.251e-23 106
LLPS-Mod-3752Monodelphis domestica22.222e-0963.5
LLPS-Ora-1715Ornithorhynchus anatinus21.763e-1066.6