LLPS-Scp-0302
SPAC521.02
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA-dependent metalloprotease WSS1 homolog; DNA damage response protein WSS1 homolog |
| Gene Name: | SPAC521.02 |
| Ensembl Gene: | SPAC521.02 |
| Ensembl Protein: | SPAC521.02.1 |
| Organism: | Schizosaccharomyces pombe |
| Taxa ID: | 284812 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (top1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped top1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | SPAC521.02.1 | SPAC521.02.1 |
| UniProt | Q9P7B5, WSS1_SCHPO | |
| GeneBank | CU329670 | CAB86466.1 |
| RefSeq | NM_001018494.2 | NP_593097.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MIAILYLYYI LTTSILLSVS FMLRINDDDH PNEKIGFISA IKGDFHDLSS DYLKRIAAMA 60 61 FPIMKEHGFG VTSLDEVAYN AKFWGRNWNK GECIELVLRD ASNRWLPFEF VMDVFLHELC 120 121 HIWQGPHDRR FFSHLSTLRA ALIALYAKGY KGPGKYMTWD SFVLANVVGN YNTVVFNGIT 180 181 LERSTMHGVE TCGGSLQRKK KIRRKPTPSS TKKRKLTRTG QKLGTDMNIR LELLKSPAKP 240 241 QAQSMRGREA RIAAALLRVD NSNEYKPKDH NSSTTLENYF VVE 283 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATCGCTA TATTGTATTT ATATTATATT CTGACTACGA GTATCCTTTT AAGTGTTAGC 60 61 TTTATGCTAC GAATAAACGA CGATGACCAT CCAAATGAGA AAATAGGATT TATATCTGCT 120 121 ATAAAAGGAG ATTTCCATGA TCTATCTTCT GATTATTTAA AAAGAATTGC CGCAATGGCA 180 181 TTTCCTATTA TGAAGGAGCA TGGATTCGGA GTCACTTCGT TGGATGAGGT TGCTTACAAT 240 241 GCAAAATTTT GGGGAAGAAA CTGGAATAAG GGAGAATGTA TTGAGCTTGT CCTTAGAGAC 300 301 GCTTCAAATC GATGGTTACC ATTTGAATTT GTCATGGACG TGTTTTTACA CGAACTCTGT 360 361 CATATTTGGC AGGGGCCGCA CGATCGTCGG TTTTTCAGTC ATTTATCAAC TCTTCGAGCT 420 421 GCCCTGATTG CTCTTTACGC CAAAGGTTAT AAAGGCCCTG GAAAGTACAT GACTTGGGAT 480 481 TCATTTGTCC TTGCCAATGT AGTAGGAAAT TATAACACCG TTGTATTTAA CGGAATAACT 540 541 TTGGAACGCA GCACAATGCA TGGTGTGGAA ACTTGTGGTG GATCTTTGCA AAGAAAAAAG 600 601 AAAATCAGAA GAAAGCCTAC CCCTTCCTCA ACAAAGAAGC GGAAGCTTAC ACGAACAGGA 660 661 CAAAAGCTTG GAACTGATAT GAACATAAGA TTAGAGCTTT TGAAATCACC TGCAAAACCC 720 721 CAAGCTCAAA GCATGCGCGG AAGGGAAGCC CGAATTGCAG CGGCACTTCT CCGAGTCGAC 780 781 AATTCTAATG AATATAAGCC TAAAGATCAC AATAGCTCTA CAACCTTGGA AAACTATTTC 840 841 GTAGTAGAAT AA 852 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | Metalloendopeptidase activity | |
Molecular Function | Zinc ion binding | |
Biological Process | Translesion synthesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scc-0759 | Schizosaccharomyces cryophilus | 60.53 | 7e-115 | 338 |
| LLPS-Coo-0404 | Colletotrichum orbiculare | 42.86 | 9e-13 | 71.6 |
| LLPS-Nef-0243 | Neosartorya fischeri | 40.95 | 1e-13 | 73.9 |
| LLPS-Mao-1155 | Magnaporthe oryzae | 40.95 | 1e-11 | 68.6 |
| LLPS-Gag-1491 | Gaeumannomyces graminis | 40.95 | 5e-12 | 69.3 |
| LLPS-Nec-1443 | Neurospora crassa | 40.95 | 8e-12 | 68.9 |
| LLPS-Asf-0975 | Aspergillus flavus | 40.95 | 7e-14 | 75.1 |
| LLPS-Aso-1312 | Aspergillus oryzae | 40.95 | 7e-14 | 75.1 |
| LLPS-Cogr-0445 | Colletotrichum graminicola | 40.52 | 5e-12 | 69.7 |
| LLPS-Asfu-1149 | Aspergillus fumigatus | 40.0 | 5e-13 | 72.4 |
| LLPS-Fuo-1176 | Fusarium oxysporum | 40.0 | 5e-12 | 69.7 |
| LLPS-Asn-1003 | Aspergillus nidulans | 40.0 | 5e-13 | 72.0 |
| LLPS-Asc-0962 | Aspergillus clavatus | 40.0 | 3e-13 | 73.2 |
| LLPS-Dos-0181 | Dothistroma septosporum | 39.64 | 2e-10 | 65.1 |
| LLPS-Hov-1221 | Hordeum vulgare | 39.62 | 6e-12 | 69.3 |
| LLPS-Brd-2156 | Brachypodium distachyon | 39.62 | 6e-13 | 72.0 |
| LLPS-Lep-2282 | Leersia perrieri | 39.62 | 4e-13 | 72.4 |
| LLPS-Asni-0484 | Aspergillus niger | 39.05 | 1e-12 | 71.2 |
| LLPS-Trv-0700 | Trichoderma virens | 38.74 | 1e-13 | 74.3 |
| LLPS-Orbr-1343 | Oryza brachyantha | 38.68 | 2e-12 | 70.9 |
| LLPS-Tra-2804 | Triticum aestivum | 38.68 | 6e-12 | 68.9 |
| LLPS-Sac-0421 | Saccharomyces cerevisiae | 38.46 | 5e-09 | 60.1 |
| LLPS-Ast-0913 | Aspergillus terreus | 38.1 | 2e-12 | 70.5 |
| LLPS-Ved-0117 | Verticillium dahliae | 38.1 | 4e-10 | 63.9 |
| LLPS-Scs-0833 | Sclerotinia sclerotiorum | 38.1 | 9e-12 | 68.9 |
| LLPS-Zyt-0525 | Zymoseptoria tritici | 38.1 | 4e-09 | 60.8 |
| LLPS-Hea-1648 | Helianthus annuus | 37.96 | 9e-15 | 76.3 |
| LLPS-Prp-1920 | Prunus persica | 37.86 | 6e-12 | 69.3 |
| LLPS-Sei-1017 | Setaria italica | 37.86 | 4e-11 | 66.6 |
| LLPS-Trr-1576 | Trichoderma reesei | 37.84 | 1e-12 | 71.2 |
| LLPS-Sob-2216 | Sorghum bicolor | 37.74 | 5e-12 | 69.3 |
| LLPS-Ors-1768 | Oryza sativa | 37.74 | 6e-12 | 68.9 |
| LLPS-Orp-2165 | Oryza punctata | 37.74 | 4e-12 | 69.7 |
| LLPS-Zem-2238 | Zea mays | 37.74 | 4e-12 | 69.7 |
| LLPS-Org-1032 | Oryza glaberrima | 37.74 | 6e-12 | 69.3 |
| LLPS-Coc-0216 | Corchorus capsularis | 37.74 | 3e-11 | 67.4 |
| LLPS-Orm-0521 | Oryza meridionalis | 37.74 | 6e-12 | 69.3 |
| LLPS-Orr-0462 | Oryza rufipogon | 37.74 | 6e-12 | 68.9 |
| LLPS-Orni-1826 | Oryza nivara | 37.74 | 2e-11 | 67.8 |
| LLPS-Thc-0375 | Theobroma cacao | 37.74 | 5e-11 | 66.6 |
| LLPS-Ori-0499 | Oryza indica | 37.74 | 2e-11 | 67.8 |
| LLPS-Pytr-1142 | Pyrenophora triticirepentis | 37.37 | 5e-08 | 57.4 |
| LLPS-Miv-0477 | Microbotryum violaceum | 37.14 | 1e-10 | 65.5 |
| LLPS-Fus-1192 | Fusarium solani | 37.14 | 2e-09 | 61.6 |
| LLPS-Phn-0470 | Phaeosphaeria nodorum | 37.14 | 2e-08 | 58.9 |
| LLPS-Pyt-0029 | Pyrenophora teres | 37.14 | 1e-09 | 62.4 |
| LLPS-Lem-0522 | Leptosphaeria maculans | 37.14 | 3e-08 | 58.5 |
| LLPS-Glm-0913 | Glycine max | 36.94 | 8e-11 | 65.9 |
| LLPS-Gor-0954 | Gossypium raimondii | 36.79 | 1e-10 | 65.5 |
| LLPS-Sol-2293 | Solanum lycopersicum | 36.79 | 3e-10 | 64.3 |
| LLPS-Orb-0964 | Oryza barthii | 36.79 | 2e-11 | 67.4 |
| LLPS-Met-1883 | Medicago truncatula | 36.79 | 3e-10 | 64.3 |
| LLPS-Mua-2501 | Musa acuminata | 36.43 | 4e-13 | 72.8 |
| LLPS-Cus-1886 | Cucumis sativus | 36.07 | 5e-12 | 69.7 |
| LLPS-Sot-1946 | Solanum tuberosum | 35.85 | 1e-09 | 62.8 |
| LLPS-Tru-1441 | Triticum urartu | 35.71 | 5e-12 | 68.9 |
| LLPS-Phv-2201 | Phaseolus vulgaris | 35.45 | 3e-10 | 64.3 |
| LLPS-Pot-1736 | Populus trichocarpa | 35.2 | 9e-13 | 71.2 |
| LLPS-Mae-1994 | Manihot esculenta | 34.4 | 1e-12 | 71.2 |
| LLPS-Crn-1113 | Cryptococcus neoformans | 34.22 | 6e-21 | 96.3 |
| LLPS-Gas-1010 | Galdieria sulphuraria | 34.21 | 4e-07 | 53.5 |
| LLPS-Dac-2274 | Daucus carota | 34.19 | 3e-10 | 64.3 |
| LLPS-Bro-2399 | Brassica oleracea | 33.96 | 3e-08 | 58.5 |
| LLPS-Brn-2810 | Brassica napus | 33.96 | 3e-08 | 58.2 |
| LLPS-Chr-0629 | Chlamydomonas reinhardtii | 33.94 | 5e-06 | 51.6 |
| LLPS-Amt-2053 | Amborella trichopoda | 33.87 | 8e-11 | 65.9 |
| LLPS-Nia-1345 | Nicotiana attenuata | 33.33 | 4e-10 | 63.9 |
| LLPS-Tum-1583 | Tuber melanosporum | 33.33 | 4e-09 | 60.8 |
| LLPS-Sem-1580 | Selaginella moellendorffii | 33.06 | 6e-09 | 60.1 |
| LLPS-Brr-0045 | Brassica rapa | 33.02 | 5e-08 | 57.4 |
| LLPS-Viv-0348 | Vitis vinifera | 32.8 | 4e-11 | 66.6 |
| LLPS-Arl-1146 | Arabidopsis lyrata | 32.14 | 3e-08 | 58.2 |
| LLPS-Vir-1224 | Vigna radiata | 32.0 | 4e-11 | 66.2 |
| LLPS-Via-0954 | Vigna angularis | 32.0 | 3e-11 | 66.6 |
| LLPS-Art-2852 | Arabidopsis thaliana | 31.75 | 1e-08 | 59.3 |
| LLPS-Kop-0434 | Komagataella pastoris | 31.43 | 4e-10 | 62.8 |
| LLPS-Yal-0280 | Yarrowia lipolytica | 31.05 | 2e-15 | 77.8 |
| LLPS-Php-0911 | Physcomitrella patens | 30.95 | 2e-09 | 61.6 |
| LLPS-Spr-0782 | Sporisorium reilianum | 30.38 | 2e-24 | 106 |