• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scf-1721
apex1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA-(apurinic or apyrimidinic site) lyase
Gene Name: apex1, Z043_113689
Ensembl Gene: ENSSFOG00015001948.1
Ensembl Protein: ENSSFOP00015002982.1
Organism: Scleropages formosus
Taxa ID: 113540
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSKRGKKKDT  GDGEQDNSAA  PPAKKGKKEK  EPEAPILYED  PPDKLSTKDG  RTANMKITSW  60
61    NVDGLRAWVK  KKGLDWVREE  LPDVICLQET  KCAEKSLPQD  ITSMPEFPHK  YWAGSEGKEG  120
121   YSGVAMLCKT  KPLNITYGIG  KEEHDKEGRV  ITAEFPSFFL  VTAYVPNAGR  GLVRLDYRKT  180
181   WDVDFRAYLS  ELDQKKPLVL  CGDLNVAHHE  IDIKNPKGNR  KNAGFTAEER  EGFTQLLAAG  240
241   FVDSFRELYP  EQANAYTFWT  YMMNARAKNV  GWRLDYFVIS  RRLLPSLCDS  KIRNKVMGSD  300
301   HCPITLHITV  310
Nucleotide CDS Sequence (FASTA)
1     ATGTCGAAGA  GAGGAAAGAA  GAAGGACACT  GGAGATGGGG  AGCAGGACAA  CAGTGCAGCC  60
61    CCCCCTGCCA  AAAAGGGTAA  GAAGGAGAAG  GAACCCGAGG  CCCCCATTCT  TTATGAAGAC  120
121   CCTCCAGACA  AACTGAGTAC  TAAAGATGGC  CGCACTGCTA  ACATGAAGAT  CACTTCATGG  180
181   AACGTGGATG  GGCTGCGGGC  CTGGGTTAAG  AAGAAGGGAT  TGGATTGGGT  GCGTGAGGAA  240
241   TTGCCAGACG  TCATCTGCCT  GCAGGAGACC  AAGTGTGCAG  AGAAGTCACT  CCCACAGGAT  300
301   ATCACCTCCA  TGCCCGAGTT  CCCCCACAAG  TACTGGGCTG  GCTCTGAGGG  CAAAGAGGGC  360
361   TACAGCGGCG  TGGCCATGCT  GTGCAAGACA  AAGCCCCTCA  ACATCACCTA  CGGCATCGGA  420
421   AAAGAGGAGC  ATGACAAGGA  AGGGCGTGTC  ATCACTGCAG  AATTCCCCAG  CTTCTTCCTT  480
481   GTCACGGCCT  ACGTGCCCAA  TGCAGGCAGA  GGACTAGTTC  GTCTCGACTA  CCGCAAGACC  540
541   TGGGACGTCG  ACTTCCGAGC  CTACCTGAGC  GAGCTGGACC  AGAAGAAACC  CTTGGTACTG  600
601   TGTGGCGACC  TGAACGTAGC  CCATCACGAG  ATCGACATCA  AGAACCCCAA  GGGCAACCGC  660
661   AAGAATGCTG  GCTTCACAGC  CGAGGAACGC  GAGGGTTTCA  CCCAGCTGCT  TGCCGCTGGC  720
721   TTTGTCGACA  GCTTCAGGGA  GCTGTACCCT  GAGCAGGCCA  ACGCCTACAC  CTTCTGGACC  780
781   TACATGATGA  ATGCCCGTGC  AAAGAATGTG  GGCTGGCGTC  TTGACTACTT  TGTGATCTCT  840
841   CGCAGGCTGC  TGCCGTCACT  GTGCGACAGC  AAGATCCGCA  ACAAAGTGAT  GGGCAGCGAC  900
901   CACTGCCCCA  TCACCCTCCA  CATCACTGTG  TAG  933

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
DNA damage
DNA repair
DNA-binding
Endonuclease
Hydrolase
Lyase
Magnesium
Metal-binding
Mitochondrion
Nuclease
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Cellular Component
Nucleus
Molecular Function
Class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Function
DNA binding
Molecular Function
Endonuclease activity
Molecular Function
Metal ion binding
Biological Process
DNA repair

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-1672Oreochromis niloticus86.910.0 519
LLPS-Xim-1249Xiphophorus maculatus86.180.0 511
LLPS-Scm-0095Scophthalmus maximus85.450.0 512
LLPS-Tar-1029Takifugu rubripes85.456e-178 502
LLPS-Gaa-1663Gasterosteus aculeatus84.737e-178 501
LLPS-Asm-0372Astyanax mexicanus83.650.0 530
LLPS-Orl-0204Oryzias latipes82.640.0 519
LLPS-Pof-1654Poecilia formosa82.580.0 512
LLPS-Icp-0429Ictalurus punctatus82.320.0 509
LLPS-Ten-2100Tetraodon nigroviridis81.490.0 514
LLPS-Dar-2320Danio rerio80.390.0 514
LLPS-Leo-1961Lepisosteus oculatus79.051e-178 503
LLPS-Lac-1402Latimeria chalumnae73.575e-169 479
LLPS-Anc-2861Anolis carolinensis68.242e-157 450
LLPS-Ora-2050Ornithorhynchus anatinus68.02e-143 417
LLPS-Aon-0291Aotus nancymaae67.643e-137 399
LLPS-Xet-0777Xenopus tropicalis67.412e-156 447
LLPS-Mod-2651Monodelphis domestica67.273e-142 411
LLPS-Caj-2531Callithrix jacchus67.275e-143 413
LLPS-Otg-0326Otolemur garnettii67.034e-143 413
LLPS-Fud-0126Fukomys damarensis67.031e-143 415
LLPS-Meg-1153Meleagris gallopavo66.995e-46 157
LLPS-Cap-3023Cavia porcellus66.911e-142 412
LLPS-Loa-2634Loxodonta africana66.912e-141 409
LLPS-Fec-0038Felis catus66.672e-141 414
LLPS-Nol-2317Nomascus leucogenys66.555e-141 408
LLPS-Rhb-1138Rhinopithecus bieti66.555e-141 409
LLPS-Hos-0493Homo sapiens66.551e-140 407
LLPS-Pap-2120Pan paniscus66.556e-141 408
LLPS-Pat-3019Pan troglodytes66.556e-141 408
LLPS-Chs-1168Chlorocebus sabaeus66.556e-141 408
LLPS-Sah-1736Sarcophilus harrisii66.435e-140 406
LLPS-Ict-3026Ictidomys tridecemlineatus66.38e-142 410
LLPS-Eqc-2364Equus caballus66.34e-141 411
LLPS-Orc-0386Oryctolagus cuniculus66.32e-143 414
LLPS-Sus-0354Sus scrofa66.34e-142 411
LLPS-Mam-0565Macaca mulatta66.182e-140 407
LLPS-Poa-2956Pongo abelii66.181e-139 404
LLPS-Man-2175Macaca nemestrina66.182e-140 407
LLPS-Mal-2188Mandrillus leucophaeus66.182e-140 407
LLPS-Paa-3796Papio anubis66.182e-140 407
LLPS-Gog-0332Gorilla gorilla66.184e-140 406
LLPS-Cea-1442Cercocebus atys66.182e-140 407
LLPS-Maf-0244Macaca fascicularis66.183e-140 406
LLPS-Urm-3107Ursus maritimus65.943e-141 409
LLPS-Myl-1635Myotis lucifugus65.947e-143 413
LLPS-Ova-0437Ovis aries65.948e-143 413
LLPS-Aim-2778Ailuropoda melanoleuca65.943e-141 409
LLPS-Dio-3504Dipodomys ordii65.941e-140 407
LLPS-Ere-0783Erinaceus europaeus65.792e-133 388
LLPS-Cas-1272Carlito syrichta65.589e-141 407
LLPS-Bot-0122Bos taurus65.588e-141 407
LLPS-Tut-1007Tursiops truncatus64.687e-116 341
LLPS-Caf-1085Canis familiaris63.213e-143 414
LLPS-Mum-1832Mus musculus62.154e-146 421
LLPS-Ran-2719Rattus norvegicus61.511e-145 420
LLPS-Mea-1030Mesocricetus auratus61.393e-131 383
LLPS-Cii-1074Ciona intestinalis59.182e-121 358
LLPS-Tag-1240Taeniopygia guttata57.873e-102 306
LLPS-Drm-1341Drosophila melanogaster55.259e-102 320
LLPS-Sot-0851Solanum tuberosum52.16e-33 124
LLPS-Zem-1733Zea mays51.493e-65 221
LLPS-Orm-0511Oryza meridionalis51.493e-63 219
LLPS-Orp-0677Oryza punctata51.498e-63 218
LLPS-Cis-0062Ciona savignyi51.496e-95 290
LLPS-Coc-0918Corchorus capsularis51.283e-34 127
LLPS-Orr-0231Oryza rufipogon50.992e-62 217
LLPS-Orgl-1153Oryza glumaepatula50.992e-62 217
LLPS-Orni-0140Oryza nivara50.992e-62 217
LLPS-Thc-0070Theobroma cacao50.381e-81 263
LLPS-Orb-0742Oryza barthii50.242e-62 217
LLPS-Met-0025Medicago truncatula50.192e-78 255
LLPS-Cus-0776Cucumis sativus50.194e-80 258
LLPS-Sob-0363Sorghum bicolor50.05e-62 216
LLPS-Gor-1167Gossypium raimondii49.817e-80 258
LLPS-Brd-0962Brachypodium distachyon49.783e-62 216
LLPS-Mae-1668Manihot esculenta49.255e-80 258
LLPS-Prp-0199Prunus persica49.047e-77 252
LLPS-Orbr-0184Oryza brachyantha49.041e-78 256
LLPS-Php-0008Physcomitrella patens48.893e-74 247
LLPS-Sol-0659Solanum lycopersicum48.852e-75 247
LLPS-Sei-0139Setaria italica48.692e-76 249
LLPS-Hov-0365Hordeum vulgare48.54e-76 249
LLPS-Nia-1451Nicotiana attenuata48.462e-75 246
LLPS-Pot-0603Populus trichocarpa48.311e-77 252
LLPS-Lep-0423Leersia perrieri48.296e-54 192
LLPS-Brn-0887Brassica napus48.295e-76 248
LLPS-Org-0072Oryza glaberrima48.282e-77 251
LLPS-Ors-1421Oryza sativa48.282e-77 251
LLPS-Ori-2020Oryza indica48.282e-77 251
LLPS-Tra-0337Triticum aestivum48.121e-75 247
LLPS-Sem-0520Selaginella moellendorffii47.763e-79 250
LLPS-Phv-0444Phaseolus vulgaris47.571e-76 249
LLPS-Brr-2157Brassica rapa47.563e-69 229
LLPS-Glm-0266Glycine max47.551e-75 248
LLPS-Amt-1040Amborella trichopoda47.332e-78 254
LLPS-Art-2137Arabidopsis thaliana46.746e-74 243
LLPS-Arl-0093Arabidopsis lyrata46.392e-73 242
LLPS-Hea-1097Helianthus annuus46.214e-74 242
LLPS-Bro-0146Brassica oleracea46.181e-70 229
LLPS-Gas-0588Galdieria sulphuraria45.961e-81 257
LLPS-Via-0039Vigna angularis45.566e-70 231
LLPS-Dac-1335Daucus carota45.112e-67 219
LLPS-Cae-1256Caenorhabditis elegans43.982e-73 234
LLPS-Tru-0484Triticum urartu43.633e-62 205
LLPS-Chr-0874Chlamydomonas reinhardtii42.761e-59 206
LLPS-Osl-0308Ostreococcus lucimarinus41.821e-53 182
LLPS-Abg-1517Absidia glauca41.416e-56 190
LLPS-Cym-0171Cyanidioschyzon merolae39.517e-48 171
LLPS-Pug-0356Puccinia graminis39.295e-58 197
LLPS-Chc-0348Chondrus crispus39.066e-60 200
LLPS-Miv-0404Microbotryum violaceum38.496e-52 181
LLPS-Put-0522Puccinia triticina37.444e-38 143
LLPS-Vir-0014Vigna radiata35.453e-24 106
LLPS-Spr-0181Sporisorium reilianum35.345e-48 171
LLPS-Usm-0296Ustilago maydis34.342e-40 150
LLPS-Mua-0636Musa acuminata30.735e-1885.5
LLPS-Mel-0550Melampsora laricipopulina27.822e-24 107