DrLLPS - Data resource of LLPS

LLPS-Sac-1346
KNS1

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Dual specificity protein kinase KNS1
Gene Name:	KNS1, YLL019C
Ensembl Gene:	YLL019C
Ensembl Protein:	YLL019C_mRNA
Organism:	Saccharomyces cerevisiae
Taxa ID:	559292
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nuclear speckle	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-0599	P22518	Client	Nuclear speckle	43.17	2e-73	252

▼ FUNCTION

Nonessential protein kinase.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	YLL019C_mRNA	YLL019C_mRNA
UniProt		P32350, KNS1_YEAST, D6VXY4, Q12399
GeneBank	X97560, Z73125, BK006945, M85200, Z73123	CAA66171.1, AAA34724.1, DAA09300.1, CAA97465.1, CAA97468.1
RefSeq	NM_001181839.1	NP_013081.1
Entrez	850641

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSQNIQIGTR KRSRANMNNS TTTGPANNTS SNKTFLDNFE ETRTNKLLDE MFARQNSFLT 60 61 DNLRNSLDLN QADNPLRPRQ HQHQLFLDNE NAIELDEEPR IINTTINNSN NHNSSRVDED 120 121 ADDDIIFIKE QPIQFSSPLI LPSSSSINNN NNIVTSNNPG CGTAATSNST YITTPKKFKK 180 181 QRTISLPQLP LSKLSYQSNY FNVPDQTNAI VPRVTQTENE LLHLTGSCAK TLEGNKAVNL 240 241 TIAHSTSPFS NPPAQIASLP QSNLKKQIGS SLRKFTSNGS SESASSNKSN FKTDKDGHYV 300 301 YQENDIFGSG GRFVVKDLLG QGTFGKVLKC IDNKYEPNYV AVKVIRAVDR YREAAKTELR 360 361 ILQTILNNDP QGQFQCLLLR ECFDYKNHIC LVTDLYGRSI YDFMCSNGIA RFPGSHIQAI 420 421 ARQLIRSVCF LHDLGIIHTD LKPENILICD ETHIAQKLPL KTVQSLSKRR REASKGKRKI 480 481 LKNPEIKIID FGSAIFHYEY HPPVISTRHY RAPEIVLGLG WSFPCDIWSI ACVLVELVIG 540 541 ESLYPIHENL EHMAMMQRIN GTPFPTDIID KMFYKSKHKL GNSPSDLNST VIKHFDRKTL 600 601 SLQWPEKNKR GDTITTEKSM KRVLQSCDRL DIYISKVLKQ DYGDSLSINW NLPPEKNWSL 660 661 INSKLAWKRQ THSSSSSTTD ELDKETFLFW YWFIDLLRKM FEFDPTKRIT AKDALDHEWF 720 721 NLGILDDGIA TYNNTQG 737
Nucleotide CDS Sequence (FASTA)
1 ATGTCACAGA ATATTCAAAT TGGCACTAGA AAACGTTCAA GAGCAAATAT GAATAATTCC 60 61 ACTACTACGG GCCCTGCTAA CAATACAAGC TCTAACAAGA CCTTTTTGGA TAATTTCGAA 120 121 GAAACGCGCA CAAACAAGCT GCTGGACGAG ATGTTTGCTC GGCAAAATTC TTTTCTAACA 180 181 GACAATCTGA GGAACAGTCT AGACCTGAAT CAAGCAGACA ATCCGCTCCG TCCTCGGCAA 240 241 CACCAACACC AGTTGTTCTT GGACAATGAA AATGCCATAG AACTAGACGA GGAGCCGCGT 300 301 ATCATTAACA CCACAATCAA TAACAGTAAT AATCATAACA GTAGTCGAGT GGACGAGGAT 360 361 GCTGACGATG ACATCATTTT TATCAAAGAG CAGCCAATTC AGTTTTCGTC ACCTTTGATT 420 421 CTGCCTAGTA GCAGCAGTAT CAATAACAAC AATAATATTG TTACTTCAAA TAATCCAGGG 480 481 TGCGGTACCG CAGCTACAAG CAATAGTACG TATATCACGA CACCAAAGAA ATTCAAGAAG 540 541 CAAAGAACCA TCTCACTGCC TCAGTTGCCT CTATCGAAGC TGAGCTACCA ATCGAACTAT 600 601 TTTAATGTTC CTGATCAAAC CAACGCTATC GTGCCAAGAG TAACGCAAAC TGAAAATGAG 660 661 CTGTTGCATC TAACGGGGTC GTGTGCAAAG ACTCTGGAGG GCAACAAGGC AGTGAATCTC 720 721 ACGATTGCTC ACAGCACTTC TCCCTTTTCC AACCCACCAG CACAAATAGC TTCCCTGCCT 780 781 CAATCCAACC TCAAGAAACA AATTGGTTCT TCACTACGGA AATTTACATC AAACGGCTCT 840 841 TCAGAAAGCG CATCATCCAA TAAATCAAAT TTCAAAACGG ACAAAGACGG TCACTACGTT 900 901 TACCAGGAAA ACGACATATT TGGCAGTGGC GGCCGCTTTG TTGTGAAGGA CCTATTGGGC 960 961 CAAGGCACGT TTGGTAAAGT ACTTAAATGC ATCGATAACA AGTATGAACC TAATTACGTG 1020 1021 GCTGTAAAAG TGATAAGGGC TGTAGATAGA TATAGAGAAG CCGCCAAAAC AGAACTAAGA 1080 1081 ATTCTACAGA CTATCCTGAA TAATGACCCT CAAGGTCAGT TCCAGTGCCT CTTGCTAAGG 1140 1141 GAGTGCTTCG ATTACAAAAA TCACATTTGT TTGGTGACAG ATCTATACGG CAGGTCCATT 1200 1201 TACGATTTTA TGTGCTCCAA CGGCATTGCC AGGTTCCCCG GCTCTCATAT TCAGGCCATT 1260 1261 GCCAGACAGC TAATCAGATC TGTCTGCTTC TTGCACGATT TGGGCATAAT ACACACGGAT 1320 1321 TTGAAACCAG AAAATATCCT GATTTGTGAC GAAACCCATA TTGCTCAAAA ATTGCCTTTG 1380 1381 AAAACCGTAC AGTCGCTAAG CAAGAGACGC CGTGAAGCCA GTAAGGGGAA GCGCAAAATC 1440 1441 TTGAAAAATC CAGAAATCAA AATCATTGAT TTCGGTAGCG CAATTTTCCA TTACGAATAT 1500 1501 CATCCTCCTG TAATATCCAC TCGTCACTAT AGAGCCCCGG AAATTGTCCT TGGCTTGGGC 1560 1561 TGGTCGTTCC CCTGCGACAT TTGGTCCATC GCGTGTGTCC TAGTAGAACT GGTTATTGGC 1620 1621 GAATCTCTTT ACCCCATTCA TGAAAATCTA GAACATATGG CTATGATGCA ACGAATCAAT 1680 1681 GGAACCCCTT TCCCCACAGA CATTATTGAT AAGATGTTTT ACAAATCTAA ACATAAATTG 1740 1741 GGCAACTCTC CATCAGACCT AAATTCAACG GTGATAAAGC ATTTCGACAG AAAAACTTTA 1800 1801 AGCTTACAAT GGCCTGAAAA AAATAAACGC GGAGATACCA TAACCACCGA AAAGTCAATG 1860 1861 AAAAGGGTCT TGCAGTCATG TGATCGCTTA GATATTTACA TCTCAAAGGT CTTGAAACAG 1920 1921 GATTACGGCG ATAGCTTAAG CATCAATTGG AATCTACCGC CGGAGAAAAA CTGGTCTTTG 1980 1981 ATAAATTCGA AATTGGCATG GAAAAGACAA ACACATTCCT CTTCTTCCTC AACTACTGAT 2040 2041 GAACTCGATA AGGAAACTTT CTTGTTTTGG TACTGGTTCA TCGATCTACT CAGGAAAATG 2100 2101 TTTGAGTTCG ACCCAACAAA AAGGATTACC GCAAAGGACG CTCTGGACCA TGAATGGTTT 2160 2161 AATCTGGGCA TACTGGATGA TGGTATTGCA ACTTATAATA ATACCCAAGG ATAG 2214

Nucleotide Sequence

>LLPS-Sac-1346|YLL019C
ATGTCACAGAATATTCAAATTGGCACTAGAAAACGTTCAAGAGCAAATATGAATAATTCCACTACTACGGGCCCTGCTAACAATACAAGCTCTAACAAGACCTTTTTGGATAATTTCGAAGAAACGCGCACAAACAAGCTGCTGGACGAGATGTTTGCTCGGCAAAATTCTTTTCTAACAGACAATCTGAGGAACAGTCTAGACCTGAATCAAGCAGACAATCCGCTCCGTCCTCGGCAACACCAACACCAGTTGTTCTTGGACAATGAAAATGCCATAGAACTAGACGAGGAGCCGCGTATCATTAACACCACAATCAATAACAGTAATAATCATAACAGTAGTCGAGTGGACGAGGATGCTGACGATGACATCATTTTTATCAAAGAGCAGCCAATTCAGTTTTCGTCACCTTTGATTCTGCCTAGTAGCAGCAGTATCAATAACAACAATAATATTGTTACTTCAAATAATCCAGGGTGCGGTACCGCAGCTACAAGCAATAGTACGTATATCACGACACCAAAGAAATTCAAGAAGCAAAGAACCATCTCACTGCCTCAGTTGCCTCTATCGAAGCTGAGCTACCAATCGAACTATTTTAATGTTCCTGATCAAACCAACGCTATCGTGCCAAGAGTAACGCAAACTGAAAATGAGCTGTTGCATCTAACGGGGTCGTGTGCAAAGACTCTGGAGGGCAACAAGGCAGTGAATCTCACGATTGCTCACAGCACTTCTCCCTTTTCCAACCCACCAGCACAAATAGCTTCCCTGCCTCAATCCAACCTCAAGAAACAAATTGGTTCTTCACTACGGAAATTTACATCAAACGGCTCTTCAGAAAGCGCATCATCCAATAAATCAAATTTCAAAACGGACAAAGACGGTCACTACGTTTACCAGGAAAACGACATATTTGGCAGTGGCGGCCGCTTTGTTGTGAAGGACCTATTGGGCCAAGGCACGTTTGGTAAAGTACTTAAATGCATCGATAACAAGTATGAACCTAATTACGTGGCTGTAAAAGTGATAAGGGCTGTAGATAGATATAGAGAAGCCGCCAAAACAGAACTAAGAATTCTACAGACTATCCTGAATAATGACCCTCAAGGTCAGTTCCAGTGCCTCTTGCTAAGGGAGTGCTTCGATTACAAAAATCACATTTGTTTGGTGACAGATCTATACGGCAGGTCCATTTACGATTTTATGTGCTCCAACGGCATTGCCAGGTTCCCCGGCTCTCATATTCAGGCCATTGCCAGACAGCTAATCAGATCTGTCTGCTTCTTGCACGATTTGGGCATAATACACACGGATTTGAAACCAGAAAATATCCTGATTTGTGACGAAACCCATATTGCTCAAAAATTGCCTTTGAAAACCGTACAGTCGCTAAGCAAGAGACGCCGTGAAGCCAGTAAGGGGAAGCGCAAAATCTTGAAAAATCCAGAAATCAAAATCATTGATTTCGGTAGCGCAATTTTCCATTACGAATATCATCCTCCTGTAATATCCACTCGTCACTATAGAGCCCCGGAAATTGTCCTTGGCTTGGGCTGGTCGTTCCCCTGCGACATTTGGTCCATCGCGTGTGTCCTAGTAGAACTGGTTATTGGCGAATCTCTTTACCCCATTCATGAAAATCTAGAACATATGGCTATGATGCAACGAATCAATGGAACCCCTTTCCCCACAGACATTATTGATAAGATGTTTTACAAATCTAAACATAAATTGGGCAACTCTCCATCAGACCTAAATTCAACGGTGATAAAGCATTTCGACAGAAAAACTTTAAGCTTACAATGGCCTGAAAAAAATAAACGCGGAGATACCATAACCACCGAAAAGTCAATGAAAAGGGTCTTGCAGTCATGTGATCGCTTAGATATTTACATCTCAAAGGTCTTGAAACAGGATTACGGCGATAGCTTAAGCATCAATTGGAATCTACCGCCGGAGAAAAACTGGTCTTTGATAAATTCGAAATTGGCATGGAAAAGACAAACACATTCCTCTTCTTCCTCAACTACTGATGAACTCGATAAGGAAACTTTCTTGTTTTGGTACTGGTTCATCGATCTACTCAGGAAAATGTTTGAGTTCGACCCAACAAAAAGGATTACCGCAAAGGACGCTCTGGACCATGAATGGTTTAATCTGGGCATACTGGATGATGGTATTGCAACTTATAATAATACCCAAGGATAG

▼ KEYWORD

ID	Family
KW-0067	ATP-binding
KW-0181	Complete proteome
KW-0418	Kinase
KW-0547	Nucleotide-binding
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0723	Serine/threonine-protein kinase
KW-0808	Transferase
KW-0829	Tyrosine-protein kinase

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0005634	Cellular Component	Nucleus
GO:0005524	Molecular Function	ATP binding
GO:0004672	Molecular Function	Protein kinase activity
GO:0004674	Molecular Function	Protein serine/threonine kinase activity
GO:0004712	Molecular Function	Protein serine/threonine/tyrosine kinase activity
GO:0004713	Molecular Function	Protein tyrosine kinase activity
GO:0016480	Biological Process	Negative regulation of transcription by RNA polymerase III
GO:0018105	Biological Process	Peptidyl-serine phosphorylation
GO:0046777	Biological Process	Protein autophosphorylation
GO:0006468	Biological Process	Protein phosphorylation

▼ KEGG

sce:YLL019C

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	dbPTM	BioGRID

Interaction
HINT	Mentha	YTRP	PINA	IID
iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
iEKPD

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Asg-0799	Ashbya gossypii	52.69	0.0	745
LLPS-Scj-0798	Schizosaccharomyces japonicus	51.3	3e-86	291
LLPS-Dos-1085	Dothistroma septosporum	51.02	2e-07	58.5
LLPS-Crn-1234	Cryptococcus neoformans	47.77	7e-87	290
LLPS-Zyt-0950	Zymoseptoria tritici	47.28	6e-85	287
LLPS-Met-0519	Medicago truncatula	46.04	7e-76	258
LLPS-Hov-0804	Hordeum vulgare	46.04	5e-75	255
LLPS-Pot-2763	Populus trichocarpa	45.52	1e-73	252
LLPS-Php-2545	Physcomitrella patens	45.32	2e-76	259
LLPS-Bro-0632	Brassica oleracea	44.8	5e-71	256
LLPS-Brr-2986	Brassica rapa	44.8	1e-71	254
LLPS-Nol-3514	Nomascus leucogenys	44.44	2e-74	254
LLPS-Glm-1075	Glycine max	44.44	6e-75	255
LLPS-Mel-1269	Melampsora laricipopulina	44.44	9e-75	257
LLPS-Hea-0816	Helianthus annuus	44.24	2e-74	253
LLPS-Dio-3024	Dipodomys ordii	44.21	2e-62	217
LLPS-Eqc-1357	Equus caballus	43.88	2e-73	256
LLPS-Ict-1666	Ictidomys tridecemlineatus	43.88	7e-75	256
LLPS-Cas-1762	Carlito syrichta	43.88	3e-74	256
LLPS-Urm-2989	Ursus maritimus	43.88	2e-74	256
LLPS-Fec-1629	Felis catus	43.88	3e-74	256
LLPS-Otg-0975	Otolemur garnettii	43.88	2e-74	255
LLPS-Pes-2932	Pelodiscus sinensis	43.88	4e-74	254
LLPS-Aim-0995	Ailuropoda melanoleuca	43.88	4e-75	257
LLPS-Myl-2303	Myotis lucifugus	43.88	1e-74	257
LLPS-Ova-1695	Ovis aries	43.88	8e-75	258
LLPS-Poa-3952	Pongo abelii	43.53	5e-75	256
LLPS-Caf-0119	Canis familiaris	43.53	6e-73	254
LLPS-Man-3958	Macaca nemestrina	43.53	1e-73	256
LLPS-Loa-3260	Loxodonta africana	43.53	2e-74	256
LLPS-Pat-3565	Pan troglodytes	43.53	3e-74	256
LLPS-Pap-3036	Pan paniscus	43.53	3e-74	256
LLPS-Hos-2364	Homo sapiens	43.53	3e-74	256
LLPS-Orc-2345	Oryctolagus cuniculus	43.53	9e-74	253
LLPS-Bot-0381	Bos taurus	43.53	9e-75	256
LLPS-Mal-3741	Mandrillus leucophaeus	43.53	3e-74	256
LLPS-Paa-0023	Papio anubis	43.53	6e-74	255
LLPS-Mup-0638	Mustela putorius furo	43.53	7e-75	256
LLPS-Aon-0530	Aotus nancymaae	43.53	1e-73	254
LLPS-Cea-2793	Cercocebus atys	43.53	7e-74	255
LLPS-Sah-2162	Sarcophilus harrisii	43.53	2e-74	255
LLPS-Maf-4022	Macaca fascicularis	43.53	3e-74	256
LLPS-Chs-2388	Chlorocebus sabaeus	43.53	5e-74	255
LLPS-Fud-1485	Fukomys damarensis	43.53	8e-74	254
LLPS-Caj-3832	Callithrix jacchus	43.53	1e-73	255
LLPS-Gog-0408	Gorilla gorilla	43.53	3e-74	256
LLPS-Ran-4218	Rattus norvegicus	43.17	2e-74	256
LLPS-Sus-0597	Sus scrofa	43.17	5e-74	254
LLPS-Mum-0599	Mus musculus	43.17	6e-74	254
LLPS-Ora-1741	Ornithorhynchus anatinus	43.17	5e-74	254
LLPS-Anc-0186	Anolis carolinensis	42.81	4e-75	257
LLPS-Anp-2894	Anas platyrhynchos	42.81	4e-74	255
LLPS-Mea-1568	Mesocricetus auratus	42.81	9e-75	256
LLPS-Mam-2922	Macaca mulatta	42.66	2e-70	246
LLPS-Cap-2337	Cavia porcellus	42.45	8e-73	251
LLPS-Amt-2146	Amborella trichopoda	41.82	2e-74	253
LLPS-Meg-1494	Meleagris gallopavo	41.81	8e-56	204
LLPS-Beb-1212	Beauveria bassiana	41.51	3e-98	326
LLPS-Lac-2886	Latimeria chalumnae	41.18	5e-69	241
LLPS-Orl-1759	Oryzias latipes	41.09	2e-66	230
LLPS-Tar-0504	Takifugu rubripes	40.93	5e-44	164
LLPS-Mod-0842	Monodelphis domestica	40.91	2e-64	229
LLPS-Via-0905	Vigna angularis	40.85	1e-75	257
LLPS-Ten-2138	Tetraodon nigroviridis	40.79	1e-67	233
LLPS-Tru-1189	Triticum urartu	40.78	8e-69	236
LLPS-Asm-1289	Astyanax mexicanus	40.74	2e-57	203
LLPS-Xet-1506	Xenopus tropicalis	40.71	4e-64	226
LLPS-Orn-3633	Oreochromis niloticus	40.71	1e-69	239
LLPS-Cus-1264	Cucumis sativus	40.36	1e-75	257
LLPS-Gaga-1183	Gallus gallus	40.29	3e-66	233
LLPS-Scm-3663	Scophthalmus maximus	40.25	4e-54	194
LLPS-Dar-3388	Danio rerio	40.21	4e-69	241
LLPS-Leo-2018	Lepisosteus oculatus	40.21	9e-70	243
LLPS-Tag-0620	Taeniopygia guttata	39.93	2e-65	231
LLPS-Pof-2617	Poecilia formosa	39.93	3e-65	228
LLPS-Fia-1017	Ficedula albicollis	39.93	1e-65	232
LLPS-Coc-0634	Corchorus capsularis	39.72	1e-75	259
LLPS-Xim-2595	Xiphophorus maculatus	39.57	3e-51	186
LLPS-Scf-1213	Scleropages formosus	39.5	4e-65	230
LLPS-Rhb-1378	Rhinopithecus bieti	39.45	7e-67	235
LLPS-Dac-2114	Daucus carota	39.34	2e-84	281
LLPS-Icp-3785	Ictalurus punctatus	38.83	2e-66	235
LLPS-Kop-0765	Komagataella pastoris	38.45	4e-119	377
LLPS-Art-3021	Arabidopsis thaliana	37.94	2e-82	276
LLPS-Arl-2891	Arabidopsis lyrata	37.94	6e-82	275
LLPS-Chr-0893	Chlamydomonas reinhardtii	37.94	1e-80	278
LLPS-Sob-0296	Sorghum bicolor	37.67	3e-78	265
LLPS-Gaa-3065	Gasterosteus aculeatus	37.46	3e-64	229
LLPS-Sol-0001	Solanum lycopersicum	37.31	1e-74	251
LLPS-Nia-2058	Nicotiana attenuata	37.24	3e-79	267
LLPS-Sot-1360	Solanum tuberosum	37.15	1e-79	268
LLPS-Zem-1594	Zea mays	37.04	2e-79	268
LLPS-Thc-1907	Theobroma cacao	37.0	9e-80	269
LLPS-Orbr-0915	Oryza brachyantha	36.77	4e-76	258
LLPS-Brd-1521	Brachypodium distachyon	36.68	1e-77	262
LLPS-Sei-1226	Setaria italica	36.59	6e-74	249
LLPS-Sem-2074	Selaginella moellendorffii	36.57	9e-78	259
LLPS-Orp-0988	Oryza punctata	36.53	1e-79	266
LLPS-Orr-2086	Oryza rufipogon	36.45	3e-74	253
LLPS-Mae-2052	Manihot esculenta	36.45	2e-75	257
LLPS-Ori-2169	Oryza indica	36.45	1e-75	256
LLPS-Orni-1486	Oryza nivara	36.45	4e-73	250
LLPS-Mua-2115	Musa acuminata	36.45	1e-78	266
LLPS-Viv-0069	Vitis vinifera	36.36	5e-77	261
LLPS-Phv-2171	Phaseolus vulgaris	36.36	5e-78	263
LLPS-Orm-1866	Oryza meridionalis	36.3	3e-79	266
LLPS-Org-0398	Oryza glaberrima	36.21	1e-75	257
LLPS-Ors-0685	Oryza sativa	36.21	1e-75	257
LLPS-Prp-1307	Prunus persica	36.13	1e-78	264
LLPS-Scp-0086	Schizosaccharomyces pombe	35.97	2e-44	176
LLPS-Gor-2306	Gossypium raimondii	35.83	5e-79	266
LLPS-Brn-0929	Brassica napus	35.66	1e-74	262
LLPS-Tra-1553	Triticum aestivum	35.43	2e-77	260
LLPS-Lep-1158	Leersia perrieri	35.15	1e-70	244
LLPS-Orb-1663	Oryza barthii	32.94	5e-51	186
LLPS-Orgl-2136	Oryza glumaepatula	32.67	6e-54	197
LLPS-Tum-1414	Tuber melanosporum	32.22	7e-42	169

LLPS-Sac-1346KNS1

Protein Sequence

Nucleotide Sequence

LLPS-Sac-1346
KNS1