LLPS-Sac-1228
YKE2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Prefoldin subunit 6; Genes involved in microtubule biogenesis protein 1; Gim complex subunit 1; GimC subunit 1 |
| Gene Name: | YKE2, GIM1, PFD6, YLR200W, L8167.8 |
| Ensembl Gene: | YLR200W |
| Ensembl Protein: | YLR200W_mRNA |
| Organism: | Saccharomyces cerevisiae |
| Taxa ID: | 559292 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YLR200W_mRNA | YLR200W_mRNA |
| UniProt | P52553, PFD6_YEAST, D6VYK2 | |
| GeneBank | U14913, X76563, BK006945 | AAB67430.1, DAA09518.1, CAA54062.1 |
| RefSeq | NM_001182087.1 | NP_013301.1 |
| Entrez | 850897 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSELGAKYQQ LQNELEEFIV ARQKLETQLQ ENKIVNEEFD QLEEDTPVYK LTGNVLLPVE 60 61 QSEARTNVDK RLEFIETEIT RCEKNIRDKQ EELEKMRSEL IKLNNTAAST GPGR 114 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGAAT TAGGTGCCAA ATATCAACAG TTGCAAAATG AGTTAGAAGA GTTTATTGTG 60 61 GCCAGACAAA AATTAGAGAC ACAATTACAA GAAAACAAGA TTGTAAATGA AGAGTTTGAC 120 121 CAATTAGAAG AAGATACACC TGTGTACAAA TTGACAGGCA ATGTCCTTTT ACCAGTTGAA 180 181 CAAAGTGAGG CACGTACCAA CGTGGACAAA AGATTAGAGT TCATCGAAAC AGAAATTACA 240 241 AGATGCGAAA AGAACATAAG GGACAAGCAG GAAGAACTAG AAAAGATGAG AAGCGAGCTA 300 301 ATTAAACTGA ACAATACAGC AGCTTCCACT GGCCCAGGAA GGTAA 345 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Prefoldin complex | |
Molecular Function | Chaperone binding | |
Molecular Function | Tubulin binding | |
Molecular Function | Unfolded protein binding | |
Biological Process | Chaperone-mediated protein complex assembly | |
Biological Process | Positive regulation of transcription elongation from RNA polymerase II promoter | |
Biological Process | Protein folding | |
Biological Process | Tubulin complex assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asg-0509 | Ashbya gossypii | 66.99 | 6e-40 | 135 |
| LLPS-Nef-0639 | Neosartorya fischeri | 54.64 | 3e-25 | 97.8 |
| LLPS-Asfu-0128 | Aspergillus fumigatus | 54.02 | 2e-21 | 88.2 |
| LLPS-Kop-0537 | Komagataella pastoris | 53.4 | 7e-28 | 104 |
| LLPS-Scf-0626 | Scleropages formosus | 53.25 | 1e-16 | 75.9 |
| LLPS-Asc-0724 | Aspergillus clavatus | 49.51 | 1e-23 | 93.6 |
| LLPS-Map-0134 | Magnaporthe poae | 49.5 | 3e-23 | 92.8 |
| LLPS-Ast-1108 | Aspergillus terreus | 49.48 | 3e-21 | 87.8 |
| LLPS-Scm-0546 | Scophthalmus maximus | 48.78 | 2e-15 | 72.4 |
| LLPS-Gag-0461 | Gaeumannomyces graminis | 48.57 | 1e-24 | 96.7 |
| LLPS-Mod-1316 | Monodelphis domestica | 48.45 | 5e-19 | 81.6 |
| LLPS-Sah-0205 | Sarcophilus harrisii | 48.45 | 3e-19 | 82.4 |
| LLPS-Asf-0532 | Aspergillus flavus | 48.0 | 8e-23 | 91.3 |
| LLPS-Aso-0190 | Aspergillus oryzae | 47.52 | 4e-23 | 92.4 |
| LLPS-Asn-0606 | Aspergillus nidulans | 47.52 | 4e-22 | 89.7 |
| LLPS-Pytr-0384 | Pyrenophora triticirepentis | 47.47 | 9e-19 | 81.3 |
| LLPS-Pyt-0307 | Pyrenophora teres | 47.47 | 1e-18 | 80.9 |
| LLPS-Cap-1155 | Cavia porcellus | 47.42 | 4e-18 | 79.7 |
| LLPS-Eqc-0727 | Equus caballus | 47.42 | 6e-18 | 79.0 |
| LLPS-Poa-0856 | Pongo abelii | 47.42 | 3e-18 | 79.7 |
| LLPS-Caf-0148 | Canis familiaris | 47.42 | 6e-18 | 79.0 |
| LLPS-Xet-1365 | Xenopus tropicalis | 47.42 | 3e-19 | 82.8 |
| LLPS-Cas-0474 | Carlito syrichta | 47.42 | 6e-18 | 79.0 |
| LLPS-Nol-0885 | Nomascus leucogenys | 47.42 | 6e-18 | 79.0 |
| LLPS-Ict-1027 | Ictidomys tridecemlineatus | 47.42 | 6e-18 | 79.0 |
| LLPS-Fec-1839 | Felis catus | 47.42 | 6e-18 | 79.0 |
| LLPS-Hos-1574 | Homo sapiens | 47.42 | 6e-18 | 79.0 |
| LLPS-Pat-1896 | Pan troglodytes | 47.42 | 6e-18 | 79.0 |
| LLPS-Pap-0397 | Pan paniscus | 47.42 | 6e-18 | 79.0 |
| LLPS-Urm-0049 | Ursus maritimus | 47.42 | 4e-18 | 79.7 |
| LLPS-Loa-0267 | Loxodonta africana | 47.42 | 4e-18 | 79.7 |
| LLPS-Man-1062 | Macaca nemestrina | 47.42 | 6e-18 | 79.0 |
| LLPS-Otg-2028 | Otolemur garnettii | 47.42 | 6e-18 | 79.0 |
| LLPS-Orn-1853 | Oreochromis niloticus | 47.42 | 9e-18 | 79.0 |
| LLPS-Rhb-2452 | Rhinopithecus bieti | 47.42 | 6e-18 | 79.0 |
| LLPS-Orc-1633 | Oryctolagus cuniculus | 47.42 | 6e-18 | 79.0 |
| LLPS-Bot-2150 | Bos taurus | 47.42 | 4e-18 | 79.7 |
| LLPS-Dio-2324 | Dipodomys ordii | 47.42 | 6e-18 | 79.0 |
| LLPS-Aim-2022 | Ailuropoda melanoleuca | 47.42 | 3e-18 | 79.3 |
| LLPS-Mup-0263 | Mustela putorius furo | 47.42 | 6e-18 | 79.0 |
| LLPS-Myl-0354 | Myotis lucifugus | 47.42 | 2e-18 | 80.1 |
| LLPS-Paa-0375 | Papio anubis | 47.42 | 6e-18 | 79.0 |
| LLPS-Mal-2272 | Mandrillus leucophaeus | 47.42 | 6e-18 | 79.0 |
| LLPS-Chs-0432 | Chlorocebus sabaeus | 47.42 | 6e-18 | 79.0 |
| LLPS-Maf-0105 | Macaca fascicularis | 47.42 | 6e-18 | 79.0 |
| LLPS-Leo-1006 | Lepisosteus oculatus | 47.42 | 1e-16 | 75.9 |
| LLPS-Aon-0607 | Aotus nancymaae | 47.42 | 6e-18 | 79.0 |
| LLPS-Cea-0315 | Cercocebus atys | 47.42 | 6e-18 | 79.0 |
| LLPS-Gog-0677 | Gorilla gorilla | 47.42 | 6e-18 | 79.0 |
| LLPS-Caj-0169 | Callithrix jacchus | 47.42 | 6e-18 | 79.0 |
| LLPS-Spr-0738 | Sporisorium reilianum | 47.0 | 4e-21 | 87.0 |
| LLPS-Mam-0659 | Macaca mulatta | 46.99 | 1e-13 | 67.0 |
| LLPS-Cus-0077 | Cucumis sativus | 46.67 | 2e-09 | 55.1 |
| LLPS-Zyt-0521 | Zymoseptoria tritici | 46.43 | 2e-23 | 93.2 |
| LLPS-Tar-1396 | Takifugu rubripes | 46.39 | 1e-17 | 78.2 |
| LLPS-Sus-0809 | Sus scrofa | 46.39 | 5e-17 | 76.6 |
| LLPS-Coo-0364 | Colletotrichum orbiculare | 46.36 | 3e-18 | 79.3 |
| LLPS-Trr-0788 | Trichoderma reesei | 45.98 | 3e-16 | 73.2 |
| LLPS-Usm-0937 | Ustilago maydis | 45.83 | 1e-20 | 85.9 |
| LLPS-Tum-0123 | Tuber melanosporum | 45.71 | 6e-24 | 94.4 |
| LLPS-Ved-0462 | Verticillium dahliae | 45.54 | 2e-19 | 82.8 |
| LLPS-Cog-0235 | Colletotrichum gloeosporioides | 45.54 | 2e-22 | 90.5 |
| LLPS-Asni-0886 | Aspergillus niger | 45.54 | 5e-20 | 84.3 |
| LLPS-Blg-0156 | Blumeria graminis | 45.45 | 4e-20 | 84.3 |
| LLPS-Ova-0762 | Ovis aries | 45.45 | 2e-17 | 77.8 |
| LLPS-Dar-1846 | Danio rerio | 45.36 | 9e-16 | 73.2 |
| LLPS-Asm-0807 | Astyanax mexicanus | 45.36 | 1e-16 | 75.1 |
| LLPS-Scj-0698 | Schizosaccharomyces japonicus | 45.0 | 4e-19 | 81.6 |
| LLPS-Beb-0088 | Beauveria bassiana | 44.9 | 9e-19 | 81.3 |
| LLPS-Abg-0579 | Absidia glauca | 44.79 | 2e-18 | 80.1 |
| LLPS-Cogr-0490 | Colletotrichum graminicola | 44.55 | 6e-17 | 76.3 |
| LLPS-Fus-0784 | Fusarium solani | 44.55 | 2e-21 | 87.0 |
| LLPS-Lac-0538 | Latimeria chalumnae | 44.33 | 4e-17 | 76.6 |
| LLPS-Scp-0746 | Schizosaccharomyces pombe | 44.33 | 7e-18 | 78.6 |
| LLPS-Icp-0433 | Ictalurus punctatus | 44.33 | 1e-16 | 75.5 |
| LLPS-Nec-0440 | Neurospora crassa | 44.14 | 5e-22 | 89.7 |
| LLPS-Cae-0173 | Caenorhabditis elegans | 43.9 | 1e-14 | 70.1 |
| LLPS-Mum-0034 | Mus musculus | 43.75 | 2e-19 | 82.8 |
| LLPS-Mea-0982 | Mesocricetus auratus | 43.75 | 2e-19 | 82.8 |
| LLPS-Mel-0038 | Melampsora laricipopulina | 43.68 | 1e-13 | 67.4 |
| LLPS-Mao-0245 | Magnaporthe oryzae | 43.36 | 5e-22 | 89.4 |
| LLPS-Fud-3267 | Fukomys damarensis | 43.36 | 6e-19 | 81.6 |
| LLPS-Orl-1905 | Oryzias latipes | 43.3 | 2e-16 | 75.1 |
| LLPS-Xim-1017 | Xiphophorus maculatus | 43.24 | 6e-18 | 79.0 |
| LLPS-Sot-0761 | Solanum tuberosum | 42.86 | 2e-09 | 55.1 |
| LLPS-Ran-1622 | Rattus norvegicus | 42.86 | 3e-18 | 79.7 |
| LLPS-Yal-0409 | Yarrowia lipolytica | 42.57 | 2e-19 | 82.8 |
| LLPS-Crn-0093 | Cryptococcus neoformans | 42.55 | 4e-18 | 79.3 |
| LLPS-Scc-0535 | Schizosaccharomyces cryophilus | 42.34 | 9e-22 | 88.6 |
| LLPS-Trv-0327 | Trichoderma virens | 42.11 | 1e-20 | 86.3 |
| LLPS-Phn-0593 | Phaeosphaeria nodorum | 42.06 | 7e-16 | 75.9 |
| LLPS-Pof-1370 | Poecilia formosa | 41.44 | 4e-17 | 77.0 |
| LLPS-Anc-0534 | Anolis carolinensis | 41.28 | 6e-17 | 76.3 |
| LLPS-Miv-0273 | Microbotryum violaceum | 40.62 | 4e-17 | 77.0 |
| LLPS-Hea-0875 | Helianthus annuus | 40.24 | 7e-11 | 59.7 |
| LLPS-Gaa-2207 | Gasterosteus aculeatus | 40.0 | 5e-16 | 73.9 |
| LLPS-Arl-0533 | Arabidopsis lyrata | 39.78 | 2e-12 | 63.9 |
| LLPS-Vir-1683 | Vigna radiata | 39.33 | 2e-09 | 56.6 |
| LLPS-Gaga-0771 | Gallus gallus | 39.13 | 2e-12 | 64.3 |
| LLPS-Prp-0179 | Prunus persica | 38.71 | 1e-12 | 64.7 |
| LLPS-Bro-1163 | Brassica oleracea | 38.71 | 3e-07 | 49.7 |
| LLPS-Brr-0644 | Brassica rapa | 38.71 | 3e-07 | 49.3 |
| LLPS-Art-0862 | Arabidopsis thaliana | 38.71 | 7e-12 | 62.8 |
| LLPS-Tut-0815 | Tursiops truncatus | 37.72 | 2e-11 | 61.2 |
| LLPS-Phv-0267 | Phaseolus vulgaris | 37.63 | 8e-12 | 62.4 |
| LLPS-Via-1310 | Vigna angularis | 37.63 | 6e-12 | 62.8 |
| LLPS-Drm-0512 | Drosophila melanogaster | 37.62 | 9e-11 | 59.3 |
| LLPS-Tru-0703 | Triticum urartu | 37.5 | 4e-06 | 46.2 |
| LLPS-Tra-0648 | Triticum aestivum | 37.5 | 8e-06 | 45.4 |
| LLPS-Orni-0401 | Oryza nivara | 37.5 | 9e-06 | 45.1 |
| LLPS-Osl-0279 | Ostreococcus lucimarinus | 36.7 | 2e-11 | 61.2 |
| LLPS-Amt-0848 | Amborella trichopoda | 36.36 | 1e-07 | 51.6 |
| LLPS-Nia-0049 | Nicotiana attenuata | 36.19 | 3e-12 | 63.5 |
| LLPS-Glm-2385 | Glycine max | 36.19 | 2e-12 | 65.1 |
| LLPS-Lem-0002 | Leptosphaeria maculans | 36.13 | 2e-14 | 69.7 |
| LLPS-Gor-0548 | Gossypium raimondii | 35.24 | 1e-12 | 64.7 |
| LLPS-Met-0171 | Medicago truncatula | 35.24 | 6e-12 | 62.8 |
| LLPS-Brn-0402 | Brassica napus | 35.24 | 3e-12 | 63.5 |
| LLPS-Cii-0806 | Ciona intestinalis | 34.95 | 1e-12 | 64.7 |
| LLPS-Org-0364 | Oryza glaberrima | 34.72 | 7e-08 | 51.2 |
| LLPS-Put-1230 | Puccinia triticina | 34.67 | 7e-06 | 45.4 |
| LLPS-Lep-0943 | Leersia perrieri | 34.67 | 6e-06 | 45.4 |
| LLPS-Ori-1864 | Oryza indica | 34.67 | 3e-06 | 46.6 |
| LLPS-Pot-0037 | Populus trichocarpa | 34.29 | 6e-11 | 60.1 |
| LLPS-Sol-0147 | Solanum lycopersicum | 34.29 | 5e-12 | 62.8 |
| LLPS-Thc-0136 | Theobroma cacao | 34.29 | 2e-11 | 61.6 |
| LLPS-Orbr-0087 | Oryza brachyantha | 33.8 | 4e-07 | 49.3 |
| LLPS-Sem-1199 | Selaginella moellendorffii | 33.71 | 3e-08 | 52.0 |
| LLPS-Chc-0198 | Chondrus crispus | 33.68 | 2e-11 | 61.6 |
| LLPS-Viv-1806 | Vitis vinifera | 33.33 | 2e-11 | 61.2 |
| LLPS-Mae-0772 | Manihot esculenta | 33.33 | 1e-11 | 62.0 |
| LLPS-Chr-0270 | Chlamydomonas reinhardtii | 33.33 | 7e-11 | 59.7 |
| LLPS-Pug-0933 | Puccinia graminis | 33.0 | 3e-11 | 60.8 |
| LLPS-Ors-0212 | Oryza sativa | 32.93 | 4e-08 | 52.0 |
| LLPS-Orp-1102 | Oryza punctata | 32.89 | 6e-07 | 48.1 |
| LLPS-Php-1095 | Physcomitrella patens | 32.65 | 4e-10 | 57.4 |
| LLPS-Orr-1179 | Oryza rufipogon | 31.71 | 1e-06 | 47.8 |