LLPS-Sac-1226
CUZ1

▼ OVERVIEW


Status: Unreviewed
Protein Name: CDC48-associated ubiquitin-like/zinc finger protein 1
Gene Name: CUZ1, YNL155W, N1751
Ensembl Gene: YNL155W
Ensembl Protein: YNL155W_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: LLPS regulator
PDB: 5IJ4 (A) More


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


Promotes efficient arsenite-induced clearance of stress granules (SGs) (PubMed:29804830). May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity (PubMed:24121501, PubMed:24297164).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MSAAIEKETG  MLDVGKHCAY  CRQLDFLPFH  CSFCNEDFCS  NHRLKEDHHC  RWLLEHEEVH  60
61    KTEKSPSKSR  DGSSSNDEAY  FKSLLPERAS  VRIQRVSETR  EPLRGSNTAK  VSSTLNSKTL  120
121   DKIFKFFQRN  EKRKSNNKSK  KNFGSSSNKI  IQLANLKKIA  KGDPKIPMQN  RIYIWCYLVD  180
181   GDETDIAKED  TRMPLYINKM  WPVGRAMDYL  SIQLNVKSST  LTNSSSNDKF  QLCKLKEGKQ  240
241   VSFYNIGASL  RVTNEIKDLD  TLYLVHNNAD  EKSN  274
Nucleotide CDS Sequence (FASTA)
1     ATGTCGGCGG  CTATCGAAAA  AGAAACCGGA  ATGTTGGATG  TAGGAAAGCA  CTGTGCATAT  60
61    TGTAGACAAC  TAGACTTCCT  ACCTTTCCAT  TGTTCGTTTT  GCAATGAAGA  TTTCTGCTCG  120
121   AACCATAGAC  TTAAGGAAGA  TCACCACTGT  AGGTGGTTGC  TAGAGCATGA  AGAAGTTCAT  180
181   AAAACTGAAA  AAAGTCCTAG  CAAAAGCCGG  GATGGCTCAA  GTTCTAACGA  TGAAGCATAT  240
241   TTCAAGAGTC  TGTTACCTGA  GAGGGCCAGT  GTTAGAATCC  AGAGAGTAAG  TGAAACAAGA  300
301   GAGCCTTTGA  GAGGTTCTAA  CACTGCCAAA  GTGAGCTCTA  CTTTGAACTC  AAAGACATTA  360
361   GACAAAATAT  TTAAGTTCTT  CCAAAGGAAT  GAGAAAAGAA  AGAGCAATAA  CAAATCAAAA  420
421   AAGAATTTCG  GTTCCTCGTC  GAATAAGATA  ATTCAATTGG  CTAATCTCAA  GAAAATTGCT  480
481   AAAGGTGACC  CCAAGATTCC  TATGCAAAAT  AGGATTTACA  TTTGGTGTTA  CTTGGTGGAT  540
541   GGTGATGAGA  CGGATATAGC  CAAGGAGGAT  ACAAGAATGC  CATTATACAT  TAACAAAATG  600
601   TGGCCTGTGG  GTAGGGCCAT  GGACTATTTG  TCTATCCAGC  TAAACGTGAA  ATCTAGCACA  660
661   CTAACTAATT  CAAGTTCTAA  TGACAAATTT  CAACTATGCA  AATTGAAAGA  GGGTAAACAA  720
721   GTTTCATTTT  ATAATATTGG  CGCTTCCTTA  AGAGTCACTA  ATGAGATCAA  AGATCTTGAT  780
781   ACTCTGTATT  TAGTACACAA  TAACGCCGAC  GAAAAATCTA  ATTAA  825

▼ KEYWORD


ID
Family
3D-structure
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Stress response
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
Proteasome binding
Molecular Function
Zinc ion binding
Biological Process
Cellular response to arsenic-containing substance
Biological Process
Cellular response to arsenite ion
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process
Stress granule disassembly

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Beb-0913Beauveria bassiana58.976e-0857.0
LLPS-Nec-1235Neurospora crassa56.411e-0653.1
LLPS-Trr-1322Trichoderma reesei56.411e-0652.8
LLPS-Cog-1103Colletotrichum gloeosporioides56.412e-0652.8
LLPS-Trv-0943Trichoderma virens56.411e-0653.1
LLPS-Fuv-0988Fusarium verticillioides53.853e-0652.0
LLPS-Scs-1138Sclerotinia sclerotiorum53.857e-0753.5
LLPS-Fus-1183Fusarium solani53.852e-0652.4
LLPS-Fuo-1147Fusarium oxysporum53.853e-0651.6
LLPS-Ran-0425Rattus norvegicus53.665e-0650.8
LLPS-Asc-0206Aspergillus clavatus51.289e-0753.5
LLPS-Mao-1059Magnaporthe oryzae51.285e-0651.2
LLPS-Aso-0622Aspergillus oryzae51.285e-0651.2
LLPS-Asf-0132Aspergillus flavus51.286e-0650.8
LLPS-Ast-0413Aspergillus terreus51.286e-0651.2
LLPS-Nef-0914Neosartorya fischeri51.285e-0651.2
LLPS-Dos-1117Dothistroma septosporum51.283e-0652.0
LLPS-Gas-0461Galdieria sulphuraria50.01e-0652.4
LLPS-Zyt-1306Zymoseptoria tritici50.01e-0653.1
LLPS-Asn-1036Aspergillus nidulans44.642e-0652.0
LLPS-Asg-1109Ashbya gossypii43.983e-57 190
LLPS-Gag-1531Gaeumannomyces graminis32.382e-0652.4
LLPS-Kop-1074Komagataella pastoris29.831e-23 102
LLPS-Ict-4106Ictidomys tridecemlineatus28.575e-1473.6
LLPS-Mod-4200Monodelphis domestica27.542e-1268.9
LLPS-Otg-1885Otolemur garnettii27.051e-1167.0
LLPS-Bot-3608Bos taurus26.692e-1063.9
LLPS-Xet-1831Xenopus tropicalis26.672e-1372.4
LLPS-Eqc-1189Equus caballus26.641e-1271.2
LLPS-Cogr-1537Colletotrichum graminicola26.452e-1578.2
LLPS-Tar-2539Takifugu rubripes26.297e-1062.0
LLPS-Fec-3795Felis catus26.252e-1269.3
LLPS-Caj-4272Callithrix jacchus26.234e-1371.2
LLPS-Fud-3308Fukomys damarensis26.235e-1370.9
LLPS-Poa-4519Pongo abelii26.231e-1269.7
LLPS-Blg-0796Blumeria graminis25.893e-1063.9
LLPS-Chs-2193Chlorocebus sabaeus25.826e-1267.8
LLPS-Aon-1978Aotus nancymaae25.829e-1370.1
LLPS-Gog-2964Gorilla gorilla25.821e-1270.1
LLPS-Mal-3027Mandrillus leucophaeus25.822e-1269.3
LLPS-Pat-3214Pan troglodytes25.823e-1268.9
LLPS-Pap-0510Pan paniscus25.822e-1268.9
LLPS-Orc-3359Oryctolagus cuniculus25.826e-1268.2
LLPS-Myl-4382Myotis lucifugus25.611e-1167.4
LLPS-Coo-0913Colletotrichum orbiculare25.548e-1679.3
LLPS-Ten-0137Tetraodon nigroviridis25.481e-0961.6
LLPS-Ved-1232Verticillium dahliae25.452e-1372.8
LLPS-Maf-4684Macaca fascicularis25.417e-1267.8
LLPS-Cea-3951Cercocebus atys25.417e-1267.8
LLPS-Hos-2218Homo sapiens25.411e-1269.7
LLPS-Man-4412Macaca nemestrina25.417e-1267.8
LLPS-Rhb-3958Rhinopithecus bieti25.412e-1166.6
LLPS-Tag-0799Taeniopygia guttata25.324e-1268.6
LLPS-Caf-4474Canis familiaris25.311e-0961.2
LLPS-Ere-0483Erinaceus europaeus25.235e-1164.7
LLPS-Cii-1384Ciona intestinalis25.225e-1268.2
LLPS-Cas-1512Carlito syrichta25.192e-1268.9
LLPS-Asfu-1224Aspergillus fumigatus25.111e-0858.9
LLPS-Sus-4537Sus scrofa25.13e-1268.6
LLPS-Mum-3878Mus musculus25.09e-1164.7
LLPS-Mup-3153Mustela putorius furo25.01e-1064.7
LLPS-Urm-0707Ursus maritimus25.09e-1164.7
LLPS-Gaa-0586Gasterosteus aculeatus24.91e-0961.2
LLPS-Nol-1696Nomascus leucogenys24.596e-1165.1
LLPS-Lac-1298Latimeria chalumnae24.571e-0755.8
LLPS-Mea-1796Mesocricetus auratus24.185e-0959.7
LLPS-Dio-1914Dipodomys ordii24.186e-0959.7
LLPS-Mam-4702Macaca mulatta24.183e-0754.7
LLPS-Dar-3908Danio rerio23.773e-0960.5
LLPS-Asm-0657Astyanax mexicanus22.321e-0755.5