LLPS-Sac-1206
HXK2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Hexokinase-2; Hexokinase PII; Hexokinase-B
Gene Name: HXK2, HEX1, HKB, YGL253W, NRB486
Ensembl Gene: YGL253W
Ensembl Protein: YGL253W_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: Client
PDB: 5UWT (A, B, C, D) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVHLGPKKPQ  ARKGSMADVP  KELMQQIENF  EKIFTVPTET  LQAVTKHFIS  ELEKGLSKKG  60
61    GNIPMIPGWV  MDFPTGKESG  DFLAIDLGGT  NLRVVLVKLG  GDRTFDTTQS  KYRLPDAMRT  120
121   TQNPDELWEF  IADSLKAFID  EQFPQGISEP  IPLGFTFSFP  ASQNKINEGI  LQRWTKGFDI  180
181   PNIENHDVVP  MLQKQITKRN  IPIEVVALIN  DTTGTLVASY  YTDPETKMGV  IFGTGVNGAY  240
241   YDVCSDIEKL  QGKLSDDIPP  SAPMAINCEY  GSFDNEHVVL  PRTKYDITID  EESPRPGQQT  300
301   FEKMSSGYYL  GEILRLALMD  MYKQGFIFKN  QDLSKFDKPF  VMDTSYPARI  EEDPFENLED  360
361   TDDLFQNEFG  INTTVQERKL  IRRLSELIGA  RAARLSVCGI  AAICQKRGYK  TGHIAADGSV  420
421   YNRYPGFKEK  AANALKDIYG  WTQTSLDDYP  IKIVPAEDGS  GAGAAVIAAL  AQKRIAEGKS  480
481   VGIIGA  486
Nucleotide CDS Sequence (FASTA)
1     ATGGTTCATT  TAGGTCCAAA  AAAACCACAA  GCCAGAAAGG  GTTCCATGGC  CGATGTGCCA  60
61    AAGGAATTGA  TGCAACAAAT  TGAGAATTTT  GAAAAAATTT  TCACTGTTCC  AACTGAAACT  120
121   TTACAAGCCG  TTACCAAGCA  CTTCATTTCC  GAATTGGAAA  AGGGTTTGTC  CAAGAAGGGT  180
181   GGTAACATTC  CAATGATTCC  AGGTTGGGTT  ATGGATTTCC  CAACTGGTAA  GGAATCCGGT  240
241   GATTTCTTGG  CCATTGATTT  GGGTGGTACC  AACTTGAGAG  TTGTCTTAGT  CAAGTTGGGC  300
301   GGTGACCGTA  CCTTTGACAC  CACTCAATCT  AAGTACAGAT  TACCAGATGC  TATGAGAACT  360
361   ACTCAAAATC  CAGACGAATT  GTGGGAATTT  ATTGCCGACT  CTTTGAAAGC  TTTTATTGAT  420
421   GAGCAATTCC  CACAAGGTAT  CTCTGAGCCA  ATTCCATTGG  GTTTCACCTT  TTCTTTCCCA  480
481   GCTTCTCAAA  ACAAAATCAA  TGAAGGTATC  TTGCAAAGAT  GGACTAAAGG  TTTTGATATT  540
541   CCAAACATTG  AAAACCACGA  TGTTGTTCCA  ATGTTGCAAA  AGCAAATCAC  TAAGAGGAAT  600
601   ATCCCAATTG  AAGTTGTTGC  TTTGATAAAC  GACACTACCG  GTACTTTGGT  TGCTTCTTAC  660
661   TACACTGACC  CAGAAACTAA  GATGGGTGTT  ATCTTCGGTA  CTGGTGTCAA  TGGTGCTTAC  720
721   TACGATGTTT  GTTCCGATAT  CGAAAAGCTA  CAAGGAAAAC  TATCTGATGA  CATTCCACCA  780
781   TCTGCTCCAA  TGGCCATCAA  CTGTGAATAC  GGTTCCTTCG  ATAATGAACA  TGTCGTTTTG  840
841   CCAAGAACTA  AATACGATAT  CACCATTGAT  GAAGAATCTC  CAAGACCAGG  CCAACAAACC  900
901   TTTGAAAAAA  TGTCTTCTGG  TTACTACTTA  GGTGAAATTT  TGCGTTTGGC  CTTGATGGAC  960
961   ATGTACAAAC  AAGGTTTCAT  CTTCAAGAAC  CAAGACTTGT  CTAAGTTCGA  CAAGCCTTTC  1020
1021  GTCATGGACA  CTTCTTACCC  AGCCAGAATC  GAGGAAGATC  CATTCGAGAA  CCTAGAAGAT  1080
1081  ACCGATGACT  TGTTCCAAAA  TGAGTTCGGT  ATCAACACTA  CTGTTCAAGA  ACGTAAATTG  1140
1141  ATCAGACGTT  TATCTGAATT  GATTGGTGCT  AGAGCTGCTA  GATTGTCCGT  TTGTGGTATT  1200
1201  GCTGCTATCT  GTCAAAAGAG  AGGTTACAAG  ACCGGTCACA  TCGCTGCAGA  CGGTTCCGTT  1260
1261  TACAACAGAT  ACCCAGGTTT  CAAAGAAAAG  GCTGCCAATG  CTTTGAAGGA  CATTTACGGC  1320
1321  TGGACTCAAA  CCTCACTAGA  CGACTACCCA  ATCAAGATTG  TTCCTGCTGA  AGATGGTTCC  1380
1381  GGTGCTGGTG  CCGCTGTTAT  TGCTGCTTTG  GCCCAAAAAA  GAATTGCTGA  AGGTAAGTCC  1440
1441  GTTGGTATCA  TCGGTGCTTA  A  1461

▼ KEYWORD

ID
Family
3D-structure
Allosteric enzyme
ATP-binding
Complete proteome
Direct protein sequencing
Glycolysis
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Mitochondrion
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
Fructokinase activity
Molecular Function
Glucokinase activity
Molecular Function
Glucose binding
Molecular Function
Hexokinase activity
Molecular Function
Mannokinase activity
Biological Process
Cellular glucose homeostasis
Biological Process
Fructose import
Biological Process
Fructose metabolic process
Biological Process
Glucose import
Biological Process
Glucose metabolic process
Biological Process
Glycolytic process
Biological Process
Mannose metabolic process
Biological Process
Regulation of cell size
Biological Process
Regulation of transcription by glucose
Biological Process
Replicative cell aging

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-1272Ashbya gossypii76.190.0 767
LLPS-Kop-1169Komagataella pastoris62.470.0 594
LLPS-Cog-0566Colletotrichum gloeosporioides57.440.0 552
LLPS-Blg-1300Blumeria graminis57.350.0 539
LLPS-Cogr-0421Colletotrichum graminicola57.230.0 543
LLPS-Scs-1135Sclerotinia sclerotiorum56.440.0 547
LLPS-Coo-0323Colletotrichum orbiculare56.210.0 541
LLPS-Asc-1208Aspergillus clavatus56.170.0 535
LLPS-Asfu-1042Aspergillus fumigatus55.760.0 535
LLPS-Trr-1298Trichoderma reesei55.710.0 540
LLPS-Asni-0366Aspergillus niger55.562e-175 509
LLPS-Ast-1486Aspergillus terreus55.350.0 527
LLPS-Asf-0668Aspergillus flavus55.350.0 536
LLPS-Aso-0012Aspergillus oryzae55.350.0 536
LLPS-Zyt-0292Zymoseptoria tritici54.790.0 531
LLPS-Fuo-1472Fusarium oxysporum54.580.0 526
LLPS-Lem-1128Leptosphaeria maculans53.22e-175 511
LLPS-Scj-1512Schizosaccharomyces japonicus51.543e-163 478
LLPS-Scp-1310Schizosaccharomyces pombe48.465e-147 437
LLPS-Scc-1229Schizosaccharomyces cryophilus48.035e-148 439
LLPS-Pug-0670Puccinia graminis47.221e-139 418
LLPS-Nef-0673Neosartorya fischeri46.122e-137 412
LLPS-Abg-0213Absidia glauca40.932e-94 301
LLPS-Put-0162Puccinia triticina38.781e-74 253
LLPS-Mao-0774Magnaporthe oryzae38.193e-79 262
LLPS-Amt-0062Amborella trichopoda37.299e-79 261
LLPS-Nec-0515Neurospora crassa36.95e-76 260
LLPS-Cae-1368Caenorhabditis elegans36.826e-71 240
LLPS-Cus-0760Cucumis sativus36.644e-77 256
LLPS-Orb-1325Oryza barthii36.639e-70 235
LLPS-Orc-3640Oryctolagus cuniculus36.411e-70 247
LLPS-Fuv-0745Fusarium verticillioides36.344e-81 268
LLPS-Miv-1063Microbotryum violaceum36.32e-88 286
LLPS-Glm-1577Glycine max36.181e-74 250
LLPS-Vir-0178Vigna radiata36.096e-53 193
LLPS-Spr-1416Sporisorium reilianum36.042e-83 272
LLPS-Pot-1954Populus trichocarpa35.881e-72 244
LLPS-Via-1668Vigna angularis35.884e-73 246
LLPS-Art-0379Arabidopsis thaliana35.861e-75 253
LLPS-Crn-0173Cryptococcus neoformans35.831e-78 260
LLPS-Usm-1038Ustilago maydis35.792e-81 267
LLPS-Orr-1166Oryza rufipogon35.753e-71 241
LLPS-Mae-2413Manihot esculenta35.718e-75 250
LLPS-Viv-1180Vitis vinifera35.651e-72 244
LLPS-Bro-1198Brassica oleracea35.632e-73 247
LLPS-Brn-2701Brassica napus35.634e-73 246
LLPS-Gor-1728Gossypium raimondii35.581e-74 250
LLPS-Orm-0730Oryza meridionalis35.511e-69 237
LLPS-Arl-2220Arabidopsis lyrata35.53e-73 246
LLPS-Ved-1192Verticillium dahliae35.44e-77 258
LLPS-Brr-2881Brassica rapa35.42e-73 246
LLPS-Phv-1421Phaseolus vulgaris35.352e-72 244
LLPS-Tra-0711Triticum aestivum35.21e-73 247
LLPS-Hov-1068Hordeum vulgare35.052e-72 245
LLPS-Orbr-1076Oryza brachyantha35.025e-73 245
LLPS-Eqc-1386Equus caballus34.99e-73 253
LLPS-Met-2060Medicago truncatula34.882e-71 241
LLPS-Lep-2014Leersia perrieri34.871e-72 245
LLPS-Orp-0214Oryza punctata34.812e-67 231
LLPS-Fec-0945Felis catus34.764e-57 208
LLPS-Paa-1383Papio anubis34.711e-69 244
LLPS-Cea-3001Cercocebus atys34.711e-69 244
LLPS-Zem-1584Zea mays34.77e-74 248
LLPS-Sob-2137Sorghum bicolor34.76e-74 248
LLPS-Caj-3566Callithrix jacchus34.612e-70 246
LLPS-Sei-0562Setaria italica34.62e-75 252
LLPS-Thc-2521Theobroma cacao34.514e-70 239
LLPS-Mam-3328Macaca mulatta34.471e-68 241
LLPS-Man-4306Macaca nemestrina34.471e-68 241
LLPS-Chs-3693Chlorocebus sabaeus34.472e-68 241
LLPS-Maf-1100Macaca fascicularis34.472e-68 241
LLPS-Sah-0487Sarcophilus harrisii34.377e-69 242
LLPS-Php-2470Physcomitrella patens34.293e-67 231
LLPS-Aon-3918Aotus nancymaae34.241e-67 238
LLPS-Urm-2399Ursus maritimus34.237e-72 251
LLPS-Aim-1477Ailuropoda melanoleuca34.233e-72 251
LLPS-Mup-4331Mustela putorius furo34.235e-72 248
LLPS-Bot-3170Bos taurus34.233e-70 246
LLPS-Caf-4165Canis familiaris34.196e-56 205
LLPS-Pes-2591Pelodiscus sinensis34.065e-69 242
LLPS-Org-2162Oryza glaberrima34.04e-70 238
LLPS-Ors-1631Oryza sativa34.03e-70 238
LLPS-Rhb-3944Rhinopithecus bieti33.988e-69 242
LLPS-Drm-1276Drosophila melanogaster33.411e-75 252
LLPS-Cii-1569Ciona intestinalis32.697e-70 237
LLPS-Tru-1884Triticum urartu32.454e-54 193
LLPS-Icp-3399Ictalurus punctatus32.12e-66 234
LLPS-Anc-1396Anolis carolinensis31.887e-68 231
LLPS-Mod-3145Monodelphis domestica31.215e-68 231
LLPS-Loa-3718Loxodonta africana30.771e-69 236