LLPS-Sac-1184
FCF2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | rRNA-processing protein FCF2; FAF1 copurifying factor 2 |
| Gene Name: | FCF2, YLR051C, L2128 |
| Ensembl Gene: | YLR051C |
| Ensembl Protein: | YLR051C_mRNA |
| Organism: | Saccharomyces cerevisiae |
| Taxa ID: | 559292 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | YLR051C_mRNA | YLR051C_mRNA |
| UniProt | Q12035, FCF2_YEAST, D6VY53 | |
| GeneBank | BK006945, Z73223, X94607 | CAA64298.1, DAA09369.1, CAA97581.1 |
| RefSeq | NM_001181938.1 | NP_013152.1 |
| Entrez | 850740 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDQSVEDLFG ALRDASASLE VKNSAKEQVS LQQEDVLQIG NNDDEVEIES KFQEIETNLK 60 61 KLPKLETGFD ALANKKKKKN VLPSVETEDK RKPNKSDKND NDWFTLPKPD DNMRREVQRD 120 121 LLLIKHRAAL DPKRHYKKQR WEVPERFAIG TIIEDKSEFY SSRMNRKERK STILETLMGD 180 181 EASNKYFKRK YNEIQEKSTS GRKAHYKKMK EMRKKRR 217 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGATCAAA GTGTGGAAGA CTTATTTGGA GCACTAAGAG ATGCTAGTGC CAGTCTAGAA 60 61 GTAAAAAATT CAGCGAAGGA ACAAGTTTCT CTTCAACAAG AGGATGTTTT GCAGATAGGC 120 121 AATAATGATG ATGAAGTAGA AATTGAAAGT AAATTTCAAG AGATCGAAAC TAATCTTAAG 180 181 AAGCTTCCTA AGTTAGAAAC CGGATTTGAT GCTTTAGCAA ACAAGAAGAA GAAGAAGAAC 240 241 GTCTTGCCTA GTGTGGAGAC AGAAGATAAA AGAAAACCCA ACAAGAGCGA CAAAAACGAT 300 301 AATGACTGGT TTACCTTACC AAAGCCAGAT GATAACATGC GTCGTGAAGT TCAACGAGAT 360 361 TTATTGCTGA TTAAACATAG AGCTGCTCTT GATCCAAAGA GACATTATAA GAAGCAACGT 420 421 TGGGAGGTGC CAGAGAGGTT TGCTATTGGT ACCATAATTG AAGACAAGAG TGAGTTTTAT 480 481 AGTAGTCGTA TGAACAGGAA GGAAAGAAAG TCGACTATTT TGGAAACACT CATGGGTGAT 540 541 GAAGCTTCTA ATAAGTATTT CAAGCGTAAA TACAACGAAA TTCAGGAGAA ATCTACGAGC 600 601 GGTAGGAAGG CACATTACAA GAAAATGAAA GAGATGAGAA AGAAGCGGAG GTGA 654 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Biological Process | Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Lem-0238 | Leptosphaeria maculans | 52.13 | 3e-22 | 95.9 |
| LLPS-Phn-1171 | Phaeosphaeria nodorum | 51.89 | 4e-27 | 108 |
| LLPS-Tum-0293 | Tuber melanosporum | 50.0 | 3e-25 | 104 |
| LLPS-Pyt-0160 | Pyrenophora teres | 48.11 | 5e-25 | 103 |
| LLPS-Pytr-0442 | Pyrenophora triticirepentis | 48.11 | 5e-25 | 103 |
| LLPS-Asg-0199 | Ashbya gossypii | 47.74 | 3e-47 | 160 |
| LLPS-Fud-0198 | Fukomys damarensis | 47.5 | 4e-16 | 75.9 |
| LLPS-Cap-2395 | Cavia porcellus | 47.5 | 1e-15 | 74.3 |
| LLPS-Fec-0448 | Felis catus | 47.5 | 4e-16 | 75.9 |
| LLPS-Cog-0166 | Colletotrichum gloeosporioides | 46.73 | 2e-22 | 95.9 |
| LLPS-Dio-0559 | Dipodomys ordii | 46.59 | 2e-16 | 77.0 |
| LLPS-Sem-0970 | Selaginella moellendorffii | 46.4 | 3e-26 | 105 |
| LLPS-Cas-0154 | Carlito syrichta | 46.25 | 7e-16 | 75.5 |
| LLPS-Scs-0085 | Sclerotinia sclerotiorum | 46.23 | 4e-24 | 100 |
| LLPS-Blg-0249 | Blumeria graminis | 45.97 | 2e-25 | 104 |
| LLPS-Cogr-0634 | Colletotrichum graminicola | 45.79 | 2e-22 | 95.9 |
| LLPS-Tru-0916 | Triticum urartu | 45.61 | 3e-08 | 53.5 |
| LLPS-Asfu-0046 | Aspergillus fumigatus | 44.86 | 2e-21 | 93.6 |
| LLPS-Nef-0484 | Neosartorya fischeri | 44.86 | 9e-22 | 94.7 |
| LLPS-Cis-0231 | Ciona savignyi | 44.79 | 1e-18 | 86.7 |
| LLPS-Fuv-0532 | Fusarium verticillioides | 44.76 | 2e-18 | 84.7 |
| LLPS-Fuo-0703 | Fusarium oxysporum | 44.76 | 2e-18 | 84.7 |
| LLPS-Yal-0008 | Yarrowia lipolytica | 44.54 | 2e-21 | 94.7 |
| LLPS-Sot-0514 | Solanum tuberosum | 44.44 | 6e-22 | 94.4 |
| LLPS-Sol-0059 | Solanum lycopersicum | 44.44 | 2e-22 | 95.5 |
| LLPS-Ved-0075 | Verticillium dahliae | 43.97 | 3e-23 | 97.8 |
| LLPS-Arl-1496 | Arabidopsis lyrata | 43.81 | 2e-17 | 81.6 |
| LLPS-Art-0604 | Arabidopsis thaliana | 43.81 | 5e-17 | 80.5 |
| LLPS-Fus-0412 | Fusarium solani | 43.81 | 2e-18 | 84.3 |
| LLPS-Dos-0409 | Dothistroma septosporum | 43.75 | 2e-25 | 104 |
| LLPS-Beb-0234 | Beauveria bassiana | 43.64 | 1e-19 | 87.8 |
| LLPS-Asf-0560 | Aspergillus flavus | 43.52 | 1e-21 | 94.4 |
| LLPS-Mea-0539 | Mesocricetus auratus | 43.21 | 2e-13 | 73.6 |
| LLPS-Sah-0050 | Sarcophilus harrisii | 43.01 | 9e-16 | 80.5 |
| LLPS-Mod-0020 | Monodelphis domestica | 43.01 | 3e-16 | 81.6 |
| LLPS-Pot-1299 | Populus trichocarpa | 42.98 | 7e-23 | 97.1 |
| LLPS-Thc-0967 | Theobroma cacao | 42.72 | 2e-16 | 79.0 |
| LLPS-Asc-0823 | Aspergillus clavatus | 42.62 | 2e-21 | 94.0 |
| LLPS-Mao-0063 | Magnaporthe oryzae | 42.61 | 3e-21 | 92.4 |
| LLPS-Myl-2029 | Myotis lucifugus | 42.42 | 1e-17 | 82.0 |
| LLPS-Scp-0769 | Schizosaccharomyces pombe | 42.37 | 4e-24 | 100 |
| LLPS-Scc-0335 | Schizosaccharomyces cryophilus | 42.37 | 9e-23 | 97.4 |
| LLPS-Coc-0184 | Corchorus capsularis | 42.27 | 8e-15 | 73.9 |
| LLPS-Ran-1023 | Rattus norvegicus | 42.11 | 1e-16 | 82.8 |
| LLPS-Mum-0424 | Mus musculus | 42.11 | 1e-16 | 83.2 |
| LLPS-Nia-1474 | Nicotiana attenuata | 42.06 | 1e-20 | 90.9 |
| LLPS-Abg-0770 | Absidia glauca | 42.0 | 9e-18 | 83.6 |
| LLPS-Tag-1322 | Taeniopygia guttata | 41.94 | 1e-15 | 77.8 |
| LLPS-Orc-0759 | Oryctolagus cuniculus | 41.94 | 5e-16 | 81.3 |
| LLPS-Php-0829 | Physcomitrella patens | 41.9 | 3e-15 | 75.5 |
| LLPS-Prp-0076 | Prunus persica | 41.9 | 4e-15 | 75.1 |
| LLPS-Coo-0073 | Colletotrichum orbiculare | 41.59 | 1e-19 | 88.2 |
| LLPS-Mal-0709 | Mandrillus leucophaeus | 41.51 | 6e-17 | 84.0 |
| LLPS-Paa-0629 | Papio anubis | 41.51 | 6e-17 | 84.0 |
| LLPS-Maf-0594 | Macaca fascicularis | 41.51 | 6e-17 | 84.0 |
| LLPS-Chs-0385 | Chlorocebus sabaeus | 41.51 | 6e-17 | 84.0 |
| LLPS-Cea-0576 | Cercocebus atys | 41.51 | 6e-17 | 84.0 |
| LLPS-Aon-0953 | Aotus nancymaae | 41.51 | 3e-17 | 85.1 |
| LLPS-Gog-2243 | Gorilla gorilla | 41.51 | 1e-17 | 85.9 |
| LLPS-Caj-0935 | Callithrix jacchus | 41.51 | 3e-17 | 84.7 |
| LLPS-Eqc-1034 | Equus caballus | 41.51 | 1e-17 | 85.9 |
| LLPS-Mam-2851 | Macaca mulatta | 41.51 | 6e-17 | 84.0 |
| LLPS-Nol-0198 | Nomascus leucogenys | 41.51 | 1e-17 | 85.9 |
| LLPS-Pap-1430 | Pan paniscus | 41.51 | 1e-17 | 85.9 |
| LLPS-Pat-0212 | Pan troglodytes | 41.51 | 1e-17 | 85.9 |
| LLPS-Hos-0815 | Homo sapiens | 41.51 | 1e-17 | 85.9 |
| LLPS-Man-1951 | Macaca nemestrina | 41.51 | 6e-17 | 84.0 |
| LLPS-Loa-2565 | Loxodonta africana | 41.51 | 3e-17 | 84.7 |
| LLPS-Ast-0514 | Aspergillus terreus | 41.46 | 4e-23 | 98.2 |
| LLPS-Glm-0088 | Glycine max | 41.35 | 8e-11 | 62.4 |
| LLPS-Gor-0624 | Gossypium raimondii | 41.35 | 2e-15 | 76.3 |
| LLPS-Tut-1200 | Tursiops truncatus | 41.3 | 2e-13 | 73.6 |
| LLPS-Cus-0626 | Cucumis sativus | 41.28 | 3e-20 | 89.4 |
| LLPS-Gag-0207 | Gaeumannomyces graminis | 41.18 | 2e-20 | 90.5 |
| LLPS-Mae-0090 | Manihot esculenta | 40.98 | 5e-16 | 77.4 |
| LLPS-Via-0775 | Vigna angularis | 40.74 | 1e-14 | 73.9 |
| LLPS-Bot-0202 | Bos taurus | 40.57 | 1e-16 | 82.8 |
| LLPS-Ova-0213 | Ovis aries | 40.57 | 1e-16 | 83.2 |
| LLPS-Mup-1828 | Mustela putorius furo | 40.57 | 1e-16 | 83.2 |
| LLPS-Aim-0980 | Ailuropoda melanoleuca | 40.57 | 1e-16 | 83.2 |
| LLPS-Sus-0292 | Sus scrofa | 40.57 | 1e-16 | 82.8 |
| LLPS-Caf-0201 | Canis familiaris | 40.57 | 1e-16 | 83.2 |
| LLPS-Urm-0715 | Ursus maritimus | 40.57 | 1e-16 | 82.8 |
| LLPS-Dar-0902 | Danio rerio | 40.57 | 3e-16 | 82.0 |
| LLPS-Otg-0313 | Otolemur garnettii | 40.57 | 1e-16 | 83.2 |
| LLPS-Viv-0671 | Vitis vinifera | 40.38 | 2e-14 | 74.3 |
| LLPS-Asm-0484 | Astyanax mexicanus | 40.19 | 9e-17 | 81.6 |
| LLPS-Bro-0373 | Brassica oleracea | 40.19 | 4e-15 | 75.1 |
| LLPS-Map-0594 | Magnaporthe poae | 40.16 | 4e-21 | 92.0 |
| LLPS-Lep-1171 | Leersia perrieri | 40.0 | 6e-19 | 85.9 |
| LLPS-Scf-1347 | Scleropages formosus | 39.83 | 1e-15 | 80.1 |
| LLPS-Phv-0214 | Phaseolus vulgaris | 39.81 | 6e-14 | 71.6 |
| LLPS-Gaa-0400 | Gasterosteus aculeatus | 39.76 | 7e-12 | 66.6 |
| LLPS-Brn-0681 | Brassica napus | 39.62 | 3e-13 | 69.3 |
| LLPS-Ict-1125 | Ictidomys tridecemlineatus | 39.62 | 1e-16 | 82.8 |
| LLPS-Brr-0852 | Brassica rapa | 39.62 | 3e-13 | 69.3 |
| LLPS-Nec-0023 | Neurospora crassa | 39.52 | 7e-16 | 77.4 |
| LLPS-Sob-0044 | Sorghum bicolor | 39.29 | 3e-19 | 87.0 |
| LLPS-Mua-0333 | Musa acuminata | 39.2 | 7e-17 | 80.1 |
| LLPS-Orbr-0116 | Oryza brachyantha | 39.2 | 4e-20 | 89.4 |
| LLPS-Zem-0593 | Zea mays | 39.09 | 5e-19 | 86.3 |
| LLPS-Asn-0122 | Aspergillus nidulans | 38.89 | 1e-19 | 88.6 |
| LLPS-Trv-0069 | Trichoderma virens | 38.71 | 3e-16 | 78.6 |
| LLPS-Icp-2576 | Ictalurus punctatus | 38.68 | 1e-15 | 80.1 |
| LLPS-Anc-0737 | Anolis carolinensis | 38.68 | 3e-16 | 81.6 |
| LLPS-Meg-0120 | Meleagris gallopavo | 38.68 | 5e-16 | 81.3 |
| LLPS-Pes-0022 | Pelodiscus sinensis | 38.68 | 5e-16 | 81.3 |
| LLPS-Orgl-0605 | Oryza glumaepatula | 38.4 | 6e-20 | 88.6 |
| LLPS-Hov-0659 | Hordeum vulgare | 38.4 | 9e-19 | 86.3 |
| LLPS-Tra-1660 | Triticum aestivum | 38.4 | 8e-19 | 85.5 |
| LLPS-Orb-0592 | Oryza barthii | 38.4 | 7e-20 | 88.6 |
| LLPS-Ori-0120 | Oryza indica | 38.4 | 7e-20 | 88.6 |
| LLPS-Orni-0229 | Oryza nivara | 38.4 | 6e-20 | 88.6 |
| LLPS-Orr-0133 | Oryza rufipogon | 38.4 | 6e-20 | 88.6 |
| LLPS-Org-0212 | Oryza glaberrima | 38.4 | 7e-20 | 88.6 |
| LLPS-Ors-1392 | Oryza sativa | 38.4 | 6e-20 | 89.0 |
| LLPS-Orp-0404 | Oryza punctata | 38.4 | 5e-20 | 89.0 |
| LLPS-Chr-0442 | Chlamydomonas reinhardtii | 38.3 | 6e-14 | 73.9 |
| LLPS-Hea-0039 | Helianthus annuus | 38.1 | 2e-14 | 73.6 |
| LLPS-Cae-0092 | Caenorhabditis elegans | 38.1 | 2e-15 | 76.3 |
| LLPS-Trr-0816 | Trichoderma reesei | 38.1 | 6e-13 | 68.6 |
| LLPS-Scj-0459 | Schizosaccharomyces japonicus | 38.04 | 2e-12 | 67.0 |
| LLPS-Fia-0348 | Ficedula albicollis | 37.74 | 2e-15 | 79.3 |
| LLPS-Sei-0788 | Setaria italica | 37.6 | 2e-19 | 87.4 |
| LLPS-Chc-0048 | Chondrus crispus | 37.25 | 2e-15 | 76.3 |
| LLPS-Met-0655 | Medicago truncatula | 37.19 | 6e-12 | 65.9 |
| LLPS-Leo-0034 | Lepisosteus oculatus | 36.97 | 2e-16 | 82.4 |
| LLPS-Brd-0260 | Brachypodium distachyon | 36.8 | 4e-17 | 80.9 |
| LLPS-Xim-0720 | Xiphophorus maculatus | 36.79 | 7e-14 | 74.7 |
| LLPS-Pof-2431 | Poecilia formosa | 36.79 | 1e-13 | 73.9 |
| LLPS-Lac-1049 | Latimeria chalumnae | 36.79 | 3e-15 | 78.6 |
| LLPS-Rhb-0868 | Rhinopithecus bieti | 36.79 | 2e-11 | 66.6 |
| LLPS-Orn-0605 | Oreochromis niloticus | 35.85 | 5e-15 | 77.8 |
| LLPS-Tar-0653 | Takifugu rubripes | 35.71 | 3e-14 | 72.8 |
| LLPS-Ora-0679 | Ornithorhynchus anatinus | 35.14 | 1e-14 | 74.3 |
| LLPS-Ten-2181 | Tetraodon nigroviridis | 34.82 | 7e-14 | 71.6 |
| LLPS-Scm-1206 | Scophthalmus maximus | 34.74 | 2e-11 | 67.0 |
| LLPS-Orl-0467 | Oryzias latipes | 33.96 | 1e-12 | 70.9 |
| LLPS-Miv-0228 | Microbotryum violaceum | 33.33 | 4e-08 | 56.6 |
| LLPS-Cym-0585 | Cyanidioschyzon merolae | 32.65 | 5e-10 | 59.7 |
| LLPS-Kop-0867 | Komagataella pastoris | 32.11 | 4e-25 | 103 |
| LLPS-Osl-0052 | Ostreococcus lucimarinus | 31.01 | 2e-11 | 63.5 |
| LLPS-Crn-0507 | Cryptococcus neoformans | 28.87 | 1e-06 | 52.4 |
| LLPS-Drm-0465 | Drosophila melanogaster | 26.53 | 1e-07 | 54.7 |