LLPS-Sac-0694
HEK2

▼ OVERVIEW

Status: Reviewed
Protein Name: Heterogeneous nuclear rnp K-like protein 2; KH domain-containing protein 1
Gene Name: HEK2, KHD1, YBL032W, YBL0418
Ensembl Gene: YBL032W
Ensembl Protein: YBL032W_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...A similar bioinformatics analysis of previously known yeast P body proteins revealed that in contrast to stress granules, a majority of P body proteins have mRNA binding activity, which suggests that mRNA-protein interactions may contribute more to P body structure than stress granule structure."
Saccharomyces cerevisiae26777405
Stress granule
"...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions. We identified novel SG components including essential aminoacyl‐tRNA synthetases."
Saccharomyces cerevisiae26484595
Stress granule
"...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions."
Saccharomyces cerevisiae26484595
Others
"...We have carried out extensive proteomic studies to quantify heat-triggered aggregation and subsequent disaggregation in budding yeast, identifying more than 170 endogenous proteins aggregating within minutes of heat shock in multiple subcellular compartments."
Saccharomyces cerevisiae26359986

▼ FUNCTION

RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Required for the asymmetric localization to the daughter cell nucleus of the ASH1 transcript, coding for a specific repressor of transcription. Overexpression inhibits translation of the ASH1 transcript. Involved in the stability of transcripts such as the MTL1 mRNA. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSQFFEAATP  VAIPTNNTNG  GSSDAGSAAT  GGAPVVGTTA  QPTINHRLLL  SLKEAAKIIG  60
61    TKGSTISRIR  AANAVKIGIS  EKVPGCSDRI  LSCAGNVINV  ANAIGDIVDV  LNKRNPENED  120
121   AAEGEAEEHY  YFHFLNHILP  APSKDEIRDL  QQLEDIGYVR  LIVANSHISS  IIGKAGATIK  180
181   SLINKHGVKI  VASKDFLPAS  DERIIEIQGF  PGSITNVLIE  ISEIILSDVD  VRFSTERSYF  240
241   PHLKKSSGEP  TSPSTSSNTR  IELKIPELYV  GAIIGRGMNR  IKNLKTFTKT  NIVVERKDDD  300
301   DKDENFRKFI  ITSKFPKNVK  LAESMLLKNL  NTEIEKRENY  KRKLEAAEGD  ATVVTERSDS  360
361   ASFLEEKEEP  QENHDNKEEQ  S  381
Nucleotide CDS Sequence (FASTA)
1     ATGTCACAGT  TCTTCGAAGC  TGCTACTCCC  GTTGCAATTC  CCACAAACAA  TACCAACGGC  60
61    GGCTCCAGTG  ATGCCGGCAG  CGCCGCCACT  GGCGGCGCCC  CCGTTGTTGG  CACCACCGCT  120
121   CAACCCACCA  TCAATCACAG  GCTTTTGCTG  TCATTGAAAG  AGGCTGCCAA  GATCATTGGC  180
181   ACTAAGGGCT  CCACCATCTC  ACGCATAAGA  GCTGCAAACG  CCGTCAAGAT  CGGTATTTCT  240
241   GAAAAGGTGC  CCGGTTGCTC  TGACAGGATC  CTGTCCTGTG  CTGGGAACGT  AATCAATGTG  300
301   GCCAATGCCA  TTGGTGATAT  TGTTGACGTG  CTTAACAAAC  GGAATCCCGA  AAATGAGGAC  360
361   GCAGCTGAGG  GCGAAGCGGA  AGAGCACTAC  TACTTCCACT  TTTTGAACCA  TATTTTACCA  420
421   GCTCCCTCAA  AGGACGAGAT  CAGAGATCTG  CAGCAACTGG  AGGACATCGG  TTATGTGAGG  480
481   CTCATTGTGG  CCAATTCCCA  TATCTCATCG  ATTATCGGGA  AAGCAGGCGC  CACCATCAAG  540
541   TCCCTGATCA  ATAAGCACGG  CGTTAAGATC  GTGGCTTCCA  AGGACTTCTT  ACCTGCTAGC  600
601   GACGAGAGAA  TTATCGAGAT  CCAGGGTTTC  CCAGGATCCA  TCACCAATGT  ACTTATCGAA  660
661   ATTAGCGAGA  TCATCTTGAG  TGACGTTGAC  GTCAGATTCA  GCACAGAAAG  ATCTTATTTC  720
721   CCTCATCTGA  AAAAGTCCTC  CGGTGAGCCA  ACTTCCCCTT  CTACCTCATC  TAACACTAGG  780
781   ATCGAATTGA  AGATTCCAGA  ACTGTATGTA  GGCGCCATTA  TTGGCCGTGG  AATGAACAGA  840
841   ATTAAGAATT  TGAAAACTTT  CACAAAAACC  AATATTGTCG  TGGAAAGGAA  GGATGACGAT  900
901   GATAAAGACG  AAAATTTTAG  AAAATTCATA  ATCACAAGTA  AATTTCCTAA  GAATGTCAAA  960
961   CTTGCTGAGT  CCATGCTTTT  GAAGAACCTG  AATACTGAAA  TTGAGAAACG  TGAAAACTAC  1020
1021  AAGAGAAAAT  TGGAAGCTGC  CGAAGGAGAT  GCCACTGTTG  TTACTGAACG  CTCTGATTCT  1080
1081  GCTTCTTTCT  TGGAAGAGAA  GGAAGAACCT  CAAGAGAATC  ATGATAACAA  AGAGGAGCAG  1140
1141  TCGTAG  1146

▼ KEYWORD

ID
Family
Chromatin regulator
Chromosome
Complete proteome
Cytoplasm
mRNA transport
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Telomere
Translation regulation
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
P-body
Molecular Function
MRNA binding
Biological Process
Chromatin organization
Biological Process
Intracellular mRNA localization
Biological Process
MRNA stabilization
Biological Process
MRNA transport
Biological Process
Regulation of translation
Biological Process
Telomere maintenance
Biological Process
Telomere maintenance via telomerase

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-1145Ashbya gossypii45.616e-69 226
LLPS-Lem-0171Leptosphaeria maculans37.666e-1268.9
LLPS-Yal-0692Yarrowia lipolytica35.871e-23 104
LLPS-Miv-1005Microbotryum violaceum34.241e-2096.3
LLPS-Nia-1240Nicotiana attenuata32.576e-1167.4
LLPS-Kop-0909Komagataella pastoris31.611e-27 116
LLPS-Scj-0122Schizosaccharomyces japonicus31.529e-1785.1
LLPS-Pug-1306Puccinia graminis31.349e-1682.0
LLPS-Mel-0644Melampsora laricipopulina31.193e-1992.0
LLPS-Put-0443Puccinia triticina31.072e-1581.6
LLPS-Crn-0314Cryptococcus neoformans30.692e-2095.1
LLPS-Spr-0117Sporisorium reilianum30.439e-1888.6
LLPS-Scc-1326Schizosaccharomyces cryophilus30.435e-1786.3
LLPS-Pot-1840Populus trichocarpa30.34e-0652.4
LLPS-Thc-1272Theobroma cacao30.237e-0651.6
LLPS-Ast-0460Aspergillus terreus30.161e-1787.4
LLPS-Nef-0333Neosartorya fischeri30.164e-1888.6
LLPS-Asfu-0586Aspergillus fumigatus30.164e-1888.2
LLPS-Asc-1048Aspergillus clavatus30.164e-1888.6
LLPS-Asni-1438Aspergillus niger30.169e-1887.4
LLPS-Aso-0295Aspergillus oryzae30.162e-1889.0
LLPS-Abg-0496Absidia glauca30.163e-1683.6
LLPS-Asf-0121Aspergillus flavus30.162e-1889.0
LLPS-Usm-1301Ustilago maydis29.953e-1992.8
LLPS-Scp-0022Schizosaccharomyces pombe29.93e-1786.3
LLPS-Cogr-0665Colletotrichum graminicola29.671e-1581.6
LLPS-Gor-0940Gossypium raimondii29.653e-0962.0
LLPS-Asn-0370Aspergillus nidulans29.632e-1787.8
LLPS-Dos-0404Dothistroma septosporum29.598e-2299.0
LLPS-Zyt-0379Zymoseptoria tritici29.599e-2299.0
LLPS-Icp-1593Ictalurus punctatus29.267e-1270.1
LLPS-Asm-3147Astyanax mexicanus29.267e-1270.1
LLPS-Trr-0057Trichoderma reesei29.11e-1684.3
LLPS-Tru-0442Triticum urartu28.992e-0653.9
LLPS-Dar-1863Danio rerio28.722e-1168.6
LLPS-Pof-1893Poecilia formosa28.723e-1168.2
LLPS-Orn-0770Oreochromis niloticus28.721e-1169.3
LLPS-Leo-2674Lepisosteus oculatus28.723e-1168.2
LLPS-Xim-1352Xiphophorus maculatus28.723e-1168.2
LLPS-Bot-0553Bos taurus28.724e-1168.2
LLPS-Gaa-3400Gasterosteus aculeatus28.722e-1168.9
LLPS-Dac-0087Daucus carota28.681e-0653.9
LLPS-Beb-0281Beauveria bassiana28.573e-1683.2
LLPS-Trv-0339Trichoderma virens28.575e-1682.4
LLPS-Coo-0075Colletotrichum orbiculare28.572e-1684.0
LLPS-Blg-0342Blumeria graminis28.572e-1684.0
LLPS-Prp-2044Prunus persica28.368e-0754.7
LLPS-Cus-0252Cucumis sativus28.366e-0754.7
LLPS-Viv-1411Vitis vinifera28.084e-0858.9
LLPS-Fec-2156Felis catus28.043e-1168.2
LLPS-Hos-1886Homo sapiens28.043e-1168.6
LLPS-Pap-0568Pan paniscus28.043e-1168.6
LLPS-Man-2516Macaca nemestrina28.043e-1168.6
LLPS-Cap-1306Cavia porcellus28.044e-1167.8
LLPS-Caf-2439Canis familiaris28.044e-1168.2
LLPS-Mam-0025Macaca mulatta28.043e-1168.6
LLPS-Ved-0191Verticillium dahliae28.044e-1683.6
LLPS-Nol-1493Nomascus leucogenys28.043e-1168.6
LLPS-Ict-3711Ictidomys tridecemlineatus28.044e-1168.2
LLPS-Mum-3426Mus musculus28.044e-1168.2
LLPS-Maf-2458Macaca fascicularis28.043e-1168.6
LLPS-Fuv-0010Fusarium verticillioides28.047e-1682.0
LLPS-Mea-0007Mesocricetus auratus28.045e-1167.8
LLPS-Cea-2843Cercocebus atys28.043e-1168.6
LLPS-Gog-0476Gorilla gorilla28.043e-1168.6
LLPS-Fud-1919Fukomys damarensis28.043e-1168.6
LLPS-Myl-1455Myotis lucifugus28.044e-1168.2
LLPS-Aim-1453Ailuropoda melanoleuca28.045e-1167.8
LLPS-Paa-1948Papio anubis28.043e-1168.6
LLPS-Mal-2833Mandrillus leucophaeus28.043e-1168.6
LLPS-Cog-0991Colletotrichum gloeosporioides28.027e-1579.3
LLPS-Ova-1546Ovis aries27.982e-1169.3
LLPS-Bro-0674Brassica oleracea27.613e-0652.8
LLPS-Fus-0281Fusarium solani27.511e-1581.6
LLPS-Fuo-0118Fusarium oxysporum27.511e-1580.9
LLPS-Scs-0328Sclerotinia sclerotiorum27.515e-1579.7
LLPS-Mao-0815Magnaporthe oryzae27.512e-1580.9
LLPS-Zem-1709Zea mays27.416e-0652.4
LLPS-Brr-1989Brassica rapa27.138e-0858.2
LLPS-Loa-1627Loxodonta africana27.135e-0755.5
LLPS-Pytr-0701Pyrenophora triticirepentis27.043e-1786.3
LLPS-Pyt-0557Pyrenophora teres27.043e-1786.3
LLPS-Gag-0493Gaeumannomyces graminis26.982e-1581.3
LLPS-Map-0149Magnaporthe poae26.981e-1581.6
LLPS-Orp-0186Oryza punctata26.91e-0757.8
LLPS-Met-1531Medicago truncatula26.677e-0754.7
LLPS-Tum-0355Tuber melanosporum26.464e-1374.3
LLPS-Ors-2247Oryza sativa26.42e-0757.0
LLPS-Orr-2132Oryza rufipogon26.42e-0757.0
LLPS-Org-1370Oryza glaberrima26.42e-0757.0
LLPS-Ori-1161Oryza indica26.42e-0757.4
LLPS-Orb-0388Oryza barthii26.42e-0757.0
LLPS-Orni-2405Oryza nivara26.42e-0757.0
LLPS-Orgl-1458Oryza glumaepatula26.41e-0757.8
LLPS-Phn-0539Phaeosphaeria nodorum26.278e-2196.3
LLPS-Urm-1033Ursus maritimus26.165e-0755.5
LLPS-Glm-0074Glycine max26.011e-0757.0
LLPS-Sem-0439Selaginella moellendorffii25.875e-0960.8
LLPS-Phv-0498Phaseolus vulgaris25.772e-0756.2
LLPS-Brn-2413Brassica napus25.382e-0653.1
LLPS-Vir-0731Vigna radiata25.265e-0755.1
LLPS-Via-2447Vigna angularis24.875e-0755.1
LLPS-Art-1223Arabidopsis thaliana24.745e-0652.0
LLPS-Arl-0303Arabidopsis lyrata24.747e-0651.6
LLPS-Hea-0342Helianthus annuus24.624e-0652.4
LLPS-Sot-1568Solanum tuberosum24.611e-1066.2
LLPS-Orl-1117Oryzias latipes24.552e-1271.2
LLPS-Sol-0198Solanum lycopersicum24.538e-1063.5
LLPS-Nec-0836Neurospora crassa24.32e-1683.6
LLPS-Ten-2497Tetraodon nigroviridis24.176e-1270.1
LLPS-Ran-0480Rattus norvegicus23.964e-1373.6
LLPS-Sus-0939Sus scrofa23.896e-1373.6
LLPS-Eqc-1114Equus caballus23.67e-1373.9
LLPS-Chs-0489Chlorocebus sabaeus23.65e-1373.6
LLPS-Tar-3105Takifugu rubripes22.263e-0858.9