LLPS-Sac-0492
TPK2

▼ OVERVIEW


Status: Reviewed
Protein Name: cAMP-dependent protein kinase type 2
Gene Name: TPK2, PKA2, YKR1, YPL203W
Ensembl Gene: YPL203W
Ensembl Protein: YPL203W_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Tpk2 and Tpk3 play different roles in SGs and PBs aggregation in response to severe heat stress."
Saccharomyces cerevisiae29045428
P-body
"...All three isoforms of the S. cerevisiae PKA were able to influence P body formation."
Saccharomyces cerevisiae23105015
Stress granule
"...Tpk2 and Tpk3 play different roles in SGs and PBs aggregation in response to severe heat stress."
Saccharomyces cerevisiae29045428
Others
"...Phosphoproteins in these kinase signaling networks were enriched for ribonucleoprotein granule components, and we observe co-localization of Kss1p, Fus3p, Ste20p, and Tpk2p with the RNP component Igo1p."
Saccharomyces cerevisiae26447709

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MEFVAERAQP  VGQTIQQQNV  NTYGQGVLQP  HHDLQQRQQQ  QQQRQHQQLL  TSQLPQKSLV  60
61    SKGKYTLHDF  QIMRTLGTGS  FGRVHLVRSV  HNGRYYAIKV  LKKQQVVKMK  QVEHTNDERR  120
121   MLKLVEHPFL  IRMWGTFQDA  RNIFMVMDYI  EGGELFSLLR  KSQRFPNPVA  KFYAAEVILA  180
181   LEYLHAHNII  YRDLKPENIL  LDRNGHIKIT  DFGFAKEVQT  VTWTLCGTPD  YIAPEVITTK  240
241   PYNKSVDWWS  LGVLIYEMLA  GYTPFYDTTP  MKTYEKILQG  KVVYPPYFHP  DVVDLLSKLI  300
301   TADLTRRIGN  LQSGSRDIKA  HPWFSEVVWE  RLLAKDIETP  YEPPITSGIG  DTSLFDQYPE  360
361   EQLDYGIQGD  DPYAEYFQDF  380
Nucleotide CDS Sequence (FASTA)
1     ATGGAATTCG  TTGCAGAAAG  GGCTCAGCCA  GTTGGTCAAA  CAATCCAGCA  GCAAAATGTT  60
61    AATACTTACG  GGCAAGGCGT  CCTACAACCG  CATCATGATT  TACAGCAGCG  ACAACAACAA  120
121   CAACAGCAGC  GTCAGCATCA  ACAACTGCTG  ACGTCTCAGT  TGCCCCAGAA  ATCTCTCGTA  180
181   TCCAAAGGCA  AATATACACT  ACATGACTTC  CAGATTATGA  GAACGCTTGG  TACTGGATCT  240
241   TTTGGTAGGG  TTCATTTGGT  GCGCTCTGTT  CACAATGGTC  GGTATTATGC  TATAAAAGTT  300
301   TTAAAGAAAC  AACAAGTTGT  CAAGATGAAA  CAGGTTGAAC  ATACCAATGA  CGAACGACGT  360
361   ATGCTAAAGC  TTGTGGAGCA  TCCGTTTCTG  ATTAGAATGT  GGGGTACGTT  TCAAGATGCT  420
421   AGGAATATCT  TTATGGTGAT  GGATTATATC  GAAGGTGGTG  AACTTTTCTC  GTTACTGAGA  480
481   AAGTCACAAA  GATTTCCTAA  TCCTGTAGCA  AAATTTTACG  CTGCGGAAGT  CATACTGGCA  540
541   TTAGAGTACT  TGCATGCTCA  TAATATCATC  TACAGGGATT  TAAAGCCAGA  AAATATCTTG  600
601   CTGGATAGAA  ATGGCCACAT  TAAAATAACC  GATTTTGGGT  TCGCCAAAGA  GGTACAAACT  660
661   GTCACATGGA  CGCTTTGTGG  GACTCCTGAT  TACATTGCTC  CTGAAGTTAT  TACCACAAAG  720
721   CCATATAATA  AGTCGGTGGA  TTGGTGGTCT  CTAGGTGTTC  TAATCTACGA  AATGTTAGCT  780
781   GGTTATACAC  CCTTTTACGA  TACTACTCCA  ATGAAGACGT  ATGAAAAGAT  TTTACAAGGT  840
841   AAAGTAGTAT  ATCCACCATA  TTTTCATCCC  GACGTCGTGG  ATCTACTAAG  CAAACTGATC  900
901   ACTGCAGATT  TGACAAGAAG  AATCGGTAAT  TTACAAAGCG  GTTCCAGGGA  CATCAAAGCT  960
961   CACCCATGGT  TTAGTGAAGT  TGTATGGGAA  AGATTGTTAG  CAAAGGATAT  TGAAACTCCA  1020
1021  TACGAGCCTC  CTATCACATC  AGGTATCGGT  GACACGTCTT  TATTCGATCA  ATATCCCGAG  1080
1081  GAGCAGCTAG  ATTATGGTAT  TCAAGGCGAT  GATCCATATG  CTGAATACTT  TCAAGATTTC  1140
1141  TAA  1143

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-0235Ashbya gossypii88.650.0 600
LLPS-Kop-0091Komagataella pastoris85.490.0 572
LLPS-Cog-1296Colletotrichum gloeosporioides72.592e-163 475
LLPS-Map-0607Magnaporthe poae72.052e-162 471
LLPS-Cogr-1184Colletotrichum graminicola71.471e-163 476
LLPS-Mao-1207Magnaporthe oryzae71.475e-164 478
LLPS-Nec-1531Neurospora crassa71.435e-162 473
LLPS-Ved-0478Verticillium dahliae71.346e-162 472
LLPS-Trv-1384Trichoderma virens70.92e-159 466
LLPS-Fus-0876Fusarium solani70.285e-159 466
LLPS-Beb-0516Beauveria bassiana69.661e-153 452
LLPS-Coo-0334Colletotrichum orbiculare67.832e-160 469
LLPS-Miv-1165Microbotryum violaceum64.892e-137 412
LLPS-Usm-1415Ustilago maydis64.092e-137 405
LLPS-Spr-0771Sporisorium reilianum64.096e-138 406
LLPS-Crn-1397Cryptococcus neoformans64.094e-138 411
LLPS-Pug-0081Puccinia graminis63.781e-137 409
LLPS-Abg-1869Absidia glauca63.555e-139 412
LLPS-Put-0207Puccinia triticina63.472e-137 408
LLPS-Mel-0930Melampsora laricipopulina63.164e-136 402
LLPS-Scm-2488Scophthalmus maximus55.226e-112 338
LLPS-Cae-1052Caenorhabditis elegans55.114e-99 311
LLPS-Tar-0090Takifugu rubripes54.73e-111 336
LLPS-Scf-3695Scleropages formosus54.71e-109 333
LLPS-Maf-0320Macaca fascicularis54.451e-107 327
LLPS-Icp-2289Ictalurus punctatus54.364e-111 336
LLPS-Asm-0421Astyanax mexicanus54.363e-111 336
LLPS-Gaa-2249Gasterosteus aculeatus54.332e-109 332
LLPS-Pof-0182Poecilia formosa54.133e-112 339
LLPS-Xim-0533Xiphophorus maculatus54.133e-112 339
LLPS-Dar-3039Danio rerio53.975e-111 336
LLPS-Lac-2304Latimeria chalumnae53.853e-80 254
LLPS-Sah-2545Sarcophilus harrisii53.823e-110 333
LLPS-Fud-1570Fukomys damarensis53.83e-110 333
LLPS-Ten-1286Tetraodon nigroviridis53.691e-108 329
LLPS-Caf-3839Canis familiaris53.312e-109 331
LLPS-Fec-2471Felis catus53.312e-109 332
LLPS-Aim-1483Ailuropoda melanoleuca53.313e-109 331
LLPS-Mup-1030Mustela putorius furo53.312e-109 332
LLPS-Ora-3291Ornithorhynchus anatinus53.288e-90 278
LLPS-Tut-1998Tursiops truncatus53.163e-109 331
LLPS-Ran-3709Rattus norvegicus52.929e-110 333
LLPS-Mum-0944Mus musculus52.922e-110 334
LLPS-Otg-0706Otolemur garnettii52.878e-111 335
LLPS-Mod-1673Monodelphis domestica52.752e-110 334
LLPS-Cap-2788Cavia porcellus52.79e-111 335
LLPS-Drm-0965Drosophila melanogaster52.71e-107 327
LLPS-Orl-3396Oryzias latipes52.72e-111 337
LLPS-Mal-1985Mandrillus leucophaeus52.552e-110 334
LLPS-Caj-0048Callithrix jacchus52.551e-110 335
LLPS-Aon-1446Aotus nancymaae52.552e-110 334
LLPS-Cea-1976Cercocebus atys52.552e-110 334
LLPS-Mam-1000Macaca mulatta52.234e-110 333
LLPS-Pap-1306Pan paniscus52.236e-110 333
LLPS-Hos-0222Homo sapiens52.234e-110 333
LLPS-Man-4123Macaca nemestrina52.234e-110 333
LLPS-Ova-2774Ovis aries52.236e-110 333
LLPS-Paa-2457Papio anubis52.234e-110 333
LLPS-Bot-3724Bos taurus52.232e-110 334
LLPS-Dio-0008Dipodomys ordii52.239e-110 332
LLPS-Gog-0008Gorilla gorilla52.234e-110 333
LLPS-Orn-0258Oreochromis niloticus52.067e-109 330
LLPS-Leo-0312Lepisosteus oculatus52.069e-110 332
LLPS-Ict-0396Ictidomys tridecemlineatus51.995e-103 315
LLPS-Sus-3710Sus scrofa51.911e-109 332
LLPS-Cas-2787Carlito syrichta51.882e-110 334
LLPS-Eqc-3426Equus caballus51.598e-109 330
LLPS-Pat-3397Pan troglodytes51.451e-104 320
LLPS-Loa-1790Loxodonta africana51.434e-108 328
LLPS-Cii-0005Ciona intestinalis51.274e-105 321
LLPS-Anp-1877Anas platyrhynchos50.881e-100 307
LLPS-Meg-3307Meleagris gallopavo50.539e-100 305
LLPS-Xet-2188Xenopus tropicalis50.352e-99 304
LLPS-Fia-1866Ficedula albicollis50.173e-103 315
LLPS-Chs-1267Chlorocebus sabaeus50.02e-103 315
LLPS-Gaga-1648Gallus gallus49.839e-103 315
LLPS-Tag-0461Taeniopygia guttata49.831e-102 313
LLPS-Urm-1780Ursus maritimus49.835e-95 296
LLPS-Cis-1101Ciona savignyi49.694e-98 303
LLPS-Mea-1306Mesocricetus auratus49.681e-92 288
LLPS-Php-0213Physcomitrella patens49.595e-79 251
LLPS-Pes-2203Pelodiscus sinensis49.138e-95 292
LLPS-Nol-2027Nomascus leucogenys48.732e-104 317
LLPS-Anc-2729Anolis carolinensis47.852e-104 319
LLPS-Chr-1124Chlamydomonas reinhardtii46.051e-83 267
LLPS-Tum-0099Tuber melanosporum45.339e-82 263
LLPS-Trr-0056Trichoderma reesei45.292e-88 279
LLPS-Fuo-0572Fusarium oxysporum44.744e-87 276
LLPS-Asni-1385Aspergillus niger42.681e-79 256
LLPS-Orc-2611Oryctolagus cuniculus42.197e-74 244
LLPS-Asn-0264Aspergillus nidulans42.172e-82 264
LLPS-Sem-1872Selaginella moellendorffii41.448e-74 239
LLPS-Blg-0881Blumeria graminis41.142e-76 248
LLPS-Scs-0970Sclerotinia sclerotiorum40.191e-75 244