DrLLPS - Data resource of LLPS

LLPS-Sac-0370
CMD1

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Calmodulin
Gene Name:	CMD1, YBR109C, YBR0904
Ensembl Gene:	YBR109C
Ensembl Protein:	YBR109C_mRNA
Organism:	Saccharomyces cerevisiae
Taxa ID:	559292
LLPS Type:	Others

PDB: 2LHI (A) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Centrosome/Spindle pole body	"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."	N/A	1639847, 7925277; 15872084; 9585415; 9950677

▼ FUNCTION

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	YBR109C_mRNA	YBR109C_mRNA
UniProt		P06787, CALM_YEAST, D6VQA8
GeneBank	X78993, BK006936, AF081667, AY558184, Z35978, M14760	CAA85064.1, AAS56510.1, AAA34504.1, DAA07228.1, AAC68888.1, CAA55612.1
RefSeq	NM_001178457.1	NP_009667.1
Entrez	852406

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSSNLTEEQI AEFKEAFALF DKDNNGSISS SELATVMRSL GLSPSEAEVN DLMNEIDVDG 60 61 NHQIEFSEFL ALMSRQLKSN DSEQELLEAF KVFDKNGDGL ISAAELKHVL TSIGEKLTDA 120 121 EVDDMLREVS DGSGEINIQQ FAALLSK 147
Nucleotide CDS Sequence (FASTA)
1 ATGTCCTCCA ATCTTACCGA AGAACAAATT GCTGAATTCA AAGAAGCCTT TGCCCTCTTT 60 61 GATAAAGATA ACAATGGCTC TATCTCATCA AGTGAATTGG CCACTGTGAT GAGGTCATTG 120 121 GGTCTTTCGC CCAGTGAAGC AGAAGTAAAT GATTTGATGA ACGAAATAGA TGTTGATGGT 180 181 AACCATCAAA TCGAATTTAG TGAATTTTTG GCTCTGATGT CTCGTCAACT CAAATCAAAT 240 241 GACTCTGAAC AAGAACTACT AGAAGCTTTT AAAGTATTCG ATAAGAACGG TGATGGTTTA 300 301 ATCTCCGCCG CTGAGTTGAA ACACGTGCTA ACATCCATTG GTGAAAAATT GACTGATGCC 360 361 GAAGTAGATG ATATGCTAAG AGAGGTTAGT GATGGATCAG GCGAGATCAA CATTCAACAA 420 421 TTCGCTGCTT TGTTATCTAA ATAG 444

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0106	Calcium
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-0903	Direct protein sequencing
KW-0479	Metal-binding
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0677	Repeat

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005933	Cellular Component	Cellular bud
GO:0005935	Cellular Component	Cellular bud neck
GO:0005934	Cellular Component	Cellular bud tip
GO:0005823	Cellular Component	Central plaque of spindle pole body
GO:0000131	Cellular Component	Incipient cellular bud site
GO:0043332	Cellular Component	Mating projection tip
GO:0005509	Molecular Function	Calcium ion binding
GO:0048306	Molecular Function	Calcium-dependent protein binding
GO:0051019	Molecular Function	Mitogen-activated protein kinase binding
GO:0019722	Biological Process	Calcium-mediated signaling
GO:0007114	Biological Process	Cell budding
GO:0007010	Biological Process	Cytoskeleton organization
GO:0006897	Biological Process	Endocytosis
GO:0000742	Biological Process	Karyogamy involved in conjugation with cellular fusion
GO:0016237	Biological Process	Lysosomal microautophagy
GO:0006661	Biological Process	Phosphatidylinositol biosynthetic process
GO:0006606	Biological Process	Protein import into nucleus
GO:0006898	Biological Process	Receptor-mediated endocytosis
GO:1903525	Biological Process	Regulation of membrane tubulation
GO:0051300	Biological Process	Spindle pole body organization
GO:0042144	Biological Process	Vacuole fusion, non-autophagic

▼ KEGG

sce:YBR109C

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
EPSD	PLMD	dbPTM	BioGRID	PTMcode

Interaction
HINT	Mentha	YTRP	PINA	IID
iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Structure
PDB	MMDB

Element
RAID

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Asg-1127	Ashbya gossypii	95.92	2e-94	276
LLPS-Osl-1020	Ostreococcus lucimarinus	63.01	2e-63	198
LLPS-Urm-2676	Ursus maritimus	62.9	4e-53	171
LLPS-Php-2323	Physcomitrella patens	62.33	9e-62	193
LLPS-Ova-2953	Ovis aries	62.07	9e-63	196
LLPS-Abg-1649	Absidia glauca	61.64	3e-61	192
LLPS-Mod-1042	Monodelphis domestica	61.22	3e-64	199
LLPS-Prp-2063	Prunus persica	60.96	9e-60	188
LLPS-Coc-2199	Corchorus capsularis	60.96	2e-59	187
LLPS-Tru-1730	Triticum urartu	60.96	2e-60	190
LLPS-Viv-0285	Vitis vinifera	60.96	7e-60	189
LLPS-Phv-2108	Phaseolus vulgaris	60.96	2e-60	190
LLPS-Amt-1383	Amborella trichopoda	60.96	3e-60	192
LLPS-Via-0491	Vigna angularis	60.96	3e-60	189
LLPS-Tra-2591	Triticum aestivum	60.96	2e-60	190
LLPS-Brd-1454	Brachypodium distachyon	60.96	2e-60	190
LLPS-Hov-1029	Hordeum vulgare	60.96	2e-60	190
LLPS-Sei-0888	Setaria italica	60.96	2e-60	190
LLPS-Sem-0626	Selaginella moellendorffii	60.96	2e-60	190
LLPS-Hea-0070	Helianthus annuus	60.96	2e-61	193
LLPS-Eqc-2788	Equus caballus	60.84	2e-61	196
LLPS-Coo-1411	Colletotrichum orbiculare	60.56	4e-58	184
LLPS-Spr-1298	Sporisorium reilianum	60.27	6e-61	191
LLPS-Usm-0279	Ustilago maydis	60.27	6e-61	191
LLPS-Orm-0384	Oryza meridionalis	60.27	8e-60	188
LLPS-Orr-1485	Oryza rufipogon	60.27	8e-60	188
LLPS-Org-1814	Oryza glaberrima	60.27	8e-60	188
LLPS-Pot-2310	Populus trichocarpa	60.27	2e-59	187
LLPS-Orp-1799	Oryza punctata	60.27	7e-60	189
LLPS-Ors-0531	Oryza sativa	60.27	8e-60	188
LLPS-Gor-2157	Gossypium raimondii	60.27	2e-59	187
LLPS-Sob-0162	Sorghum bicolor	60.27	8e-60	188
LLPS-Orbr-1096	Oryza brachyantha	60.27	1e-59	188
LLPS-Sot-0967	Solanum tuberosum	60.27	5e-59	186
LLPS-Lep-0558	Leersia perrieri	60.27	1e-59	188
LLPS-Orgl-1427	Oryza glumaepatula	60.27	2e-59	188
LLPS-Vir-0806	Vigna radiata	60.27	8e-60	188
LLPS-Met-0584	Medicago truncatula	60.27	8e-60	188
LLPS-Ori-2425	Oryza indica	60.27	8e-60	188
LLPS-Orb-0342	Oryza barthii	60.27	1e-59	188
LLPS-Glm-2428	Glycine max	60.27	8e-60	188
LLPS-Sol-1845	Solanum lycopersicum	60.27	2e-59	187
LLPS-Orni-1131	Oryza nivara	60.27	8e-59	188
LLPS-Mua-0920	Musa acuminata	60.27	7e-60	189
LLPS-Ast-0895	Aspergillus terreus	60.0	2e-52	169
LLPS-Mam-0374	Macaca mulatta	59.86	2e-62	195
LLPS-Cap-0879	Cavia porcellus	59.86	2e-62	195
LLPS-Poa-3724	Pongo abelii	59.86	2e-62	195
LLPS-Caf-1320	Canis familiaris	59.86	2e-62	195
LLPS-Ten-1265	Tetraodon nigroviridis	59.86	2e-62	195
LLPS-Anc-1562	Anolis carolinensis	59.86	2e-62	195
LLPS-Ict-1866	Ictidomys tridecemlineatus	59.86	2e-62	195
LLPS-Xet-0366	Xenopus tropicalis	59.86	2e-62	195
LLPS-Cas-1129	Carlito syrichta	59.86	2e-62	195
LLPS-Man-3541	Macaca nemestrina	59.86	2e-62	195
LLPS-Fec-2223	Felis catus	59.86	2e-62	195
LLPS-Scm-1890	Scophthalmus maximus	59.86	2e-62	195
LLPS-Lac-1044	Latimeria chalumnae	59.86	2e-62	195
LLPS-Hos-2179	Homo sapiens	59.86	2e-62	195
LLPS-Dar-2976	Danio rerio	59.86	2e-62	195
LLPS-Pof-1191	Poecilia formosa	59.86	2e-62	195
LLPS-Pat-1463	Pan troglodytes	59.86	2e-62	195
LLPS-Pap-1185	Pan paniscus	59.86	2e-62	195
LLPS-Orn-0125	Oreochromis niloticus	59.86	2e-62	195
LLPS-Rhb-1760	Rhinopithecus bieti	59.86	2e-62	195
LLPS-Orc-2127	Oryctolagus cuniculus	59.86	2e-62	195
LLPS-Pes-0995	Pelodiscus sinensis	59.86	3e-62	194
LLPS-Miv-1025	Microbotryum violaceum	59.86	6e-59	186
LLPS-Otg-2647	Otolemur garnettii	59.86	2e-62	195
LLPS-Scf-0046	Scleropages formosus	59.86	2e-62	195
LLPS-Dio-1960	Dipodomys ordii	59.86	2e-62	195
LLPS-Gaa-2588	Gasterosteus aculeatus	59.86	2e-62	195
LLPS-Tar-0827	Takifugu rubripes	59.86	2e-62	195
LLPS-Xim-1932	Xiphophorus maculatus	59.86	2e-62	195
LLPS-Drm-0630	Drosophila melanogaster	59.86	1e-62	196
LLPS-Mup-2634	Mustela putorius furo	59.86	2e-62	195
LLPS-Paa-2786	Papio anubis	59.86	2e-62	195
LLPS-Mal-1066	Mandrillus leucophaeus	59.86	2e-62	195
LLPS-Ran-1593	Rattus norvegicus	59.86	2e-62	195
LLPS-Sus-1072	Sus scrofa	59.86	2e-62	195
LLPS-Leo-0624	Lepisosteus oculatus	59.86	2e-62	195
LLPS-Aon-2072	Aotus nancymaae	59.86	2e-62	195
LLPS-Cea-1451	Cercocebus atys	59.86	2e-62	195
LLPS-Sah-3724	Sarcophilus harrisii	59.86	2e-62	195
LLPS-Orl-3820	Oryzias latipes	59.86	2e-62	195
LLPS-Chs-3852	Chlorocebus sabaeus	59.86	2e-62	195
LLPS-Maf-1132	Macaca fascicularis	59.86	2e-62	195
LLPS-Mum-4105	Mus musculus	59.86	2e-62	195
LLPS-Mea-0309	Mesocricetus auratus	59.86	2e-62	195
LLPS-Caj-0141	Callithrix jacchus	59.86	2e-62	195
LLPS-Icp-2641	Ictalurus punctatus	59.86	2e-62	195
LLPS-Cae-1599	Caenorhabditis elegans	59.86	9e-63	196
LLPS-Asm-0544	Astyanax mexicanus	59.86	2e-62	195
LLPS-Gog-1051	Gorilla gorilla	59.86	2e-62	195
LLPS-Put-0255	Puccinia triticina	59.59	3e-60	190
LLPS-Fuo-0543	Fusarium oxysporum	59.59	4e-58	187
LLPS-Trv-1073	Trichoderma virens	59.59	7e-59	186
LLPS-Tag-1922	Taeniopygia guttata	59.59	1e-61	193
LLPS-Cogr-0465	Colletotrichum graminicola	59.59	7e-59	186
LLPS-Nol-0060	Nomascus leucogenys	59.59	9e-62	193
LLPS-Dos-1135	Dothistroma septosporum	59.59	1e-58	185
LLPS-Bro-1951	Brassica oleracea	59.59	4e-59	187
LLPS-Ved-0339	Verticillium dahliae	59.59	7e-59	186
LLPS-Gaga-3253	Gallus gallus	59.59	1e-61	193
LLPS-Anp-3110	Anas platyrhynchos	59.59	1e-61	193
LLPS-Beb-1389	Beauveria bassiana	59.59	2e-59	187
LLPS-Loa-1836	Loxodonta africana	59.59	1e-61	193
LLPS-Pug-0970	Puccinia graminis	59.59	3e-60	190
LLPS-Brr-1744	Brassica rapa	59.59	4e-59	187
LLPS-Meg-1962	Meleagris gallopavo	59.59	1e-61	193
LLPS-Nia-0759	Nicotiana attenuata	59.59	3e-59	187
LLPS-Fus-1106	Fusarium solani	59.59	7e-59	186
LLPS-Mae-0814	Manihot esculenta	59.59	4e-59	188
LLPS-Trr-0148	Trichoderma reesei	59.59	7e-59	186
LLPS-Tut-1656	Tursiops truncatus	59.59	1e-61	193
LLPS-Lem-0958	Leptosphaeria maculans	59.59	7e-59	186
LLPS-Aim-0802	Ailuropoda melanoleuca	59.59	1e-61	193
LLPS-Myl-1882	Myotis lucifugus	59.59	1e-61	193
LLPS-Arl-1891	Arabidopsis lyrata	59.59	3e-59	187
LLPS-Nec-1126	Neurospora crassa	59.59	7e-59	186
LLPS-Ere-0798	Erinaceus europaeus	59.59	1e-61	193
LLPS-Chr-1232	Chlamydomonas reinhardtii	59.59	2e-59	188
LLPS-Cus-1573	Cucumis sativus	59.59	3e-59	187
LLPS-Brn-1868	Brassica napus	59.59	5e-59	187
LLPS-Crn-0239	Cryptococcus neoformans	59.59	1e-59	188
LLPS-Fuv-1085	Fusarium verticillioides	59.59	3e-58	187
LLPS-Mao-1208	Magnaporthe oryzae	59.59	7e-59	186
LLPS-Thc-0210	Theobroma cacao	59.59	5e-59	187
LLPS-Fud-3063	Fukomys damarensis	59.59	1e-61	193
LLPS-Mel-1409	Melampsora laricipopulina	59.59	2e-60	190
LLPS-Bot-4177	Bos taurus	59.18	6e-62	194
LLPS-Cis-0990	Ciona savignyi	59.18	2e-61	192
LLPS-Asfu-0863	Aspergillus fumigatus	58.9	1e-58	186
LLPS-Art-1736	Arabidopsis thaliana	58.9	1e-58	186
LLPS-Blg-1348	Blumeria graminis	58.9	3e-58	184
LLPS-Zyt-0468	Zymoseptoria tritici	58.9	2e-58	185
LLPS-Asf-0902	Aspergillus flavus	58.9	1e-58	186
LLPS-Asc-0895	Aspergillus clavatus	58.9	1e-58	186
LLPS-Gag-0796	Gaeumannomyces graminis	58.9	3e-58	184
LLPS-Map-0434	Magnaporthe poae	58.9	3e-58	184
LLPS-Asn-0881	Aspergillus nidulans	58.9	1e-58	186
LLPS-Asni-1070	Aspergillus niger	58.9	1e-58	186
LLPS-Scj-1384	Schizosaccharomyces japonicus	58.74	4e-55	176
LLPS-Cii-0257	Ciona intestinalis	58.5	2e-61	193
LLPS-Nef-1503	Neosartorya fischeri	58.22	4e-58	184
LLPS-Kop-1387	Komagataella pastoris	57.53	2e-53	172
LLPS-Gas-0108	Galdieria sulphuraria	57.53	2e-53	173
LLPS-Scp-0514	Schizosaccharomyces pombe	56.85	2e-56	180
LLPS-Scc-0992	Schizosaccharomyces cryophilus	56.85	1e-56	180
LLPS-Yal-1228	Yarrowia lipolytica	56.85	4e-55	177
LLPS-Ora-1726	Ornithorhynchus anatinus	56.76	8e-43	144
LLPS-Aso-0961	Aspergillus oryzae	56.16	7e-54	173
LLPS-Fia-3366	Ficedula albicollis	56.08	1e-57	182
LLPS-Dac-1400	Daucus carota	54.11	1e-49	162
LLPS-Zem-0596	Zea mays	53.06	4e-50	165
LLPS-Chc-0539	Chondrus crispus	50.0	4e-46	153

LLPS-Sac-0370CMD1

Protein Sequence

Nucleotide Sequence

LLPS-Sac-0370
CMD1