LLPS-Sac-0365
GPM1

▼ OVERVIEW

Status: Reviewed
Protein Name: Phosphoglycerate mutase 1
Gene Name: GPM1, GPM, YKL152C, YKL607
Ensembl Gene: YKL152C
Ensembl Protein: YKL152C_mRNA
Organism: Saccharomyces cerevisiae
Taxa ID: 559292
LLPS Type: Client
PDB: 3PGM (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions."
Saccharomyces cerevisiae26484595
Stress granule
"...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions. We identified novel SG components including essential aminoacyl‐tRNA synthetases."
Saccharomyces cerevisiae26484595

▼ FUNCTION

Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also Catalyzes the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPKLVLVRHG  QSEWNEKNLF  TGWVDVKLSA  KGQQEAARAG  ELLKEKKVYP  DVLYTSKLSR  60
61    AIQTANIALE  KADRLWIPVN  RSWRLNERHY  GDLQGKDKAE  TLKKFGEEKF  NTYRRSFDVP  120
121   PPPIDASSPF  SQKGDERYKY  VDPNVLPETE  SLALVIDRLL  PYWQDVIAKD  LLSGKTVMIA  180
181   AHGNSLRGLV  KHLEGISDAD  IAKLNIPTGI  PLVFELDENL  KPSKPSYYLD  PEAAAAGAAA  240
241   VANQGKK  247
Nucleotide CDS Sequence (FASTA)
1     ATGCCAAAGT  TAGTTTTAGT  TAGACACGGT  CAATCCGAAT  GGAACGAAAA  GAACTTATTC  60
61    ACCGGTTGGG  TTGATGTTAA  ATTGTCTGCC  AAGGGTCAAC  AAGAAGCCGC  TAGAGCCGGT  120
121   GAATTGTTGA  AGGAAAAGAA  GGTCTACCCA  GACGTCTTGT  ACACTTCCAA  GTTGTCCAGA  180
181   GCTATCCAAA  CTGCTAACAT  TGCTTTGGAA  AAGGCTGACA  GATTATGGAT  TCCAGTCAAC  240
241   AGATCCTGGA  GATTGAACGA  AAGACATTAC  GGTGACTTAC  AAGGTAAGGA  CAAGGCTGAA  300
301   ACTTTGAAGA  AGTTCGGTGA  AGAAAAATTC  AACACCTACA  GAAGATCCTT  CGATGTTCCA  360
361   CCTCCCCCAA  TCGACGCTTC  TTCTCCATTC  TCTCAAAAGG  GTGATGAAAG  ATACAAGTAC  420
421   GTTGACCCAA  ATGTCTTGCC  AGAAACTGAA  TCTTTGGCTT  TGGTCATTGA  CAGATTGTTG  480
481   CCATACTGGC  AAGATGTCAT  TGCCAAGGAC  TTGTTGAGTG  GTAAGACCGT  CATGATCGCC  540
541   GCTCACGGTA  ACTCCTTGAG  AGGTTTGGTT  AAGCACTTGG  AAGGTATCTC  TGATGCTGAC  600
601   ATTGCTAAGT  TGAACATCCC  AACTGGTATT  CCATTGGTCT  TCGAATTGGA  CGAAAACTTG  660
661   AAGCCATCTA  AGCCATCTTA  CTACTTGGAC  CCAGAAGCTG  CCGCTGCTGG  TGCCGCTGCT  720
721   GTTGCCAACC  AAGGTAAGAA  ATAA  744

▼ KEYWORD

ID
Family
3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Glycolysis
Isomerase
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion outer membrane
Phosphoprotein
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Mitochondrial intermembrane space
Cellular Component
Mitochondrial outer membrane
Cellular Component
Mitochondrion
Molecular Function
Phosphoglycerate mutase activity
Biological Process
Gluconeogenesis
Biological Process
Glycolytic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asg-1163Ashbya gossypii88.661e-150 427
LLPS-Kop-0207Komagataella pastoris78.145e-133 382
LLPS-Yal-1482Yarrowia lipolytica72.872e-118 345
LLPS-Zyt-1058Zymoseptoria tritici56.822e-78 243
LLPS-Drm-1759Drosophila melanogaster56.051e-87 269
LLPS-Fuv-1130Fusarium verticillioides55.455e-81 249
LLPS-Xim-1812Xiphophorus maculatus54.662e-86 265
LLPS-Orl-1040Oryzias latipes54.664e-87 266
LLPS-Orn-3567Oreochromis niloticus54.666e-88 268
LLPS-Gaa-1131Gasterosteus aculeatus54.252e-87 266
LLPS-Tar-2925Takifugu rubripes54.256e-88 268
LLPS-Pof-4002Poecilia formosa54.259e-86 264
LLPS-Mup-2348Mustela putorius furo53.855e-87 266
LLPS-Fuo-0368Fusarium oxysporum53.856e-79 244
LLPS-Caf-3200Canis familiaris53.852e-87 267
LLPS-Ten-2789Tetraodon nigroviridis53.852e-87 266
LLPS-Lac-2243Latimeria chalumnae53.854e-86 263
LLPS-Aim-0135Ailuropoda melanoleuca53.441e-86 265
LLPS-Icp-3693Ictalurus punctatus53.447e-85 260
LLPS-Sus-4041Sus scrofa53.442e-86 264
LLPS-Leo-0547Lepisosteus oculatus53.447e-84 258
LLPS-Scm-1875Scophthalmus maximus53.444e-86 263
LLPS-Xet-2809Xenopus tropicalis53.22e-84 259
LLPS-Bot-4336Bos taurus53.041e-85 262
LLPS-Asm-4131Astyanax mexicanus53.041e-84 259
LLPS-Sah-1780Sarcophilus harrisii53.041e-85 262
LLPS-Mum-3726Mus musculus53.045e-85 260
LLPS-Anc-0138Anolis carolinensis53.041e-85 262
LLPS-Eqc-2766Equus caballus53.044e-85 261
LLPS-Orc-3860Oryctolagus cuniculus53.042e-85 262
LLPS-Otg-3558Otolemur garnettii53.045e-85 261
LLPS-Fec-2710Felis catus53.043e-86 264
LLPS-Dar-2519Danio rerio53.042e-84 259
LLPS-Myl-2712Myotis lucifugus52.634e-85 261
LLPS-Ova-3712Ovis aries52.634e-85 261
LLPS-Ran-3655Rattus norvegicus52.632e-84 259
LLPS-Scf-2985Scleropages formosus52.635e-83 256
LLPS-Dio-1023Dipodomys ordii52.639e-86 263
LLPS-Cap-1395Cavia porcellus52.633e-85 261
LLPS-Mal-1383Mandrillus leucophaeus52.233e-84 259
LLPS-Caj-3963Callithrix jacchus52.239e-84 257
LLPS-Fud-3929Fukomys damarensis52.232e-82 254
LLPS-Gog-4234Gorilla gorilla52.232e-84 259
LLPS-Aon-0064Aotus nancymaae52.236e-84 258
LLPS-Cea-1962Cercocebus atys52.233e-84 259
LLPS-Ict-1123Ictidomys tridecemlineatus52.235e-84 258
LLPS-Nol-1140Nomascus leucogenys52.232e-84 259
LLPS-Gaga-3570Gallus gallus52.238e-81 250
LLPS-Poa-1215Pongo abelii52.232e-84 259
LLPS-Rhb-0962Rhinopithecus bieti52.232e-84 259
LLPS-Pap-4038Pan paniscus52.232e-84 259
LLPS-Pat-1572Pan troglodytes52.232e-84 259
LLPS-Hos-3629Homo sapiens52.232e-84 259
LLPS-Ori-1867Oryza indica51.976e-74 248
LLPS-Cis-0335Ciona savignyi51.843e-77 241
LLPS-Paa-4688Papio anubis51.821e-83 257
LLPS-Chs-2596Chlorocebus sabaeus51.821e-83 257
LLPS-Maf-4344Macaca fascicularis51.821e-83 257
LLPS-Cas-2863Carlito syrichta51.821e-83 257
LLPS-Mam-3889Macaca mulatta51.821e-83 257
LLPS-Man-2491Macaca nemestrina51.821e-83 257
LLPS-Mod-2073Monodelphis domestica51.823e-84 259
LLPS-Ere-0161Erinaceus europaeus51.427e-83 255
LLPS-Meg-0925Meleagris gallopavo51.02e-78 244
LLPS-Cii-1602Ciona intestinalis50.814e-74 233
LLPS-Urm-1573Ursus maritimus50.612e-78 243
LLPS-Pes-2220Pelodiscus sinensis50.62e-76 239
LLPS-Loa-1287Loxodonta africana50.22e-77 241
LLPS-Anp-0974Anas platyrhynchos50.25e-76 238
LLPS-Ora-0171Ornithorhynchus anatinus49.82e-74 238
LLPS-Tag-0069Taeniopygia guttata49.84e-75 235
LLPS-Fia-1487Ficedula albicollis49.42e-74 234
LLPS-Chr-1534Chlamydomonas reinhardtii48.475e-60 205
LLPS-Mea-4267Mesocricetus auratus48.192e-75 236
LLPS-Tut-1070Tursiops truncatus47.793e-74 233
LLPS-Pug-1230Puccinia graminis44.867e-55 182
LLPS-Zem-1234Zea mays44.544e-2198.2
LLPS-Miv-0507Microbotryum violaceum43.697e-50 169
LLPS-Scc-1367Schizosaccharomyces cryophilus42.24e-49 167
LLPS-Scp-1211Schizosaccharomyces pombe41.742e-48 165
LLPS-Mel-0532Melampsora laricipopulina41.264e-49 167
LLPS-Put-1028Puccinia triticina40.938e-48 164
LLPS-Spr-0030Sporisorium reilianum40.197e-47 161
LLPS-Scj-0745Schizosaccharomyces japonicus39.916e-47 161
LLPS-Usm-1488Ustilago maydis39.912e-46 160
LLPS-Orbr-0045Oryza brachyantha39.759e-47 167
LLPS-Orgl-1258Oryza glumaepatula39.516e-48 167
LLPS-Orni-0573Oryza nivara39.516e-48 167
LLPS-Orb-2274Oryza barthii39.516e-48 167
LLPS-Org-1129Oryza glaberrima39.516e-48 167
LLPS-Orr-1899Oryza rufipogon39.515e-48 167
LLPS-Ors-2018Oryza sativa39.516e-48 167
LLPS-Pot-1135Populus trichocarpa39.55e-47 165
LLPS-Orm-0037Oryza meridionalis39.341e-44 165
LLPS-Cus-1663Cucumis sativus39.261e-48 169
LLPS-Thc-0913Theobroma cacao39.267e-47 167
LLPS-Art-3038Arabidopsis thaliana39.262e-46 164
LLPS-Glm-2788Glycine max39.091e-49 171
LLPS-Php-2324Physcomitrella patens39.01e-48 169
LLPS-Arl-2784Arabidopsis lyrata38.844e-46 162
LLPS-Mae-0909Manihot esculenta38.842e-47 166
LLPS-Gor-1393Gossypium raimondii38.842e-47 166
LLPS-Prp-2362Prunus persica38.663e-46 163
LLPS-Tra-2193Triticum aestivum38.435e-47 165
LLPS-Coc-0097Corchorus capsularis38.433e-46 163
LLPS-Lep-0559Leersia perrieri38.276e-48 167
LLPS-Dac-1437Daucus carota38.243e-46 163
LLPS-Amt-1778Amborella trichopoda38.029e-46 162
LLPS-Brd-0077Brachypodium distachyon37.862e-47 166
LLPS-Via-1685Vigna angularis37.61e-45 160
LLPS-Sob-2330Sorghum bicolor37.551e-47 167
LLPS-Sem-0151Selaginella moellendorffii37.392e-43 154
LLPS-Sot-1543Solanum tuberosum37.194e-46 163
LLPS-Sei-0653Setaria italica37.168e-47 164
LLPS-Mua-2098Musa acuminata36.972e-45 162
LLPS-Brn-1829Brassica napus36.975e-43 155
LLPS-Brr-0699Brassica rapa36.977e-43 154
LLPS-Vir-1448Vigna radiata36.925e-46 163
LLPS-Met-0120Medicago truncatula36.922e-46 164
LLPS-Orp-2140Oryza punctata36.922e-48 169
LLPS-Phv-1820Phaseolus vulgaris36.85e-46 162
LLPS-Viv-2155Vitis vinifera36.786e-45 160
LLPS-Nia-2370Nicotiana attenuata36.365e-46 162
LLPS-Hea-1581Helianthus annuus36.152e-47 164
LLPS-Bro-2210Brassica oleracea36.137e-43 154
LLPS-Hov-0138Hordeum vulgare35.382e-44 160
LLPS-Tru-1790Triticum urartu35.385e-45 160
LLPS-Sol-1688Solanum lycopersicum34.574e-41 149