LLPS-Ran-a842
Nsmf

▼ OVERVIEW


Status: Unreviewed
Protein Name: NMDA receptor synaptonuclear signaling and neuronal migration factor; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; Jacob protein; Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
Gene Name: Nsmf, Jac, Nelf
Ensembl Gene: ENSRNOG00000008810.8
Ensembl Protein: ENSRNOP00000012129.6
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MGAAASRRRA  LRSEAMSSVA  AKVRAARAFG  EYLSQSHPEN  RNGADHLLAD  AYSGHEGSPE  60
61    MQPAPHNKRR  LSLVSNGRYE  GSISDEAVSG  KTATEGPQPR  VYTISREPAL  LPGSEAEAIE  120
121   LAVVKGRRQR  ERHPHHHSQP  LRASPGSSRE  DISRPCQSWA  GSRQGSKECP  GCAQLVPGPS  180
181   PRAFGLEQPP  LPEASGRHKK  LERMYSVDGV  SDDVPIRTWF  PKENPFSFQT  ATTTMQAISV  240
241   FRGYAERKRR  KRENDSASVI  QRNFRKHLRM  VGSRRVKAQT  FAERRERSFS  RSWSDPTPMK  300
301   ADTSHDSRDS  SDLQSSHCTL  DEACEDLDWD  TEKGLEATAC  DTEGFLPPKV  MLISSKVPKA  360
361   EYIPTIIRRD  DPSIIPILYD  HEHATFEDIL  EEIEKKLNIY  HKGAKIWKML  IFCQGGPGHL  420
421   YLLKNKVATF  AKVEKEEDMI  HFWKRLSRLM  SKVNPEPNVI  HIMGCYILGN  PNGEKLFQNL  480
481   RTLMTPYKVT  FESPLELSAQ  GKQMIETYFD  FRLYRLWKSR  QHSKLLDFDD  VL  532
Nucleotide CDS Sequence (FASTA)
1     ATGGGTGCCG  CCGCCTCCAG  GAGGAGGGCG  CTGAGGAGCG  AGGCCATGTC  CTCGGTAGCG  60
61    GCCAAAGTAA  GAGCAGCCCG  AGCGTTTGGA  GAGTACCTGT  CCCAGAGTCA  CCCTGAGAAC  120
121   CGCAACGGTG  CAGACCACCT  GCTGGCCGAC  GCCTACTCTG  GCCACGAAGG  GTCCCCAGAG  180
181   ATGCAGCCTG  CACCCCACAA  CAAGCGCCGC  CTCTCCCTCG  TCTCCAATGG  CCGCTATGAG  240
241   GGCAGCATCT  CAGATGAGGC  AGTCAGCGGG  AAGACGGCTA  CAGAGGGCCC  CCAGCCCCGT  300
301   GTGTACACCA  TCTCTAGAGA  GCCAGCCCTG  CTGCCTGGCT  CTGAAGCCGA  AGCCATTGAG  360
361   CTAGCAGTGG  TGAAAGGGAG  GAGGCAGCGG  GAGCGGCACC  CTCACCACCA  CAGCCAGCCC  420
421   CTGCGCGCCA  GCCCAGGCAG  CAGCCGTGAG  GACATCAGCA  GGCCCTGCCA  AAGCTGGGCA  480
481   GGAAGCCGCC  AGGGCTCCAA  AGAATGCCCC  GGATGTGCCC  AGCTGGTCCC  TGGTCCCTCC  540
541   CCTCGGGCCT  TCGGGTTGGA  ACAGCCACCT  CTACCTGAGG  CTTCCGGCCG  TCACAAGAAG  600
601   CTGGAAAGGA  TGTATAGTGT  TGATGGAGTG  TCTGATGACG  TCCCCATCCG  TACCTGGTTC  660
661   CCCAAGGAAA  ACCCTTTCAG  CTTCCAGACG  GCAACCACAA  CTATGCAAGC  CCGCCTGAAC  720
721   TTCCGCAAAC  ACCTGCGCAT  GGTTGGCAGT  CGGCGGGTGA  AGGCCCAGAG  CAGTGACCTA  780
781   CAGAGCTCAC  ACTGCACCCT  GGATGAGGCT  TGTGAGGACC  TGGACTGGGA  CACAGAGAAA  840
841   GGCCTGGAGG  CCACGGCCTG  CGACACTGAG  GGCTTCTTGC  CACCCAAGGT  CATGCTAATC  900
901   TCCTCCAAGG  TGCCCAAGGC  CGAGTACATC  CCAACCATCA  TCCGCAGAGA  CGACCCATCC  960
961   ATCATCCCCA  TCCTCTATGA  CCATGAGCAC  GCAACGTTCG  AGGACATCCT  GGAGGAAATA  1020
1021  GAGAAGAAGT  TGAACATCTA  TCACAAGGGG  GCCAAGATCT  GGAAGATGCT  GATTTTCTGC  1080
1081  CAGGGCGGCC  CTGGGCACCT  TTATTTGCTC  AAGAACAAGG  TGGCCACCTT  TGCCAAAGTG  1140
1141  GAGAAGGAAG  AGGACATGAT  CCACTTCTGG  AAGAGGCTGA  GCCGTCTGAT  GAGCAAAGTG  1200
1201  AACCCTGAGC  CAAATGTCAT  CCACATCATG  GGCTGCTACA  TCCTGGGGAA  CCCTAACGGG  1260
1261  GAGAAGCTAT  TCCAGAACCT  CAGGACCCTC  ATGACCCCTT  ACAAGGTTAC  CTTTGAGTCG  1320
1321  CCCCTGGAGC  TCTCTGCCCA  AGGGAAGCAA  ATGATTGAGA  CCTACTTTGA  TTTCCGGCTG  1380
1381  TACCGCCTGT  GGAAAAGCCG  CCAGCACTCA  AAGCTGCTGG  ACTTTGATGA  CGTCCTGTGA  1440

▼ KEYWORD


ID
Family
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Lipoprotein
Membrane
Myristate
Nucleus
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Synapse
Synaptosome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Apical dendrite
Cellular Component
Cell junction
Cellular Component
Cortical cytoskeleton
Cellular Component
Cytoplasm
Cellular Component
Dendrite
Cellular Component
Dendritic spine
Cellular Component
Glutamatergic synapse
Cellular Component
Membrane
Cellular Component
Neuron projection
Cellular Component
Nuclear envelope
Cellular Component
Nuclear euchromatin
Cellular Component
Nuclear matrix
Cellular Component
Nuclear membrane
Cellular Component
Nucleus
Cellular Component
Perikaryon
Cellular Component
Postsynapse
Cellular Component
Postsynaptic density
Cellular Component
Postsynaptic membrane
Cellular Component
Synapse
Molecular Function
Calcium-dependent protein binding
Biological Process
Cellular response to amino acid stimulus
Biological Process
Cellular response to electrical stimulus
Biological Process
Cellular response to gonadotropin stimulus
Biological Process
Positive regulation of neuron migration
Biological Process
Positive regulation of protein dephosphorylation
Biological Process
Postsynapse to nucleus signaling pathway
Biological Process
Regulation of dendrite morphogenesis
Biological Process
Regulation of neuron apoptotic process
Biological Process
Regulation of neuronal synaptic plasticity

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hos-a862Homo sapiens0.0991undefined
LLPS-Mum-a848Mus musculus0.01084undefined