LLPS-Ran-a795
Pea15
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes |
| Gene Name: | Pea15 |
| Ensembl Gene: | ENSRNOG00000046996.1 |
| Ensembl Protein: | ENSRNOP00000064962.1 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000070812.1 | ENSRNOP00000064962.1 |
| UniProt | Q5U318, PEA15_RAT, Q78ZC9 | |
| GeneBank | BC085766, AJ243949 | AAH85766.1, CAB51573.1 |
| RefSeq | NM_001013231.1 | NP_001013249.1 |
| Entrez | 364052 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL 60 61 SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI 120 121 IKLAPPPKKA 130 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGAGT ACGGGACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 60 61 GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA AGAGATCACT 120 121 ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 180 181 TCCTACATTG AGCACATCTT TGAGATCTCC CGCCGTCCTG ACCTACTCAC GATGGTGGTT 240 241 GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGATG AGCTGGACAC CAAGCTAACC 300 301 CGTATCCCCA GCGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA GGAAGAAATC 360 361 ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA 393 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Biological Process | Apoptotic process | |
Biological Process | Carbohydrate transport | |
Biological Process | DNA damage checkpoint | |
Biological Process | Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | |
Biological Process | Negative regulation of glucose import | |
Biological Process | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | |
Biological Process | Response to morphine |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TISSUES | ||||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a815 | Homo sapiens | 5e-88 | 261 | undefined |
| LLPS-Mum-a802 | Mus musculus | 4e-88 | 261 | undefined |