LLPS-Ran-a461
Vgf
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Neurosecretory protein VGF; VGF8a protein |
| Gene Name: | Vgf |
| Ensembl Gene: | ENSRNOG00000001416.5 |
| Ensembl Protein: | ENSRNOP00000050024.2 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Neurosecretory protein VGF: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (PubMed:12065665, PubMed:7595538). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000041808.2 | ENSRNOP00000050024.2 |
| UniProt | P20156, VGF_RAT | |
| GeneBank | M74223, M60525, M60522 | AAA42336.1, AAA41700.1, AAA86428.1 |
| RefSeq | NM_030997.1 | NP_112259.1 |
| Entrez | 29461 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKTFTLPASV LFCFLLLIRG LGAAPPGRSD VYPPPLGSEH NGQVAEDAVS RPKDDSVPEV 60 61 RAARNSEPQD QGELFQGVDP RALAAVLLQA LDRPASPPAV PAGSQQGTPE EAAEALLTES 120 121 VRSQTHSLPA SEIQASAVAP PRPQTQDNDP EADDRSEELE ALASLLQELR DFSPSNAKRQ 180 181 QETAAAETET RTHTLTRVNL ESPGPERVWR ASWGEFQARV PERAPLPPSV PSQFQARMSE 240 241 NVPLPETHQF GEGVSSPKTH LGETLTPLSK AYQSLSAPFP KVRRLEGSFL GGSEAGERLL 300 301 QQGLAQVEAG RRQAEATRQA AAQEERLADL ASDLLLQYLL QGGARQRDLG GRGLQETQQE 360 361 RENEREEEAE QERRGGGEDE VGEEDEEAAE AEAEAEEAER ARQNALLFAE EEDGEAGAED 420 421 KRSQEEAPGH RRKDAEGTEE GGEEDDDDEE MDPQTIDSLI ELSTKLHLPA DDVVSIIEEV 480 481 EEKRKRKKNA PPEPVPPPRA APAPTHVRSP QPPPPAPARD ELPDWNEVLP PWDREEDEVF 540 541 PPGPYHPFPE YIRPRTLQPP ASSRRRHFHH ALPPARHHPD LEAQARRAQE EADAEERRLQ 600 601 EQEELENYIE HVLLHRP 617 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAAACCT TCACGTTGCC AGCATCCGTC CTCTTCTGCT TCCTTCTACT CATCCGGGGG 60 61 TTGGGAGCAG CACCCCCCGG GCGCTCCGAT GTTTATCCTC CTCCCCTCGG CTCTGAGCAT 120 121 AATGGGCAGG TAGCTGAGGA CGCAGTGTCC CGGCCAAAGG ATGACAGCGT CCCAGAGGTC 180 181 CGAGCGGCTC GGAATTCCGA GCCTCAGGAC CAGGGAGAGC TCTTCCAGGG CGTGGATCCC 240 241 CGGGCGCTGG CCGCGGTACT GTTGCAGGCA CTGGACCGTC CGGCCTCGCC CCCGGCTGTC 300 301 CCGGCAGGTT CCCAGCAGGG AACACCCGAA GAAGCAGCAG AAGCTCTGCT GACCGAGTCC 360 361 GTGCGCAGTC AGACCCATAG CCTCCCGGCA TCAGAAATCC AAGCGTCCGC TGTGGCGCCC 420 421 CCTCGCCCTC AGACTCAGGA CAACGATCCC GAGGCAGACG ACCGCTCAGA AGAGCTGGAG 480 481 GCACTAGCAT CCTTGCTCCA AGAACTTCGA GATTTCAGTC CGAGTAATGC TAAGCGCCAG 540 541 CAAGAGACGG CGGCAGCAGA GACTGAAACC CGCACGCACA CGCTGACCCG AGTCAATCTG 600 601 GAGAGCCCCG GGCCAGAGCG CGTATGGCGC GCTTCCTGGG GAGAGTTCCA GGCGCGCGTC 660 661 CCGGAGCGTG CTCCTCTGCC GCCCTCGGTC CCTTCTCAAT TCCAGGCTCG AATGTCCGAA 720 721 AACGTTCCCC TTCCCGAAAC CCATCAGTTC GGGGAAGGAG TGTCCTCCCC TAAAACACAT 780 781 CTTGGTGAGA CTTTGACACC CTTATCCAAG GCGTACCAAA GTCTAAGTGC CCCCTTCCCC 840 841 AAGGTGCGTC GGCTCGAGGG CTCATTCCTG GGCGGTTCCG AGGCAGGAGA GCGCCTGCTT 900 901 CAACAAGGGT TAGCTCAGGT AGAGGCAGGG AGGAGGCAGG CGGAGGCCAC CCGGCAGGCC 960 961 GCAGCGCAAG AAGAGCGGCT GGCCGATCTC GCCTCCGACC TGCTGCTCCA GTATTTGCTG 1020 1021 CAGGGCGGCG CCCGGCAGCG CGATCTCGGG GGTCGCGGGC TGCAGGAGAC GCAGCAAGAG 1080 1081 CGGGAGAACG AGAGGGAGGA GGAGGCGGAG CAGGAGAGAC GCGGTGGTGG GGAGGACGAG 1140 1141 GTGGGGGAAG AGGATGAGGA GGCGGCAGAG GCGGAGGCGG AGGCAGAGGA GGCGGAGAGG 1200 1201 GCGCGGCAGA ACGCGCTCCT GTTCGCCGAG GAGGAGGACG GGGAAGCCGG AGCCGAGGAC 1260 1261 AAGCGCTCCC AGGAGGAGGC GCCAGGCCAT CGGCGGAAGG ATGCTGAGGG GACAGAGGAG 1320 1321 GGCGGGGAGG AGGATGACGA CGACGAAGAG ATGGATCCGC AGACGATCGA TAGTCTCATT 1380 1381 GAACTGTCCA CCAAACTCCA CCTGCCAGCA GACGATGTGG TCAGCATCAT CGAAGAGGTG 1440 1441 GAGGAGAAAC GGAAGCGGAA GAAGAACGCC CCTCCCGAGC CGGTGCCGCC CCCCAGGGCT 1500 1501 GCCCCAGCCC CGACCCATGT CCGCTCCCCG CAGCCCCCAC CTCCCGCCCC GGCCCGGGAT 1560 1561 GAGTTGCCGG ACTGGAACGA AGTACTCCCA CCCTGGGATC GGGAGGAGGA TGAGGTGTTT 1620 1621 CCCCCGGGGC CCTATCACCC CTTCCCAGAA TACATTCGGC CGCGGACACT GCAGCCGCCC 1680 1681 GCATCCTCCC GCCGCCGTCA CTTCCATCAC GCGTTGCCAC CTGCGCGCCA CCATCCCGAT 1740 1741 CTGGAGGCCC AGGCCAGGCG CGCGCAGGAG GAAGCGGACG CGGAGGAGCG CCGGCTGCAG 1800 1801 GAGCAGGAGG AGCTGGAGAA TTACATTGAG CACGTGCTGC TGCACCGCCC GTGA 1854 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Extracellular space | |
Cellular Component | Neuron projection | |
Cellular Component | Neuronal cell body | |
Cellular Component | Secretory granule membrane | |
Cellular Component | Synapse | |
Cellular Component | Transport vesicle | |
Molecular Function | Growth factor activity | |
Molecular Function | Neuropeptide hormone activity | |
Biological Process | Neuron differentiation | |
Biological Process | Penile erection | |
Biological Process | Regulation of neuronal synaptic plasticity |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a468 | Homo sapiens | 0.0 | 734 | undefined |
| LLPS-Mum-a464 | Mus musculus | 0.0 | 1162 | undefined |