LLPS-Ran-a392
Rab14
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ras-related protein Rab-14 |
| Gene Name: | Rab14 |
| Ensembl Gene: | ENSRNOG00000018901.5 |
| Ensembl Protein: | ENSRNOP00000075991.1 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000092787.1 | ENSRNOP00000075991.1 |
| Ensembl | ENSRNOT00000025649.5 | ENSRNOP00000025649.2 |
| UniProt | P61107, RAB14_RAT, P35287, Q969L0, Q9UI11 | |
| GeneBank | M83680 | AAA41994.1 |
| RefSeq | NM_053589.1 | NP_446041.1 |
| Entrez | 94197 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT RIIEVSGQKI 60 61 KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN HLSSWLTDAR NLTNPNTVII 120 121 LIGNKADLEA QRDVTYEEAK QFAEENGLLF LEASAKTGEN VEDAFLEAAK KIYQNIQDGS 180 181 LDLNAAESGV QHKPSAPQGG RLTSEPQPQR EGCGC 215 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAACTG CACCGTACAA CTACTCTTAC ATCTTTAAGT ATATTATTAT TGGGGATATG 60 61 GGAGTAGGAA AATCTTGCTT GCTTCATCAA TTTACAGAAA AAAAGTTTAT GGCTGATTGT 120 121 CCTCACACAA TTGGTGTTGA ATTTGGTACA AGAATAATTG AAGTTAGTGG CCAAAAAATC 180 181 AAACTGCAGA TTTGGGATAC AGCAGGACAG GAGAGGTTCA GAGCTGTTAC ACGGAGCTAC 240 241 TATAGAGGAG CTGCAGGTGC GCTCATGGTG TATGACATCA CCAGAAGAAG TACATATAAC 300 301 CACTTAAGCA GCTGGTTGAC AGATGCAAGG AACCTCACCA ACCCAAACAC TGTAATAATT 360 361 CTCATAGGAA ATAAAGCAGA TTTGGAAGCA CAGAGAGATG TTACCTATGA AGAAGCCAAA 420 421 CAGTTTGCTG AAGAAAACGG CTTATTGTTC CTTGAAGCAA GTGCAAAAAC GGGAGAGAAT 480 481 GTAGAAGATG CTTTTCTTGA GGCTGCCAAG AAAATCTATC AGAACATTCA GGATGGAAGC 540 541 CTGGATCTGA ATGCTGCCGA GTCTGGTGTA CAACACAAAC CCTCAGCCCC GCAGGGAGGA 600 601 CGGCTAACCA GTGAACCCCA ACCCCAGAGA GAAGGCTGTG GCTGCTAG 648 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Alveolar lamellar body | |
Cellular Component | Anchored component of synaptic vesicle membrane | |
Cellular Component | Apical plasma membrane | |
Cellular Component | Cytoplasmic vesicle membrane | |
Cellular Component | Cytosol | |
Cellular Component | Early endosome | |
Cellular Component | Early endosome membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | Golgi stack | |
Cellular Component | Late endosome | |
Cellular Component | Lysosome | |
Cellular Component | Nuclear outer membrane-endoplasmic reticulum membrane network | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Phagocytic vesicle | |
Cellular Component | Plasma membrane | |
Cellular Component | Recycling endosome | |
Cellular Component | Rough endoplasmic reticulum | |
Cellular Component | Trans-Golgi network | |
Cellular Component | Trans-Golgi network transport vesicle | |
Cellular Component | Transport vesicle | |
Molecular Function | GDP binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Biological Process | Apical protein localization | |
Biological Process | Body fluid secretion | |
Biological Process | Defense response to bacterium | |
Biological Process | Endocytic recycling | |
Biological Process | Fibroblast growth factor receptor signaling pathway | |
Biological Process | Golgi to endosome transport | |
Biological Process | Intracellular protein transport | |
Biological Process | Intracellular transport | |
Biological Process | Phagolysosome assembly involved in apoptotic cell clearance | |
Biological Process | Rab protein signal transduction | |
Biological Process | Regulation of embryonic development | |
Biological Process | Regulation of protein localization | |
Biological Process | Vesicle-mediated transport |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a396 | Homo sapiens | 1e-160 | 452 | undefined |
| LLPS-Mum-a395 | Mus musculus | 1e-160 | 452 | undefined |