LLPS-Ran-a312
Ppm1h
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein phosphatase 1H |
| Gene Name: | Ppm1h |
| Ensembl Gene: | ENSRNOG00000004314.7 |
| Ensembl Protein: | ENSRNOP00000061506.2 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000066381.1 | ENSRNOP00000061506.2 |
| Ensembl | ENSRNOT00000005798.7 | ENSRNOP00000005798.4 |
| UniProt | Q5M821, PPM1H_RAT | |
| GeneBank | AABR03055960, AABR03058942, AABR03055580, AABR03058099, BC088307, AABR03056562, AABR03056001 | , AAH88307.1 |
| RefSeq | NM_001271079.2 | NP_001258008.1 |
| Entrez | 314897 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLTRVKSAVA NFMGGIMAGS SGSEHGGSGC GGSDLPLRFP YGRPEFLGLS QDEVECSADH 60 61 IARPILILKE TRRLPWATGY AEVINAGKST HNEDQASCEV LTVKKKVGTI TSTPNRNSKR 120 121 RSSLPNGEGL QLKENSESEG ISCHYWSLFD GHAGSGAAVV ASRLLQHHIT QQLQDIVEIL 180 181 KNSAILPPTC LGEEPESTPA HGRTLTRAAS LRGGVGAPGS PSTPPTRFFT EKKIPHECLV 240 241 IGALESAFKE MDLQIERERS AYNISGGCTA LIVVCLLGKL YVANAGDSRA IIIRNGEIIP 300 301 MSSEFTPETE RQRLQYLAFM QPHLLGNEFT HLEFPRRVQR KELGKKMLYR DFNMTGWAYK 360 361 TIEDDDLKFP LIYGEGKKAR VMATIGVTRG LGDHDLKVHD SNIYIKPFLS SAPEVRVYDL 420 421 SKYEHGADDV LILATDGLWD VLSNEEVAEA ITQFLPNCDP DDPHRYTLAA QDLVMRARGV 480 481 LKDRGWRISN DRLGSGDDIS VYVIPLIHGN KLS 513 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTCACTC GGGTGAAATC TGCCGTGGCC AATTTCATGG GCGGCATCAT GGCTGGCAGC 60 61 TCCGGCTCCG AGCACGGCGG CAGCGGCTGC GGAGGCTCGG ACCTGCCCCT GCGCTTCCCG 120 121 TACGGGCGGC CAGAGTTCCT CGGGCTGTCT CAGGATGAGG TGGAGTGCAG CGCAGACCAC 180 181 ATCGCCCGCC CCATCCTCAT CCTCAAGGAG ACCCGGCGGC TGCCCTGGGC CACGGGCTAC 240 241 GCAGAGGTTA TTAATGCTGG AAAGAGCACA CACAATGAGG ACCAAGCCAG CTGCGAGGTG 300 301 CTCACAGTGA AGAAGAAAGT TGGGACCATT ACTTCCACCC CGAACAGAAA TTCCAAGCGA 360 361 AGGTCATCCC TTCCCAACGG GGAAGGCCTG CAGTTAAAGG AGAACTCTGA GTCTGAGGGC 420 421 ATCTCCTGCC ACTACTGGTC CCTGTTTGAT GGCCACGCAG GCTCAGGTGC TGCTGTGGTG 480 481 GCATCGCGCC TGCTGCAGCA CCACATCACA CAACAGCTGC AGGACATCGT GGAGATCCTG 540 541 AAGAACTCCG CCATCCTTCC CCCGACCTGC CTAGGGGAGG AGCCAGAGAG CACGCCGGCC 600 601 CATGGCAGGA CCCTAACCCG CGCAGCCTCA CTGCGTGGAG GGGTGGGTGC CCCCGGCTCC 660 661 CCCAGCACAC CACCCACGCG CTTCTTCACG GAGAAGAAGA TTCCTCATGA GTGTTTGGTC 720 721 ATCGGGGCCC TGGAGAGCGC CTTCAAGGAA ATGGACCTTC AAATTGAACG GGAGAGGAGT 780 781 GCATATAATA TATCCGGTGG CTGCACGGCC CTCATCGTGG TTTGCCTTCT GGGGAAGCTC 840 841 TACGTGGCAA ATGCAGGTGA CAGCAGGGCC ATAATCATCC GAAATGGAGA AATCATCCCC 900 901 ATGTCTTCCG AATTCACCCC TGAGACTGAG CGTCAGAGAC TTCAGTACCT GGCGTTCATG 960 961 CAGCCTCACT TGCTGGGAAA TGAGTTCACA CACTTGGAGT TTCCAAGGAG AGTACAGAGG 1020 1021 AAAGAACTCG GGAAGAAGAT GCTGTACCGG GACTTTAACA TGACAGGCTG GGCATACAAA 1080 1081 ACCATTGAGG ATGATGACTT GAAGTTTCCC CTTATATATG GAGAAGGCAA GAAGGCCCGG 1140 1141 GTAATGGCAA CTATTGGAGT GACAAGGGGA CTTGGGGACC ATGACCTGAA GGTTCATGAC 1200 1201 TCCAACATCT ACATAAAACC ATTCCTGTCT TCAGCTCCAG AGGTCAGAGT CTACGATCTC 1260 1261 TCCAAATACG AGCACGGAGC GGATGACGTG CTGATCCTGG CTACTGATGG ACTCTGGGAT 1320 1321 GTCTTATCAA ATGAAGAAGT AGCGGAAGCA ATCACTCAGT TTCTTCCTAA CTGTGATCCA 1380 1381 GATGACCCTC ACAGGTACAC ACTGGCAGCT CAGGACCTGG TGATGCGTGC CCGAGGCGTC 1440 1441 CTGAAGGACC GAGGATGGCG GATATCAAAT GACCGACTGG GCTCAGGAGA TGACATTTCT 1500 1501 GTATACGTCA TTCCTTTAAT ACACGGAAAC AAACTGTCAT GA 1542 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Nucleoplasm | |
Cellular Component | Nucleus | |
Molecular Function | Magnesium-dependent protein serine/threonine phosphatase activity | |
Molecular Function | Phosphoprotein phosphatase activity | |
Molecular Function | Protein serine/threonine phosphatase activity |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a316 | Homo sapiens | 0.0 | 1033 | undefined |
| LLPS-Mum-a316 | Mus musculus | 0.0 | 1059 | undefined |