LLPS-Ran-a255
Atp4a
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Potassium-transporting ATPase alpha chain 1; Gastric H(+)/K(+) ATPase subunit alpha; Proton pump |
| Gene Name: | Atp4a, Hka |
| Ensembl Gene: | ENSRNOG00000020985.7 |
| Ensembl Protein: | ENSRNOP00000028508.4 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000028508.7 | ENSRNOP00000028508.4 |
| UniProt | P09626, ATP4A_RAT, P70511, P97892, Q63253, Q6LD86 | |
| GeneBank | J02649, X61934, X61935, L11569, S74801 | CAA43939.1, CAA43938.1, AAP31528.1, AAA72354.1, AAA66036.1 |
| Entrez | 24216 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGKENYELYS VELGTGPGGN MAAKMSKKKA GGGGGKKKEK LENMKKEMEM NDHQLSVSEL 60 61 EQKYQTSATK GLKASLAAEL LLRDGPNALR PPRGTPEYVK FARQLAGGLQ CLMWVAAAIC 120 121 LIAFAIQASE GDLTTDDNLY LALALIAVVV VTGCFGYYQE FKSTNIIASF KNLVPQQATV 180 181 IRDGDKFQIN ADQLVVGDLV EMKGGDRVPA DIRILSAQGC KVDNSSLTGE SEPQTRSPEC 240 241 THESPLETRN IAFFSTMCLE GTAQGLVVST GDRTIIGRIA SLASGVENEK TPIAIEIEHF 300 301 VDIIAGLAIL FGATFFVVAM CIGYTFLRAM VFFMAIVVAY VPEGLLATVT VCLSLTAKRL 360 361 ASKNCVVKNL EAVETLGSTS VICSDKTGTL TQNRMTVSHL WFDNHIHTAD TTEDQSGQTF 420 421 DQSSETWRAL CRVLTLCNRA AFKSGQDAVP VPKRIVIGDA SETALLKFSE LTLGNAMGYR 480 481 DRFPKVCEIP FNSTNKFQLS IHTLEDPRDP RHLLVMKGAP ERVLERCSSI LIKGQELPLD 540 541 EQWREAFQTA YLSLGGLGER VLGFCQLYLN EKDYPPGYTF DVEAMNFPSS GLCFAGLVSM 600 601 IDPPRATVPD AVLKCRTAGI RVIMVTGDHP ITAKAIAASV GIISEGSETV EDIAARLRMP 660 661 VDQVNKKDAR ACVINGMQLK DMDPSELVEA LRTHPEMVFA RTSPQQKLVI VESCQRLGAI 720 721 VAVTGDGVND SPALKKADIG VAMGIAGSDA AKNAADMILL DDNFASIVTG VEQGRLIFDN 780 781 LKKSIAYTLT KNIPELTPYL IYITVSVPLP LGCITILFIE LCTDIFPSVS LAYEKAESDI 840 841 MHLRPRNPRR DRLVNEPLAA YSYFQIGAIQ SFAGFADYFT AMAQEGWFPL LCVGLRPQWE 900 901 DHHLQDLQDS YGQEWTFGQR LYQQYTCYTV FFISIEMCQI ADVLIRKTRR LSAFQQGFFR 960 961 NRILVIAIVF QVCIGCFLCY CPGMPNIFNF MPIRFQWWLV PMPFGLLIFV YDEIRKLGVR 1020 1021 CCPGSWWDQE LYY 1033 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGAAGG AGAATTATGA ATTGTACTCA GTGGAACTGG GGACTGGCCC TGGTGGGAAC 60 61 ATGGCTGCCA AGATGAGCAA GAAGAAGGCG GGAGGCGGGG GAGGCAAGAA GAAGGAGAAG 120 121 CTAGAGAACA TGAAGAAGGA GATGGAGATG AACGACCACC AGTTGTCAGT GTCTGAGCTG 180 181 GAGCAGAAGT ACCAGACCAG TGCCACCAAG GGCCTGAAGG CGAGTCTGGC AGCTGAGCTG 240 241 CTGCTGAGGG ATGGGCCCAA TGCACTCCGG CCACCTCGGG GCACCCCTGA GTACGTGAAG 300 301 TTCGCCCGGC AGCTGGCAGG CGGTCTGCAG TGCCTCATGT GGGTGGCTGC AGCCATCTGC 360 361 CTCATTGCCT TTGCGATTCA GGCCAGCGAG GGAGACCTGA CCACTGATGA CAATTTGTAC 420 421 CTGGCGTTGG CACTCATTGC TGTGGTTGTG GTCACTGGCT GTTTTGGCTA CTACCAGGAG 480 481 TTCAAGAGCA CAAATATCAT CGCCAGCTTC AAGAATCTTG TACCCCAGCA AGCCACAGTG 540 541 ATCCGAGACG GGGATAAGTT CCAGATCAAC GCGGATCAGC TTGTGGTGGG CGACCTGGTA 600 601 GAGATGAAAG GCGGGGACCG CGTCCCAGCA GACATCCGAA TTCTGTCAGC CCAGGGCTGC 660 661 AAGGTGGACA ACTCCTCGCT TACTGGAGAG TCTGAACCGC AGACCCGCTC ACCTGAGTGT 720 721 ACACACGAGA GTCCCCTTGA GACCCGCAAC ATCGCCTTCT TCTCCACCAT GTGTCTGGAG 780 781 GGCACGGCGC AGGGCTTGGT GGTGAGCACC GGTGATCGCA CCATCATTGG ACGCATCGCC 840 841 TCTCTGGCTT CGGGTGTGGA AAACGAGAAG ACTCCTATCG CGATCGAGAT CGAACATTTT 900 901 GTGGACATCA TTGCTGGCCT GGCCATCCTC TTCGGTGCCA CATTCTTTGT GGTGGCCATG 960 961 TGTATCGGCT ATACCTTCCT TCGGGCCATG GTCTTCTTCA TGGCCATTGT GGTAGCCTAT 1020 1021 GTGCCTGAGG GGCTGCTGGC TACTGTCACG GTCTGCCTGT CACTGACAGC AAAGAGGCTG 1080 1081 GCCAGTAAAA ACTGTGTGGT CAAAAATCTG GAAGCAGTGG AGACCCTGGG TTCCACGTCA 1140 1141 GTCATCTGCT CAGACAAGAC AGGAACTCTT ACTCAGAACC GCATGACGGT GTCTCATCTA 1200 1201 TGGTTTGACA ACCATATCCA CACGGCGGAC ACCACAGAAG ACCAGTCAGG GCAAACGTTC 1260 1261 GACCAATCGT CGGAGACCTG GCGGGCGCTG TGCCGCGTGC TCACCCTGTG CAACCGCGCT 1320 1321 GCCTTCAAGT CTGGCCAGGA CGCCGTGCCA GTGCCCAAGC GCATCGTGAT CGGAGACGCA 1380 1381 TCTGAGACTG CGCTGCTCAA GTTCTCGGAG TTGACGTTGG GCAACGCCAT GGGTTATCGG 1440 1441 GACCGCTTCC CCAAAGTTTG CGAGATCCCC TTCAACTCCA CCAACAAGTT TCAGCTGTCC 1500 1501 ATTCACACTC TGGAGGATCC GCGCGACCCC CGGCACTTGC TGGTGATGAA GGGCGCCCCA 1560 1561 GAGCGCGTGC TGGAGCGTTG CAGCTCCATC CTCATCAAGG GCCAGGAGCT GCCCCTGGAC 1620 1621 GAGCAATGGC GTGAGGCCTT CCAGACAGCC TACCTTAGCC TGGGAGGCCT AGGCGAACGC 1680 1681 GTTCTTGGTT TCTGCCAGCT CTACCTGAAT GAGAAGGACT ACCCGCCTGG CTACACCTTT 1740 1741 GATGTGGAGG CCATGAACTT TCCAAGTAGT GGCCTCTGCT TTGCGGGACT TGTATCCATG 1800 1801 ATTGACCCTC CCCGGGCCAC CGTTCCAGAT GCTGTGCTCA AATGCCGTAC GGCAGGCATC 1860 1861 CGGGTGATCA TGGTGACTGG TGACCATCCC ATCACAGCCA AGGCCATTGC AGCCAGTGTG 1920 1921 GGGATCATCT CGGAAGGCAG CGAGACAGTG GAAGACATCG CCGCCCGCCT CCGAATGCCT 1980 1981 GTAGACCAGG TTAATAAGAA GGATGCCCGG GCCTGTGTGA TCAATGGCAT GCAGTTGAAG 2040 2041 GACATGGACC CATCTGAGCT GGTGGAGGCG CTGCGCACCC ACCCTGAGAT GGTGTTTGCT 2100 2101 CGAACCAGTC CTCAGCAGAA GCTGGTGATT GTGGAGAGCT GTCAGCGACT GGGTGCCATT 2160 2161 GTGGCTGTAA CAGGGGATGG TGTGAATGAC TCCCCAGCCC TGAAGAAGGC TGACATTGGT 2220 2221 GTAGCCATGG GCATTGCTGG CTCCGATGCT GCTAAAAATG CTGCTGACAT GATCTTGCTG 2280 2281 GATGACAACT TCGCTTCCAT TGTGACGGGC GTGGAGCAGG GCCGACTGAT CTTTGACAAC 2340 2341 CTGAAGAAAT CCATCGCCTA TACACTGACC AAGAACATTC CAGAACTGAC ACCCTACCTT 2400 2401 ATCTATATCA CTGTCAGTGT GCCCCTACCC CTTGGGTGTA TCACCATTCT CTTCATAGAA 2460 2461 CTCTGCACAG ATATCTTTCC ATCTGTGTCC CTGGCATATG AAAAGGCCGA GAGTGACATC 2520 2521 ATGCACCTGC GCCCACGGAA CCCCAGGCGG GACCGGTTGG TCAATGAACC CCTGGCTGCT 2580 2581 TATTCCTATT TTCAGATTGG TGCCATTCAG TCATTTGCCG GCTTTGCTGA CTACTTCACG 2640 2641 GCCATGGCCC AGGAGGGCTG GTTCCCTCTG CTGTGTGTGG GGCTGCGACC ACAATGGGAG 2700 2701 GACCACCATC TACAAGATCT TCAAGACAGC TACGGCCAGG AATGGACATT TGGTCAGCGT 2760 2761 CTGTACCAGC AGTACACCTG TTACACCGTG TTCTTCATCA GCATCGAGAT GTGCCAGATC 2820 2821 GCTGATGTCC TCATCCGCAA GACACGCCGC CTCTCCGCTT TCCAGCAGGG ATTCTTCAGG 2880 2881 AACAGGATCC TGGTGATCGC CATCGTGTTT CAGGTCTGCA TTGGCTGCTT CCTGTGCTAC 2940 2941 TGCCCAGGGA TGCCCAACAT CTTCAACTTC ATGCCCATCC GGTTCCAGTG GTGGCTGGTC 3000 3001 CCCATGCCCT TTGGCCTTCT CATCTTTGTC TATGATGAGA TCCGGAAACT TGGAGTTCGC 3060 3061 TGTTGCCCAG GGAGCTGGTG GGACCAGGAA CTCTACTATT AG 3102 |
▼ KEYWORD
ID | Family |
ATP-binding | |
Cell membrane | |
Complete proteome | |
Hydrogen ion transport | |
Ion transport | |
Magnesium | |
Membrane | |
Metal-binding | |
Nucleotide-binding | |
Phosphoprotein | |
Potassium | |
Potassium transport | |
Reference proteome | |
Translocase | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | ATP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Potassium:proton exchanging ATPase activity | |
Molecular Function | Sodium:potassium-exchanging ATPase activity | |
Biological Process | ATP hydrolysis coupled proton transport | |
Biological Process | Cellular potassium ion homeostasis | |
Biological Process | Cellular sodium ion homeostasis | |
Biological Process | Gastric acid secretion | |
Biological Process | Potassium ion import across plasma membrane | |
Biological Process | Sodium ion export across plasma membrane |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a259 | Homo sapiens | 0.0 | 2101 | undefined |
| LLPS-Mum-a257 | Mus musculus | 0.0 | 2119 | undefined |