LLPS-Ran-a200
Hck
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK; p56Hck; p59Hck |
| Gene Name: | Hck |
| Ensembl Gene: | ENSRNOG00000009331.6 |
| Ensembl Protein: | ENSRNOP00000012432.6 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000012432.6 | ENSRNOP00000012432.6 |
| UniProt | P50545, HCK_RAT, Q64647, Q6AYV7 | |
| GeneBank | S74141, X62345, BC078890, M83666 | AAA41312.1, AAB20754.1, CAA44218.1, AAH78890.2 |
| RefSeq | NM_013185.3 | NP_037317.2 |
| Entrez | 25734 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGCVKSRFLR EGSKASKIEP NANQKGPVYV PDPTSPKKLG PNSINSLPPG VVEGSEDTIV 60 61 VALYDYEAIH REDLSFQKGD QMVVLEESGE WWKARSLATK KEGYIPSNYV ARVNSLETEE 120 121 WFFKGISRKD AERHLLAPGN MLGSFMIRDS ETTKGSYSLS VRDFDPQHGD TVKHYKIRTL 180 181 DSGGFYISPR STFSSLQELV VHYKKGKDGL CQKLSVPCVS PKPQKPWEKD AWEIPRESLQ 240 241 MEKKLGAGQF GEVWMATYNK HTKVAVKTMK PGSMSVEAFL AEANLMKTLQ HDKLVKLHAV 300 301 VSQEPIFIVT EFMAKGSLLD FLKSEEGSKQ PLPKLIDFSA QISEGMAFIE QRNYIHRDLR 360 361 AANILVSASL VCKIADFGLA RIIEDNEYTA REGAKFPIKW TAPEAINFGS FTIKSDVWSF 420 421 GILLMEIVTY GRIPYPGMSN PEVIRALEHG YRMPRPDNCP EELYSIMIRC WKNRPEERPT 480 481 FEYIQSVLDD FYTATESQYQ QQP 503 |
| Nucleotide CDS Sequence (FASTA) |
1 CTGGGGGGTC GTTCGAGCTG CGAGGATCCG GGCTGCCCGC GAGGCGAAGG GCGGGTGCCC 60 61 AGGATGGGAT GTGTGAAGTC CAGGTTCCTC CGAGAAGGAA GCAAGGCCTC AAAAATAGAG 120 121 CCAAATGCCA ACCAGAAAGG CCCTGTGTAT GTGCCGGATC CCACGTCCCC TAAGAAGCTG 180 181 GGACCGAACA GCATCAACAG CCTGCCCCCG GGGGTCGTGG AGGGCTCTGA GGACACCATT 240 241 GTGGTCGCAC TGTACGACTA TGAGGCCATT CACCGTGAAG ACCTCAGCTT CCAGAAGGGA 300 301 GACCAGATGG TGGTTCTGGA GGAGTCTGGG GAGTGGTGGA AGGCCCGTTC CCTGGCTACC 360 361 AAGAAAGAAG GCTATATCCC AAGCAATTAT GTAGCTCGAG TTAACTCTTT GGAGACTGAG 420 421 GAGTGGTTCT TCAAGGGTAT CAGCCGGAAG GATGCAGAGC GCCACCTGCT GGCTCCCGGG 480 481 AACATGCTGG GCTCCTTCAT GATCCGGGAC AGTGAGACCA CCAAAGGGAG CTACTCACTT 540 541 TCTGTTCGAG ACTTTGACCC CCAGCACGGA GACACGGTGA AGCATTATAA AATCCGGACA 600 601 CTGGACAGTG GAGGCTTCTA CATCTCTCCG AGGAGCACCT TCAGCAGCCT GCAGGAACTT 660 661 GTCGTCCACT ACAAGAAGGG GAAGGATGGG CTCTGCCAGA AGCTGTCAGT GCCCTGTGTG 720 721 TCTCCCAAAC CCCAGAAGCC ATGGGAGAAA GATGCCTGGG AGATTCCTCG AGAATCCCTC 780 781 CAGATGGAGA AGAAACTGGG AGCCGGGCAG TTTGGAGAAG TGTGGATGGC CACCTACAAC 840 841 AAGCACACCA AAGTGGCGGT GAAGACAATG AAGCCAGGGA GCATGTCTGT GGAGGCCTTC 900 901 CTGGCAGAGG CCAACCTGAT GAAGACGTTA CAGCATGATA AACTGGTGAA GCTGCACGCC 960 961 GTGGTCTCTC AGGAGCCCAT CTTTATTGTC ACCGAGTTCA TGGCCAAAGG AAGCCTGCTG 1020 1021 GACTTTCTCA AGAGTGAAGA AGGCAGCAAG CAGCCACTGC CAAAACTCAT TGACTTCTCA 1080 1081 GCCCAGATTT CAGAGGGCAT GGCTTTCATT GAGCAGAGGA ACTACATCCA CCGAGACCTC 1140 1141 CGGGCTGCCA ACATCTTGGT TTCTGCATCA CTGGTGTGTA AGATCGCTGA CTTTGGACTG 1200 1201 GCACGGATCA TCGAGGACAA TGAGTACACA GCTCGGGAAG GAGCCAAGTT CCCCATCAAG 1260 1261 TGGACAGCTC CTGAAGCCAT CAACTTTGGC TCCTTCACCA TCAAGTCAGA TGTCTGGTCC 1320 1321 TTTGGTATCC TGCTGATGGA AATCGTCACC TACGGCCGGA TCCCTTACCC AGGTATGTCA 1380 1381 AACCCAGAGG TGATTCGAGC ACTAGAGCAT GGGTACCGTA TGCCTCGACC AGATAACTGC 1440 1441 CCAGAGGAGC TCTACAGTAT CATGATCCGC TGCTGGAAGA ACCGTCCAGA GGAACGGCCC 1500 1501 ACTTTCGAAT ACATCCAGAG CGTGCTGGAT GACTTCTACA CGGCCACTGA GAGCCAGTAT 1560 1561 CAGCAGCAAC CTTGA 1575 |
▼ KEYWORD
ID | Family |
Alternative initiation | |
ATP-binding | |
Cell junction | |
Cell membrane | |
Cell projection | |
Complete proteome | |
Cytoplasm | |
Cytoplasmic vesicle | |
Cytoskeleton | |
Exocytosis | |
Golgi apparatus | |
Immunity | |
Inflammatory response | |
Innate immunity | |
Kinase | |
Lipoprotein | |
Lysosome | |
Membrane | |
Myristate | |
Nucleotide-binding | |
Nucleus | |
Palmitate | |
Phagocytosis | |
Phosphoprotein | |
Proto-oncogene | |
Reference proteome | |
SH2 domain | |
SH3 domain | |
Transferase | |
Tyrosine-protein kinase | |
Ubl conjugation
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Caveola | |
Cellular Component | Cell projection | |
Cellular Component | Cytoskeleton | |
Cellular Component | Cytosol | |
Cellular Component | Extrinsic component of cytoplasmic side of plasma membrane | |
Cellular Component | Focal adhesion | |
Cellular Component | Golgi apparatus | |
Cellular Component | Lysosome | |
Cellular Component | Nucleoplasm | |
Cellular Component | Transport vesicle | |
Molecular Function | ATP binding | |
Molecular Function | Non-membrane spanning protein tyrosine kinase activity | |
Molecular Function | Protein tyrosine kinase activity | |
Molecular Function | Signaling receptor binding | |
Biological Process | Cell differentiation | |
Biological Process | Exocytosis | |
Biological Process | Inflammatory response | |
Biological Process | Innate immune response | |
Biological Process | Peptidyl-tyrosine autophosphorylation | |
Biological Process | Peptidyl-tyrosine phosphorylation | |
Biological Process | Phagocytosis | |
Biological Process | Positive regulation of actin cytoskeleton reorganization | |
Biological Process | Positive regulation of cell population proliferation | |
Biological Process | Protein autophosphorylation | |
Biological Process | Regulation of cell shape | |
Biological Process | Regulation of phagocytosis | |
Biological Process | Regulation of podosome assembly | |
Biological Process | Transmembrane receptor protein tyrosine kinase signaling pathway |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a203 | Homo sapiens | 0.0 | 940 | undefined |
| LLPS-Mum-a199 | Mus musculus | 0.0 | 1025 | undefined |