LLPS-Ran-a196
Abhd12
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12 |
| Gene Name: | Abhd12 |
| Ensembl Gene: | ENSRNOG00000036934.2 |
| Ensembl Protein: | ENSRNOP00000010640.5 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000010641.5 | ENSRNOP00000010640.5 |
| UniProt | Q6AYT7, ABD12_RAT | |
| GeneBank | BC078918, CH474050 | AAH78918.1, EDL86136.1 |
| RefSeq | NM_001024314.1 | NP_001019485.1 |
| Entrez | 499913 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP HSASDAGMKR 60 61 ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL IFLNFVRVPY FIDLKKPQDQ 120 121 GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK NAQGKDQMWY EDALASNHPI ILYLHGNAGT 180 181 RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV 240 241 YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF 300 301 FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP SRSFRDFKVQ 360 361 FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH 398 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGAAGC GGACCGAGCC CGTCACCTTG GAGCATGAGC GCTGCGCCGC CTCAGGCTCG 60 61 TCTTCCTCCG GCTCGGCCGC CGCGGCGCTG GACGCCGACT GCAGCTTGAA GCAGAACCTG 120 121 CGTCTGGCGG GCAAGGGGAC GGCAGAGCCG CACAGCGCAT CCGACGCGGG CATGAAGCGG 180 181 GCTCTGGGCA GACGGAAGAG CCTGTGGTTC CGACTAAGGA AGATACTTCT CTGTGTTTTG 240 241 GGGTTCTACA TTGCCATTCC ATTTCTTGTC AAACTGTGTC CTGGGATACA GGCCAAACTG 300 301 ATATTCTTAA ATTTCGTGAG GGTTCCCTAT TTCATTGACT TAAAAAAGCC ACAGGATCAA 360 361 GGTTTGAATC ACACCTGCAA TTACTACCTC CAGCCCGAGG ATGATGTCAC TATTGGAGTC 420 421 TGGCACACCA TTCCCTCTGT CTGGTGGAAG AATGCCCAAG GGAAGGACCA GATGTGGTAT 480 481 GAGGATGCTC TGGCTTCTAA CCACCCCATC ATCCTGTACC TGCATGGGAA TGCAGGCACC 540 541 AGAGGAGGTG ACCACCGTGT GGAGCTGTAC AAGGTGCTGA GTTCCCTTGG TTACCACGTG 600 601 GTCACCTTCG ACTACAGAGG TTGGGGTGAC TCAGTAGGAA CACCATCAGA GCGAGGCATG 660 661 ACATATGATG CACTCCATGT TTTTGACTGG ATCAAAGCAA GAAGTGGTGA TAATCCTGTG 720 721 TATATCTGGG GCCATTCGCT GGGCACTGGA GTGGCAACAA ATCTGGTCCG GCGCCTTTGT 780 781 GAGCGAGAGA CGCCACCAGA TGCCCTTATA TTGGAGTCTC CGTTCACAAA TATTCGTGAA 840 841 GAAGCAAAGA GTCATCCATT TTCAGTGATA TACAGATACT TCCCAGGCTT TGACTGGTTC 900 901 TTCCTCGACC CCATTACAAG CAGTGGAATT AAATTTGCAA ATGACGAAAA CATGAAGCAC 960 961 ATCTCCTGTC CCCTGCTCAT CTTGCACGCT GAGGATGACC CAGTTGTACC CTTTCATCTC 1020 1021 GGCAGGAAGC TATACAATAT TGCTGCGCCA TCCCGAAGTT TCCGAGACTT CAAAGTCCAG 1080 1081 TTCATCCCCT TTCACTCAGA CCTTGGCTAC AGACATAAGT ACATCTACAA GAGCCCAGAG 1140 1141 CTTCCACGGA TACTGAGGGA ATTCCTAGGG AAGTCGGAAC CAGAGCGCCA GCACTGA 1197 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | AMPA glutamate receptor complex | |
Cellular Component | Dendrite cytoplasm | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | Acylglycerol lipase activity | |
Molecular Function | Lysophospholipase activity | |
Molecular Function | Palmitoyl-(protein) hydrolase activity | |
Molecular Function | Phospholipase activity | |
Biological Process | Acylglycerol catabolic process | |
Biological Process | Adult walking behavior | |
Biological Process | Monoacylglycerol catabolic process | |
Biological Process | Phosphatidylserine catabolic process | |
Biological Process | Phospholipid catabolic process | |
Biological Process | Protein depalmitoylation | |
Biological Process | Regulation of inflammatory response | |
Biological Process | Response to auditory stimulus |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a199 | Homo sapiens | 0.0 | 735 | undefined |
| LLPS-Mum-a195 | Mus musculus | 0.0 | 826 | undefined |