LLPS-Ran-a168
Jph4
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Junctophilin-4 |
| Gene Name: | Jph4, Jphl1 |
| Ensembl Gene: | ENSRNOG00000025589.4 |
| Ensembl Protein: | ENSRNOP00000034702.4 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000033722.4 | ENSRNOP00000034702.4 |
| UniProt | Q69FB3, JPH4_RAT | |
| GeneBank | AY341260 | AAR08902.1 |
| RefSeq | NM_001003711.1 | NP_001003711.1 |
| Entrez | 445271 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MHVPGGKFDF DDGGCYVGGW EAGRAHGYGV CTGPGAQGEY SGCWAHGFES LGVFTGPGGH 60 61 SYQGHWQQGK REGLGVERKS RWTYRGEWLG GLKGRSGVWE SVSGLRYAGL WKDGFQDGYG 120 121 TETYSDGGTY QGQWQAGKRH GYGVRQSVPY HQAALLRSPR RTSLDSGHSD PPTPPPPLPL 180 181 PGDEGGSPAS GSRGGFVLAG PGDADGASSR KRTPAAGGFF RRSLLLSGLR AGGRRSSLGS 240 241 KRGSLRSEVS SEVGSTGPPG SEASGPPIPA PPALIEGSAT EVYAGEWRAD RRSGYGVSQR 300 301 SNGLRYEGEW LGNRRHGYGR TTRPDGSREE GKYKRNRLVH GGRVRSLLPL ALRRGKVKEK 360 361 VDRAVEGARR AVSAARQRQE IAAARAADAL LKAVAASSVA EKAVEAARMA KLIAQDLQPM 420 421 LEAPGRRPRQ DSGGSDTEPL DEDSPGVYEN GLTPSEGSPE LPSSPASSHQ PWRAPPCRSP 480 481 LPPGGNWGPF SSPKAWPEEW GGPGEQAEEL AGYEAEDEAG MQGPGPRDGS PLLGGCSDSS 540 541 GSLREEEGED EESLPQLRAP GGSESEPVTT PVLRGLSSRG PDAGCLTEEF EEPAATERPA 600 601 QPGAANPLVV GAVALLDLSL AFLFSQLLT 629 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCATGTCC CCCGGGGGAA GTTCGACTTT GACGACGGGG GCTGCTACGT GGGGGGCTGG 60 61 GAGGCGGGGC GGGCACATGG CTACGGCGTG TGCACCGGGC CCGGCGCCCA GGGAGAGTAC 120 121 AGCGGCTGCT GGGCTCACGG CTTCGAGTCG CTGGGTGTCT TCACGGGGCC CGGCGGACAC 180 181 AGTTACCAGG GCCACTGGCA GCAGGGCAAG CGCGAAGGGC TGGGCGTGGA GCGCAAGAGC 240 241 CGCTGGACCT ACCGCGGCGA GTGGCTGGGC GGGCTGAAGG GGCGCAGCGG CGTGTGGGAG 300 301 AGCGTGTCCG GCCTGCGCTA CGCCGGGCTC TGGAAGGACG GCTTCCAGGA CGGCTACGGC 360 361 ACCGAGACCT ACTCCGATGG AGGCACTTAC CAAGGCCAGT GGCAAGCCGG AAAACGCCAT 420 421 GGCTACGGGG TACGCCAGAG TGTACCCTAC CACCAGGCGG CGCTTCTGCG CTCACCCCGC 480 481 CGCACCTCCC TGGACTCCGG CCACAGCGAC CCCCCGACGC CGCCTCCACC CCTACCCCTA 540 541 CCAGGAGATG AAGGAGGCAG CCCTGCCTCC GGCTCCAGAG GCGGCTTCGT ACTGGCGGGG 600 601 CCAGGGGACG CCGATGGGGC GTCTTCCCGT AAGCGCACCC CAGCAGCAGG TGGATTCTTC 660 661 CGCCGTTCAC TGCTGCTCAG CGGGCTCCGG GCTGGTGGGC GCCGCAGCTC CCTGGGCAGC 720 721 AAGAGGGGAT CACTACGAAG CGAGGTGAGC AGCGAAGTGG GCAGTACAGG ACCCCCGGGC 780 781 TCCGAGGCCA GCGGGCCCCC TATCCCAGCG CCACCTGCCC TCATCGAGGG CTCTGCCACT 840 841 GAGGTGTACG CCGGTGAGTG GCGTGCGGAC CGGCGCAGTG GCTACGGAGT GAGCCAGAGA 900 901 TCCAACGGGC TGCGCTATGA AGGCGAGTGG CTGGGCAACC GACGGCACGG ATACGGGCGC 960 961 ACCACCCGGC CCGATGGCTC CCGTGAGGAG GGCAAGTACA AGCGCAACCG GCTGGTACAC 1020 1021 GGGGGACGTG TCCGCAGCCT CCTGCCTCTG GCCCTTAGAC GGGGCAAAGT CAAGGAGAAA 1080 1081 GTGGACAGGG CTGTCGAAGG TGCCCGTCGA GCTGTGAGTG CTGCCCGCCA GCGCCAGGAA 1140 1141 ATTGCTGCTG CCAGGGCAGC AGACGCCCTC CTCAAAGCAG TGGCAGCCAG CAGCGTCGCG 1200 1201 GAGAAGGCCG TGGAGGCGGC GCGGATGGCC AAGCTGATAG CCCAGGATCT ACAACCCATG 1260 1261 TTAGAGGCCC CAGGCCGCAG ACCCCGACAG GATTCTGGAG GTTCTGACAC AGAGCCTTTG 1320 1321 GATGAGGACA GCCCCGGGGT ATACGAGAAT GGACTGACCC CCTCAGAGGG ATCTCCGGAA 1380 1381 CTGCCCAGCA GCCCTGCTTC CTCCCACCAA CCTTGGCGGG CCCCTCCCTG CCGGAGCCCA 1440 1441 CTGCCTCCCG GAGGGAACTG GGGCCCCTTC TCCAGTCCTA AAGCTTGGCC TGAGGAGTGG 1500 1501 GGGGGTCCTG GTGAGCAGGC AGAGGAACTG GCTGGCTATG AGGCTGAGGA TGAGGCTGGG 1560 1561 ATGCAGGGTC CAGGACCGAG AGATGGTTCC CCACTTCTCG GAGGCTGCAG TGACAGTTCA 1620 1621 GGAAGTCTTC GAGAGGAGGA AGGGGAAGAT GAAGAGTCCT TGCCCCAGCT GAGGGCCCCA 1680 1681 GGAGGCTCAG AATCTGAGCC TGTCACCACT CCAGTTTTGA GGGGCCTGTC TTCAAGGGGT 1740 1741 CCTGATGCTG GGTGCCTGAC AGAAGAGTTT GAGGAGCCTG CTGCCACCGA GAGGCCTGCC 1800 1801 CAGCCGGGAG CTGCCAACCC CCTGGTGGTA GGAGCTGTGG CCTTGCTGGA TCTCAGCCTG 1860 1861 GCGTTCCTGT TCTCCCAGCT CCTCACCTGA 1890 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Junctional membrane complex | |
Cellular Component | Plasma membrane | |
Molecular Function | Calcium-release channel activity | |
Biological Process | Regulation of synaptic plasticity |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TISSUES | ||||
| Element | ||||
| miRWalk | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a168 | Homo sapiens | 0.0 | 1088 | undefined |
| LLPS-Mum-a169 | Mus musculus | 0.0 | 1215 | undefined |