LLPS-Ran-a150
Snx5
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin. Plays a role in the internalization of EGFR after EGF stimulation. Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C and is retromer-independent. Together with PIP5K1C facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation. Plays a role in macropinocytosis (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000074606.2 | ENSRNOP00000066353.2 |
| Ensembl | ENSRNOT00000008934.8 | ENSRNOP00000008934.5 |
| UniProt | B1H267, SNX5_RAT | |
| GeneBank | BC160883 | AAI60883.1 |
| RefSeq | XM_006235119.2 | XP_006235181.1 |
| Entrez | 296199 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAVPELLEQ QEEDRSKLRS VSVDLNVDPS LQIDIPDALS ERDKVKFTVH TKTTLPTFQS 60 61 PEFSVTRQHE DFVWLHDTLT ETTDYAGLII PPAPTKPDFD GPREKMQKLG EGEGSMTKEE 120 121 FAKMKQELEA EYLAVFKKTV SSHEVFLQRL SSHPVLSKDR NFHVFLEYDQ DLSVRRKNTK 180 181 EMFGGFFKSV VKSADEVLFS GVKEVDDFFE QEKNFLINYY NRIKDSCAKA DKMTRSHKNV 240 241 ADDYIHTAAC LHSLALEEPT VIKKYLLKVA ELFEKLRKVE GRVSSDEDLK LTELLRYYML 300 301 NIEAAKDLLY RRTKALIDYE NSNKALDKAR LKSKDVKLAE THQQECCQKF EQLSESAKEE 360 361 LINFKRKRVA AFRKNLIEMS ELEIKHARNN VSLLQSCIDL FKNN 404 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGCGG TTCCCGAGTT ACTGGAGCAG CAGGAGGAGG ATCGCAGCAA GTTGAGGTCT 60 61 GTGTCTGTGG ACCTGAATGT TGACCCATCG CTTCAGATTG ACATACCTGA TGCACTCAGT 120 121 GAGAGAGATA AGGTCAAGTT TACAGTTCAC ACCAAGACCA CACTGCCCAC ATTTCAGAGC 180 181 CCAGAGTTTT CTGTTACAAG GCAACATGAA GACTTTGTGT GGCTGCATGA CACTCTTACT 240 241 GAAACAACAG ATTATGCCGG GCTTATCATC CCTCCTGCTC CTACAAAGCC AGACTTTGAT 300 301 GGCCCTCGAG AGAAGATGCA GAAACTGGGA GAAGGTGAAG GATCTATGAC AAAAGAAGAA 360 361 TTTGCCAAGA TGAAGCAAGA ACTGGAAGCT GAGTATCTCG CTGTCTTTAA GAAGACTGTG 420 421 TCCTCACATG AAGTCTTTCT TCAGCGGCTT TCTTCTCACC CTGTTCTCAG TAAAGACCGA 480 481 AACTTCCATG TTTTCTTGGA ATATGATCAG GATCTAAGTG TTAGGCGGAA AAATACCAAG 540 541 GAGATGTTTG GAGGCTTTTT TAAAAGTGTT GTGAAGAGCG CTGATGAGGT CCTTTTTTCT 600 601 GGAGTTAAGG AGGTGGATGA CTTCTTTGAG CAAGAGAAGA ACTTCCTTAT TAACTATTAC 660 661 AACAGGATCA AGGACTCCTG TGCTAAAGCG GACAAGATGA CCAGATCTCA CAAAAATGTT 720 721 GCTGATGATT ACATCCACAC TGCAGCCTGC TTGCATAGCC TGGCCTTAGA AGAGCCCACA 780 781 GTCATCAAAA AGTACCTGTT GAAAGTTGCA GAGCTATTTG AAAAACTTAG GAAAGTGGAA 840 841 GGTCGAGTCT CATCAGATGA AGATTTAAAA CTGACAGAGC TCCTCCGATA CTACATGCTC 900 901 AACATAGAGG CTGCAAAGGA TCTCCTATAC AGACGCACAA AGGCCCTAAT TGACTATGAG 960 961 AATTCAAACA AAGCTTTGGA CAAGGCCCGG TTAAAAAGCA AAGATGTCAA GTTGGCAGAG 1020 1021 ACTCATCAGC AGGAATGCTG CCAGAAGTTT GAACAGCTTT CTGAATCTGC AAAAGAAGAG 1080 1081 CTGATAAACT TCAAACGGAA GAGAGTGGCA GCATTTCGAA AGAACCTAAT TGAAATGTCT 1140 1141 GAACTGGAAA TAAAGCATGC CAGAAACAAT GTCTCCCTGT TGCAGAGCTG CATTGATTTA 1200 1201 TTCAAGAACA ACTGA 1215 |
▼ KEYWORD
ID | Family |
3D-structure | |
Acetylation | |
Cell membrane | |
Cell projection | |
Complete proteome | |
Cytoplasm | |
Cytoplasmic vesicle | |
Endocytosis | |
Endosome | |
Lipid-binding | |
Membrane | |
Phosphoprotein | |
Protein transport | |
Reference proteome | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Brush border | |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoplasmic vesicle membrane | |
Cellular Component | Cytosol | |
Cellular Component | Early endosome membrane | |
Cellular Component | Endosome | |
Cellular Component | Extrinsic component of cytoplasmic side of plasma membrane | |
Cellular Component | Extrinsic component of endosome membrane | |
Cellular Component | Macropinocytic cup | |
Cellular Component | Phagocytic cup | |
Cellular Component | Plasma membrane | |
Cellular Component | Retromer complex | |
Cellular Component | Ruffle | |
Cellular Component | Tubular endosome | |
Molecular Function | D1 dopamine receptor binding | |
Molecular Function | Dynactin binding | |
Molecular Function | Phosphatidylinositol binding | |
Molecular Function | Phosphatidylinositol-3,5-bisphosphate binding | |
Molecular Function | Phosphatidylinositol-4-phosphate binding | |
Molecular Function | Phosphatidylinositol-5-phosphate binding | |
Biological Process | Epidermal growth factor catabolic process | |
Biological Process | Intracellular protein transport | |
Biological Process | Negative regulation of blood pressure | |
Biological Process | Pinocytosis | |
Biological Process | Positive regulation of renal sodium excretion | |
Biological Process | Retrograde transport, endosome to Golgi |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a150 | Homo sapiens | 0.0 | 821 | undefined |
| LLPS-Mum-a151 | Mus musculus | 0.0 | 825 | undefined |