LLPS-Ran-a1155
Vps52
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Vacuolar protein sorting-associated protein 52 homolog; SAC2 suppressor of actin mutations 2-like protein |
| Gene Name: | Vps52, Are1, Sacm2l |
| Ensembl Gene: | ENSRNOG00000000470.7 |
| Ensembl Protein: | ENSRNOP00000000549.3 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000000549.5 | ENSRNOP00000000549.3 |
| UniProt | O55166, VPS52_RAT | |
| GeneBank | AJ223830, BX883042 | CAA11566.1, CAE83926.1 |
| RefSeq | NM_033097.2 | NP_149088.1 |
| Entrez | 25218 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAAATMAAA ARELVLRAGA SDMEEEEGPL GAGSGLQEPL QLGELDITSD EFILDEVDVH 60 61 IQANLEDELV KEALKTGVDL RHYSKQVELE LQQIEQKSIR DYIQESENIA SLHNQITACD 120 121 AVLERMEQML GAFQSDLSSI SCEIRTLQEQ SGAMNIRLRN RQAVRGKLGE LVDGLVVPSA 180 181 LVTAILEAPV TEPRFLEQLQ ELDAKAAAVR EQEARGTAAC ADVRGVLDRL RVKAVTKIRE 240 241 FILQKIYSFR KPMTNYQIPQ TALLKYRFFY QFLLGNERAT AKEVRDEYVE TLSKIYLSYY 300 301 RSYVGRLMKV QYEEVAEKDD LMGVEDTAKK GFFSKPSLRS RNTIFTLGTR GAVISPAELE 360 361 APILVPHTAQ RGEQRYPFEA LFRSQHYALL DNSCREYLFI CEFFVVSGPA AHDLFHAVMG 420 421 RTLSMTLKHL ESYLADCYDA IAVFLCIHIV LRFRNIAAKR DVPALDRYWE QVLALLWPRF 480 481 ELILEMNVQS VRSTDPQRLG GLDTRPHYIT RRYAEFSSAL VSINQTIPNE RTLQLLGQLQ 540 541 VEVENFVLRV AAEFSSRKEQ LVFLINNYDM MLGVLMERAA DDSKEVESFQ QLLNARTQEF 600 601 IEELLSPPFG GLVAFVKEAE ALIERGQAER LRGEEARVTQ LIRGFGSSWK ASVESLSQDV 660 661 MRSFTNFRNG TSIIQGALTQ LIQLYHRFHR VLSQPQLRAL PARAELINIH HLMVELKKHK 720 721 PNF 723 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGCCG CGGCGACCAT GGCGGCTGCT GCCCGGGAGC TGGTGTTGCG GGCCGGCGCT 60 61 TCAGATATGG AGGAGGAGGA GGGCCCGCTG GGGGCTGGTT CTGGACTCCA AGAGCCCCTA 120 121 CAACTCGGGG AGTTGGATAT CACCTCTGAT GAATTCATCT TGGATGAAGT GGATGTTCAC 180 181 ATCCAGGCAA ATCTGGAAGA CGAGTTAGTG AAGGAAGCTC TCAAAACGGG TGTGGATCTT 240 241 CGACACTATT CAAAGCAGGT GGAGCTAGAG CTGCAGCAGA TTGAGCAGAA GTCAATCCGG 300 301 GACTACATCC AAGAGAGTGA AAACATAGCC TCTCTGCACA ATCAGATCAC AGCCTGTGAT 360 361 GCCGTCCTAG AGCGCATGGA GCAGATGCTG GGAGCTTTTC AGAGCGACCT CAGCTCCATC 420 421 AGCTGTGAGA TCCGCACCCT GCAGGAGCAG TCGGGGGCCA TGAACATCCG ACTTCGTAAC 480 481 CGGCAGGCAG TTCGGGGGAA ACTTGGGGAA CTCGTCGATG GGCTAGTGGT GCCCTCTGCT 540 541 CTGGTCACAG CAATTCTCGA AGCTCCAGTG ACAGAGCCCA GGTTCCTGGA GCAGCTCCAG 600 601 GAGCTGGACG CCAAGGCGGC TGCGGTCAGA GAGCAGGAGG CGAGAGGCAC GGCCGCCTGT 660 661 GCAGACGTCA GAGGCGTGCT CGACCGGCTC CGGGTCAAGG CGGTGACAAA GATCCGTGAG 720 721 TTCATTCTCC AGAAGATTTA CTCGTTCCGA AAGCCGATGA CCAACTATCA GATCCCCCAG 780 781 ACGGCCCTGC TGAAGTACAG GTTTTTCTAT CAGTTTCTGC TGGGCAACGA GCGTGCTACA 840 841 GCCAAGGAGG TCAGGGATGA GTACGTAGAG ACGCTGAGCA AGATCTACCT GTCATACTAC 900 901 CGCTCGTACG TGGGGCGGCT CATGAAAGTG CAGTACGAGG AAGTTGCTGA GAAAGACGAT 960 961 CTAATGGGTG TAGAAGACAC AGCAAAGAAA GGATTCTTCT CGAAGCCGTC CCTGCGAAGC 1020 1021 AGGAACACCA TCTTTACCCT GGGCACCCGT GGTGCTGTCA TCTCACCGGC CGAGCTCGAG 1080 1081 GCCCCCATCC TGGTGCCCCA TACTGCCCAG CGTGGAGAGC AGAGGTACCC GTTTGAAGCA 1140 1141 CTCTTCCGCA GCCAGCACTA TGCCCTCCTT GACAATTCTT GCCGTGAATA TCTCTTCATC 1200 1201 TGTGAATTTT TCGTCGTCTC TGGCCCGGCT GCCCATGACC TGTTCCACGC CGTCATGGGC 1260 1261 CGCACGCTGT CCATGACGCT GAAACACCTG GAGTCCTACC TGGCCGACTG CTACGACGCC 1320 1321 ATTGCTGTTT TTCTCTGTAT CCACATCGTT CTCCGGTTCC GCAACATAGC AGCAAAGAGG 1380 1381 GACGTCCCTG CCCTGGACAG ATACTGGGAG CAGGTGCTGG CCCTGCTGTG GCCTCGATTT 1440 1441 GAGCTCATCC TGGAGATGAA TGTGCAGAGC GTCCGCAGCA CTGACCCCCA GCGCCTCGGG 1500 1501 GGGCTGGACA CCCGGCCCCA CTATATCACA CGCCGCTACG CCGAGTTCTC CTCCGCGCTT 1560 1561 GTCAGCATCA ACCAGACCAT CCCCAATGAG CGCACGCTGC AGCTGCTGGG ACAGCTACAG 1620 1621 GTGGAGGTGG AGAACTTTGT CCTCCGCGTG GCTGCGGAGT TCTCCTCCAG GAAGGAGCAG 1680 1681 CTCGTGTTTC TGATCAACAA CTATGACATG ATGCTGGGTG TGCTGATGGA GCGGGCTGCT 1740 1741 GACGACAGCA AAGAGGTGGA GAGTTTCCAG CAGCTGCTCA ATGCTCGGAC ACAGGAGTTC 1800 1801 ATTGAAGAGT TGCTGTCACC CCCCTTTGGA GGTCTGGTGG CATTTGTGAA GGAGGCTGAA 1860 1861 GCCTTGATTG AGCGTGGGCA GGCTGAGCGG CTCCGAGGGG AGGAAGCCCG AGTCACCCAG 1920 1921 CTGATCCGCG GCTTTGGTAG TTCCTGGAAG GCGTCAGTGG AGTCCCTGAG TCAGGATGTA 1980 1981 ATGCGGAGTT TTACCAACTT TCGAAATGGA ACCAGCATCA TCCAGGGGGC GCTCACACAG 2040 2041 CTGATCCAGC TCTACCATCG CTTCCACCGT GTGCTGTCCC AGCCTCAGCT CCGTGCCCTC 2100 2101 CCTGCCAGGG CCGAACTCAT CAACATCCAT CACCTCATGG TGGAGCTGAA GAAACACAAG 2160 2161 CCGAACTTCT GA 2172 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | EARP complex | |
Cellular Component | Endosome membrane | |
Cellular Component | GARP complex | |
Cellular Component | Perinuclear region of cytoplasm | |
Cellular Component | Recycling endosome | |
Molecular Function | Rab GTPase binding | |
Molecular Function | Syntaxin binding | |
Biological Process | Ectodermal cell differentiation | |
Biological Process | Embryonic ectodermal digestive tract development | |
Biological Process | Endocytic recycling | |
Biological Process | Golgi to vacuole transport | |
Biological Process | Lysosomal transport | |
Biological Process | Protein transport | |
Biological Process | Retrograde transport, endosome to Golgi |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||