LLPS-Ran-a1082
Grk6
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6 |
| Gene Name: | Grk6, Gprk6 |
| Ensembl Gene: | ENSRNOG00000014615.6 |
| Ensembl Protein: | ENSRNOP00000050134.4 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000047958.4 | ENSRNOP00000050134.4 |
| Ensembl | ENSRNOT00000079063.1 | ENSRNOP00000073781.1 |
| UniProt | P97711, GRK6_RAT | |
| GeneBank | Y09365 | CAA70542.1 |
| Entrez | 59076 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ 60 61 PIGRLLFREF CATRPELTRC TAFLDGVAEY EVTPDEKRKA CGRRLMQNFL SHTGPDLIPE 120 121 VPRQLVSNCA QRLEQGPCKD LFQELTRLTH EYLSMAPFAD YLDSIYFNRF LQWKWLERQP 180 181 VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK 240 241 VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE 300 301 DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE 360 361 RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVAEEYTD RFSPQARSLC 420 421 SQLLNKDPAE RLGCRGGGAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI 480 481 EQFSTVKGVD LEPTDQDFYQ KFATGSVSIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK 540 541 GQPTAPPKKG LLQRLFSRQR IAVGTAATVK KSSPPASSPQ AEAPTGGWR 589 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGCTCG AGAACATCGT AGCGAACACG GTGCTACTCA AGGCCCGGGA AGGTGGTGGC 60 61 GGGAATCGTA AAGGCAAGAG CAAGAAATGG CGCCAGATGC TGCAGTTCCC CCACATCAGC 120 121 CAGTGTGAAG AGCTCCGGCT CAGCCTTGAA CGTGACTACC ACAGCCTGTG TGAGCGTCAG 180 181 CCCATTGGGC GCCTGTTATT TCGTGAGTTC TGCGCTACGA GGCCTGAGCT GACCCGCTGT 240 241 ACTGCCTTCC TGGATGGGGT GGCTGAGTAT GAGGTGACCC CTGATGAGAA ACGGAAGGCA 300 301 TGTGGGCGTC GGCTAATGCA GAATTTTCTG AGCCACACGG GTCCTGACCT CATCCCTGAA 360 361 GTTCCCCGGC AGCTGGTGAG TAACTGTGCC CAGCGGCTAG AGCAGGGACC CTGCAAAGAC 420 421 CTCTTCCAGG AGCTGACCCG GCTGACCCAT GAGTACCTAA GCATGGCCCC TTTTGCCGAC 480 481 TACCTCGACA GCATCTACTT CAACCGTTTC CTGCAGTGGA AGTGGCTGGA AAGGCAGCCA 540 541 GTGACCAAAA ACACCTTTAG GCAGTACCGA GTCCTGGGCA AAGGTGGCTT TGGGGAGGTG 600 601 TGTGCCTGCC AGGTGCGGGC AACAGGCAAG ATGTATGCGT GCAAAAAACT GGAAAAGAAA 660 661 CGAATAAAGA AGCGGAAGGG GGAGGCCATG GCTCTCAACG AGAAGCAGAT CCTGGAGAAA 720 721 GTGAACAGTA GGTTTGTAGT GAGCTTAGCC TACGCATATG AGACCAAGGA TGCACTGTGC 780 781 CTGGTGCTGA CATTGATGAA TGGAGGCGAC CTCAAGTTCC ACATCTACCA CATGGGCCAG 840 841 GCTGGCTTTC CCGAAGCACG TGCTGTCTTC TATGCTGCCG AGATCTGCTG TGGTCTGGAG 900 901 GACTTACACC GGGAACGCAT CGTGTACAGG GACCTAAAGC CAGAGAATAT CCTTCTGGAT 960 961 GACCATGGCC ACATTCGAAT CTCCGACCTG GGCCTGGCTG TGCATGTTCC TGAGGGCCAG 1020 1021 ACCATCAAAG GCCGTGTGGG CACTGTGGGC TACATGGCTC CAGAGGTGGT GAAGAATGAG 1080 1081 CGCTACACAT TCAGTCCTGA CTGGTGGGCG CTAGGCTGCC TCCTGTACGA GATGATTGCG 1140 1141 GGACAGTCGC CCTTCCAGCA GAGGAAGAAG AAGATCAAGC GGGAGGAGGT GGAGCGGCTG 1200 1201 GTCAAGGAGG TGGCTGAGGA GTACACCGAC CGCTTCTCCC CACAGGCACG CTCACTCTGT 1260 1261 TCTCAGCTTC TCAACAAGGA CCCTGCTGAG CGCCTGGGGT GTCGTGGAGG TGGTGCCCGT 1320 1321 GAGGTAAAGG AGCACCCCCT TTTCAAGAAA CTGAATTTCA AGCGGCTGGG AGCTGGAATG 1380 1381 CTAGAACCAC CTTTTAAACC TGACCCCCAG GCCATTTACT GCAAGGACGT GCTGGACATT 1440 1441 GAACAGTTCT CCACAGTTAA AGGTGTGGAT CTGGAGCCCA CAGACCAAGA CTTCTACCAG 1500 1501 AAGTTTGCCA CGGGTAGTGT GTCCATCCCC TGGCAGAACG AGATGGTGGA GACTGAGTGC 1560 1561 TTCCAGGAAC TAAATGTCTT TGGGCTGGAT GGGTCTGTTC CCCCAGACCT GGACTGGAAG 1620 1621 GGCCAGCCCA CTGCACCCCC CAAGAAGGGA TTGCTACAGA GACTCTTCAG TAGACAAGAT 1680 1681 TGCTGTGGGA ACTGCAGCGA CAGTGAAGAA GAGCTCCCCA CCCGCCTCTA G 1731 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | G protein-coupled receptor kinase activity | |
Biological Process | Cellular response to lipopolysaccharide | |
Biological Process | Desensitization of G protein-coupled receptor signaling pathway | |
Biological Process | Negative regulation of anion channel activity | |
Biological Process | Protein phosphorylation | |
Biological Process | Wnt signaling pathway |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a1106 | Homo sapiens | 0.0 | 1179 | undefined |
| LLPS-Mum-a1091 | Mus musculus | 0.0 | 1213 | undefined |