LLPS-Ran-a069
Nckap1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Nck-associated protein 1 |
| Gene Name: | Nckap1, Hem2, Nap1 |
| Ensembl Gene: | ENSRNOG00000007518.7 |
| Ensembl Protein: | ENSRNOP00000059233.3 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000064851.3 | ENSRNOP00000059233.3 |
| UniProt | P55161, NCKP1_RAT | |
| GeneBank | X80029, D84346 | CAA56333.1, BAA12319.1 |
| RefSeq | NM_031618.1 | NP_113806.1 |
| Entrez | 58823 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 QACGDPKAKP SYLIDKNLES AVKFIVRKFP AVETRNNNQQ LAQLQKEKSE ILKNLALYYF 60 61 TFVDVMEFKD HVCDLLNTID VCQVFFDITV NFDLTKNYLD LTVTYTTLMI LLSRIEERKA 120 121 IIGLYNYAHE MTHGASDREY PRLGQMIVDY EHPLKKMMEE FVPHSKSLSD ALISLQMVYP 180 181 RRNLSADQWR NAQLLSLISA PSTMLNPAQS DTMPCEYLSL DAMEKWIIFG FILCHGMLNT 240 241 EATALNLWKL ALQSSSCLSL FRDEVFHIHK AAEDLFVNIR GYNKRINDIR ECKEAAVSHA 300 301 GSMHRERRKF LRSALKELAT VLSDQPGLLG PKALFVFMAL SFARDEIIWL LRHADNMPKK 360 361 SADDFIDKKI TNLLKHFQHL SVHLHAYGII LYNLFVLFLS KNNSAVLTFC SQNLSVCPED 420 421 ESIIMSSFVN TMTSLSVKQV EDGEVFDFRG MRLDWFRLQA YTSVSKASLS LADHRELGKM 480 481 MNTIIFHTKM VDSLVEMLVE TSDLSIFCFY SRAFEKMFQQ CLELPSQSRY SIAFPLLCTH 540 541 FMSCTHELCP EERHHIGDRS LSLCNMFLDE MAKQARNLIT DICTEQCTLS DQLLPKHCAK 600 601 TISQAVNKKS KKQTGKKGEP EREKPGVESM RKNRLVVTNL DKLHTALSEL CFSINYVPNM 660 661 AVWEHTFTPR EYLTSHLEIR FTKSIVGMTM YNQATQEIAK PSELLTSVRA YMTVLQSIEN 720 721 YVQIDITRVF NNVLLQQTQH LDSHGEPTIT SLYTNWYLET LLRQVSNGHI AYFPAMKAFV 780 781 NLPTENELTF NAEEYSDISE MRSLSELLGP YGMKFLSESL MWHISSQVAE LKKLVVENVD 840 841 VLTQMRTSFD KPDQMAALFK RLSSVDSVLK RMTIIGVILS FRSLAQEALR DVLSYHIPFL 900 901 VSSIEDFKDH IPRETDMKVA MNVYELSSAA GLPCEIDPAL VVALSSQKSE NISPEEEYKI 960 961 ACLLMVFVAV SLPTLASNVM SQYSPAIEGH CNNIHCLAKA INQIAAALFT IHKGSIEDRL 1020 1021 KEFLALASSS LLKIGQETDK TTTRNRESVY LLLDMIVQES PFLTMDLLES CFPYVLLRNA 1080 1081 YHAVYKQSVT SSA 1093 |
| Nucleotide CDS Sequence (FASTA) |
1 CAGGCATGTG GAGATCCCAA GGCTAAACCA TCCTACCTTA TTGACAAAAA CCTGGAATCT 60 61 GCTGTGAAAT TCATAGTCAG AAAATTTCCT GCTGTAGAAA CACGCAACAA CAATCAACAG 120 121 CTTGCACAAC TACAGAAAGA AAAATCAGAG ATTCTGAAAA ATCTGGCATT ATATTACTTT 180 181 ACATTTGTAG ATGTTATGGA ATTTAAGGAC CATGTCTGTG ACTTGCTGAA TACTATCGAC 240 241 GTCTGCCAAG TCTTCTTTGA TATTACTGTG AACTTTGATT TAACAAAGAA CTACTTAGAC 300 301 TTGACTGTGA CCTACACAAC ATTAATGATA CTGCTGTCCC GGATTGAAGA AAGGAAGGCC 360 361 ATCATTGGAC TGTACAATTA TGCACATGAA ATGACCCACG GAGCAAGTGA CCGAGAATAC 420 421 CCACGCCTTG GTCAGATGAT TGTGGACTAT GAACACCCTT TAAAGAAGAT GATGGAAGAA 480 481 TTCGTACCCC ACAGCAAGTC TCTTTCAGAT GCGCTAATTT CTCTTCAGAT GGTGTATCCT 540 541 AGACGGAATC TTTCAGCAGA TCAGTGGAGG AATGCCCAGT TGTTGAGTCT CATCAGTGCA 600 601 CCCAGTACAA TGCTTAATCC TGCACAGTCT GACACCATGC CTTGTGAATA TCTCTCTTTG 660 661 GATGCAATGG AGAAATGGAT TATCTTTGGC TTTATTCTGT GCCATGGGAT GCTAAATACC 720 721 GAGGCTACAG CACTGAACCT TTGGAAGCTA GCTCTTCAGA GTAGCTCCTG CCTCTCTCTC 780 781 TTTCGGGATG AAGTTTTCCA CATTCACAAA GCTGCAGAAG ATTTATTTGT AAACATTCGG 840 841 GGCTATAATA AACGGATTAA CGACATAAGA GAATGTAAGG AGGCGGCTGT ATCCCACGCT 900 901 GGCTCAATGC ACAGAGAGAG ACGCAAGTTT TTACGGTCTG CACTGAAAGA ACTGGCAACT 960 961 GTCCTCTCGG ATCAGCCTGG CCTGCTTGGT CCCAAGGCAC TTTTTGTTTT CATGGCATTA 1020 1021 TCTTTTGCCC GTGATGAAAT TATCTGGCTA CTCCGTCATG CAGACAACAT GCCAAAGAAG 1080 1081 AGTGCAGATG ACTTTATAGA TAAAATACAT GTTGGAGATA TAACATTGAT AGTTAGATAC 1140 1141 TTGAAACTAG AAAAGAAGCA CAAACCAATT TTTAAAAAAT ATATTATTCC ACATTTTTCT 1200 1201 TCCTATTATT TTGTTGATAT AAAAGAATTT TTAAAGAATC TCTCTGTTTG CCCTGAAGAT 1260 1261 GAATCAATCA TCATGTCCTC CTTTGTTAAC ACCATGACTT CCCTAAGTGT GAAACAAGTT 1320 1321 GAAGATGGGG AAGTGTTTGA TTTCAGAGGA ATGAGATTAG ATTGGTTTAG GTTACAGGCA 1380 1381 TACACTAGTG TCTCCAAAGC TTCACTTAGC CTTGCAGATC ACCGAGAACT CGGAAAGATG 1440 1441 ATGAACACAA TAATATTCCA TACAAAGATG GTCGATTCCT TGGTGGAAAT GTTGGTGGAA 1500 1501 ACATCCGATC TCTCCATATT TTGTTTTTAT AGCCGTGCTT TTGAGAAGAT GTTTCAGCAG 1560 1561 TGCTTGGAGT TGCCTTCTCA GTCGCGATAC TCCATCGCCT TTCCTCTGCT CTGCACTCAC 1620 1621 TTCATGAGCT GCACACATGA GCTGTGTCCC GAAGAGCGCC ATCATATAGG GGATCGTAGC 1680 1681 CTTTCCCTGT GTAATATGTT CCTCGATGAG ATGGCCAAAC AAGCTCGGAA CCTCATCACT 1740 1741 GATATTTGCA CAGAACAGTG TACTCTTAGT GACCAGTTAC TGCCGAAGCA TTGTGCCAAA 1800 1801 ACCATCAGTC AAGCAGTGAA TAAGAAGTCA AAAAAACAGA CTGGCAAGAA AGGGGAACCT 1860 1861 GAAAGGGAAA AGCCGGGTGT CGAGAGCATG AGGAAAAACA GGCTGGTAGT GACCAACCTT 1920 1921 GATAAGTTGC ACACTGCACT TTCGGAGTTA TGCTTCTCCA TAAATTATGT TCCAAACATG 1980 1981 GCAGTGTGGG AACACACCTT CACACCGCGG GAGTACTTGA CTTCTCATCT GGAAATCCGA 2040 2041 TTCACTAAAT CAATTGTTGG AATGACCATG TATAATCAGG CTACACAGGA GATTGCAAAG 2100 2101 CCATCAGAAC TTCTGACAAG CGTAAGAGCA TATATGACTG TACTCCAGTC CATAGAGAAC 2160 2161 TACGTGCAGA TTGATATCAC CAGAGTATTT AATAATGTTC TCCTTCAACA AACACAACAC 2220 2221 TTAGACAGCC ATGGAGAACC AACCATCACA AGCCTGTATA CAAATTGGTA CTTGGAAACG 2280 2281 TTATTAAGAC AAGTCAGCAA TGGCCATATA GCTTATTTTC CTGCAATGAA AGCATTTGTG 2340 2341 AATTTACCCA CAGAAAATGA ATTAACATTC AATGCAGAGG AATACTCTGA TATATCAGAA 2400 2401 ATGAGGTCGT TGTCAGAGCT CTTAGGCCCA TATGGGATGA AGTTCCTAAG CGAGAGTCTT 2460 2461 ATGTGGCATA TTTCATCACA AGTTGCTGAA CTTAAGAAAC TTGTGGTGGA GAATGTTGAT 2520 2521 GTTCTAACAC AAATGAGGAC CAGCTTTGAC AAACCAGACC AGATGGCTGC ACTCTTTAAA 2580 2581 AGATTATCAT CTGTTGACAG TGTCTTGAAA AGGATGACGA TAATTGGTGT TATTTTATCC 2640 2641 TTCCGGTCAC TGGCACAAGA AGCACTGAGA GATGTTTTGT CCTACCACAT TCCTTTTCTC 2700 2701 GTGAGCTCCA TTGAGGATTT CAAGGACCAC ATTCCACGGG AAACCGATAT GAAGGTTGCA 2760 2761 ATGAATGTGT ATGAGCTGTC ATCTGCTGCT GGATTACCAT GCGAGATTGA TCCTGCCTTA 2820 2821 GTAGTAGCTC TTTCCTCACA AAAATCAGAG AACATTAGTC CAGAAGAAGA ATATAAGATC 2880 2881 GCTTGCCTCC TGATGGTCTT TGTAGCAGTT TCCCTGCCTA CACTGGCCAG CAATGTGATG 2940 2941 TCCCAGTACA GCCCTGCAAT AGAAGGACAC TGCAACAATA TTCATTGTCT GGCCAAAGCC 3000 3001 ATCAACCAAA TTGCTGCTGC TTTGTTTACA ATTCACAAAG GAAGCATTGA AGACAGACTT 3060 3061 AAAGAATTCC TGGCGCTTGC GTCCTCCAGT CTACTGAAAA TCGGCCAAGA GACAGATAAA 3120 3121 ACTACAACGA GAAATAGAGA ATCTGTTTAT TTGCTACTGG ATATGATTGT ACAAGAATCA 3180 3181 CCGTTCCTGA CAATGGATCT CTTGGAATCT TGTTTTCCTT ATGTGTTGCT GAGAAATGCA 3240 3241 TACCACGCTG TCTACAAACA AAGTGTCACA TCCTCTGCAT AG 3282 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Lamellipodium membrane | |
Cellular Component | SCAR complex | |
Biological Process | Cell migration | |
Biological Process | Cell morphogenesis | |
Biological Process | Cell projection assembly | |
Biological Process | Cortical actin cytoskeleton organization | |
Biological Process | Neuron projection morphogenesis |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a066 | Homo sapiens | 0.0 | 2165 | undefined |
| LLPS-Mum-a068 | Mus musculus | 0.0 | 2202 | undefined |