LLPS-Ran-a059
Gpm6b
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Neuronal membrane glycoprotein M6-b |
| Gene Name: | Gpm6b, M6b, rhombex-29 |
| Ensembl Gene: | ENSRNOG00000004613.7 |
| Ensembl Protein: | ENSRNOP00000006777.5 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000006777.5 | ENSRNOP00000006777.5 |
| Ensembl | ENSRNOT00000086721.1 | ENSRNOP00000070988.1 |
| UniProt | Q9JJK1, GPM6B_RAT | |
| GeneBank | AB036421 | BAA98020.1 |
| RefSeq | NM_138846.1 | NP_620201.1 |
| Entrez | 192179 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MKPAMETAAE ENTEQSQERK VNSRAEMEIG RYHWMYPGSK NHQYRPVPTL GDRAGPLSSP 60 61 GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA GTVAILEQHF STNTSDHALL 120 121 SEVIQLMQYV IYGIASFFFL YGIILLAEGF YTTSAVKELH GEFKTTACGR CISGMFVFLT 180 181 YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQSNGTS GVEQICVDVR QYGIIPWNAF 240 241 PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALF AGSTSGCLVT D 291 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAAGCCAG CCATGGAAAC TGCAGCCGAG GAAAATACTG AACAAAGCCA AGAGAGAAAA 60 61 GGTTGCTTCG AATGCTGCAT CAAGTGTCTG GGAGGAGTTC CCTATGCCTC CCTAGTGGCC 120 121 ACCATCCTAT GTTTCTCGGG AGTCGCCTTG TTCTGTGGCT GTGGACATGT GGCTCTTGCA 180 181 GGCACCGTGG CAATTCTTGA GCAACACTTC TCCACCAACA CCAGTGACCA TGCCTTGCTG 240 241 AGCGAAGTGA TCCAACTGAT GCAGTATGTC ATCTATGGAA TCGCGTCCTT TTTCTTCCTG 300 301 TACGGTATCA TTCTGCTGGC AGAAGGCTTC TACACCACAA GTGCAGTGAA AGAGCTGCAC 360 361 GGTGAGTTTA AAACAACTGC CTGTGGACGA TGCATCAGTG GAATGTTCGT GTTCCTCACC 420 421 TATGTGCTGG GAGTGGCCTG GCTGGGTGTG TTCGGCTTTT CTGCAGTGCC AGTGTTTATG 480 481 TTCTACAATA TCTGGTCAAC CTGTGAAGTC ATCAAGTCCC CACAAAGCAA TGGGACCTCG 540 541 GGTGTGGAGC AGATCTGTGT GGATGTCCGG CAATACGGTA TCATTCCTTG GAACGCTTTC 600 601 CCAGGCAAAA TCTGTGGCTC TGCCCTGGAG AACATCTGCA ACACCAATGA GTTCTACATG 660 661 TCCTATCATC TGTTCATTGT GGCTTGTGCT GGAGCTGGTG CCACCGTCAT TGCCCTGCTG 720 721 ATCTACATGA TGGCTACTAC ATATAACTAT GCGGTTTTGA AGTTTAAGAG TCGGGAAGAC 780 781 TGCTGCACTA AGTTCTAA 798 |
▼ KEYWORD
ID | Family |
Cell membrane | |
Complete proteome | |
Developmental protein | |
Differentiation | |
Glycoprotein | |
Membrane | |
Neurogenesis | |
Osteogenesis | |
Phosphoprotein | |
Protein transport | |
Reference proteome | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Membrane raft | |
Cellular Component | Plasma membrane | |
Biological Process | Extracellular matrix assembly | |
Biological Process | Negative regulation of protein localization to cell surface | |
Biological Process | Negative regulation of serotonin uptake | |
Biological Process | Neuron projection development | |
Biological Process | Ossification | |
Biological Process | Positive regulation of bone mineralization | |
Biological Process | Protein transport | |
Biological Process | Regulation of actin cytoskeleton organization | |
Biological Process | Regulation of focal adhesion assembly |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a056 | Homo sapiens | 0.0 | 572 | undefined |
| LLPS-Mum-a058 | Mus musculus | 0.0 | 581 | undefined |