LLPS-Ran-a045
Snx1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Sorting nexin-1 |
| Gene Name: | Snx1 |
| Ensembl Gene: | ENSRNOG00000017029.6 |
| Ensembl Protein: | ENSRNOP00000022960.5 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1). Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000022960.6 | ENSRNOP00000022960.5 |
| UniProt | Q99N27, SNX1_RAT, Q56A25 | |
| GeneBank | BC092201, AF218916 | AAG59616.1, AAH92201.1 |
| RefSeq | NM_053411.1 | NP_445863.1 |
| Entrez | 84471 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASGGGGCSA SERLPPPFPG MDPESEGAAG GSEPEAGDSD TEGEDIFTGA AAASKPQSPK 60 61 KTTSLFPIKN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKTMPG KTLIPHPTQE 120 121 ATNSPKPQPS YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPMFRSRQ 180 181 FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA 240 241 ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQALS GAGLLKMFNK ATDAVSKMTI 300 301 KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTALFAKS LAMLGSSEDN 360 361 TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW 420 421 QDAQATLQKK RESEARLLWA NKPDKLQQAK DEITEWESRV TQYERDFERI STVVRKEVTR 480 481 FEKEKSKDFK NHVIKYLETL LHSQQQLAKY WEAFLPEARA IS 522 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGTCGG GAGGTGGTGG CTGTAGCGCT TCGGAGCGAC TCCCTCCGCC CTTCCCTGGA 60 61 ATGGATCCGG AGTCCGAAGG GGCTGCCGGG GGGTCAGAAC CCGAGGCTGG GGACAGCGAC 120 121 ACCGAGGGGG AGGATATTTT CACTGGCGCC GCGGCAGCTA GTAAGCCCCA GTCTCCAAAG 180 181 AAAACCACAT CCCTTTTTCC TATCAAAAAT GGTTCCAAAG AAAATGGGAT CCATGAAGAA 240 241 CAAGACCAAG AGCCACAGGA CCTCTTTGCA GATGCCACAG TGGAACTATC CCTGGACAGC 300 301 ACACAGAATA ACCAGAAGAC AATGCCAGGC AAAACACTTA TTCCTCATCC TACGCAAGAA 360 361 GCCACAAATT CTCCTAAGCC ACAGCCAAGC TATGAAGAGC TGGAGGAAGA AGAACAGGAG 420 421 GATCAGTTTG ATTTGACAGT TGGTATCACT GATCCTGAGA AGATCGGGGA CGGTATGAAT 480 481 GCCTATGTAG CCTACAAAGT CACCACACAG ACAAGCTTAC CGATGTTCAG AAGTAGGCAG 540 541 TTTGCAGTGA AAAGAAGATT CAGTGACTTT CTGGGTCTTT ATGAGAAGCT CTCAGAGAAG 600 601 CACTCCCAGA ATGGTTTCAT TGTCCCTCCT CCACCTGAGA AGAGCCTAAT AGGAATGACA 660 661 AAGGTGAAGG TTGGGAAGGA AGATTCTTCT TCTGCAGAGT TTCTTGAGAA ACGGAGGGCT 720 721 GCTTTGGAAA GGTACCTTCA AAGAATTGTG AATCATCCTA CCATGTTACA GGACCCAGAT 780 781 GTCAGGGAGT TTTTAGAAAA AGAAGAGCTG CCTCGAGCTG TAGGTACGCA GGCTCTAAGT 840 841 GGTGCTGGTC TCCTTAAGAT GTTCAACAAA GCTACAGATG CAGTCAGCAA AATGACCATC 900 901 AAGATGAATG AATCAGACAT TTGGTTCGAG GAGAAGCTCC AGGAGGTGGA GTGTGAGGAA 960 961 CAGCGCCTAC GGAAGCTGCA CGCTGTGGTG GAGACTCTAG TCAACCATAG GAAAGAACTA 1020 1021 GCACTGAATA CAGCCCTGTT TGCCAAGAGT CTAGCCATGC TTGGCAGCTC CGAGGACAAC 1080 1081 ACAGCACTGT CTCGAGCACT CTCCCAACTG GCTGAGGTGG AAGAAAAGAT TGAGCAGCTC 1140 1141 CACCAGGAAC AGGCCAACAA TGACTTCTTC CTCCTGGCTG AACTCCTGAG TGACTATATC 1200 1201 CGCCTCCTGG CCATTGTCCG AGCCGCCTTC GACCAGCGCA TGAAGACATG GCAGCGCTGG 1260 1261 CAGGATGCTC AAGCCACGCT GCAGAAGAAG CGGGAGTCTG AGGCTCGGCT GCTGTGGGCC 1320 1321 AACAAGCCTG ACAAACTGCA GCAGGCTAAG GATGAGATTA CAGAGTGGGA ATCTCGGGTG 1380 1381 ACTCAGTATG AAAGGGACTT TGAAAGGATT TCAACAGTTG TCCGAAAGGA GGTGACACGA 1440 1441 TTTGAGAAAG AGAAATCCAA GGACTTCAAA AACCACGTGA TCAAGTACCT GGAGACACTC 1500 1501 CTGCATTCCC AGCAGCAGCT GGCAAAATAC TGGGAAGCCT TCCTTCCTGA GGCCAGGGCC 1560 1561 ATCTCCTGA 1569 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Early endosome membrane | |
Cellular Component | Endosome | |
Cellular Component | Endosome membrane | |
Cellular Component | Golgi apparatus | |
Cellular Component | Lamellipodium | |
Cellular Component | Lysosome | |
Cellular Component | Membrane | |
Cellular Component | Retromer, tubulation complex | |
Molecular Function | Epidermal growth factor receptor binding | |
Molecular Function | Insulin receptor binding | |
Molecular Function | Leptin receptor binding | |
Molecular Function | Phosphatidylinositol binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Protein homodimerization activity | |
Molecular Function | Transferrin receptor binding | |
Biological Process | Early endosome to Golgi transport | |
Biological Process | Endosomal transport | |
Biological Process | Intracellular protein transport | |
Biological Process | Lamellipodium morphogenesis | |
Biological Process | Positive regulation of protein catabolic process | |
Biological Process | Receptor internalization | |
Biological Process | Retrograde transport, endosome to Golgi |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TISSUES | ||||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a042 | Homo sapiens | 0.0 | 966 | undefined |
| LLPS-Mum-a044 | Mus musculus | 0.0 | 1056 | undefined |