LLPS-Ran-a002
Hist1h1e
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Histone H1.4; H1d |
| Gene Name: | Hist1h1e, H1f4 |
| Ensembl Gene: | ENSRNOG00000047459.1 |
| Ensembl Protein: | ENSRNOP00000066786.1 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000072564.1 | ENSRNOP00000066786.1 |
| UniProt | P15865, H14_RAT | |
| GeneBank | M31229, X67320 | CAA47734.1, AAA41327.1 |
| RefSeq | NM_133285.1 | NP_579819.1 |
| Entrez | 201097 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSETAPAAPA APAPAEKTPI KKKARKAAGG AKRKASGPPV SELITKAVAA SKERSGVSLA 60 61 ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA 120 121 KKAGAAKAKK PAGAAKKPKK ATGTATPKKS TKKTPKKAKK PAAAAGAKKA KSPKKAKATK 180 181 AKKAPKSPAK ARAVKPKAAK PKTSKPKAAK PKKTAAKKK 219 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGAGA CTGCCCCTGC TGCGCCCGCC GCACCGGCCC CCGCAGAGAA GACACCCATA 60 61 AAGAAGAAGG CCCGCAAGGC CGCAGGTGGT GCGAAGCGCA AAGCGTCCGG ACCCCCGGTG 120 121 TCCGAGCTCA TCACCAAGGC TGTGGCCGCC TCCAAGGAGC GCAGCGGCGT GTCTCTGGCC 180 181 GCGCTCAAGA AAGCGCTGGC TGCCGCCGGC TACGATGTGG AAAAGAATAA CAGCCGCATC 240 241 AAGCTCGGGC TGAAGAGCCT GGTGAGCAAG GGCACCCTGG TGCAGACCAA GGGCACCGGC 300 301 GCCTCCGGCT CCTTCAAACT CAACAAGAAG GCGGCTTCCG GCGAAGCCAA GCCCAAAGCA 360 361 AAGAAGGCAG GCGCGGCTAA GGCGAAGAAG CCTGCAGGCG CTGCCAAGAA GCCCAAGAAG 420 421 GCTACGGGAA CAGCCACTCC CAAGAAGAGC ACTAAGAAGA CTCCAAAGAA AGCAAAGAAG 480 481 CCGGCTGCAG CTGCAGGAGC CAAAAAAGCT AAAAGCCCGA AAAAAGCAAA AGCTACTAAG 540 541 GCTAAGAAGG CCCCCAAGAG CCCTGCCAAG GCGAGAGCGG TAAAGCCCAA AGCGGCCAAA 600 601 CCAAAAACCT CCAAGCCTAA AGCAGCTAAG CCAAAGAAAA CAGCAGCCAA GAAGAAATAA 660 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromatin | |
Cellular Component | Nuclear chromatin | |
Cellular Component | Nuclear euchromatin | |
Cellular Component | Nuclear heterochromatin | |
Cellular Component | Nuclear nucleosome | |
Cellular Component | Nucleus | |
Molecular Function | ADP binding | |
Molecular Function | AMP binding | |
Molecular Function | ATP binding | |
Molecular Function | Calcium ion binding | |
Molecular Function | DATP binding | |
Molecular Function | Double-stranded DNA binding | |
Molecular Function | GTP binding | |
Molecular Function | Nucleosomal DNA binding | |
Molecular Function | Nucleotide binding | |
Biological Process | Chromosome condensation | |
Biological Process | Histone H3-K27 trimethylation | |
Biological Process | Histone H3-K4 trimethylation | |
Biological Process | Negative regulation of chromatin silencing | |
Biological Process | Negative regulation of DNA recombination | |
Biological Process | Negative regulation of transcription by RNA polymerase II | |
Biological Process | Nucleosome assembly | |
Biological Process | Nucleosome positioning | |
Biological Process | Regulation of transcription, DNA-templated |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TISSUES | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bot-a003 | Bos taurus | 2e-46 | 161 | undefined |
| LLPS-Mum-a002 | Mus musculus | 2e-122 | 355 | undefined |