LLPS-Ran-4553
Akr1b1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Aldo-keto reductase family 1 member B1
Gene Name: Akr1b1, Akr1b4, Aldr1
Ensembl Gene: ENSRNOG00000009513.3
Ensembl Protein: ENSRNOP00000012879.2
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASHLELNNG  TKMPTLGLGT  WKSPPGQVTE  AVKVAIDMGY  RHIDCAQVYQ  NEKEVGVALQ  60
61    EKLKEQVVKR  QDLFIVSKLW  CTFHDQSMVK  GACQKTLSDL  QLDYLDLYLI  HWPTGFKPGP  120
121   DYFPLDASGN  VIPSDTDFVD  TWTAMEQLVD  EGLVKAIGVS  NFNPLQIERI  LNKPGLKYKP  180
181   AVNQIECHPY  LTQEKLIEYC  HCKGIVVTAY  SPLGSPDRPW  AKPEDPSLLE  DPRIKEIAAK  240
241   YNKTTAQVLI  RFPIQRNLVV  IPKSVTPARI  AENFKVFDFE  LSNEDMATLL  SYNRNWRVCA  300
301   LMSCAKHKDY  PFHAEV  316
Nucleotide CDS Sequence (FASTA)
1     ATGGCTAGCC  ATCTGGAACT  CAACAACGGC  ACCAAGATGC  CCACCCTGGG  TCTGGGCACC  60
61    TGGAAGTCTC  CTCCTGGCCA  GGTGACCGAG  GCTGTGAAGG  TTGCTATCGA  CATGGGGTAT  120
121   CGCCACATTG  ACTGCGCCCA  GGTGTACCAG  AATGAGAAGG  AGGTGGGGGT  GGCCCTCCAG  180
181   GAGAAGCTCA  AGGAGCAGGT  GGTGAAGCGC  CAGGATCTCT  TCATTGTCAG  CAAGCTGTGG  240
241   TGCACGTTCC  ACGACCAGAG  CATGGTGAAA  GGGGCCTGCC  AGAAGACGCT  GAGCGACCTG  300
301   CAGCTGGACT  ACCTGGACCT  CTACCTTATT  CACTGGCCAA  CTGGCTTCAA  GCCTGGGCCT  360
361   GACTATTTCC  CCCTGGATGC  ATCGGGAAAC  GTGATTCCTA  GTGACACCGA  TTTTGTGGAC  420
421   ACTTGGACGG  CTATGGAGCA  ACTAGTGGAT  GAAGGTTTGG  TAAAAGCAAT  CGGAGTCTCC  480
481   AACTTCAACC  CTCTTCAGAT  TGAGAGGATC  TTGAACAAAC  CTGGCTTAAA  GTATAAGCCT  540
541   GCTGTTAACC  AGATCGAGTG  CCACCCATAC  CTAACTCAGG  AGAAGCTGAT  TGAGTACTGC  600
601   CATTGCAAAG  GCATCGTGGT  GACTGCATAC  AGTCCCCTTG  GTTCTCCTGA  CAGGCCCTGG  660
661   GCCAAGCCTG  AGGACCCCTC  TCTCCTGGAG  GATCCCAGGA  TCAAGGAAAT  TGCAGCCAAG  720
721   TACAATAAAA  CTACAGCCCA  GGTGCTGATC  CGGTTCCCCA  TCCAAAGGAA  CCTGGTCGTG  780
781   ATCCCCAAGT  CTGTGACACC  AGCACGTATT  GCTGAGAACT  TTAAGGTCTT  TGACTTTGAG  840
841   CTGAGCAATG  AGGACATGGC  CACTCTACTC  AGCTACAACA  GGAACTGGAG  GGTGTGCGCC  900
901   TTGATGAGCT  GTGCCAAACA  CAAGGATTAC  CCCTTCCACG  CAGAAGTCTG  A  951

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
NADP
Oxidoreductase
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Extracellular space
Cellular Component
Mast cell granule
Cellular Component
Nucleoplasm
Cellular Component
Paranodal junction
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
Plasma membrane bounded cell projection cytoplasm
Cellular Component
Schmidt-Lanterman incisure
Cellular Component
Schwann cell microvillus
Molecular Function
Alcohol dehydrogenase (NADP+) activity
Molecular Function
Alditol:NADP+ 1-oxidoreductase activity
Molecular Function
Glyceraldehyde oxidoreductase activity
Molecular Function
Oxidoreductase activity
Biological Process
Cellular hyperosmotic salinity response
Biological Process
Cellular response to methylglyoxal
Biological Process
Cellular response to peptide
Biological Process
Daunorubicin metabolic process
Biological Process
Doxorubicin metabolic process
Biological Process
Inner medullary collecting duct development
Biological Process
Maternal process involved in female pregnancy
Biological Process
Monosaccharide metabolic process
Biological Process
Naphthalene metabolic process
Biological Process
Negative regulation of apoptotic process
Biological Process
Norepinephrine metabolic process
Biological Process
Positive regulation of receptor signaling pathway via JAK-STAT
Biological Process
Positive regulation of smooth muscle cell proliferation
Biological Process
Regulation of urine volume
Biological Process
Renal water homeostasis
Biological Process
Response to organic substance
Biological Process
Response to thyroid hormone
Biological Process
Response to water deprivation
Biological Process
Sorbitol biosynthetic process
Biological Process
Stress-activated protein kinase signaling cascade
Biological Process
Tissue homeostasis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4702Mus musculus96.840.0 610
LLPS-Mea-3855Mesocricetus auratus94.620.0 597
LLPS-Cap-3672Cavia porcellus90.480.0 572
LLPS-Ict-0636Ictidomys tridecemlineatus89.840.0 569
LLPS-Fud-2445Fukomys damarensis88.570.0 562
LLPS-Dio-0873Dipodomys ordii87.30.0 558
LLPS-Maf-2669Macaca fascicularis86.980.0 560
LLPS-Mal-3562Mandrillus leucophaeus86.980.0 560
LLPS-Man-0512Macaca nemestrina86.980.0 560
LLPS-Mam-1535Macaca mulatta86.980.0 560
LLPS-Caf-2325Canis familiaris86.980.0 551
LLPS-Chs-4809Chlorocebus sabaeus86.966e-167 479
LLPS-Fec-4232Felis catus86.670.0 551
LLPS-Paa-0825Papio anubis86.350.0 557
LLPS-Mup-3421Mustela putorius furo86.350.0 550
LLPS-Rhb-0003Rhinopithecus bieti86.350.0 556
LLPS-Cea-2120Cercocebus atys86.030.0 556
LLPS-Urm-1089Ursus maritimus85.821e-165 473
LLPS-Aon-1902Aotus nancymaae85.710.0 547
LLPS-Pat-4014Pan troglodytes85.710.0 549
LLPS-Hos-0085Homo sapiens85.710.0 551
LLPS-Nol-2665Nomascus leucogenys85.710.0 552
LLPS-Caj-1793Callithrix jacchus85.40.0 544
LLPS-Gog-3135Gorilla gorilla85.40.0 549
LLPS-Aim-2836Ailuropoda melanoleuca85.40.0 549
LLPS-Poa-3857Pongo abelii85.40.0 551
LLPS-Tut-2328Tursiops truncatus85.080.0 548
LLPS-Sus-4150Sus scrofa84.440.0 537
LLPS-Bot-0313Bos taurus84.440.0 542
LLPS-Eqc-3495Equus caballus83.830.0 519
LLPS-Ova-2048Ovis aries83.810.0 538
LLPS-Cas-2653Carlito syrichta83.490.0 535
LLPS-Ere-0643Erinaceus europaeus82.860.0 531
LLPS-Loa-0853Loxodonta africana81.850.0 530
LLPS-Orc-1688Oryctolagus cuniculus78.690.0 541
LLPS-Otg-0013Otolemur garnettii75.234e-172 488
LLPS-Mod-3496Monodelphis domestica74.928e-170 482
LLPS-Pap-1123Pan paniscus74.61e-162 462
LLPS-Sah-3365Sarcophilus harrisii73.895e-94 288
LLPS-Ora-0925Ornithorhynchus anatinus73.44e-149 428
LLPS-Leo-3698Lepisosteus oculatus72.065e-164 467
LLPS-Dar-0015Danio rerio69.974e-153 439
LLPS-Myl-3119Myotis lucifugus69.884e-152 437
LLPS-Orl-3850Oryzias latipes69.732e-136 398
LLPS-Anp-0666Anas platyrhynchos69.454e-150 432
LLPS-Gaga-0313Gallus gallus69.139e-152 436
LLPS-Meg-1826Meleagris gallopavo68.179e-147 423
LLPS-Xet-1818Xenopus tropicalis67.514e-140 407
LLPS-Asm-4045Astyanax mexicanus66.241e-144 417
LLPS-Pof-1441Poecilia formosa66.037e-142 410
LLPS-Fia-2111Ficedula albicollis65.385e-141 408
LLPS-Tar-2546Takifugu rubripes61.273e-131 384
LLPS-Ten-2870Tetraodon nigroviridis61.278e-132 385
LLPS-Lac-3742Latimeria chalumnae56.419e-103 311
LLPS-Tag-2314Taeniopygia guttata53.293e-104 315
LLPS-Pes-2638Pelodiscus sinensis52.681e-97 298
LLPS-Anc-2947Anolis carolinensis52.482e-102 311
LLPS-Orn-0568Oreochromis niloticus52.052e-96 295
LLPS-Xim-0474Xiphophorus maculatus51.594e-98 299
LLPS-Icp-0665Ictalurus punctatus51.258e-102 310
LLPS-Scm-0333Scophthalmus maximus50.772e-106 320
LLPS-Scf-3669Scleropages formosus50.461e-95 293
LLPS-Drm-0539Drosophila melanogaster50.163e-93 286
LLPS-Gaa-3806Gasterosteus aculeatus47.654e-96 294