LLPS-Ran-4309
Fez1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1
Gene Name: Fez1
Ensembl Gene: ENSRNOG00000006075.3
Ensembl Protein: ENSRNOP00000008285.3
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEAPLVSLDE  EFEDIRPCCT  EDPEEKPQSL  YGTSPHHLED  PSLSELENFS  SEIISFKSME  60
61    DLVNEFDEKL  NVCFRNYNAK  TENLAPVKNQ  LQIQEEEETL  RDEEVWDALT  DNYIPSLSED  120
121   WRDPNIEALN  GNSSDTEIHE  KEEEDEFIEK  SENDSGINEE  PLLTADQVIE  EIEEMMQNSP  180
181   DPEEEVEVLE  EEDGGEISSQ  ADSVLLQEMQ  ALTQTFNNNW  SYEGLRHMSG  SELTELLDQV  240
241   EGAIRDFSEE  LVHQLARRDE  LEFEKEVKNS  FITVLIEVQN  KQKEQRELMK  KRRKEKGLSL  300
301   QSSRIEKGNQ  MPLKRFSMEG  ISNILQSGIR  QTFGSSGADR  QYLNTVIPYE  KKSSPPSVED  360
361   LQMLTNILFA  MKEDNEKVPT  LLTDYILKVL  CPT  393
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCTC  CACTGGTGAG  TCTGGATGAA  GAGTTTGAAG  ATATCAGGCC  CTGCTGCACT  60
61    GAGGACCCAG  AGGAAAAGCC  ACAAAGTCTC  TATGGCACAT  CTCCTCACCA  CCTGGAGGAC  120
121   CCTTCCCTCT  CCGAGCTTGA  GAATTTTTCT  TCCGAAATAA  TCAGCTTCAA  GTCCATGGAG  180
181   GACCTCGTGA  ATGAATTTGA  TGAGAAGCTC  AATGTCTGCT  TTCGGAACTA  CAATGCCAAG  240
241   ACCGAGAACC  TGGCTCCAGT  GAAGAACCAG  TTGCAGATCC  AGGAGGAGGA  GGAGACTCTT  300
301   CGGGATGAGG  AGGTTTGGGA  TGCTCTGACA  GACAATTACA  TCCCTTCACT  CTCAGAAGAC  360
361   TGGAGGGACC  CAAACATTGA  AGCTCTGAAT  GGCAACAGCT  CTGACACTGA  GATCCACGAG  420
421   AAGGAAGAAG  AAGATGAGTT  CATTGAGAAG  AGTGAAAACG  ACTCTGGTAT  CAACGAGGAG  480
481   CCTCTCCTCA  CAGCTGACCA  GGTGATTGAG  GAGATCGAAG  AAATGATGCA  GAACTCCCCA  540
541   GATCCTGAGG  AGGAAGTGGA  GGTGCTGGAA  GAGGAGGATG  GAGGAGAAAT  CTCGTCTCAG  600
601   GCAGATTCAG  TCCTGCTACA  AGAGATGCAG  GCCCTGACGC  AGACCTTCAA  CAACAACTGG  660
661   TCCTATGAAG  GGCTGAGACA  CATGTCTGGG  TCTGAGCTGA  CAGAGCTGCT  GGACCAGGTG  720
721   GAGGGTGCCA  TCCGTGACTT  CTCGGAGGAG  CTGGTCCACC  AGCTGGCCCG  CAGAGATGAG  780
781   CTGGAGTTTG  AGAAGGAAGT  GAAGAACTCT  TTCATCACGG  TGCTCATTGA  GGTTCAGAAT  840
841   AAGCAGAAGG  AGCAGCGGGA  ACTGATGAAG  AAGAGGCGGA  AAGAGAAGGG  GTTAAGCCTG  900
901   CAGAGCAGTC  GGATAGAGAA  GGGGAACCAG  ATGCCTCTCA  AGCGTTTCAG  CATGGAGGGC  960
961   ATCTCCAACA  TCCTGCAGAG  TGGCATCCGC  CAGACCTTTG  GCTCCTCAGG  AGCTGACAGA  1020
1021  CAGTACCTGA  ACACAGTCAT  CCCTTATGAG  AAGAAATCTT  CTCCTCCCTC  TGTGGAAGAC  1080
1081  CTGCAGATGC  TGACAAACAT  TCTCTTCGCC  ATGAAGGAGG  ATAACGAGAA  GGTGCCTACT  1140
1141  TTGCTAACGG  ACTACATTTT  AAAAGTGCTC  TGTCCAACCT  AA  1182

▼ KEYWORD

ID
Family
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Membrane
Microtubule
Phosphoprotein
Reference proteome
Transport
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cell projection
Cellular Component
Centrosome
Cellular Component
Cytoplasm
Cellular Component
Dendrite
Cellular Component
Growth cone
Cellular Component
Microtubule
Cellular Component
Neuronal cell body
Cellular Component
Plasma membrane
Molecular Function
Gamma-tubulin binding
Molecular Function
Protein kinase C binding
Molecular Function
Protein N-terminus binding
Biological Process
Cellular response to growth factor stimulus
Biological Process
Establishment of cell polarity
Biological Process
Establishment of mitochondrion localization
Biological Process
Hippocampus development
Biological Process
Mitochondrion morphogenesis
Biological Process
Negative regulation of autophagosome assembly
Biological Process
Positive regulation of anterograde axonal transport of mitochondrion
Biological Process
Positive regulation of neuron differentiation
Biological Process
Positive regulation of neuron projection development

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-2274Ictidomys tridecemlineatus95.898e-135 392
LLPS-Mum-3147Mus musculus95.170.0 669
LLPS-Man-1596Macaca nemestrina94.150.0 666
LLPS-Hos-2551Homo sapiens94.150.0 663
LLPS-Pat-4349Pan troglodytes94.150.0 663
LLPS-Rhb-4039Rhinopithecus bieti94.150.0 666
LLPS-Mam-3071Macaca mulatta94.150.0 666
LLPS-Nol-2479Nomascus leucogenys94.150.0 665
LLPS-Cea-3026Cercocebus atys94.150.0 666
LLPS-Aon-2540Aotus nancymaae94.150.0 665
LLPS-Chs-3936Chlorocebus sabaeus94.150.0 666
LLPS-Paa-2505Papio anubis94.150.0 666
LLPS-Mal-0617Mandrillus leucophaeus94.150.0 666
LLPS-Cap-4671Cavia porcellus94.070.0 655
LLPS-Gog-2536Gorilla gorilla94.070.0 649
LLPS-Poa-4568Pongo abelii93.890.0 663
LLPS-Maf-3588Macaca fascicularis93.890.0 664
LLPS-Orc-2905Oryctolagus cuniculus93.380.0 660
LLPS-Cas-2841Carlito syrichta93.380.0 660
LLPS-Fud-3283Fukomys damarensis93.380.0 659
LLPS-Eqc-2755Equus caballus93.130.0 650
LLPS-Ova-0450Ovis aries92.620.0 656
LLPS-Mup-2439Mustela putorius furo92.530.0 641
LLPS-Loa-2833Loxodonta africana92.370.0 655
LLPS-Aim-2626Ailuropoda melanoleuca92.370.0 656
LLPS-Bot-4693Bos taurus92.270.0 639
LLPS-Mea-1435Mesocricetus auratus92.250.0 656
LLPS-Caf-4573Canis familiaris92.110.0 649
LLPS-Otg-3265Otolemur garnettii91.980.0 651
LLPS-Myl-1270Myotis lucifugus91.860.0 655
LLPS-Urm-2709Ursus maritimus91.750.0 640
LLPS-Sus-3471Sus scrofa91.750.0 634
LLPS-Caj-4505Callithrix jacchus90.360.0 609
LLPS-Mod-4308Monodelphis domestica90.330.0 644
LLPS-Fec-0405Felis catus89.550.0 638
LLPS-Dio-2639Dipodomys ordii89.180.0 619
LLPS-Pap-2577Pan paniscus87.790.0 609
LLPS-Sah-1672Sarcophilus harrisii86.162e-105 318
LLPS-Pes-1967Pelodiscus sinensis85.50.0 613
LLPS-Anc-3292Anolis carolinensis83.040.0 580
LLPS-Xet-2559Xenopus tropicalis76.90.0 542
LLPS-Ora-2872Ornithorhynchus anatinus75.243e-131 386
LLPS-Lac-3421Latimeria chalumnae73.860.0 528
LLPS-Scf-3311Scleropages formosus67.093e-163 471
LLPS-Icp-1340Ictalurus punctatus66.754e-156 453
LLPS-Dar-3989Danio rerio65.756e-159 460
LLPS-Leo-3135Lepisosteus oculatus64.38e-153 445
LLPS-Asm-0711Astyanax mexicanus63.214e-140 413
LLPS-Pof-2321Poecilia formosa63.081e-147 432
LLPS-Xim-1557Xiphophorus maculatus62.383e-146 428
LLPS-Tar-3323Takifugu rubripes62.091e-144 424
LLPS-Orn-2459Oreochromis niloticus61.932e-140 414
LLPS-Orl-1571Oryzias latipes61.652e-149 436
LLPS-Gaa-0485Gasterosteus aculeatus61.021e-140 414
LLPS-Gaga-3167Gallus gallus58.581e-123 370
LLPS-Scm-2306Scophthalmus maximus57.647e-144 427
LLPS-Meg-2137Meleagris gallopavo57.496e-123 368
LLPS-Ten-1992Tetraodon nigroviridis57.453e-90 281
LLPS-Fia-1247Ficedula albicollis55.268e-115 348
LLPS-Anp-0659Anas platyrhynchos54.119e-108 329
LLPS-Cae-1306Caenorhabditis elegans29.682e-31 127