LLPS-Ran-4172
Fhl1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Four and a half LIM domains protein 1
Gene Name: Fhl1
Ensembl Gene: ENSRNOG00000000875.8
Ensembl Protein: ENSRNOP00000074817.1
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASQRHSGPS  SYKVGTMSEK  FDCHYCRDPL  QGKKYVQKDG  RHCCLKCFDK  FCANTCVECR  60
61    KPISADAKEV  HYKNRYWHDT  CFRCAKCLHP  LASETFVSKD  GKILCNKCAT  REDSPRCKGC  120
121   FKAIVAGDQN  VEYKGTIWHK  DCFTCSNCKQ  VIGTGSFFPK  GEDFYCVTCH  ETKFAKHCVK  180
181   CNKAITSGGI  TYQDQPWHAE  CFVCVTCSKK  LAGQRFTAVE  DQYYCVDCYK  NFVAKKCAGC  240
241   KNPITGKRTV  SRVSHPVSKA  RKSPVCHGKR  LPLTLFPSAN  LRGRHPGGER  TCPSWVVVLY  300
301   RKNRSLAAPR  GPGLVKAPVW  WPMKDNPGTT  TASTAKNAP  339
Nucleotide CDS Sequence (FASTA)
1     ATGGCTTCTC  AAAGACACTC  AGGTCCCTCC  AGCTATAAGG  TGGGCACCAT  GTCTGAGAAG  60
61    TTCGACTGTC  ACTACTGCAG  GGACCCCTTG  CAGGGGAAGA  AGTATGTGCA  GAAGGATGGC  120
121   CGTCACTGCT  GCCTGAAGTG  CTTTGACAAG  TTCTGCGCCA  ACACCTGCGT  GGAATGCCGC  180
181   AAGCCCATAA  GCGCTGATGC  TAAGGAGGTG  CACTATAAGA  ATCGCTACTG  GCACGACACC  240
241   TGCTTCCGCT  GTGCCAAGTG  CCTTCACCCC  TTGGCCAGTG  AGACCTTTGT  GTCCAAGGAT  300
301   GGCAAGATCC  TGTGCAACAA  GTGCGCCACT  CGGGAGGACT  CCCCCAGGTG  CAAAGGGTGC  360
361   TTCAAGGCCA  TTGTGGCAGG  AGACCAGAAT  GTGGAGTACA  AGGGCACCAT  CTGGCATAAA  420
421   GACTGCTTCA  CCTGCAGCAA  CTGCAAGCAA  GTCATTGGGA  CCGGAAGCTT  CTTCCCGAAA  480
481   GGGGAGGACT  TCTACTGTGT  GACTTGCCAT  GAGACCAAGT  TTGCCAAGCA  TTGCGTGAAA  540
541   TGCAACAAGG  GTTTGGTAAA  GGCTCCAGTG  TGGTGGCCTA  TGAAGGACAA  TCCTGGCACG  600
601   ACTACTGCTT  CCACTGCAAA  AAATGCTCCG  TGA  633

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Isopeptide bond
LIM domain
Metal-binding
Reference proteome
Repeat
Ubl conjugation
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
Metal ion binding
Biological Process
Cell differentiation
Biological Process
Multicellular organism development

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4915Mus musculus99.070.0 664
LLPS-Mea-2458Mesocricetus auratus99.070.0 662
LLPS-Fud-3288Fukomys damarensis97.350.0 684
LLPS-Caj-2985Callithrix jacchus96.690.0 553
LLPS-Cap-2436Cavia porcellus96.590.0 649
LLPS-Eqc-1714Equus caballus96.590.0 648
LLPS-Cas-1248Carlito syrichta96.590.0 649
LLPS-Aon-0777Aotus nancymaae96.280.0 649
LLPS-Mal-4612Mandrillus leucophaeus95.980.0 647
LLPS-Gog-4112Gorilla gorilla95.980.0 647
LLPS-Nol-0849Nomascus leucogenys95.980.0 647
LLPS-Hos-0000Homo sapiens95.980.0 647
LLPS-Paa-1930Papio anubis95.870.0 677
LLPS-Chs-4122Chlorocebus sabaeus95.870.0 677
LLPS-Maf-1730Macaca fascicularis95.870.0 677
LLPS-Poa-3854Pongo abelii95.870.0 677
LLPS-Mam-0000Macaca mulatta95.870.0 677
LLPS-Pat-0190Pan troglodytes95.870.0 677
LLPS-Pap-0950Pan paniscus95.870.0 677
LLPS-Man-4807Macaca nemestrina95.870.0 677
LLPS-Rhb-4542Rhinopithecus bieti95.870.0 677
LLPS-Tut-1958Tursiops truncatus95.050.0 638
LLPS-Aim-1061Ailuropoda melanoleuca95.050.0 632
LLPS-Cea-0091Cercocebus atys95.050.0 642
LLPS-Fec-4126Felis catus94.690.0 668
LLPS-Sus-4864Sus scrofa94.583e-167 477
LLPS-Dio-2768Dipodomys ordii94.440.0 638
LLPS-Ova-2389Ovis aries94.430.0 637
LLPS-Ict-0461Ictidomys tridecemlineatus94.430.0 638
LLPS-Bot-0671Bos taurus93.50.0 546
LLPS-Loa-3290Loxodonta africana91.640.0 622
LLPS-Mod-3736Monodelphis domestica83.649e-163 464
LLPS-Caf-1107Canis familiaris82.311e-171 486
LLPS-Orc-3933Oryctolagus cuniculus82.311e-171 486
LLPS-Mup-1076Mustela putorius furo81.631e-169 481
LLPS-Myl-1233Myotis lucifugus81.531e-165 471
LLPS-Otg-3712Otolemur garnettii79.862e-163 466
LLPS-Ora-2810Ornithorhynchus anatinus79.791e-162 464
LLPS-Sah-0200Sarcophilus harrisii78.572e-162 464
LLPS-Xet-2374Xenopus tropicalis75.21e-138 402
LLPS-Anc-3192Anolis carolinensis74.718e-138 400
LLPS-Tag-2940Taeniopygia guttata73.861e-132 387
LLPS-Fia-1912Ficedula albicollis73.162e-125 368
LLPS-Meg-2654Meleagris gallopavo71.782e-129 379
LLPS-Gaga-2866Gallus gallus71.669e-133 387
LLPS-Pes-1063Pelodiscus sinensis71.312e-130 381
LLPS-Anp-1099Anas platyrhynchos70.568e-92 280
LLPS-Leo-2517Lepisosteus oculatus70.042e-128 375
LLPS-Dar-4014Danio rerio68.021e-118 352
LLPS-Orn-4097Oreochromis niloticus67.15e-110 329
LLPS-Orl-2801Oryzias latipes65.991e-116 347
LLPS-Pof-0357Poecilia formosa65.993e-110 330
LLPS-Icp-1622Ictalurus punctatus65.562e-115 344
LLPS-Asm-1460Astyanax mexicanus64.785e-116 345
LLPS-Xim-3111Xiphophorus maculatus64.521e-107 323
LLPS-Scf-2218Scleropages formosus64.235e-116 345
LLPS-Ten-2790Tetraodon nigroviridis62.968e-108 324
LLPS-Gaa-2667Gasterosteus aculeatus62.71e-111 334
LLPS-Lac-0472Latimeria chalumnae62.282e-93 285
LLPS-Tar-0999Takifugu rubripes61.946e-107 322
LLPS-Scm-0414Scophthalmus maximus58.643e-116 345
LLPS-Urm-3849Ursus maritimus46.152e-71 230