LLPS-Ran-4170
Nfe2l2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Nuclear factor erythroid 2-related factor 2
Gene Name: Nfe2l2, Nrf2
Ensembl Gene: ENSRNOG00000001548.6
Ensembl Protein: ENSRNOP00000002114.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear body, OthersPredicted from orthologs(View)

▼ FUNCTION

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMDLELPPPG  LQSQQDMDLI  DILWRQDIDL  GVSREVFDFS  QRQKDYELEK  QKKLEKERQE  60
61    QLQKEQEKAF  FAQLQLDEET  GEFLPIQPAQ  HIQTDTSGSV  SYSQVAHIPK  QDALYFEDCM  120
121   QLLAETFPFV  DDHESLALDI  PSHVESSVFT  TPDQAQSLDS  SLETAMTDLS  SIQQDMEQVW  180
181   QELFSIPELQ  CLNTENKQQA  ETTTVPSPEA  TLTEMDSNYH  FYSSIPSLEK  EVDSCSPHFL  240
241   HGFEDSFSSI  LSTDDASQLN  SLDSNPTLNT  DFGDEFYSAF  LAEPSGGGSM  PSSAAISQSL  300
301   SELLGGPIEG  CDLSLCKAFN  QKHTEGTVEF  NDSDSGISLN  TSPSRASPEH  SVESSIYGDP  360
361   PPGFSDSEME  ELDSAPGSVK  QNGPKAQPTH  SSGDTVQPLS  PAQGHSAAVH  ESQCENTTKK  420
421   EVPVSPGHQK  VPFTKDKHSS  RLEAHLTRDE  LRAKALHIPF  PVEKIINLPV  DDFNEMMSKE  480
481   QFNEAQLALI  RDIRRRGKNK  VAAQNCRKRK  LENIVELEQD  LGHLKDEREK  LLREKGENDR  540
541   NLHLLKRKLS  TLYLEVFSML  RDEDGKPYSP  SEYSLQQTRD  GNVFLVPKSK  KPDTKKN  597
Nucleotide CDS Sequence (FASTA)
1     ATGATGGACT  TGGAATTGCC  ACCGCCAGGA  CTACAGTCCC  AGCAGGACAT  GGATTTGATT  60
61    GACATCCTTT  GGAGGCAAGA  CATAGATCTT  GGGGTAAGTC  GAGAAGTGTT  TGACTTTAGT  120
121   CAGCGACAGA  AGGATTATGA  GCTGGAAAAA  CAGAAAAAAC  TCGAAAAGGA  GAGACAAGAG  180
181   CAACTCCAGA  AGGAACAGGA  GAAGGCCTTT  TTCGCTCAGT  TACAACTGGA  TGAAGAGACC  240
241   GGAGAATTCC  TCCCAATTCA  GCCAGCCCAG  CACATCCAGA  CAGACACCAG  TGGATCTGTC  300
301   AGCTACTCCC  AGGTTGCCCA  CATTCCCAAA  CAAGATGCCT  TGTACTTTGA  AGACTGTATG  360
361   CAGCTTTTGG  CAGAGACATT  CCCATTTGTA  GATGACCATG  AGTCGCTTGC  CCTGGATATT  420
421   CCCAGCCACG  TTGAGAGCTC  AGTCTTCACC  ACCCCTGATC  AGGCTCAGTC  ACTCGATAGC  480
481   TCTCTGGAGA  CGGCCATGAC  TGATTTAAGC  AGCATACAGC  AGGACATGGA  GCAAGTTTGG  540
541   CAGGAGCTAT  TTTCCATTCC  CGAGTTACAG  TGTCTTAATA  CGGAAAACAA  GCAGCAGGCT  600
601   GAGACTACCA  CTGTCCCCAG  CCCAGAGGCC  ACACTGACAG  AGATGGACAG  CAATTACCAT  660
661   TTTTACTCAT  CGATCCCCTC  ACTGGAAAAA  GAAGTGGACA  GCTGTAGTCC  ACATTTCCTT  720
721   CATGGTTTTG  AGGATTCTTT  TAGTAGCATC  CTCTCCACGG  ATGATGCCAG  CCAGCTGAAC  780
781   TCCTTAGACT  CAAATCCCAC  CTTGAACACA  GATTTCGGTG  ATGAATTTTA  CTCTGCTTTC  840
841   CTAGCAGAGC  CCAGTGGCGG  TGGCAGCATG  CCTTCCTCTG  CTGCCATTAG  TCAGTCGCTC  900
901   TCTGAACTTC  TGGGCGGGCC  CATTGAGGGC  TGTGATCTGT  CCCTGTGTAA  AGCTTTCAAC  960
961   CAGAAGCACA  CTGAAGGCAC  GGTGGAGTTC  AATGACTCTG  ACTCCGGCAT  TTCGCTGAAC  1020
1021  ACAAGTCCCA  GCCGAGCATC  CCCAGAGCAC  TCTGTGGAGT  CTTCCATTTA  CGGAGACCCA  1080
1081  CCGCCTGGGT  TCAGTGACTC  GGAAATGGAA  GAGCTAGACA  GTGCCCCTGG  AAGTGTCAAA  1140
1141  CAGAATGGAC  CTAAAGCACA  GCCAACACAT  TCTTCTGGGG  ATACAGTACA  GCCTCTGTCG  1200
1201  CCAGCTCAAG  GGCACAGTGC  TGCTGTGCAC  GAATCCCAGT  GTGAAAATAC  AACAAAAAAA  1260
1261  GAAGTACCTG  TGAGTCCTGG  TCATCAAAAA  GTCCCATTCA  CAAAAGACAA  ACATTCAAGC  1320
1321  CGATTAGAGG  CTCATCTCAC  AAGAGATGAG  CTTAGGGCAA  AAGCTCTCCA  TATTCCATTC  1380
1381  CCTGTTGAAA  AAATCATTAA  TCTCCCTGTT  GATGACTTCA  ATGAAATGAT  GTCCAAGGAG  1440
1441  CAATTCAACG  AAGCTCAGCT  TGCATTAATT  CGAGATATAC  GCAGGAGAGG  GAAGAATAAA  1500
1501  GTTGCCGCTC  AGAACTGTAG  GAAAAGGAAG  CTGGAAAACA  TTGTAGAGCT  GGAGCAAGAC  1560
1561  TTGGGCCACT  TAAAAGACGA  GAGAGAAAAA  CTACTCAGAG  AAAAGGGAGA  AAACGACAGA  1620
1621  AACCTCCATC  TTCTGAAAAG  AAAACTCAGC  ACTTTGTATC  TGGAAGTCTT  CAGCATGTTA  1680
1681  CGTGATGAGG  ATGGGAAACC  TTACTCTCCC  AGTGAGTACT  CTCTGCAGCA  GACCAGAGAT  1740
1741  GGCAACGTGT  TCCTTGTTCC  CAAGAGCAAG  AAGCCAGATA  CAAAGAAAAA  CTAG  1794

▼ KEYWORD

ID
Family
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Chromatin
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Cellular Component
Protein-DNA complex
Molecular Function
DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function
DNA-binding transcription factor activity
Molecular Function
Protein domain specific binding
Molecular Function
RNA polymerase II activating transcription factor binding
Molecular Function
RNA polymerase II distal enhancer sequence-specific DNA binding
Molecular Function
Sequence-specific DNA binding
Molecular Function
Transcription cofactor binding
Molecular Function
Transcription regulatory region sequence-specific DNA binding
Biological Process
Aflatoxin catabolic process
Biological Process
Aging
Biological Process
Cell redox homeostasis
Biological Process
Cellular response to angiotensin
Biological Process
Cellular response to fluid shear stress
Biological Process
Cellular response to glucose starvation
Biological Process
Cellular response to hydrogen peroxide
Biological Process
Cellular response to hypoxia
Biological Process
Cellular response to laminar fluid shear stress
Biological Process
Cellular response to oxidative stress
Biological Process
Cellular response to tumor necrosis factor
Biological Process
Inflammatory response
Biological Process
Negative regulation of cardiac muscle cell apoptotic process
Biological Process
Negative regulation of cell death
Biological Process
Negative regulation of endothelial cell apoptotic process
Biological Process
Negative regulation of hematopoietic stem cell differentiation
Biological Process
Negative regulation of hydrogen peroxide-induced cell death
Biological Process
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process
Negative regulation of vascular associated smooth muscle cell migration
Biological Process
PERK-mediated unfolded protein response
Biological Process
Positive regulation of angiogenesis
Biological Process
Positive regulation of blood coagulation
Biological Process
Positive regulation of blood vessel endothelial cell migration
Biological Process
Positive regulation of glucose import
Biological Process
Positive regulation of glutathione biosynthetic process
Biological Process
Positive regulation of neuron projection development
Biological Process
Positive regulation of reactive oxygen species metabolic process
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process
Positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
Biological Process
Positive regulation of transcription, DNA-templated
Biological Process
Proteasomal ubiquitin-independent protein catabolic process
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process
Protein ubiquitination
Biological Process
Regulation of embryonic development
Biological Process
Regulation of removal of superoxide radicals

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4495Mus musculus94.970.01070
LLPS-Mea-3952Mesocricetus auratus89.570.01006
LLPS-Ict-1969Ictidomys tridecemlineatus83.990.0 939
LLPS-Fec-2533Felis catus81.880.0 928
LLPS-Hos-0997Homo sapiens81.550.0 914
LLPS-Poa-1010Pongo abelii81.550.0 919
LLPS-Cea-1701Cercocebus atys81.550.0 917
LLPS-Maf-3390Macaca fascicularis81.550.0 917
LLPS-Chs-2655Chlorocebus sabaeus81.550.0 920
LLPS-Mam-4361Macaca mulatta81.380.0 915
LLPS-Sus-4076Sus scrofa81.250.0 900
LLPS-Man-2565Macaca nemestrina81.140.0 898
LLPS-Cas-3714Carlito syrichta81.050.0 889
LLPS-Aon-0196Aotus nancymaae81.050.0 916
LLPS-Mal-2013Mandrillus leucophaeus80.830.0 894
LLPS-Aim-0061Ailuropoda melanoleuca80.780.0 892
LLPS-Caj-3603Callithrix jacchus80.720.0 915
LLPS-Urm-0705Ursus maritimus80.710.0 889
LLPS-Fud-2899Fukomys damarensis80.670.0 886
LLPS-Gog-1992Gorilla gorilla80.50.0 887
LLPS-Rhb-1606Rhinopithecus bieti80.40.0 885
LLPS-Pat-3581Pan troglodytes80.330.0 889
LLPS-Pap-4191Pan paniscus80.330.0 889
LLPS-Otg-4578Otolemur garnettii80.270.0 879
LLPS-Tut-1418Tursiops truncatus80.260.0 901
LLPS-Paa-2828Papio anubis80.070.0 889
LLPS-Nol-0039Nomascus leucogenys80.00.0 894
LLPS-Dio-1478Dipodomys ordii79.730.0 883
LLPS-Orc-3865Oryctolagus cuniculus78.950.0 851
LLPS-Cap-1517Cavia porcellus78.410.0 850
LLPS-Caf-3387Canis familiaris77.890.0 841
LLPS-Bot-4453Bos taurus77.630.0 853
LLPS-Ova-2032Ovis aries77.590.0 847
LLPS-Loa-3212Loxodonta africana77.520.0 868
LLPS-Myl-3388Myotis lucifugus77.190.0 868
LLPS-Eqc-3822Equus caballus75.080.0 855
LLPS-Mod-2294Monodelphis domestica70.240.0 720
LLPS-Sah-3610Sarcophilus harrisii69.170.0 745
LLPS-Mup-3991Mustela putorius furo68.421e-86 278
LLPS-Anp-0402Anas platyrhynchos61.590.0 637
LLPS-Meg-2075Meleagris gallopavo60.230.0 619
LLPS-Fia-3302Ficedula albicollis60.070.0 586
LLPS-Gaga-3439Gallus gallus60.030.0 620
LLPS-Tag-0499Taeniopygia guttata59.930.0 593
LLPS-Anc-4059Anolis carolinensis58.80.0 581
LLPS-Ora-0718Ornithorhynchus anatinus58.060.0 544
LLPS-Pes-0528Pelodiscus sinensis57.870.0 582
LLPS-Lac-0821Latimeria chalumnae54.624e-179 527
LLPS-Xet-3847Xenopus tropicalis50.082e-161 481
LLPS-Leo-2927Lepisosteus oculatus49.677e-155 466
LLPS-Dar-1192Danio rerio45.716e-128 395
LLPS-Gaa-1489Gasterosteus aculeatus45.615e-130 401
LLPS-Scf-3458Scleropages formosus45.311e-115 364
LLPS-Asm-3788Astyanax mexicanus44.288e-126 391
LLPS-Icp-4032Ictalurus punctatus43.729e-119 372
LLPS-Scm-0321Scophthalmus maximus43.417e-124 386
LLPS-Tar-2193Takifugu rubripes42.91e-109 348
LLPS-Orl-1927Oryzias latipes42.811e-110 351
LLPS-Xim-3368Xiphophorus maculatus42.673e-117 369
LLPS-Orn-0846Oreochromis niloticus42.443e-122 381
LLPS-Pof-3150Poecilia formosa42.143e-107 342
LLPS-Ere-0124Erinaceus europaeus41.98e-1788.6
LLPS-Ten-1949Tetraodon nigroviridis41.786e-111 352
LLPS-Cae-0357Caenorhabditis elegans36.251e-0655.1
LLPS-Cis-1354Ciona savignyi34.293e-1170.5