LLPS-Ran-3912
Tbrg1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transforming growth factor beta regulator 1 |
| Gene Name: | Tbrg1 |
| Ensembl Gene: | ENSRNOG00000023850.4 |
| Ensembl Protein: | ENSRNOP00000037323.4 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000039729.4 | ENSRNOP00000037323.4 |
| UniProt | Q5PQK8, TBRG1_RAT | |
| GeneBank | BC087142 | AAH87142.1 |
| RefSeq | NM_001009344.2 | NP_001009344.2 |
| Entrez | 300521 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSVLSGLASE PRTPLSSKAR MKRLPKKNQN EKYRLKYLRL RRAAKATVFE NAAVCDEIAR 60 61 LEEKFLKAKE ERRYLLKKLL QIHALTEGEP QAAAPSHSSS LPLAYGVTSS VGTIQGAGPS 120 121 TGAEEPFAKK SKKEKKEKGK ENSKLEVLKK TSKRKKMEGG ARKLVRPIAL DPSGQPVFPI 180 181 GLGGLTVYSL GEIITNRPGF HDENAIYPVG YCSTRVYASM KCPDQKCLYT CQIKDGGVQP 240 241 QFEIVPEDDP RNTIVGSSAD ACYEELLRAI SAATGKLMPN PLSCGADFFG FSHPTIHNLI 300 301 QSCPEAQNCV NYQWVKFDAC KPRKGQLSQE LPENDAAMSL EAFPTQTFDD DHEDSILPGS 360 361 LDLPELQHEA FVSSYQPEFL THEPLVDTDL QHLKSPSQCS PIQSSD 406 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGCGTGT TGAGCGGCCT GGCTTCCGAG CCGCGCACCC CGCTGTCCAG CAAGGCCAGG 60 61 ATGAAAAGGC TCCCGAAGAA GAACCAGAAT GAGAAGTACC GGTTGAAGTA CCTGCGGCTG 120 121 CGCAGAGCAG CTAAGGCCAC GGTGTTTGAG AATGCTGCTG TTTGTGATGA AATTGCTCGT 180 181 CTTGAGGAAA AATTCCTTAA AGCAAAGGAG GAAAGAAGAT ACTTGCTGAA GAAGCTCCTC 240 241 CAGATCCATG CTCTAACTGA AGGGGAACCA CAGGCTGCCG CTCCTTCCCA CAGCTCCAGT 300 301 TTGCCCCTGG CTTATGGTGT CACCAGCTCT GTGGGAACCA TCCAGGGAGC CGGGCCCAGC 360 361 ACTGGGGCCG AGGAACCATT TGCGAAGAAA TCCAAGAAGG AGAAGAAAGA AAAGGGCAAA 420 421 GAGAACAGCA AACTGGAAGT GCTGAAGAAA ACATCCAAGA GAAAGAAAAT GGAGGGAGGT 480 481 GCTCGCAAGC TGGTCCGGCC CATTGCCCTG GATCCCTCAG GACAGCCTGT GTTCCCCATC 540 541 GGACTAGGGG GTCTGACAGT ATATAGCCTG GGGGAGATCA TCACCAACCG ACCCGGCTTC 600 601 CATGATGAGA ATGCCATCTA TCCTGTGGGC TACTGCAGCA CTCGAGTGTA CGCCAGCATG 660 661 AAGTGCCCAG ACCAGAAGTG CCTATATACC TGTCAGATCA AGGATGGCGG TGTACAGCCT 720 721 CAGTTTGAAA TCGTTCCTGA AGATGACCCC CGGAATACCA TCGTTGGCTC CTCTGCAGAT 780 781 GCCTGTTACG AAGAACTGCT CAGGGCCATC AGTGCCGCAA CGGGGAAACT GATGCCTAAC 840 841 CCACTTTCAT GTGGCGCCGA CTTCTTTGGG TTTTCTCATC CAACCATCCA CAACCTGATT 900 901 CAGAGTTGTC CAGAAGCTCA GAACTGCGTC AATTACCAGT GGGTGAAATT CGATGCGTGC 960 961 AAACCCAGGA AGGGGCAGCT CTCTCAGGAG CTGCCAGAGA ATGATGCAGC TATGAGCCTT 1020 1021 GAAGCCTTTC CGACACAGAC GTTTGATGAT GACCATGAGG ATTCCATTCT GCCAGGCTCC 1080 1081 CTGGACCTGC CTGAGCTTCA GCATGAAGCC TTCGTGTCGT CTTACCAGCC CGAGTTCCTG 1140 1141 ACACATGAAC CCTTGGTTGA CACTGACCTG CAGCACCTCA AGTCTCCATC CCAGTGTAGC 1200 1201 CCAATTCAGT CTTCAGACTG A 1221 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Biological Process | Cell cycle | |
Biological Process | Negative regulation of cell population proliferation |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| TISSUES | ||||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-1748 | Mus musculus | 97.04 | 0.0 | 651 |
| LLPS-Mea-4277 | Mesocricetus auratus | 91.13 | 0.0 | 595 |
| LLPS-Cas-2614 | Carlito syrichta | 84.43 | 0.0 | 534 |
| LLPS-Gog-1815 | Gorilla gorilla | 83.94 | 0.0 | 534 |
| LLPS-Mal-1600 | Mandrillus leucophaeus | 83.94 | 0.0 | 531 |
| LLPS-Paa-1484 | Papio anubis | 83.94 | 0.0 | 531 |
| LLPS-Pat-0302 | Pan troglodytes | 83.94 | 0.0 | 535 |
| LLPS-Pap-1598 | Pan paniscus | 83.94 | 0.0 | 535 |
| LLPS-Poa-1998 | Pongo abelii | 83.94 | 0.0 | 536 |
| LLPS-Maf-1654 | Macaca fascicularis | 83.7 | 0.0 | 530 |
| LLPS-Cea-1238 | Cercocebus atys | 83.7 | 0.0 | 530 |
| LLPS-Hos-0056 | Homo sapiens | 83.7 | 0.0 | 533 |
| LLPS-Ict-3763 | Ictidomys tridecemlineatus | 83.7 | 9e-176 | 504 |
| LLPS-Nol-3341 | Nomascus leucogenys | 83.7 | 0.0 | 533 |
| LLPS-Mam-1743 | Macaca mulatta | 83.7 | 0.0 | 530 |
| LLPS-Chs-2298 | Chlorocebus sabaeus | 83.45 | 0.0 | 528 |
| LLPS-Otg-2165 | Otolemur garnettii | 83.45 | 0.0 | 527 |
| LLPS-Man-3449 | Macaca nemestrina | 83.45 | 0.0 | 528 |
| LLPS-Eqc-1421 | Equus caballus | 83.45 | 0.0 | 528 |
| LLPS-Caj-2738 | Callithrix jacchus | 83.21 | 0.0 | 528 |
| LLPS-Rhb-2073 | Rhinopithecus bieti | 83.21 | 0.0 | 527 |
| LLPS-Aon-2349 | Aotus nancymaae | 82.97 | 0.0 | 526 |
| LLPS-Loa-1715 | Loxodonta africana | 82.97 | 0.0 | 519 |
| LLPS-Fud-0772 | Fukomys damarensis | 82.73 | 0.0 | 521 |
| LLPS-Aim-0002 | Ailuropoda melanoleuca | 82.0 | 4e-177 | 508 |
| LLPS-Sus-1683 | Sus scrofa | 81.51 | 3e-178 | 510 |
| LLPS-Mup-1176 | Mustela putorius furo | 81.51 | 0.0 | 521 |
| LLPS-Fec-0112 | Felis catus | 81.27 | 2e-175 | 503 |
| LLPS-Orc-2642 | Oryctolagus cuniculus | 81.02 | 0.0 | 518 |
| LLPS-Caf-2572 | Canis familiaris | 81.02 | 4e-175 | 503 |
| LLPS-Ova-1668 | Ovis aries | 80.95 | 1e-165 | 478 |
| LLPS-Dio-2430 | Dipodomys ordii | 80.54 | 8e-170 | 489 |
| LLPS-Myl-2893 | Myotis lucifugus | 80.51 | 1e-170 | 491 |
| LLPS-Bot-3004 | Bos taurus | 80.45 | 2e-164 | 475 |
| LLPS-Cap-1502 | Cavia porcellus | 80.29 | 1e-173 | 499 |
| LLPS-Ere-0421 | Erinaceus europaeus | 79.08 | 7e-170 | 489 |
| LLPS-Urm-1318 | Ursus maritimus | 78.6 | 4e-118 | 352 |
| LLPS-Mod-1033 | Monodelphis domestica | 77.37 | 4e-166 | 479 |
| LLPS-Sah-1986 | Sarcophilus harrisii | 76.24 | 2e-152 | 444 |
| LLPS-Ora-1059 | Ornithorhynchus anatinus | 72.43 | 1e-110 | 330 |
| LLPS-Pof-1746 | Poecilia formosa | 64.1 | 1e-84 | 275 |
| LLPS-Icp-2775 | Ictalurus punctatus | 60.96 | 2e-95 | 303 |
| LLPS-Asm-1538 | Astyanax mexicanus | 58.88 | 1e-96 | 306 |
| LLPS-Dar-1035 | Danio rerio | 58.43 | 2e-100 | 315 |
| LLPS-Tar-2240 | Takifugu rubripes | 58.29 | 5e-94 | 298 |
| LLPS-Scf-2064 | Scleropages formosus | 58.07 | 7e-101 | 318 |
| LLPS-Scm-2427 | Scophthalmus maximus | 56.82 | 1e-94 | 301 |
| LLPS-Xim-2437 | Xiphophorus maculatus | 56.8 | 3e-92 | 295 |
| LLPS-Leo-0592 | Lepisosteus oculatus | 56.09 | 3e-103 | 323 |
| LLPS-Lac-1649 | Latimeria chalumnae | 55.82 | 2e-98 | 312 |
| LLPS-Gaa-0097 | Gasterosteus aculeatus | 54.42 | 1e-94 | 296 |
| LLPS-Orn-2023 | Oreochromis niloticus | 53.76 | 4e-94 | 300 |
| LLPS-Xet-3087 | Xenopus tropicalis | 53.15 | 9e-106 | 325 |
| LLPS-Ten-0959 | Tetraodon nigroviridis | 53.07 | 1e-99 | 308 |
| LLPS-Orl-0223 | Oryzias latipes | 52.19 | 7e-91 | 291 |
| LLPS-Anc-3918 | Anolis carolinensis | 47.13 | 7e-81 | 258 |
| LLPS-Php-1076 | Physcomitrella patens | 42.04 | 5e-31 | 130 |
| LLPS-Drm-0935 | Drosophila melanogaster | 39.29 | 1e-28 | 117 |
| LLPS-Abg-0639 | Absidia glauca | 37.5 | 7e-29 | 121 |
| LLPS-Miv-1373 | Microbotryum violaceum | 35.86 | 6e-24 | 108 |
| LLPS-Hov-1700 | Hordeum vulgare | 34.04 | 6e-14 | 77.8 |
| LLPS-Lep-1688 | Leersia perrieri | 31.88 | 2e-13 | 76.6 |
| LLPS-Viv-1959 | Vitis vinifera | 30.43 | 6e-08 | 59.3 |
| LLPS-Amt-1876 | Amborella trichopoda | 28.47 | 1e-09 | 64.7 |