DrLLPS - Data resource of LLPS

LLPS-Ran-2980
Hsd17b10

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10
Gene Name:	Hsd17b10, Erab, Hadh2
Ensembl Gene:	ENSRNOG00000003049.7
Ensembl Protein:	ENSRNOP00000043608.3
Organism:	Rattus norvegicus
Taxa ID:	10116
LLPS Type:	Client

PDB: 1E3W (A, B) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Mitochondrial RNA granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-1830	Q99714	Client	Mitochondrial RNA granule	88.12	6e-156	442

▼ FUNCTION

Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural and functional integrity of mitochondria.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSRNOT00000043559.4	ENSRNOP00000043608.3
UniProt		O70351, HCD2_RAT, Q9QYD4
GeneBank	AF049878, AF069770	AAF14853.1, AAC05747.1
RefSeq	NM_031682.1	NP_113870.1
Entrez	63864

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAAACRSVKG LVAVITGGAS GLGLSTAKRL VGQGATAVLL DVPNSEGETE AKKLGGNCIF 60 61 APANVTSEKE VQAALTLAKE KFGRIDVAVN CAGIAVAIKT YHEKKNQVHT LEDFQRVINV 120 121 NLIGTFNVIR LVAGVMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL 180 181 PIARDLAPIG IRVVTIAPGL FATPLLTTLP DKVRNFLASQ VPFPSRLGDP AEYAHLVQMV 240 241 IENPFLNGEV IRLDGAIRMQ P 261
Nucleotide CDS Sequence (FASTA)
1 ATGGCTGCGG CGTGTCGGAG CGTGAAGGGC CTGGTGGCAG TAATAACCGG AGGAGCCTCG 60 61 GGCCTTGGCC TGTCTACAGC CAAAAGACTG GTGGGACAAG GAGCCACAGC TGTACTTCTG 120 121 GACGTCCCTA ACTCAGAGGG TGAGACCGAA GCCAAGAAGT TAGGAGGAAA CTGCATATTT 180 181 GCCCCAGCAA ATGTGACCTC TGAGAAGGAG GTACAAGCAG CTTTGACTCT AGCAAAAGAA 240 241 AAGTTTGGCC GTATAGATGT GGCTGTCAAC TGTGCAGGCA TTGCAGTGGC CATTAAGACA 300 301 TACCACGAAA AGAAGAACCA GGTCCACACC TTGGAGGACT TCCAGCGGGT TATCAATGTG 360 361 AATCTCATAG GCACTTTCAA TGTGATCCGC CTGGTTGCTG GTGTGATGGG CCAGAATGAA 420 421 CCAGACCAGG GAGGTCAACG TGGAGTTATC ATTAACACTG CCAGTGTGGC TGCTTTTGAG 480 481 GGCCAGGTTG GACAAGCTGC ATACTCTGCA TCCAAAGGGG GCATAGTGGG CATGACACTG 540 541 CCCATTGCTC GAGATCTGGC TCCTATAGGC ATCCGTGTGG TAACAATTGC TCCAGGTCTG 600 601 TTTGCCACCC CACTGCTTAC CACTCTGCCA GACAAAGTGC GCAACTTCTT GGCCAGCCAG 660 661 GTACCCTTCC CCAGCCGACT AGGTGACCCC GCGGAATATG CTCATCTGGT ACAGATGGTA 720 721 ATCGAGAACC CATTCTTGAA TGGAGAGGTC ATCCGGCTGG ATGGGGCCAT TCGAATGCAG 780 781 CCTTAA 786

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0181	Complete proteome
KW-0903	Direct protein sequencing
KW-0496	Mitochondrion
KW-0520	NAD
KW-0560	Oxidoreductase
KW-1185	Reference proteome
KW-0819	tRNA processing

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0030678	Cellular Component	Mitochondrial ribonuclease P complex
GO:0005739	Cellular Component	Mitochondrion
GO:0047015	Molecular Function	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
GO:0003857	Molecular Function	3-hydroxyacyl-CoA dehydrogenase activity
GO:0018454	Molecular Function	Acetoacetyl-CoA reductase activity
GO:0001540	Molecular Function	Amyloid-beta binding
GO:0035410	Molecular Function	Dihydrotestosterone 17-beta-dehydrogenase activity
GO:0004303	Molecular Function	Estradiol 17-beta-dehydrogenase activity
GO:0030331	Molecular Function	Estrogen receptor binding
GO:0042802	Molecular Function	Identical protein binding
GO:0051287	Molecular Function	NAD binding
GO:0005496	Molecular Function	Steroid binding
GO:0030283	Molecular Function	Testosterone dehydrogenase [NAD(P)] activity
GO:0000049	Molecular Function	TRNA binding
GO:0007569	Biological Process	Cell aging
GO:0033327	Biological Process	Leydig cell differentiation
GO:1990180	Biological Process	Mitochondrial tRNA 3'-end processing
GO:0097745	Biological Process	Mitochondrial tRNA 5'-end processing
GO:0070901	Biological Process	Mitochondrial tRNA methylation
GO:0051289	Biological Process	Protein homotetramerization

▼ KEGG

rno:63864

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PRINTS
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	PTMcode

Interaction
RAIN	Mentha	IID	iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
RaftProt

Structure
PDB	MMDB	SCOP

Localization
COMPARTMENTS

Expression
ArrayExpress	TISSUES

Element
miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Mea-0929	Mesocricetus auratus	90.42	2e-172	483
LLPS-Bot-1555	Bos taurus	90.42	2e-171	481
LLPS-Cea-1745	Cercocebus atys	90.04	9e-171	479
LLPS-Mum-4721	Mus musculus	90.04	5e-174	488
LLPS-Paa-2557	Papio anubis	90.04	9e-171	479
LLPS-Mal-1993	Mandrillus leucophaeus	90.04	9e-171	479
LLPS-Man-2031	Macaca nemestrina	89.66	1e-169	476
LLPS-Mam-3646	Macaca mulatta	89.66	4e-170	478
LLPS-Chs-4560	Chlorocebus sabaeus	89.66	4e-170	478
LLPS-Maf-1777	Macaca fascicularis	89.66	5e-170	478
LLPS-Fia-2900	Ficedula albicollis	89.33	5e-40	139
LLPS-Rhb-1160	Rhinopithecus bieti	89.27	1e-169	477
LLPS-Otg-2204	Otolemur garnettii	88.89	1e-167	471
LLPS-Ict-0513	Ictidomys tridecemlineatus	88.89	1e-168	474
LLPS-Nol-0819	Nomascus leucogenys	88.89	6e-169	475
LLPS-Ova-1425	Ovis aries	88.89	2e-168	473
LLPS-Fec-1652	Felis catus	88.51	2e-170	479
LLPS-Caf-4353	Canis familiaris	88.51	3e-169	476
LLPS-Gog-4387	Gorilla gorilla	88.51	1e-167	471
LLPS-Aim-2062	Ailuropoda melanoleuca	88.51	3e-169	476
LLPS-Tut-0053	Tursiops truncatus	88.51	3e-162	457
LLPS-Poa-2100	Pongo abelii	88.49	2e-160	455
LLPS-Urm-3122	Ursus maritimus	88.24	7e-164	463
LLPS-Orc-2281	Oryctolagus cuniculus	88.12	5e-167	470
LLPS-Pat-1081	Pan troglodytes	88.12	6e-166	467
LLPS-Pap-0904	Pan paniscus	88.12	6e-166	467
LLPS-Hos-1830	Homo sapiens	88.12	6e-166	467
LLPS-Caj-4546	Callithrix jacchus	88.12	6e-167	469
LLPS-Eqc-4468	Equus caballus	87.89	1e-163	461
LLPS-Aon-1232	Aotus nancymaae	87.74	2e-167	471
LLPS-Mup-2775	Mustela putorius furo	87.36	6e-167	470
LLPS-Myl-0258	Myotis lucifugus	86.97	8e-166	467
LLPS-Ere-0259	Erinaceus europaeus	86.97	3e-168	473
LLPS-Cas-0374	Carlito syrichta	86.59	5e-164	462
LLPS-Cap-2682	Cavia porcellus	86.59	1e-165	466
LLPS-Anc-3551	Anolis carolinensis	86.01	2e-82	251
LLPS-Xim-2731	Xiphophorus maculatus	86.0	8e-53	180
LLPS-Dio-1757	Dipodomys ordii	85.82	1e-163	461
LLPS-Sus-1576	Sus scrofa	85.71	1e-159	452
LLPS-Tag-2438	Taeniopygia guttata	85.0	1e-55	180
LLPS-Loa-3507	Loxodonta africana	84.5	2e-163	461
LLPS-Fud-1036	Fukomys damarensis	84.29	2e-161	456
LLPS-Ora-1856	Ornithorhynchus anatinus	79.7	5e-113	330
LLPS-Meg-3208	Meleagris gallopavo	79.31	8e-79	241
LLPS-Sah-3461	Sarcophilus harrisii	76.26	1e-138	398
LLPS-Lac-3443	Latimeria chalumnae	76.06	4e-142	407
LLPS-Mod-2246	Monodelphis domestica	74.4	4e-134	386
LLPS-Xet-3926	Xenopus tropicalis	73.95	9e-139	398
LLPS-Orn-2491	Oreochromis niloticus	73.83	1e-138	398
LLPS-Gaga-3382	Gallus gallus	73.36	6e-137	399
LLPS-Asm-3851	Astyanax mexicanus	73.36	4e-137	394
LLPS-Scf-1219	Scleropages formosus	73.36	3e-137	394
LLPS-Tar-0207	Takifugu rubripes	73.12	1e-134	388
LLPS-Ten-1825	Tetraodon nigroviridis	72.97	1e-136	393
LLPS-Scm-3489	Scophthalmus maximus	72.59	2e-136	392
LLPS-Pof-3228	Poecilia formosa	72.59	3e-133	384
LLPS-Icp-1212	Ictalurus punctatus	72.59	4e-136	392
LLPS-Orl-0849	Oryzias latipes	72.59	1e-136	393
LLPS-Dar-3092	Danio rerio	71.81	2e-134	387
LLPS-Gaa-2455	Gasterosteus aculeatus	71.65	1e-135	390
LLPS-Drm-1494	Drosophila melanogaster	66.54	7e-125	363
LLPS-Cis-1984	Ciona savignyi	64.98	4e-115	338
LLPS-Cii-2170	Ciona intestinalis	63.81	1e-115	339
LLPS-Cae-1107	Caenorhabditis elegans	59.14	2e-100	301
LLPS-Abg-1437	Absidia glauca	47.66	9e-68	217
LLPS-Zyt-0170	Zymoseptoria tritici	43.41	2e-56	188
LLPS-Miv-0930	Microbotryum violaceum	43.19	2e-48	168
LLPS-Ved-1577	Verticillium dahliae	43.08	3e-53	179
LLPS-Fuo-0509	Fusarium oxysporum	42.91	1e-58	194
LLPS-Spr-0273	Sporisorium reilianum	42.86	1e-54	183
LLPS-Fuv-0738	Fusarium verticillioides	42.8	5e-58	192
LLPS-Phn-0886	Phaeosphaeria nodorum	42.63	4e-51	174
LLPS-Lem-0628	Leptosphaeria maculans	42.58	1e-52	178
LLPS-Fus-1286	Fusarium solani	42.41	3e-59	195
LLPS-Pytr-1430	Pyrenophora triticirepentis	42.0	1e-50	173
LLPS-Usm-1149	Ustilago maydis	41.89	1e-54	184
LLPS-Pyt-1602	Pyrenophora teres	41.83	2e-49	170
LLPS-Dos-1358	Dothistroma septosporum	41.63	1e-57	191
LLPS-Beb-1202	Beauveria bassiana	41.5	2e-51	175
LLPS-Cog-0828	Colletotrichum gloeosporioides	41.34	4e-51	174
LLPS-Trv-0085	Trichoderma virens	41.25	1e-52	178
LLPS-Mao-0943	Magnaporthe oryzae	41.15	5e-50	171
LLPS-Scs-0930	Sclerotinia sclerotiorum	41.09	4e-51	174
LLPS-Trr-0504	Trichoderma reesei	40.08	1e-47	165
LLPS-Blg-0472	Blumeria graminis	39.77	9e-48	166
LLPS-Nec-1532	Neurospora crassa	39.38	2e-49	170
LLPS-Cogr-1473	Colletotrichum graminicola	39.3	7e-53	179
LLPS-Coo-0786	Colletotrichum orbiculare	39.3	2e-52	178
LLPS-Pug-1020	Puccinia graminis	38.89	3e-47	164
LLPS-Prp-2569	Prunus persica	38.76	7e-30	118
LLPS-Lep-2303	Leersia perrieri	38.07	1e-25	111
LLPS-Gag-1356	Gaeumannomyces graminis	38.01	5e-46	161
LLPS-Mel-0283	Melampsora laricipopulina	37.69	5e-50	171
LLPS-Cus-2041	Cucumis sativus	37.62	2e-31	122
LLPS-Hea-1651	Helianthus annuus	36.79	9e-29	116
LLPS-Sei-0993	Setaria italica	35.55	5e-34	130
LLPS-Zem-1002	Zea mays	34.47	1e-32	127
LLPS-Via-2080	Vigna angularis	34.26	3e-26	108
LLPS-Tra-2341	Triticum aestivum	34.23	9e-33	127
LLPS-Orp-1851	Oryza punctata	33.87	4e-24	103
LLPS-Put-1340	Puccinia triticina	33.82	5e-29	116
LLPS-Org-1741	Oryza glaberrima	33.59	5e-27	111
LLPS-Orr-1918	Oryza rufipogon	33.59	7e-27	111
LLPS-Orm-1226	Oryza meridionalis	33.59	7e-27	111
LLPS-Orni-0648	Oryza nivara	33.59	7e-27	111
LLPS-Orb-1259	Oryza barthii	33.59	2e-27	111
LLPS-Brd-1484	Brachypodium distachyon	33.59	2e-32	126
LLPS-Orgl-0352	Oryza glumaepatula	33.59	3e-27	111
LLPS-Sob-0995	Sorghum bicolor	33.08	2e-30	120
LLPS-Osl-1219	Ostreococcus lucimarinus	32.95	5e-31	122
LLPS-Vir-2097	Vigna radiata	32.58	1e-27	113
LLPS-Orbr-1726	Oryza brachyantha	32.28	4e-28	114
LLPS-Phv-1296	Phaseolus vulgaris	32.2	6e-27	111
LLPS-Coc-1088	Corchorus capsularis	32.2	6e-32	125
LLPS-Amt-0996	Amborella trichopoda	32.06	9e-32	124
LLPS-Asni-0123	Aspergillus niger	32.06	1e-26	109
LLPS-Chc-0926	Chondrus crispus	32.02	3e-27	110
LLPS-Sem-2113	Selaginella moellendorffii	31.92	3e-28	115
LLPS-Thc-2240	Theobroma cacao	31.82	8e-28	114
LLPS-Dac-1125	Daucus carota	31.68	7e-26	108
LLPS-Tru-1911	Triticum urartu	31.65	3e-29	118
LLPS-Mae-0722	Manihot esculenta	31.64	2e-26	110
LLPS-Gor-1023	Gossypium raimondii	31.64	9e-23	99.4
LLPS-Pot-2344	Populus trichocarpa	31.58	4e-31	123
LLPS-Mua-2294	Musa acuminata	31.56	5e-29	117
LLPS-Hov-2133	Hordeum vulgare	31.5	2e-27	112
LLPS-Nia-2208	Nicotiana attenuata	31.25	2e-22	98.6
LLPS-Art-0197	Arabidopsis thaliana	31.15	1e-23	102
LLPS-Php-1032	Physcomitrella patens	31.15	2e-28	115
LLPS-Bro-2351	Brassica oleracea	31.01	4e-25	106
LLPS-Brn-0368	Brassica napus	31.01	4e-25	106
LLPS-Glm-0027	Glycine max	31.01	2e-27	112
LLPS-Anp-2574	Anas platyrhynchos	30.98	1e-27	112
LLPS-Cym-0550	Cyanidioschyzon merolae	30.83	5e-23	100
LLPS-Gas-1406	Galdieria sulphuraria	30.8	1e-20	93.2
LLPS-Arl-0761	Arabidopsis lyrata	30.77	3e-25	106
LLPS-Brr-2557	Brassica rapa	30.71	2e-25	107
LLPS-Met-2063	Medicago truncatula	30.68	4e-28	114
LLPS-Sol-1275	Solanum lycopersicum	30.47	2e-22	98.6
LLPS-Viv-0895	Vitis vinifera	30.3	1e-28	115
LLPS-Ast-0301	Aspergillus terreus	30.23	8e-29	115
LLPS-Crn-0822	Cryptococcus neoformans	30.19	4e-26	108
LLPS-Tum-0596	Tuber melanosporum	30.19	1e-21	95.5
LLPS-Chr-0614	Chlamydomonas reinhardtii	30.08	2e-20	92.4
LLPS-Ors-1531	Oryza sativa	29.69	9e-26	107
LLPS-Ori-2074	Oryza indica	29.69	9e-26	107
LLPS-Sot-1695	Solanum tuberosum	29.55	7e-26	108
LLPS-Pes-1843	Pelodiscus sinensis	29.34	7e-24	101
LLPS-Leo-1682	Lepisosteus oculatus	29.32	1e-21	95.1
LLPS-Asf-0295	Aspergillus flavus	29.07	3e-26	108
LLPS-Aso-1294	Aspergillus oryzae	29.07	3e-26	108

LLPS-Ran-2980Hsd17b10

Protein Sequence

Nucleotide Sequence

LLPS-Ran-2980
Hsd17b10