LLPS-Ran-1955
Hspe1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 10 kDa heat shock protein, mitochondrial |
| Gene Name: | Hspe1 |
| Ensembl Gene: | ENSRNOG00000051624.1 |
| Ensembl Protein: | ENSRNOP00000068700.1 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000082300.1 | ENSRNOP00000068700.1 |
| UniProt | P26772, CH10_RAT | |
| GeneBank | BC058492, X71429 | AAH58492.1, CAA50560.1 |
| Entrez | 25462 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 AGQAFRKFLP LFDRVLVERS AAETVTKGGI MLPEKSQGKV LQATVVAVGS GGKGKGGEIQ 60 61 PVSVKVGDKV LLPEYGGTKV VLDDKKFFL 89 |
| Nucleotide CDS Sequence (FASTA) |
1 GCTGGACAAG CTTTTAGGAA GTTTCTTCCG CTATTTGACA GAGTATTGGT TGAAAGGAGT 60 61 GCCGCTGAAA CTGTGACCAA AGGTGGCATT ATGCTTCCAG AAAAGTCTCA AGGAAAAGTA 120 121 TTGCAAGCAA CGGTCGTGGC TGTGGGATCA GGCGGGAAAG GAAAGGGTGG AGAGATTCAG 180 181 CCTGTCAGTG TGAAAGTTGG AGATAAAGTT CTTCTCCCAG AATATGGAGG CACCAAAGTA 240 241 GTACTAGACG ACAAGAAATT TTTTTTA 267 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial matrix | |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | Chaperone binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Unfolded protein binding | |
Biological Process | Chaperone cofactor-dependent protein refolding |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mam-3986 | Macaca mulatta | 100.0 | 2e-24 | 98.2 |
| LLPS-Caj-2923 | Callithrix jacchus | 96.63 | 5e-46 | 149 |
| LLPS-Gog-2516 | Gorilla gorilla | 96.63 | 5e-46 | 149 |
| LLPS-Chs-4526 | Chlorocebus sabaeus | 96.63 | 4e-46 | 149 |
| LLPS-Maf-2855 | Macaca fascicularis | 96.63 | 4e-46 | 149 |
| LLPS-Ova-2060 | Ovis aries | 96.63 | 5e-46 | 149 |
| LLPS-Aim-3867 | Ailuropoda melanoleuca | 96.63 | 5e-46 | 149 |
| LLPS-Paa-4165 | Papio anubis | 96.63 | 4e-46 | 149 |
| LLPS-Mal-2175 | Mandrillus leucophaeus | 96.63 | 4e-46 | 149 |
| LLPS-Bot-0641 | Bos taurus | 96.63 | 4e-45 | 152 |
| LLPS-Rhb-3637 | Rhinopithecus bieti | 96.63 | 5e-46 | 149 |
| LLPS-Loa-1779 | Loxodonta africana | 96.63 | 6e-46 | 149 |
| LLPS-Man-0672 | Macaca nemestrina | 96.63 | 4e-46 | 149 |
| LLPS-Fec-3217 | Felis catus | 96.63 | 5e-46 | 149 |
| LLPS-Hos-0660 | Homo sapiens | 96.63 | 5e-46 | 149 |
| LLPS-Pat-0348 | Pan troglodytes | 96.63 | 5e-46 | 149 |
| LLPS-Nol-3565 | Nomascus leucogenys | 96.63 | 5e-46 | 149 |
| LLPS-Ict-3974 | Ictidomys tridecemlineatus | 96.63 | 6e-46 | 149 |
| LLPS-Cap-3408 | Cavia porcellus | 96.63 | 4e-46 | 149 |
| LLPS-Poa-3691 | Pongo abelii | 96.63 | 5e-46 | 149 |
| LLPS-Fud-1135 | Fukomys damarensis | 95.51 | 2e-46 | 150 |
| LLPS-Sus-3104 | Sus scrofa | 95.51 | 1e-45 | 148 |
| LLPS-Mum-4475 | Mus musculus | 95.51 | 1e-45 | 148 |
| LLPS-Mup-4507 | Mustela putorius furo | 95.51 | 3e-45 | 147 |
| LLPS-Dio-0930 | Dipodomys ordii | 95.51 | 7e-46 | 149 |
| LLPS-Orc-3227 | Oryctolagus cuniculus | 95.51 | 6e-46 | 149 |
| LLPS-Otg-3720 | Otolemur garnettii | 95.51 | 2e-45 | 147 |
| LLPS-Urm-2896 | Ursus maritimus | 95.51 | 4e-45 | 147 |
| LLPS-Eqc-2005 | Equus caballus | 95.24 | 2e-42 | 140 |
| LLPS-Caf-1752 | Canis familiaris | 94.38 | 4e-44 | 144 |
| LLPS-Aon-0764 | Aotus nancymaae | 93.26 | 1e-43 | 143 |
| LLPS-Cea-1807 | Cercocebus atys | 93.26 | 2e-45 | 148 |
| LLPS-Myl-4021 | Myotis lucifugus | 93.26 | 8e-45 | 146 |
| LLPS-Sah-0103 | Sarcophilus harrisii | 92.13 | 2e-44 | 145 |
| LLPS-Cas-1176 | Carlito syrichta | 92.13 | 1e-43 | 143 |
| LLPS-Mod-3900 | Monodelphis domestica | 91.53 | 4e-23 | 90.1 |
| LLPS-Mea-2194 | Mesocricetus auratus | 90.16 | 2e-23 | 90.5 |
| LLPS-Ora-0797 | Ornithorhynchus anatinus | 88.76 | 4e-43 | 142 |
| LLPS-Fia-3575 | Ficedula albicollis | 86.52 | 9e-43 | 141 |
| LLPS-Pes-3811 | Pelodiscus sinensis | 86.52 | 3e-42 | 140 |
| LLPS-Tag-1226 | Taeniopygia guttata | 86.52 | 2e-42 | 140 |
| LLPS-Anc-0340 | Anolis carolinensis | 86.52 | 2e-41 | 137 |
| LLPS-Pap-0934 | Pan paniscus | 86.36 | 3e-36 | 124 |
| LLPS-Orn-1878 | Oreochromis niloticus | 86.21 | 2e-41 | 137 |
| LLPS-Xet-1862 | Xenopus tropicalis | 85.06 | 2e-40 | 135 |
| LLPS-Anp-3168 | Anas platyrhynchos | 84.27 | 2e-41 | 137 |
| LLPS-Lac-3506 | Latimeria chalumnae | 84.27 | 3e-41 | 137 |
| LLPS-Meg-2924 | Meleagris gallopavo | 84.27 | 2e-41 | 137 |
| LLPS-Gaga-3060 | Gallus gallus | 84.27 | 5e-41 | 138 |
| LLPS-Ten-1499 | Tetraodon nigroviridis | 83.72 | 1e-39 | 134 |
| LLPS-Orl-0691 | Oryzias latipes | 82.95 | 2e-40 | 135 |
| LLPS-Leo-2466 | Lepisosteus oculatus | 82.76 | 7e-40 | 133 |
| LLPS-Tar-1289 | Takifugu rubripes | 82.56 | 2e-39 | 134 |
| LLPS-Pof-2579 | Poecilia formosa | 82.56 | 8e-39 | 131 |
| LLPS-Scf-4125 | Scleropages formosus | 81.61 | 2e-39 | 132 |
| LLPS-Gaa-2421 | Gasterosteus aculeatus | 81.61 | 5e-38 | 129 |
| LLPS-Xim-4125 | Xiphophorus maculatus | 81.61 | 9e-37 | 125 |
| LLPS-Scm-0879 | Scophthalmus maximus | 81.4 | 7e-36 | 123 |
| LLPS-Asm-3449 | Astyanax mexicanus | 79.55 | 2e-38 | 134 |
| LLPS-Icp-1334 | Ictalurus punctatus | 79.31 | 8e-38 | 128 |
| LLPS-Dar-0769 | Danio rerio | 78.16 | 3e-37 | 127 |
| LLPS-Cii-0011 | Ciona intestinalis | 67.42 | 2e-30 | 109 |
| LLPS-Cae-1395 | Caenorhabditis elegans | 64.37 | 8e-29 | 105 |
| LLPS-Drm-0836 | Drosophila melanogaster | 53.93 | 1e-20 | 84.7 |
| LLPS-Dac-2426 | Daucus carota | 53.57 | 2e-15 | 70.5 |
| LLPS-Php-1384 | Physcomitrella patens | 52.87 | 3e-14 | 67.8 |
| LLPS-Glm-2059 | Glycine max | 52.38 | 4e-17 | 75.1 |
| LLPS-Mua-2090 | Musa acuminata | 51.19 | 1e-15 | 71.6 |
| LLPS-Vir-0326 | Vigna radiata | 51.19 | 3e-17 | 75.5 |
| LLPS-Cus-1795 | Cucumis sativus | 51.19 | 1e-16 | 73.9 |
| LLPS-Via-1842 | Vigna angularis | 51.19 | 3e-17 | 75.5 |
| LLPS-Nia-2193 | Nicotiana attenuata | 51.19 | 2e-15 | 70.5 |
| LLPS-Phv-0258 | Phaseolus vulgaris | 51.19 | 5e-17 | 74.7 |
| LLPS-Prp-1908 | Prunus persica | 51.19 | 9e-15 | 68.9 |
| LLPS-Cym-1095 | Cyanidioschyzon merolae | 50.59 | 3e-17 | 75.9 |
| LLPS-Sob-2171 | Sorghum bicolor | 50.59 | 1e-12 | 63.5 |
| LLPS-Zem-1301 | Zea mays | 50.59 | 2e-13 | 65.5 |
| LLPS-Chc-0620 | Chondrus crispus | 50.56 | 1e-20 | 84.3 |
| LLPS-Met-0792 | Medicago truncatula | 50.0 | 2e-16 | 73.2 |
| LLPS-Chr-0887 | Chlamydomonas reinhardtii | 50.0 | 3e-18 | 78.2 |
| LLPS-Lep-1220 | Leersia perrieri | 50.0 | 6e-14 | 66.6 |
| LLPS-Map-1030 | Magnaporthe poae | 49.43 | 6e-16 | 72.4 |
| LLPS-Sem-0910 | Selaginella moellendorffii | 49.38 | 2e-14 | 68.2 |
| LLPS-Crn-1312 | Cryptococcus neoformans | 49.38 | 6e-14 | 67.0 |
| LLPS-Sol-1277 | Solanum lycopersicum | 48.81 | 2e-14 | 68.2 |
| LLPS-Sot-1496 | Solanum tuberosum | 48.81 | 9e-15 | 68.9 |
| LLPS-Mae-0943 | Manihot esculenta | 48.81 | 5e-15 | 69.7 |
| LLPS-Amt-2313 | Amborella trichopoda | 48.81 | 2e-14 | 67.8 |
| LLPS-Coc-1852 | Corchorus capsularis | 48.81 | 9e-15 | 68.9 |
| LLPS-Brn-0438 | Brassica napus | 48.24 | 8e-15 | 68.9 |
| LLPS-Arl-0491 | Arabidopsis lyrata | 48.24 | 9e-15 | 68.9 |
| LLPS-Brr-0057 | Brassica rapa | 48.24 | 1e-14 | 68.6 |
| LLPS-Art-2100 | Arabidopsis thaliana | 48.24 | 9e-15 | 68.9 |
| LLPS-Bro-2532 | Brassica oleracea | 48.24 | 8e-15 | 68.9 |
| LLPS-Orni-0993 | Oryza nivara | 48.19 | 8e-13 | 63.5 |
| LLPS-Ors-2053 | Oryza sativa | 47.67 | 4e-14 | 67.4 |
| LLPS-Org-1004 | Oryza glaberrima | 47.67 | 3e-14 | 67.8 |
| LLPS-Hea-1163 | Helianthus annuus | 47.62 | 3e-14 | 67.4 |
| LLPS-Pot-0027 | Populus trichocarpa | 47.62 | 3e-14 | 67.8 |
| LLPS-Gag-1420 | Gaeumannomyces graminis | 47.13 | 2e-14 | 67.8 |
| LLPS-Fuv-0831 | Fusarium verticillioides | 47.13 | 2e-13 | 66.2 |
| LLPS-Fuo-1031 | Fusarium oxysporum | 47.13 | 7e-14 | 66.6 |
| LLPS-Asg-1312 | Ashbya gossypii | 47.06 | 1e-12 | 63.5 |
| LLPS-Pug-1319 | Puccinia graminis | 46.91 | 3e-12 | 62.4 |
| LLPS-Put-0084 | Puccinia triticina | 46.91 | 3e-12 | 62.4 |
| LLPS-Tra-1838 | Triticum aestivum | 46.51 | 9e-13 | 63.5 |
| LLPS-Brd-1991 | Brachypodium distachyon | 46.51 | 1e-11 | 60.5 |
| LLPS-Thc-1299 | Theobroma cacao | 46.43 | 2e-13 | 65.5 |
| LLPS-Ori-2422 | Oryza indica | 46.43 | 7e-11 | 58.5 |
| LLPS-Orb-2196 | Oryza barthii | 46.43 | 7e-11 | 58.5 |
| LLPS-Orgl-1267 | Oryza glumaepatula | 46.43 | 7e-11 | 58.5 |
| LLPS-Gor-0849 | Gossypium raimondii | 46.43 | 2e-13 | 65.5 |
| LLPS-Orr-0866 | Oryza rufipogon | 46.43 | 7e-11 | 58.5 |
| LLPS-Orm-0562 | Oryza meridionalis | 46.43 | 7e-11 | 58.5 |
| LLPS-Asf-0944 | Aspergillus flavus | 46.25 | 1e-10 | 58.2 |
| LLPS-Kop-1038 | Komagataella pastoris | 46.25 | 1e-15 | 71.6 |
| LLPS-Blg-0637 | Blumeria graminis | 45.98 | 4e-13 | 64.7 |
| LLPS-Beb-1569 | Beauveria bassiana | 45.98 | 8e-14 | 66.6 |
| LLPS-Orbr-2053 | Oryza brachyantha | 45.24 | 3e-10 | 57.0 |
| LLPS-Orp-1662 | Oryza punctata | 45.24 | 2e-12 | 62.4 |
| LLPS-Osl-1306 | Ostreococcus lucimarinus | 45.12 | 6e-11 | 58.5 |
| LLPS-Sac-1348 | Saccharomyces cerevisiae | 45.0 | 1e-10 | 57.8 |
| LLPS-Hov-2078 | Hordeum vulgare | 44.94 | 1e-11 | 61.2 |
| LLPS-Scs-0093 | Sclerotinia sclerotiorum | 44.83 | 3e-12 | 62.4 |
| LLPS-Tum-1587 | Tuber melanosporum | 44.83 | 9e-13 | 64.7 |
| LLPS-Fus-1244 | Fusarium solani | 44.83 | 1e-12 | 63.5 |
| LLPS-Cogr-0889 | Colletotrichum graminicola | 44.83 | 5e-15 | 70.1 |
| LLPS-Trv-1472 | Trichoderma virens | 44.83 | 1e-12 | 63.5 |
| LLPS-Sei-2105 | Setaria italica | 44.29 | 5e-06 | 46.6 |
| LLPS-Yal-0957 | Yarrowia lipolytica | 44.05 | 1e-14 | 68.6 |
| LLPS-Gas-1211 | Galdieria sulphuraria | 44.05 | 2e-14 | 68.2 |
| LLPS-Viv-0061 | Vitis vinifera | 44.05 | 3e-13 | 65.1 |
| LLPS-Mao-1351 | Magnaporthe oryzae | 43.68 | 2e-13 | 65.5 |
| LLPS-Scp-1278 | Schizosaccharomyces pombe | 43.68 | 3e-13 | 65.1 |
| LLPS-Ved-0546 | Verticillium dahliae | 43.68 | 5e-14 | 67.0 |
| LLPS-Usm-1345 | Ustilago maydis | 43.18 | 7e-13 | 64.3 |
| LLPS-Asni-0254 | Aspergillus niger | 42.86 | 4e-10 | 57.0 |
| LLPS-Coo-0851 | Colletotrichum orbiculare | 42.53 | 8e-13 | 63.9 |
| LLPS-Nec-1441 | Neurospora crassa | 42.53 | 1e-12 | 63.2 |
| LLPS-Asfu-1256 | Aspergillus fumigatus | 42.35 | 2e-11 | 60.8 |
| LLPS-Scj-0585 | Schizosaccharomyces japonicus | 41.67 | 6e-11 | 58.9 |
| LLPS-Pytr-1432 | Pyrenophora triticirepentis | 41.57 | 5e-10 | 57.0 |
| LLPS-Nef-1138 | Neosartorya fischeri | 41.38 | 2e-11 | 60.5 |
| LLPS-Tru-1856 | Triticum urartu | 41.25 | 4e-10 | 56.2 |
| LLPS-Trr-1597 | Trichoderma reesei | 41.05 | 5e-10 | 56.2 |
| LLPS-Mel-0963 | Melampsora laricipopulina | 40.91 | 9e-11 | 58.2 |
| LLPS-Spr-1135 | Sporisorium reilianum | 40.91 | 5e-12 | 62.0 |
| LLPS-Asc-1174 | Aspergillus clavatus | 40.23 | 4e-11 | 59.7 |
| LLPS-Pyt-0962 | Pyrenophora teres | 40.23 | 2e-09 | 55.5 |
| LLPS-Lem-1197 | Leptosphaeria maculans | 40.23 | 9e-10 | 55.5 |
| LLPS-Ast-1564 | Aspergillus terreus | 40.23 | 2e-10 | 57.8 |
| LLPS-Miv-1397 | Microbotryum violaceum | 39.77 | 1e-08 | 52.4 |
| LLPS-Asn-0695 | Aspergillus nidulans | 39.29 | 2e-10 | 57.0 |
| LLPS-Scc-0698 | Schizosaccharomyces cryophilus | 39.08 | 8e-12 | 61.2 |
| LLPS-Dos-1159 | Dothistroma septosporum | 39.08 | 1e-12 | 63.5 |
| LLPS-Abg-0226 | Absidia glauca | 38.2 | 3e-11 | 59.7 |
| LLPS-Zyt-1466 | Zymoseptoria tritici | 37.93 | 4e-11 | 59.3 |
| LLPS-Phn-0832 | Phaeosphaeria nodorum | 36.78 | 2e-08 | 51.6 |