LLPS-Ran-1911
Lim2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lens fiber membrane intrinsic protein; MP17; MP18; MP19; MP20
Gene Name: Lim2
Ensembl Gene: ENSRNOG00000017681.2
Ensembl Protein: ENSRNOP00000023858.1
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MYSFMGGGLF  CAWVGTILLV  VATATDHWMQ  YRLSGSFAHQ  GLWRYCLGNK  CFLQTESIAY  60
61    WNATRAFMIL  SALCATSGII  MGVLAFAQQS  TFTRLSRPFS  AGIMFFASTL  FVLLALAIYT  120
121   GVTVSFLGRR  FGDWRFSWSY  ILGWVALLMT  FFAGIFYMCA  YRMHECRRLS  TPR  173
Nucleotide CDS Sequence (FASTA)
1     ATGTACAGCT  TCATGGGTGG  CGGCCTCTTC  TGTGCCTGGG  TGGGGACCAT  CCTGTTGGTG  60
61    GTAGCCACAG  CGACGGACCA  TTGGATGCAA  TACCGGCTGT  CAGGGTCCTT  TGCACACCAG  120
121   GGCCTGTGGC  GTTACTGCCT  GGGCAACAAG  TGCTTCCTGC  AGACAGAGAG  CATCGCATAC  180
181   TGGAATGCCA  CGCGGGCTTT  CATGATCCTG  TCTGCCCTGT  GTGCCACCTC  GGGCATCATC  240
241   ATGGGTGTCC  TGGCCTTTGC  GCAGCAATCC  ACCTTCACCC  GCCTCTCCAG  GCCCTTCTCT  300
301   GCTGGCATCA  TGTTTTTTGC  CTCCACCCTT  TTCGTCCTGT  TGGCCTTGGC  CATTTACACC  360
361   GGAGTCACCG  TTAGTTTCCT  CGGCCGCCGC  TTTGGGGACT  GGCGCTTTTC  ATGGTCTTAC  420
421   ATCCTGGGCT  GGGTGGCCCT  GCTCATGACC  TTCTTTGCAG  GAATTTTCTA  CATGTGTGCC  480
481   TACCGGATGC  ATGAGTGCCG  GCGCCTATCC  ACCCCACGCT  GA  522

▼ KEYWORD

ID
Family
Complete proteome
Direct protein sequencing
Disulfide bond
Eye lens protein
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Plasma membrane
Cellular Component
Vesicle
Molecular Function
Structural constituent of eye lens
Biological Process
Lens development in camera-type eye

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-3841Mus musculus99.423e-121 347
LLPS-Mea-3488Mesocricetus auratus98.847e-121 345
LLPS-Orc-1049Oryctolagus cuniculus97.698e-120 343
LLPS-Otg-0509Otolemur garnettii97.114e-119 341
LLPS-Fec-2608Felis catus96.614e-33 123
LLPS-Aim-3918Ailuropoda melanoleuca96.539e-119 340
LLPS-Caf-3477Canis familiaris96.531e-118 340
LLPS-Sus-3524Sus scrofa95.952e-118 339
LLPS-Mup-3193Mustela putorius furo95.955e-118 338
LLPS-Dio-4083Dipodomys ordii95.389e-118 338
LLPS-Bot-3521Bos taurus95.381e-117 337
LLPS-Ova-0350Ovis aries95.381e-117 337
LLPS-Cas-1712Carlito syrichta95.384e-117 336
LLPS-Cap-4039Cavia porcellus94.85e-116 333
LLPS-Chs-2782Chlorocebus sabaeus91.911e-114 330
LLPS-Sah-2625Sarcophilus harrisii89.022e-109 317
LLPS-Eqc-0637Equus caballus88.893e-99 293
LLPS-Fud-2306Fukomys damarensis87.863e-107 311
LLPS-Urm-3438Ursus maritimus85.711e-84 255
LLPS-Ora-2518Ornithorhynchus anatinus83.121e-88 263
LLPS-Asm-2638Astyanax mexicanus80.922e-99 291
LLPS-Xim-3388Xiphophorus maculatus80.922e-99 291
LLPS-Tar-3598Takifugu rubripes80.922e-99 291
LLPS-Scm-3163Scophthalmus maximus80.922e-99 291
LLPS-Orn-2307Oreochromis niloticus80.922e-99 291
LLPS-Ten-2725Tetraodon nigroviridis80.922e-99 291
LLPS-Xet-2258Xenopus tropicalis80.922e-96 283
LLPS-Leo-1609Lepisosteus oculatus80.357e-99 290
LLPS-Scf-2020Scleropages formosus80.351e-98 289
LLPS-Pof-0438Poecilia formosa80.358e-99 290
LLPS-Gaa-3396Gasterosteus aculeatus79.776e-98 288
LLPS-Dar-3531Danio rerio79.774e-97 285
LLPS-Pes-2162Pelodiscus sinensis78.061e-81 246
LLPS-Icp-4163Ictalurus punctatus78.032e-95 281
LLPS-Orl-2991Oryzias latipes76.36e-95 280
LLPS-Loa-1020Loxodonta africana76.176e-108 314
LLPS-Tut-1040Tursiops truncatus75.73e-106 310
LLPS-Maf-2774Macaca fascicularis74.883e-107 313
LLPS-Cea-0104Cercocebus atys74.883e-107 313
LLPS-Caj-4762Callithrix jacchus74.883e-107 313
LLPS-Mal-4516Mandrillus leucophaeus74.883e-107 313
LLPS-Man-3742Macaca nemestrina74.883e-107 313
LLPS-Poa-4115Pongo abelii74.881e-107 313
LLPS-Gog-0493Gorilla gorilla74.427e-107 311
LLPS-Aon-3662Aotus nancymaae73.959e-106 309
LLPS-Pat-4220Pan troglodytes73.957e-106 309
LLPS-Pap-3424Pan paniscus73.957e-106 309
LLPS-Hos-1956Homo sapiens73.956e-106 309
LLPS-Rhb-3438Rhinopithecus bieti73.497e-106 309
LLPS-Nol-2284Nomascus leucogenys73.36e-88 263
LLPS-Mod-1737Monodelphis domestica70.326e-100 294
LLPS-Anc-1185Anolis carolinensis69.643e-51 167
LLPS-Lac-3105Latimeria chalumnae67.155e-91 271
LLPS-Paa-4685Papio anubis66.231e-59 190