LLPS-Ran-1637
Rtf2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Replication termination factor 2
Gene Name: Rtf2, Rtfdc1
Ensembl Gene: ENSRNOG00000005083.5
Ensembl Protein: ENSRNOP00000006884.3
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGCDGGTIPK  RHELVKGPKK  VEKVDKDAEL  VAQWNYCTLS  QEVLRRPIVA  CELGRLYNKD  60
61    AVIEFLLDKS  AEKALGKATS  HIRSIKNVTE  LKLSDNPAWE  GDKGNTKGDK  HDDLQRARFI  120
121   CPVVGLEMNG  RHRFCFLRCC  GCVFSERALK  EIKAEVCHTC  GAAFQEEDII  VLNGTKEDVE  180
181   MLKRRMEERR  LRAKLEKKTK  KPKTAESASK  LGISQDSAGP  SKAKAGKSEE  ADPDPREKKS  240
241   SLAPRGTASN  GSASGKVGKP  PCGALKRSIA  DSEESETYKS  IFTSHSSAKR  SKEESAHWVT  300
301   HTSYCF  306
Nucleotide CDS Sequence (FASTA)
1     ATGGGTTGCG  ACGGAGGCAC  AATCCCCAAG  AGGCACGAGC  TGGTGAAGGG  GCCGAAGAAG  60
61    GTCGAGAAGG  TTGACAAAGA  TGCCGAACTG  GTGGCCCAGT  GGAACTACTG  TACTCTAAGT  120
121   CAGGAAGTCC  TGAGGCGCCC  AATAGTTGCC  TGTGAGCTTG  GCAGACTGTA  TAACAAAGAT  180
181   GCTGTCATCG  AGTTTCTGCT  GGACAAATCT  GCTGAGAAGG  CCCTAGGGAA  GGCCACCTCA  240
241   CACATTAGAA  GCATCAAGAA  TGTGACAGAG  CTCAAGCTGT  CTGACAACCC  TGCCTGGGAA  300
301   GGAGATAAAG  GGAACACCAA  GGGTGACAAG  CATGACGACC  TTCAGCGAGC  ACGGTTCATC  360
361   TGCCCTGTGG  TGGGCCTGGA  GATGAACGGC  CGGCACAGGT  TTTGCTTCCT  CCGATGCTGT  420
421   GGTTGTGTGT  TTTCTGAGCG  CGCCTTGAAG  GAGATAAAAG  CTGAAGTTTG  TCACACATGC  480
481   GGGGCTGCCT  TCCAGGAGGA  GGACATCATT  GTGCTCAATG  GCACCAAGGA  GGATGTGGAG  540
541   ATGCTGAAGA  GGAGGATGGA  AGAGAGGAGG  CTGCGGGCCA  AGCTGGAGAA  GAAAACAAAG  600
601   AAACCGAAGA  CAGCCGAGAG  TGCTTCAAAG  CTGGGCATCT  CACAAGACTC  TGCAGGGCCA  660
661   TCAAAGGCGA  AGGCGGGCAA  GTCTGAGGAG  GCGGACCCCG  ATCCTAGGGA  GAAGAAAAGC  720
721   TCCTTGGCGC  CCAGGGGCAC  AGCATCTAAT  GGCAGTGCTT  CTGGGAAAGT  TGGCAAGCCC  780
781   CCATGTGGGG  CCCTGAAGAG  ATCCATCGCA  GACAGTGAGG  AGTCTGAAAC  CTACAAGTCC  840
841   ATCTTCACAA  GCCACAGCTC  TGCCAAGCGC  TCCAAGGAGG  AGTCTGCCCA  CTGGGTCACC  900
901   CACACGTCCT  ACTGCTTCTA  A  921

▼ KEYWORD

ID
Family
Chromosome
Complete proteome
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Biological Process
Mitotic DNA replication termination
Biological Process
Site-specific DNA replication termination at RTS1 barrier

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-1836Mus musculus94.460.0 530
LLPS-Mea-1454Mesocricetus auratus90.21e-174 493
LLPS-Poa-1493Pongo abelii88.561e-179 506
LLPS-Aon-1589Aotus nancymaae87.912e-176 497
LLPS-Mup-1202Mustela putorius furo87.252e-174 492
LLPS-Chs-1674Chlorocebus sabaeus87.256e-176 496
LLPS-Aim-2467Ailuropoda melanoleuca86.971e-171 485
LLPS-Eqc-2474Equus caballus86.931e-177 501
LLPS-Otg-0302Otolemur garnettii86.932e-175 495
LLPS-Sus-0221Sus scrofa86.66e-175 494
LLPS-Ict-0579Ictidomys tridecemlineatus86.271e-172 488
LLPS-Urm-1564Ursus maritimus86.276e-171 483
LLPS-Loa-0234Loxodonta africana86.277e-175 493
LLPS-Caf-1643Canis familiaris85.953e-173 489
LLPS-Orc-3117Oryctolagus cuniculus85.952e-171 484
LLPS-Tut-0891Tursiops truncatus85.623e-175 494
LLPS-Ova-3825Ovis aries84.979e-167 473
LLPS-Bot-2103Bos taurus84.642e-167 474
LLPS-Dio-2905Dipodomys ordii84.312e-168 477
LLPS-Cap-1982Cavia porcellus83.128e-162 461
LLPS-Fec-0270Felis catus82.871e-166 473
LLPS-Mal-0785Mandrillus leucophaeus82.076e-172 487
LLPS-Maf-0130Macaca fascicularis81.962e-170 483
LLPS-Cea-3272Cercocebus atys81.762e-171 486
LLPS-Caj-1176Callithrix jacchus81.761e-169 481
LLPS-Rhb-0696Rhinopithecus bieti81.761e-171 486
LLPS-Man-2546Macaca nemestrina80.971e-169 481
LLPS-Mam-3164Macaca mulatta80.663e-169 480
LLPS-Hos-2214Homo sapiens80.362e-171 486
LLPS-Pat-2247Pan troglodytes80.369e-171 484
LLPS-Mod-2114Monodelphis domestica80.23e-149 431
LLPS-Gog-3504Gorilla gorilla80.121e-171 486
LLPS-Cas-3860Carlito syrichta80.063e-164 467
LLPS-Pap-2122Pan paniscus80.062e-170 483
LLPS-Nol-3981Nomascus leucogenys79.821e-169 481
LLPS-Paa-0913Papio anubis79.598e-168 477
LLPS-Myl-1250Myotis lucifugus79.554e-160 456
LLPS-Fud-3108Fukomys damarensis73.29e-154 439
LLPS-Tag-0562Taeniopygia guttata72.314e-134 390
LLPS-Pes-1381Pelodiscus sinensis71.755e-140 405
LLPS-Sah-1527Sarcophilus harrisii71.736e-147 424
LLPS-Anc-2735Anolis carolinensis70.93e-89 271
LLPS-Meg-1232Meleagris gallopavo70.681e-129 379
LLPS-Gaga-2686Gallus gallus69.711e-127 374
LLPS-Anp-3121Anas platyrhynchos68.643e-115 341
LLPS-Fia-0502Ficedula albicollis64.837e-109 326
LLPS-Xet-0795Xenopus tropicalis64.292e-108 324
LLPS-Leo-2322Lepisosteus oculatus61.596e-118 349
LLPS-Icp-1160Ictalurus punctatus60.711e-109 327
LLPS-Asm-0728Astyanax mexicanus60.393e-105 316
LLPS-Scf-1669Scleropages formosus58.99e-116 343
LLPS-Pof-1789Poecilia formosa57.984e-113 337
LLPS-Xim-2378Xiphophorus maculatus57.652e-115 343
LLPS-Scm-0466Scophthalmus maximus57.652e-109 326
LLPS-Dar-0328Danio rerio57.464e-108 324
LLPS-Orl-1090Oryzias latipes57.334e-109 326
LLPS-Orn-2057Oreochromis niloticus56.353e-107 321
LLPS-Tar-1943Takifugu rubripes55.051e-100 304
LLPS-Ora-2019Ornithorhynchus anatinus54.676e-76 241
LLPS-Lac-1159Latimeria chalumnae54.581e-100 303
LLPS-Gaa-2126Gasterosteus aculeatus52.926e-105 315
LLPS-Cii-1421Ciona intestinalis50.846e-57 192
LLPS-Mua-0514Musa acuminata50.04e-1370.1
LLPS-Cis-0693Ciona savignyi47.963e-25 105
LLPS-Abg-0860Absidia glauca44.261e-44 159
LLPS-Cae-0897Caenorhabditis elegans43.021e-44 159
LLPS-Viv-1520Vitis vinifera42.241e-33 132
LLPS-Hea-0604Helianthus annuus41.617e-32 127
LLPS-Miv-1123Microbotryum violaceum41.259e-30 120
LLPS-Orbr-1077Oryza brachyantha41.224e-25 107
LLPS-Brd-1731Brachypodium distachyon40.999e-27 112
LLPS-Orp-1164Oryza punctata40.992e-28 117
LLPS-Sei-1165Setaria italica40.372e-27 114
LLPS-Brn-1873Brassica napus40.372e-27 114
LLPS-Bro-2027Brassica oleracea40.372e-27 114
LLPS-Brr-0460Brassica rapa40.372e-27 114
LLPS-Phv-1295Phaseolus vulgaris40.375e-28 115
LLPS-Via-1193Vigna angularis39.757e-28 115
LLPS-Orgl-1125Oryza glumaepatula39.752e-26 111
LLPS-Sot-1590Solanum tuberosum39.754e-27 113
LLPS-Vir-0752Vigna radiata39.756e-28 115
LLPS-Glm-2736Glycine max39.759e-29 118
LLPS-Orb-1501Oryza barthii39.752e-26 111
LLPS-Ori-1890Oryza indica39.753e-26 110
LLPS-Orni-0804Oryza nivara39.753e-26 110
LLPS-Orr-0447Oryza rufipogon39.753e-26 110
LLPS-Org-1616Oryza glaberrima39.752e-26 111
LLPS-Zem-0499Zea mays39.753e-27 113
LLPS-Ors-1187Oryza sativa39.753e-26 110
LLPS-Drm-1830Drosophila melanogaster39.622e-55 188
LLPS-Chr-1065Chlamydomonas reinhardtii39.532e-22 100
LLPS-Met-1298Medicago truncatula39.491e-26 112
LLPS-Lep-0394Leersia perrieri39.131e-25 109
LLPS-Arl-0253Arabidopsis lyrata39.131e-26 112
LLPS-Sol-0714Solanum lycopersicum39.132e-26 111
LLPS-Orm-0306Oryza meridionalis39.138e-26 109
LLPS-Gor-1519Gossypium raimondii39.133e-26 110
LLPS-Art-2577Arabidopsis thaliana39.132e-26 111
LLPS-Pot-2355Populus trichocarpa39.138e-26 110
LLPS-Sob-0091Sorghum bicolor39.139e-27 112
LLPS-Nia-1171Nicotiana attenuata39.134e-28 116
LLPS-Cus-1394Cucumis sativus38.851e-27 114
LLPS-Crn-0920Cryptococcus neoformans38.821e-29 120
LLPS-Hov-1397Hordeum vulgare38.517e-25 106
LLPS-Tra-1714Triticum aestivum38.516e-26 108
LLPS-Thc-0895Theobroma cacao38.512e-27 114
LLPS-Tru-1150Triticum urartu38.517e-25 105
LLPS-Php-0935Physcomitrella patens37.892e-24 105
LLPS-Prp-1569Prunus persica37.892e-28 117
LLPS-Coc-2129Corchorus capsularis37.85e-1989.0
LLPS-Dac-0943Daucus carota37.274e-26 109
LLPS-Mae-1264Manihot esculenta37.274e-27 113
LLPS-Amt-1252Amborella trichopoda37.279e-28 115
LLPS-Scj-0532Schizosaccharomyces japonicus36.674e-27 110
LLPS-Tum-1308Tuber melanosporum35.336e-2091.7
LLPS-Sem-0812Selaginella moellendorffii35.274e-29 118
LLPS-Spr-0634Sporisorium reilianum35.21e-28 116
LLPS-Trr-0231Trichoderma reesei34.974e-2194.7
LLPS-Asc-0745Aspergillus clavatus34.742e-23 102
LLPS-Pyt-0885Pyrenophora teres34.542e-2093.2
LLPS-Fuv-0054Fusarium verticillioides34.433e-2092.0
LLPS-Scp-1020Schizosaccharomyces pombe34.077e-30 119
LLPS-Fuo-0782Fusarium oxysporum33.884e-2091.7
LLPS-Blg-0749Blumeria graminis33.686e-1680.1
LLPS-Aso-0260Aspergillus oryzae33.683e-2298.6
LLPS-Asf-1017Aspergillus flavus33.683e-2298.6
LLPS-Usm-0580Ustilago maydis33.511e-25 108
LLPS-Pytr-0356Pyrenophora triticirepentis33.511e-1990.9
LLPS-Gas-0822Galdieria sulphuraria33.03e-1886.3
LLPS-Lem-0117Leptosphaeria maculans32.822e-2196.7
LLPS-Ast-0138Aspergillus terreus32.812e-2196.3
LLPS-Trv-0972Trichoderma virens32.792e-1990.1
LLPS-Dos-0131Dothistroma septosporum32.623e-1989.4
LLPS-Pug-0265Puccinia graminis32.433e-2298.6
LLPS-Map-0928Magnaporthe poae32.424e-1268.9
LLPS-Asni-0302Aspergillus niger32.287e-23 100
LLPS-Osl-0778Ostreococcus lucimarinus31.947e-1165.9
LLPS-Nef-0804Neosartorya fischeri31.755e-23 101
LLPS-Yal-0445Yarrowia lipolytica31.722e-2297.8
LLPS-Mel-1170Melampsora laricipopulina31.698e-23 100
LLPS-Zyt-0297Zymoseptoria tritici30.815e-1782.8
LLPS-Scc-0929Schizosaccharomyces cryophilus30.776e-24 102
LLPS-Fus-0846Fusarium solani30.62e-1989.7
LLPS-Ved-0479Verticillium dahliae30.437e-1371.2
LLPS-Phn-0389Phaeosphaeria nodorum30.267e-1579.0
LLPS-Kop-1410Komagataella pastoris30.168e-1781.6
LLPS-Mao-1026Magnaporthe oryzae30.052e-1269.7
LLPS-Asfu-0980Aspergillus fumigatus29.83e-1784.0
LLPS-Gag-0875Gaeumannomyces graminis28.86e-1165.5
LLPS-Beb-0197Beauveria bassiana28.499e-1782.0
LLPS-Cogr-1151Colletotrichum graminicola28.279e-1268.2
LLPS-Coo-0706Colletotrichum orbiculare27.986e-1371.2
LLPS-Asg-0532Ashbya gossypii27.721e-1372.4