LLPS-Ran-1121
Tcea2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Transcription elongation factor A protein 2; Protein S-II-T1; Testis-specific S-II; Transcription elongation factor S-II protein 2; Transcription elongation factor TFIIS.l |
| Gene Name: | Tcea2, Siit1 |
| Ensembl Gene: | ENSRNOG00000016288.7 |
| Ensembl Protein: | ENSRNOP00000022073.5 |
| Organism: | Rattus norvegicus |
| Taxa ID: | 10116 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRNOT00000022073.7 | ENSRNOP00000022073.5 |
| UniProt | Q63799, TCEA2_RAT | |
| GeneBank | D12927 | BAA02310.1 |
| RefSeq | NM_057098.1 | NP_476439.1 |
| Entrez | 29575 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGKEEEIARI ARRLDKMVTR KNAEGAMDLL RELKNMPITL HLLQSTRVGM SVNALRKQSS 60 61 DEELIALAKS LIKSWKKLLD VSDGKSRDQG RGTPLPTSSS KDASGTTDLS CKKPDPPRTS 120 121 STPRITTFPQ VPITCDAVRN KCREMLTLAL QTDHDHVAVG VSCEHLSSQI EECIFLDVGN 180 181 TDMKYKNRVR SRISNLKDAK NPGLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK 240 241 EAIREHQMAR TGGTQTDLFT CNKCRKKNCT YTQVQTRSSD EPMTTYVVCN ECGNRWKFC 299 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGCAAGG AGGAGGAGAT TGCTCGTATC GCCCGGAGGC TGGACAAAAT GGTGACCAGG 60 61 AAGAACGCGG AGGGAGCCAT GGATTTGCTG CGGGAGCTGA AGAATATGCC TATTACATTG 120 121 CACTTGCTCC AGTCCACCCG TGTTGGGATG TCTGTCAACG CTCTGCGGAA GCAGAGTTCA 180 181 GACGAGGAGC TCATTGCACT TGCCAAGTCC CTCATCAAGT CCTGGAAGAA GCTCTTGGAT 240 241 GTTTCTGATG GCAAATCCAG GGATCAAGGG AGGGGCACAC CTTTGCCTAC ATCGTCCTCA 300 301 AAGGATGCCT CAGGGACTAC GGATCTCAGC TGCAAGAAAC CAGACCCACC TAGGACCTCA 360 361 TCCACTCCGA GGATCACCAC ATTTCCCCAA GTGCCCATCA CCTGTGATGC TGTGCGAAAC 420 421 AAATGTCGTG AGATGCTGAC TTTGGCCCTG CAAACTGACC ACGACCACGT GGCTGTTGGT 480 481 GTGAGCTGTG AGCATCTGTC ATCTCAGATC GAGGAGTGCA TCTTCCTGGA TGTGGGAAAC 540 541 ACTGACATGA AGTACAAGAA CCGTGTTCGG AGCCGAATCT CTAACCTGAA AGATGCCAAG 600 601 AACCCTGGCC TACGCCGGAA TGTGTTGTGT GGTGCCATTA CACCCCAGCA GATAGCTGTG 660 661 ATGACATCAG AGGAGATGGC CAGTGACGAG CTGAAGGAGA TCCGCAAGGC TATGACCAAG 720 721 GAGGCCATCC GAGAGCACCA GATGGCCCGT ACAGGTGGCA CACAGACCGA CCTGTTCACC 780 781 TGCAACAAGT GCAGGAAGAA GAACTGCACC TACACGCAGG TGCAGACCCG TAGCTCTGAT 840 841 GAGCCCATGA CCACCTATGT TGTCTGCAAT GAGTGTGGGA ATCGATGGAA GTTCTGCTGA 900 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | Zinc ion binding | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Transcription, DNA-templated |
▼ ANNOTATION
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | TISSUES | |||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-4550 | Mus musculus | 98.66 | 0.0 | 580 |
| LLPS-Mea-1279 | Mesocricetus auratus | 95.99 | 0.0 | 568 |
| LLPS-Gog-0442 | Gorilla gorilla | 88.96 | 0.0 | 525 |
| LLPS-Cap-1027 | Cavia porcellus | 88.96 | 0.0 | 525 |
| LLPS-Ict-4217 | Ictidomys tridecemlineatus | 88.96 | 0.0 | 528 |
| LLPS-Pap-1898 | Pan paniscus | 88.63 | 0.0 | 523 |
| LLPS-Pat-2762 | Pan troglodytes | 88.63 | 0.0 | 523 |
| LLPS-Hos-0593 | Homo sapiens | 88.63 | 0.0 | 523 |
| LLPS-Poa-0003 | Pongo abelii | 88.63 | 0.0 | 524 |
| LLPS-Dio-0324 | Dipodomys ordii | 88.29 | 0.0 | 520 |
| LLPS-Rhb-0132 | Rhinopithecus bieti | 87.97 | 7e-180 | 506 |
| LLPS-Chs-1291 | Chlorocebus sabaeus | 87.96 | 0.0 | 520 |
| LLPS-Paa-0761 | Papio anubis | 87.96 | 0.0 | 520 |
| LLPS-Cea-1028 | Cercocebus atys | 87.63 | 0.0 | 518 |
| LLPS-Maf-4359 | Macaca fascicularis | 87.63 | 0.0 | 518 |
| LLPS-Man-0694 | Macaca nemestrina | 87.63 | 0.0 | 518 |
| LLPS-Mam-0123 | Macaca mulatta | 87.63 | 0.0 | 518 |
| LLPS-Mal-0582 | Mandrillus leucophaeus | 87.55 | 3e-167 | 473 |
| LLPS-Bot-1162 | Bos taurus | 86.29 | 0.0 | 514 |
| LLPS-Fec-3517 | Felis catus | 86.29 | 0.0 | 514 |
| LLPS-Caj-0087 | Callithrix jacchus | 86.23 | 0.0 | 511 |
| LLPS-Urm-1545 | Ursus maritimus | 86.23 | 1e-165 | 473 |
| LLPS-Ova-3004 | Ovis aries | 85.99 | 5e-152 | 436 |
| LLPS-Caf-4492 | Canis familiaris | 85.77 | 3e-165 | 468 |
| LLPS-Sus-2938 | Sus scrofa | 85.62 | 0.0 | 509 |
| LLPS-Aim-2606 | Ailuropoda melanoleuca | 85.62 | 0.0 | 508 |
| LLPS-Fud-2719 | Fukomys damarensis | 85.56 | 9e-161 | 456 |
| LLPS-Ere-0802 | Erinaceus europaeus | 85.22 | 3e-67 | 212 |
| LLPS-Aon-2741 | Aotus nancymaae | 84.82 | 3e-173 | 496 |
| LLPS-Nol-0959 | Nomascus leucogenys | 80.94 | 8e-164 | 464 |
| LLPS-Sah-0474 | Sarcophilus harrisii | 80.67 | 5e-169 | 478 |
| LLPS-Mod-2002 | Monodelphis domestica | 80.07 | 4e-164 | 467 |
| LLPS-Ora-0365 | Ornithorhynchus anatinus | 79.03 | 3e-144 | 414 |
| LLPS-Gaga-3183 | Gallus gallus | 77.33 | 3e-160 | 456 |
| LLPS-Pes-2763 | Pelodiscus sinensis | 77.29 | 1e-141 | 407 |
| LLPS-Tag-1180 | Taeniopygia guttata | 77.26 | 4e-149 | 427 |
| LLPS-Meg-2300 | Meleagris gallopavo | 77.06 | 1e-144 | 416 |
| LLPS-Anc-1211 | Anolis carolinensis | 76.82 | 4e-159 | 453 |
| LLPS-Fia-1748 | Ficedula albicollis | 76.25 | 1e-156 | 447 |
| LLPS-Otg-3626 | Otolemur garnettii | 75.87 | 5e-177 | 500 |
| LLPS-Anp-1179 | Anas platyrhynchos | 73.24 | 5e-145 | 417 |
| LLPS-Leo-1663 | Lepisosteus oculatus | 69.77 | 3e-86 | 269 |
| LLPS-Tut-1703 | Tursiops truncatus | 69.46 | 1e-81 | 257 |
| LLPS-Eqc-4671 | Equus caballus | 68.54 | 5e-108 | 330 |
| LLPS-Xim-3705 | Xiphophorus maculatus | 68.07 | 6e-77 | 254 |
| LLPS-Dar-2021 | Danio rerio | 68.07 | 7e-78 | 249 |
| LLPS-Mup-2530 | Mustela putorius furo | 67.66 | 6e-78 | 248 |
| LLPS-Orl-1632 | Oryzias latipes | 67.47 | 4e-76 | 253 |
| LLPS-Pof-1125 | Poecilia formosa | 67.47 | 8e-78 | 253 |
| LLPS-Asm-2747 | Astyanax mexicanus | 67.07 | 2e-76 | 252 |
| LLPS-Orn-3531 | Oreochromis niloticus | 66.87 | 4e-78 | 250 |
| LLPS-Icp-3049 | Ictalurus punctatus | 66.67 | 5e-73 | 236 |
| LLPS-Tar-2809 | Takifugu rubripes | 66.27 | 5e-78 | 249 |
| LLPS-Scm-0877 | Scophthalmus maximus | 65.66 | 1e-74 | 246 |
| LLPS-Gaa-1010 | Gasterosteus aculeatus | 65.06 | 1e-74 | 241 |
| LLPS-Ten-0008 | Tetraodon nigroviridis | 64.74 | 5e-76 | 244 |
| LLPS-Myl-0359 | Myotis lucifugus | 62.67 | 3e-132 | 385 |
| LLPS-Orc-0722 | Oryctolagus cuniculus | 62.12 | 9e-108 | 321 |
| LLPS-Scf-0743 | Scleropages formosus | 61.89 | 1e-126 | 371 |
| LLPS-Lac-3993 | Latimeria chalumnae | 61.68 | 9e-105 | 316 |
| LLPS-Xet-2056 | Xenopus tropicalis | 59.8 | 1e-125 | 368 |
| LLPS-Cas-0838 | Carlito syrichta | 56.67 | 4e-111 | 330 |
| LLPS-Loa-4422 | Loxodonta africana | 50.14 | 4e-110 | 330 |
| LLPS-Cii-1767 | Ciona intestinalis | 46.33 | 9e-90 | 276 |
| LLPS-Cis-1183 | Ciona savignyi | 46.08 | 4e-88 | 273 |
| LLPS-Drm-1208 | Drosophila melanogaster | 45.87 | 3e-88 | 273 |
| LLPS-Cae-2038 | Caenorhabditis elegans | 42.55 | 5e-65 | 213 |
| LLPS-Sol-0018 | Solanum lycopersicum | 41.86 | 5e-34 | 132 |
| LLPS-Sot-0746 | Solanum tuberosum | 41.86 | 5e-34 | 132 |
| LLPS-Osl-0589 | Ostreococcus lucimarinus | 41.86 | 8e-32 | 122 |
| LLPS-Nia-1482 | Nicotiana attenuata | 41.71 | 8e-35 | 135 |
| LLPS-Vir-0808 | Vigna radiata | 41.52 | 4e-35 | 135 |
| LLPS-Phv-1851 | Phaseolus vulgaris | 41.52 | 7e-35 | 135 |
| LLPS-Gas-0096 | Galdieria sulphuraria | 41.32 | 2e-31 | 122 |
| LLPS-Glm-1623 | Glycine max | 40.94 | 3e-33 | 130 |
| LLPS-Via-0527 | Vigna angularis | 40.94 | 9e-35 | 134 |
| LLPS-Mao-0017 | Magnaporthe oryzae | 40.15 | 2e-26 | 110 |
| LLPS-Gor-1174 | Gossypium raimondii | 39.77 | 2e-33 | 131 |
| LLPS-Prp-1723 | Prunus persica | 39.77 | 5e-30 | 122 |
| LLPS-Dac-1525 | Daucus carota | 39.18 | 1e-33 | 132 |
| LLPS-Arl-1562 | Arabidopsis lyrata | 39.18 | 6e-33 | 130 |
| LLPS-Pot-1216 | Populus trichocarpa | 39.18 | 6e-33 | 129 |
| LLPS-Ori-1787 | Oryza indica | 39.13 | 2e-27 | 114 |
| LLPS-Orgl-1633 | Oryza glumaepatula | 39.13 | 1e-27 | 114 |
| LLPS-Ors-0126 | Oryza sativa | 39.13 | 1e-27 | 114 |
| LLPS-Orm-1950 | Oryza meridionalis | 39.13 | 2e-27 | 114 |
| LLPS-Mua-1833 | Musa acuminata | 38.8 | 9e-30 | 120 |
| LLPS-Hea-1986 | Helianthus annuus | 38.6 | 1e-29 | 120 |
| LLPS-Art-0040 | Arabidopsis thaliana | 38.6 | 1e-32 | 129 |
| LLPS-Orp-0564 | Oryza punctata | 38.51 | 6e-27 | 112 |
| LLPS-Thc-0219 | Theobroma cacao | 38.01 | 1e-31 | 125 |
| LLPS-Brr-2738 | Brassica rapa | 38.01 | 3e-32 | 127 |
| LLPS-Bro-2414 | Brassica oleracea | 38.01 | 5e-32 | 127 |
| LLPS-Php-0034 | Physcomitrella patens | 37.43 | 2e-30 | 122 |
| LLPS-Viv-0854 | Vitis vinifera | 37.14 | 2e-29 | 119 |
| LLPS-Cus-0166 | Cucumis sativus | 37.08 | 4e-29 | 119 |
| LLPS-Chc-0856 | Chondrus crispus | 37.06 | 1e-30 | 120 |
| LLPS-Miv-0763 | Microbotryum violaceum | 36.81 | 1e-27 | 114 |
| LLPS-Brd-2501 | Brachypodium distachyon | 35.96 | 1e-26 | 112 |
| LLPS-Yal-0360 | Yarrowia lipolytica | 35.6 | 4e-41 | 150 |
| LLPS-Scc-1070 | Schizosaccharomyces cryophilus | 35.33 | 3e-43 | 156 |
| LLPS-Hov-1780 | Hordeum vulgare | 34.83 | 2e-26 | 111 |
| LLPS-Sob-0010 | Sorghum bicolor | 34.83 | 2e-26 | 111 |
| LLPS-Scp-0229 | Schizosaccharomyces pombe | 34.72 | 2e-43 | 156 |
| LLPS-Kop-1212 | Komagataella pastoris | 34.48 | 1e-34 | 132 |
| LLPS-Scj-1291 | Schizosaccharomyces japonicus | 33.67 | 2e-42 | 154 |
| LLPS-Brn-3128 | Brassica napus | 33.0 | 5e-43 | 156 |
| LLPS-Trv-0800 | Trichoderma virens | 32.87 | 4e-32 | 126 |
| LLPS-Sem-2158 | Selaginella moellendorffii | 32.75 | 5e-37 | 139 |
| LLPS-Cog-1407 | Colletotrichum gloeosporioides | 32.61 | 3e-31 | 124 |
| LLPS-Coo-1457 | Colletotrichum orbiculare | 32.35 | 8e-34 | 130 |
| LLPS-Chr-1357 | Chlamydomonas reinhardtii | 31.56 | 9e-39 | 145 |
| LLPS-Coc-0507 | Corchorus capsularis | 31.42 | 4e-34 | 132 |
| LLPS-Abg-1777 | Absidia glauca | 31.19 | 2e-37 | 141 |
| LLPS-Lem-0719 | Leptosphaeria maculans | 30.9 | 1e-33 | 130 |
| LLPS-Cogr-1656 | Colletotrichum graminicola | 30.77 | 2e-32 | 127 |
| LLPS-Fus-1193 | Fusarium solani | 30.49 | 3e-28 | 115 |
| LLPS-Usm-0925 | Ustilago maydis | 30.48 | 6e-39 | 145 |
| LLPS-Mae-1063 | Manihot esculenta | 30.42 | 2e-33 | 130 |
| LLPS-Amt-1541 | Amborella trichopoda | 30.34 | 3e-34 | 133 |
| LLPS-Met-1496 | Medicago truncatula | 30.33 | 7e-35 | 135 |
| LLPS-Pyt-0967 | Pyrenophora teres | 30.0 | 4e-33 | 129 |
| LLPS-Asni-0651 | Aspergillus niger | 29.89 | 1e-27 | 113 |
| LLPS-Asc-0610 | Aspergillus clavatus | 29.84 | 3e-28 | 115 |
| LLPS-Fuv-0629 | Fusarium verticillioides | 29.33 | 7e-27 | 112 |
| LLPS-Pytr-1628 | Pyrenophora triticirepentis | 29.24 | 1e-32 | 127 |
| LLPS-Asfu-1038 | Aspergillus fumigatus | 29.24 | 9e-28 | 114 |
| LLPS-Sac-1478 | Saccharomyces cerevisiae | 28.81 | 7e-28 | 114 |
| LLPS-Phn-1460 | Phaeosphaeria nodorum | 28.81 | 9e-34 | 130 |
| LLPS-Nef-0569 | Neosartorya fischeri | 28.29 | 2e-26 | 110 |
| LLPS-Spr-1348 | Sporisorium reilianum | 28.25 | 3e-34 | 132 |
| LLPS-Dos-1369 | Dothistroma septosporum | 28.18 | 1e-28 | 117 |
| LLPS-Aso-0973 | Aspergillus oryzae | 28.01 | 3e-27 | 112 |
| LLPS-Asf-1148 | Aspergillus flavus | 28.01 | 3e-27 | 112 |
| LLPS-Scs-0361 | Sclerotinia sclerotiorum | 27.06 | 1e-28 | 116 |