LLPS-Ran-1013
Jtb

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein JTB
Gene Name: Jtb
Ensembl Gene: ENSRNOG00000016379.7
Ensembl Protein: ENSRNOP00000060227.1
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLVGAGRRGL  PRGGHLCWLL  CAFTLKLCEA  EAPVREEKLS  VSTSTSPCWL  VEEFVVTEEC  60
61    TPCSNFQIKT  TPECGSTGYV  EKITCSSSKR  NEFKSCRSAL  LEQHLFWKFE  GIVVGVALVF  120
121   ACLVIIRQRQ  LDRKALEKVR  KQIESI  146
Nucleotide CDS Sequence (FASTA)
1     ATGCTCGTGG  GCGCGGGGAG  GCGTGGCCTC  CCCCGGGGCG  GCCACCTCTG  TTGGTTGCTG  60
61    TGCGCTTTCA  CCTTAAAGCT  CTGCGAAGCA  GAGGCCCCGG  TGCGCGAGGA  GAAGCTATCA  120
121   GTGAGCACAT  CAACTTCACC  ATGTTGGTTG  GTAGAAGAGT  TTGTGGTGAC  CGAAGAGTGT  180
181   ACTCCGTGTT  CTAACTTCCA  GATTAAAACG  ACACCTGAGT  GTGGTTCTAC  AGGGTATGTG  240
241   GAGAAAATCA  CATGCAGCTC  ATCTAAGAGG  AATGAATTCA  AAAGCTGCCG  TTCAGCTCTT  300
301   CTGGAACAAC  ACTTATTTTG  GAAGTTTGAA  GGCATCGTGG  TGGGGGTAGC  TTTAGTCTTC  360
361   GCTTGCCTTG  TCATCATTCG  TCAGCGACAG  CTGGACAGAA  AGGCTCTTGA  AAAAGTCCGG  420
421   AAGCAAATTG  AATCCATATA  G  441

▼ KEYWORD

ID
Family
Apoptosis
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Membrane
Mitochondrion
Mitosis
Reference proteome
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Integral component of membrane
Cellular Component
Microtubule organizing center
Cellular Component
Midbody
Cellular Component
Mitochondrion
Cellular Component
Spindle
Molecular Function
Protein kinase binding
Biological Process
Apoptotic mitochondrial changes
Biological Process
Mitotic cell cycle
Biological Process
Mitotic cytokinesis
Biological Process
Positive regulation of protein kinase activity
Biological Process
Regulation of cell population proliferation

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINIIDMIST
Physicochemical
Compute pI/MwAAindex
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4766Mus musculus95.895e-91 268
LLPS-Urm-1338Ursus maritimus89.787e-86 254
LLPS-Sus-3609Sus scrofa89.738e-91 267
LLPS-Ova-1618Ovis aries89.313e-80 240
LLPS-Fec-4025Felis catus89.045e-91 268
LLPS-Aim-3795Ailuropoda melanoleuca89.042e-86 256
LLPS-Tut-2186Tursiops truncatus88.365e-91 268
LLPS-Dio-0489Dipodomys ordii87.882e-75 228
LLPS-Eqc-2659Equus caballus87.674e-88 260
LLPS-Bot-2757Bos taurus87.678e-90 265
LLPS-Pap-3656Pan paniscus86.991e-87 259
LLPS-Pat-4747Pan troglodytes86.991e-87 259
LLPS-Hos-2707Homo sapiens86.991e-87 259
LLPS-Poa-2812Pongo abelii86.993e-87 258
LLPS-Gog-3437Gorilla gorilla86.991e-87 259
LLPS-Myl-4068Myotis lucifugus86.992e-86 256
LLPS-Man-2373Macaca nemestrina86.37e-87 257
LLPS-Chs-3655Chlorocebus sabaeus86.37e-87 257
LLPS-Cea-3023Cercocebus atys86.37e-87 257
LLPS-Aon-1974Aotus nancymaae86.34e-86 255
LLPS-Paa-2908Papio anubis86.37e-87 257
LLPS-Mal-1637Mandrillus leucophaeus86.37e-87 257
LLPS-Rhb-4617Rhinopithecus bieti85.622e-86 256
LLPS-Orc-4217Oryctolagus cuniculus85.623e-83 248
LLPS-Ict-3262Ictidomys tridecemlineatus85.623e-84 251
LLPS-Nol-3277Nomascus leucogenys85.621e-86 256
LLPS-Mam-3530Macaca mulatta85.624e-86 255
LLPS-Caj-4848Callithrix jacchus85.622e-84 251
LLPS-Maf-2116Macaca fascicularis85.624e-86 255
LLPS-Fud-2681Fukomys damarensis84.41e-81 244
LLPS-Loa-1359Loxodonta africana81.518e-80 239
LLPS-Cap-0346Cavia porcellus80.821e-80 241
LLPS-Cas-2593Carlito syrichta78.082e-65 202
LLPS-Mod-3065Monodelphis domestica77.064e-47 155
LLPS-Mea-4261Mesocricetus auratus69.865e-60 188
LLPS-Tag-0288Taeniopygia guttata64.01e-34 122
LLPS-Icp-3820Ictalurus punctatus60.717e-41 140
LLPS-Scf-2370Scleropages formosus60.349e-42 142
LLPS-Lac-2532Latimeria chalumnae59.828e-40 137
LLPS-Orl-1488Oryzias latipes58.262e-43 147
LLPS-Gaga-3223Gallus gallus57.784e-2495.5
LLPS-Pof-2703Poecilia formosa57.663e-40 138
LLPS-Fia-2682Ficedula albicollis57.06e-28 105
LLPS-Xim-3665Xiphophorus maculatus56.765e-39 135
LLPS-Asm-2777Astyanax mexicanus56.036e-42 142
LLPS-Tar-2946Takifugu rubripes53.336e-34 122
LLPS-Gaa-1012Gasterosteus aculeatus53.153e-36 130
LLPS-Scm-2251Scophthalmus maximus52.594e-38 133
LLPS-Leo-3722Lepisosteus oculatus49.666e-39 135
LLPS-Dar-2284Danio rerio46.975e-1469.7
LLPS-Cii-1371Ciona intestinalis33.023e-1572.8
LLPS-Cis-1791Ciona savignyi33.01e-1368.2
LLPS-Drm-1628Drosophila melanogaster29.057e-1160.8