LLPS-Ran-0986
Casp3

▼ OVERVIEW

Status: Unreviewed
Protein Name: Caspase-3
Gene Name: Casp3, Cpp32
Ensembl Gene: ENSRNOG00000010475.5
Ensembl Protein: ENSRNOP00000014096.3
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDNNETSVDS  KSINNFETKT  IHGSKSMDSG  IYLDSSYKMD  YPEMGLCIII  NNKNFHKSTG  60
61    MSARNGTDVD  AANLRETFMA  LKYEVRNKND  LTREEIMELM  DSVSKEDHSK  RSSFVCVILS  120
121   HGDEGVIFGT  NGPVDLKKLT  SFFRGDYCRS  LTGKPKLFII  QACRGTELDC  GIETDSGTDD  180
181   DMACQKIPVE  ADFLYAYSTA  PGYYSWRNSR  DGSWFIQSLC  AMLKLYAHKL  EFMHILTRVN  240
241   RKVATEFESF  SLDATFHAKK  QIPCIVSMLT  KELYFYH  277
Nucleotide CDS Sequence (FASTA)
1     ATGGACAACA  ACGAAACCTC  CGTGGATTCA  AAATCCATTA  ATAATTTTGA  AACAAAGACT  60
61    ATCCATGGAA  GCAAGTCGAT  GGACTCTGGA  ATATATCTGG  ACAGCAGTTA  CAAAATGGAT  120
121   TACCCTGAAA  TGGGCTTGTG  TATAATAATT  AATAATAAGA  ACTTCCATAA  AAGCACTGGA  180
181   ATGTCAGCTC  GCAATGGTAC  CGATGTCGAT  GCAGCTAACC  TCAGAGAGAC  ATTCATGGCC  240
241   CTGAAATACG  AAGTCAGGAA  TAAAAATGAC  CTTACTCGTG  AAGAAATTAT  GGAATTGATG  300
301   GATAGTGTTT  CTAAGGAAGA  TCACAGCAAA  AGGAGCAGTT  TTGTGTGTGT  GATTCTAAGT  360
361   CATGGAGATG  AAGGAGTAAT  TTTTGGAACG  AACGGACCTG  TGGACCTGAA  AAAACTAACT  420
421   AGTTTCTTCA  GAGGCGACTA  CTGCCGGAGT  CTGACTGGAA  AGCCGAAACT  CTTCATCATT  480
481   CAGGCCTGCC  GAGGTACAGA  GCTGGACTGC  GGTATTGAGA  CAGACAGTGG  AACTGACGAT  540
541   GATATGGCAT  GCCAGAAGAT  ACCAGTGGAG  GCCGACTTCC  TGTATGCTTA  CTCTACCGCA  600
601   CCCGGTTACT  ATTCCTGGAG  AAATTCAAGG  GACGGGTCAT  GGTTCATCCA  GTCACTTTGC  660
661   GCCATGCTGA  AACTGTACGC  GCACAAGCTG  GAATTCATGC  ACATCCTCAC  TCGTGTTAAC  720
721   CGGAAGGTGG  CCACGGAATT  TGAGTCCTTC  TCCCTGGACG  CCACTTTCCA  TGCAAAGAAA  780
781   CAGATCCCGT  GTATTGTGTC  AATGCTCACA  AAAGAACTGT  ACTTTTATCA  CTAA  834

▼ KEYWORD

ID
Family
Acetylation
Apoptosis
Complete proteome
Cytoplasm
Hydrolase
Phosphoprotein
Protease
Reference proteome
S-nitrosylation
Thiol protease
Zymogen

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Death-inducing signaling complex
Cellular Component
Membrane raft
Cellular Component
Neuronal cell body
Cellular Component
Nucleus
Molecular Function
Aspartic-type endopeptidase activity
Molecular Function
Cyclin-dependent protein serine/threonine kinase inhibitor activity
Molecular Function
Cysteine-type endopeptidase activity involved in apoptotic process
Molecular Function
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Molecular Function
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
Molecular Function
Cysteine-type peptidase activity
Molecular Function
Death receptor binding
Molecular Function
Phospholipase A2 activator activity
Molecular Function
Protease binding
Molecular Function
Protein-containing complex binding
Biological Process
Apoptotic process
Biological Process
Axonal fasciculation
Biological Process
B cell homeostasis
Biological Process
Cell fate commitment
Biological Process
Cellular response to DNA damage stimulus
Biological Process
Cellular response to organic cyclic compound
Biological Process
Cellular response to staurosporine
Biological Process
Erythrocyte differentiation
Biological Process
Glial cell apoptotic process
Biological Process
Heart development
Biological Process
Hippocampus development
Biological Process
Intracellular signal transduction
Biological Process
Intrinsic apoptotic signaling pathway in response to osmotic stress
Biological Process
Keratinocyte differentiation
Biological Process
Learning or memory
Biological Process
Leukocyte apoptotic process
Biological Process
Luteolysis
Biological Process
Negative regulation of activated T cell proliferation
Biological Process
Negative regulation of apoptotic process
Biological Process
Negative regulation of B cell proliferation
Biological Process
Neuron apoptotic process
Biological Process
Neuron differentiation
Biological Process
Neurotrophin TRK receptor signaling pathway
Biological Process
Positive regulation of amyloid-beta formation
Biological Process
Positive regulation of apoptotic process
Biological Process
Positive regulation of neuron apoptotic process
Biological Process
Protein processing
Biological Process
Proteolysis
Biological Process
Regulation of protein stability
Biological Process
Response to amino acid
Biological Process
Response to antibiotic
Biological Process
Response to cobalt ion
Biological Process
Response to drug
Biological Process
Response to estradiol
Biological Process
Response to glucocorticoid
Biological Process
Response to glucose
Biological Process
Response to hydrogen peroxide
Biological Process
Response to hypoxia
Biological Process
Response to lipopolysaccharide
Biological Process
Response to metal ion
Biological Process
Response to nicotine
Biological Process
Response to organic cyclic compound
Biological Process
Response to organic substance
Biological Process
Response to UV
Biological Process
Response to X-ray
Biological Process
Sensory perception of sound
Biological Process
Striated muscle cell differentiation
Biological Process
T cell homeostasis
Biological Process
Wound healing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4843Mus musculus93.50.0 555
LLPS-Ict-2978Ictidomys tridecemlineatus90.940.0 533
LLPS-Orc-0649Oryctolagus cuniculus90.290.0 526
LLPS-Cas-1656Carlito syrichta90.250.0 530
LLPS-Caj-2526Callithrix jacchus89.890.0 525
LLPS-Otg-2173Otolemur garnettii89.890.0 528
LLPS-Nol-2059Nomascus leucogenys89.530.0 525
LLPS-Gog-1057Gorilla gorilla89.170.0 523
LLPS-Pap-2827Pan paniscus89.170.0 522
LLPS-Pat-1815Pan troglodytes89.170.0 523
LLPS-Hos-1700Homo sapiens89.170.0 522
LLPS-Poa-0772Pongo abelii89.170.0 524
LLPS-Chs-2739Chlorocebus sabaeus88.810.0 521
LLPS-Maf-4410Macaca fascicularis88.810.0 521
LLPS-Cea-4668Cercocebus atys88.810.0 522
LLPS-Fud-2158Fukomys damarensis88.810.0 523
LLPS-Aim-2718Ailuropoda melanoleuca88.810.0 528
LLPS-Mal-1671Mandrillus leucophaeus88.810.0 523
LLPS-Paa-2934Papio anubis88.810.0 521
LLPS-Urm-2023Ursus maritimus88.810.0 529
LLPS-Aon-1334Aotus nancymaae88.450.0 515
LLPS-Myl-3618Myotis lucifugus88.450.0 518
LLPS-Mup-2548Mustela putorius furo88.090.0 522
LLPS-Caf-3451Canis familiaris88.090.0 523
LLPS-Fec-2347Felis catus87.360.0 525
LLPS-Sus-2676Sus scrofa87.00.0 509
LLPS-Dio-4251Dipodomys ordii86.640.0 509
LLPS-Man-0924Macaca nemestrina86.644e-180 504
LLPS-Eqc-2771Equus caballus86.640.0 509
LLPS-Cap-1217Cavia porcellus83.335e-94 281
LLPS-Ova-0466Ovis aries83.275e-175 491
LLPS-Bot-2452Bos taurus82.913e-175 492
LLPS-Loa-3892Loxodonta africana82.553e-170 479
LLPS-Mam-4027Macaca mulatta81.152e-148 423
LLPS-Rhb-1721Rhinopithecus bieti78.73e-154 438
LLPS-Sah-0711Sarcophilus harrisii78.621e-158 450
LLPS-Mod-3955Monodelphis domestica78.344e-162 459
LLPS-Mea-0943Mesocricetus auratus76.171e-147 421
LLPS-Ora-0069Ornithorhynchus anatinus72.162e-144 414
LLPS-Tag-1031Taeniopygia guttata72.017e-139 400
LLPS-Fia-3511Ficedula albicollis70.521e-136 394
LLPS-Meg-3043Meleagris gallopavo69.662e-135 392
LLPS-Icp-2322Ictalurus punctatus68.25e-115 340
LLPS-Anp-2579Anas platyrhynchos67.656e-134 387
LLPS-Gaga-1105Gallus gallus67.42e-133 386
LLPS-Scf-3633Scleropages formosus66.953e-114 338
LLPS-Orn-1537Oreochromis niloticus66.116e-113 334
LLPS-Pes-0493Pelodiscus sinensis65.949e-129 374
LLPS-Scm-3036Scophthalmus maximus65.691e-111 330
LLPS-Ten-1210Tetraodon nigroviridis65.691e-112 333
LLPS-Tar-2987Takifugu rubripes65.273e-111 330
LLPS-Orl-2100Oryzias latipes65.07e-112 331
LLPS-Asm-0496Astyanax mexicanus64.852e-110 328
LLPS-Xet-2042Xenopus tropicalis64.851e-114 339
LLPS-Pof-4087Poecilia formosa64.443e-111 330
LLPS-Xim-2928Xiphophorus maculatus63.63e-111 330
LLPS-Gaa-1748Gasterosteus aculeatus62.347e-107 318
LLPS-Lac-3647Latimeria chalumnae62.249e-109 323
LLPS-Dar-2920Danio rerio62.146e-107 319
LLPS-Cis-1311Ciona savignyi43.34e-68 219
LLPS-Cae-1526Caenorhabditis elegans33.728e-37 141
LLPS-Leo-1996Lepisosteus oculatus31.39e-34 132
LLPS-Cii-1485Ciona intestinalis30.744e-31 124
LLPS-Anc-4010Anolis carolinensis29.961e-31 126
LLPS-Ere-0331Erinaceus europaeus27.852e-25 108