LLPS-Ran-0891
Rfc2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Replication factor C subunit 2; Activator 1 subunit C2
Gene Name: Rfc2
Ensembl Gene: ENSRNOG00000001457.5
Ensembl Protein: ENSRNOP00000001989.3
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSRNOT00000001989.4ENSRNOP00000001989.3
UniProtQ641W4, RFC2_RAT
GeneBankBC082110AAH82110.1
RefSeqNM_053786.1NP_446238.1
Entrez116468

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEVQESGSGS  AESGTQEPSP  VPSKTTGHYE  LPWVEKYRPV  KLNEIVGNED  TVSRLEVFAR  60
61    EGNVPNIIIA  GPPGTGKTTS  ILCLARALLG  PALKDAVLEL  NASNDRGIDV  VRNKIKMFAQ  120
121   QKVTLPKGRH  KIIILDEADS  MTDGAQQALR  RTMEIYSKTT  RFALACNASD  KIIEPIQSRC  180
181   AVLRYTKLTD  AQVLSRLMNV  IEKEKVPYTD  DGLEAIIFTA  QGDMRQALNN  LQSTFSGFGY  240
241   INSENVFKVC  DEPHPLLVKE  MIQHCVDANI  DEAYKILAHL  WHLGYSPEDV  IGNIFRVCKT  300
301   FPMAEYLKLE  FIKEIGYTHM  KVAEGVNSLL  QMAGLLARLC  QKTMAPVAS  349
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGTTC  AGGAGAGCGG  CAGTGGCTCG  GCTGAGAGTG  GGACGCAGGA  GCCCTCGCCT  60
61    GTCCCCAGCA  AGACCACCGG  CCACTACGAG  CTGCCGTGGG  TTGAAAAATA  CAGACCAGTG  120
121   AAGCTCAATG  AAATAGTGGG  AAACGAAGAC  ACTGTGAGCA  GGCTGGAGGT  CTTTGCAAGA  180
181   GAAGGCAATG  TACCCAATAT  CATCATCGCT  GGCCCTCCAG  GAACTGGCAA  GACAACCAGC  240
241   ATCCTCTGCT  TGGCGAGAGC  GCTGCTGGGC  CCGGCCCTGA  AGGATGCAGT  TCTGGAACTC  300
301   AATGCGTCCA  ACGACAGGGG  CATCGATGTG  GTAAGGAATA  AAATCAAAAT  GTTCGCCCAG  360
361   CAGAAAGTCA  CCCTTCCCAA  GGGCCGACAC  AAGATCATCA  TTCTGGATGA  GGCAGACAGC  420
421   ATGACGGATG  GTGCCCAGCA  GGCCCTCAGG  AGAACCATGG  AAATCTACTC  CAAAACGACT  480
481   CGCTTCGCTC  TGGCTTGTAA  TGCTTCAGAC  AAAATCATAG  AGCCCATCCA  GTCCCGCTGT  540
541   GCGGTGCTCC  GCTACACCAA  GCTCACCGAT  GCACAGGTCC  TCAGCAGGCT  CATGAATGTC  600
601   ATCGAGAAGG  AAAAAGTGCC  ATACACAGAT  GACGGCCTGG  AAGCCATCAT  TTTCACAGCC  660
661   CAGGGAGACA  TGCGCCAGGC  TCTGAACAAC  TTGCAGTCCA  CCTTCTCAGG  ATTTGGCTAT  720
721   ATCAACAGCG  AGAATGTATT  CAAGGTCTGT  GACGAGCCCC  ACCCCCTGCT  GGTGAAGGAG  780
781   ATGATCCAGC  ACTGTGTGGA  CGCCAACATT  GATGAGGCCT  ATAAGATTCT  TGCTCACCTG  840
841   TGGCACCTGG  GCTACTCGCC  AGAAGATGTC  ATCGGCAATA  TTTTCCGTGT  GTGTAAAACC  900
901   TTCCCAATGG  CTGAATACTT  GAAACTGGAG  TTCATCAAGG  AGATTGGATA  CACCCACATG  960
961   AAAGTGGCCG  AAGGAGTGAA  CTCCCTGCTG  CAGATGGCCG  GGCTCCTGGC  CAGGCTGTGT  1020
1021  CAGAAGACCA  TGGCTCCGGT  GGCCAGCTGA  1050

▼ KEYWORD

ID
Family
Acetylation
ATP-binding
Complete proteome
DNA replication
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Ctf18 RFC-like complex
Cellular Component
DNA replication factor C complex
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
DNA clamp loader activity
Molecular Function
Enzyme binding
Molecular Function
Single-stranded DNA-dependent ATPase activity
Biological Process
DNA-dependent DNA replication
Biological Process
Positive regulation of DNA-directed DNA polymerase activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4072Mus musculus97.710.0 712
LLPS-Ova-1261Ovis aries95.890.0 637
LLPS-Fud-0325Fukomys damarensis94.620.0 634
LLPS-Ora-0167Ornithorhynchus anatinus94.30.0 628
LLPS-Myl-3141Myotis lucifugus94.030.0 694
LLPS-Ict-1428Ictidomys tridecemlineatus93.770.0 625
LLPS-Sah-0820Sarcophilus harrisii93.670.0 621
LLPS-Tag-1407Taeniopygia guttata93.350.0 622
LLPS-Meg-2089Meleagris gallopavo93.190.0 640
LLPS-Loa-3346Loxodonta africana93.130.0 652
LLPS-Gaga-0725Gallus gallus92.90.0 640
LLPS-Sus-4587Sus scrofa92.90.0 684
LLPS-Anc-0489Anolis carolinensis92.770.0 620
LLPS-Urm-1558Ursus maritimus92.613e-119 355
LLPS-Mam-4576Macaca mulatta92.330.0 678
LLPS-Cea-2037Cercocebus atys92.330.0 678
LLPS-Maf-1881Macaca fascicularis92.330.0 678
LLPS-Paa-0091Papio anubis92.330.0 678
LLPS-Mal-3693Mandrillus leucophaeus92.330.0 678
LLPS-Otg-1149Otolemur garnettii92.070.0 668
LLPS-Rhb-3519Rhinopithecus bieti92.050.0 677
LLPS-Caf-1833Canis familiaris92.050.0 682
LLPS-Eqc-3216Equus caballus92.050.0 678
LLPS-Cap-2881Cavia porcellus91.760.0 680
LLPS-Bot-1987Bos taurus91.760.0 677
LLPS-Hos-1573Homo sapiens91.530.0 675
LLPS-Cas-0748Carlito syrichta91.480.0 672
LLPS-Aon-3615Aotus nancymaae91.480.0 676
LLPS-Caj-3482Callithrix jacchus91.480.0 676
LLPS-Pat-4350Pan troglodytes91.240.0 676
LLPS-Fec-3746Felis catus91.190.0 674
LLPS-Mup-1020Mustela putorius furo91.190.0 679
LLPS-Gog-0623Gorilla gorilla90.960.0 674
LLPS-Orc-2947Oryctolagus cuniculus90.70.0 657
LLPS-Pes-0422Pelodiscus sinensis89.460.0 618
LLPS-Orn-2017Oreochromis niloticus88.160.0 601
LLPS-Icp-1381Ictalurus punctatus87.690.0 605
LLPS-Anp-1933Anas platyrhynchos87.640.0 631
LLPS-Chs-1753Chlorocebus sabaeus87.250.0 630
LLPS-Scm-3267Scophthalmus maximus87.230.0 593
LLPS-Fia-1399Ficedula albicollis86.820.0 628
LLPS-Lac-0455Latimeria chalumnae86.00.0 622
LLPS-Scf-2699Scleropages formosus85.280.0 574
LLPS-Aim-1210Ailuropoda melanoleuca84.750.0 620
LLPS-Dar-0574Danio rerio83.950.0 611
LLPS-Man-2684Macaca nemestrina83.810.0 595
LLPS-Tar-1513Takifugu rubripes83.480.0 599
LLPS-Leo-2170Lepisosteus oculatus83.290.0 600
LLPS-Orl-2993Oryzias latipes82.620.0 602
LLPS-Asm-1278Astyanax mexicanus82.540.0 545
LLPS-Ten-0397Tetraodon nigroviridis82.10.0 608
LLPS-Pof-1414Poecilia formosa81.980.0 593
LLPS-Xim-2813Xiphophorus maculatus81.980.0 593
LLPS-Pap-2859Pan paniscus81.640.0 589
LLPS-Nol-0019Nomascus leucogenys80.790.0 585
LLPS-Gaa-1634Gasterosteus aculeatus79.340.0 562
LLPS-Xet-0572Xenopus tropicalis78.780.0 557
LLPS-Poa-2502Pongo abelii78.250.0 553
LLPS-Cis-1034Ciona savignyi77.320.0 529
LLPS-Cii-1765Ciona intestinalis76.90.0 526
LLPS-Drm-1326Drosophila melanogaster73.545e-180 509
LLPS-Nia-0251Nicotiana attenuata69.681e-164 470
LLPS-Sot-1598Solanum tuberosum69.354e-163 466
LLPS-Glm-1897Glycine max69.235e-163 466
LLPS-Coc-0461Corchorus capsularis69.138e-165 471
LLPS-Dac-1767Daucus carota69.139e-162 463
LLPS-Mua-1383Musa acuminata68.913e-165 472
LLPS-Prp-0815Prunus persica68.813e-162 464
LLPS-Zem-1038Zea mays68.815e-165 471
LLPS-Vir-1027Vigna radiata68.818e-164 468
LLPS-Cus-0152Cucumis sativus68.593e-163 467
LLPS-Gor-0200Gossypium raimondii68.578e-166 473
LLPS-Brr-1001Brassica rapa68.491e-163 468
LLPS-Mae-1944Manihot esculenta68.498e-163 466
LLPS-Bro-0045Brassica oleracea68.497e-163 467
LLPS-Brn-1422Brassica napus68.491e-163 468
LLPS-Sei-0696Setaria italica68.496e-165 471
LLPS-Met-0122Medicago truncatula68.473e-166 474
LLPS-Arl-1839Arabidopsis lyrata68.379e-163 466
LLPS-Art-0343Arabidopsis thaliana68.174e-160 459
LLPS-Via-0696Vigna angularis68.178e-162 463
LLPS-Phv-2083Phaseolus vulgaris68.145e-165 471
LLPS-Orbr-0413Oryza brachyantha67.851e-163 468
LLPS-Hea-1909Helianthus annuus67.855e-161 461
LLPS-Amt-2102Amborella trichopoda67.719e-167 476
LLPS-Thc-1234Theobroma cacao67.711e-162 468
LLPS-Sob-1330Sorghum bicolor67.632e-162 465
LLPS-Lep-0217Leersia perrieri67.632e-164 470
LLPS-Orp-0296Oryza punctata67.521e-160 462
LLPS-Org-1831Oryza glaberrima67.521e-162 465
LLPS-Orb-0579Oryza barthii67.521e-162 465
LLPS-Ori-1622Oryza indica67.521e-162 466
LLPS-Orgl-1679Oryza glumaepatula67.521e-162 465
LLPS-Php-1257Physcomitrella patens67.411e-168 481
LLPS-Hov-0145Hordeum vulgare67.316e-162 464
LLPS-Tra-0347Triticum aestivum67.317e-162 464
LLPS-Brd-1707Brachypodium distachyon67.31e-163 468
LLPS-Pot-1524Populus trichocarpa67.196e-164 469
LLPS-Viv-1153Vitis vinifera67.193e-164 469
LLPS-Beb-0733Beauveria bassiana67.082e-166 476
LLPS-Chr-1085Chlamydomonas reinhardtii67.086e-164 469
LLPS-Asn-0468Aspergillus nidulans67.052e-130 382
LLPS-Ors-0491Oryza sativa66.995e-162 464
LLPS-Sol-0339Solanum lycopersicum66.883e-159 457
LLPS-Fuo-1319Fusarium oxysporum66.771e-166 476
LLPS-Abg-0522Absidia glauca66.673e-156 449
LLPS-Blg-0062Blumeria graminis66.252e-163 468
LLPS-Ved-1040Verticillium dahliae66.142e-164 471
LLPS-Sem-1105Selaginella moellendorffii66.139e-163 466
LLPS-Scp-0501Schizosaccharomyces pombe65.834e-157 452
LLPS-Nec-0074Neurospora crassa65.837e-161 462
LLPS-Orm-1401Oryza meridionalis65.637e-163 466
LLPS-Orr-0541Oryza rufipogon65.623e-159 457
LLPS-Orni-1255Oryza nivara65.622e-159 457
LLPS-Put-0893Puccinia triticina65.615e-138 402
LLPS-Scs-0030Sclerotinia sclerotiorum65.194e-131 385
LLPS-Pug-0848Puccinia graminis65.091e-157 453
LLPS-Trr-1116Trichoderma reesei64.922e-163 468
LLPS-Trv-1182Trichoderma virens64.924e-163 468
LLPS-Asc-0513Aspergillus clavatus64.891e-158 456
LLPS-Asni-0497Aspergillus niger64.584e-158 455
LLPS-Fuv-0133Fusarium verticillioides64.53e-168 481
LLPS-Asg-0566Ashbya gossypii64.225e-145 420
LLPS-Kop-0581Komagataella pastoris64.16e-145 420
LLPS-Crn-1023Cryptococcus neoformans63.742e-159 457
LLPS-Lem-1581Leptosphaeria maculans63.532e-158 455
LLPS-Asf-0460Aspergillus flavus63.076e-132 386
LLPS-Cog-1490Colletotrichum gloeosporioides63.022e-164 471
LLPS-Scc-0555Schizosaccharomyces cryophilus62.895e-148 428
LLPS-Map-0198Magnaporthe poae62.773e-158 455
LLPS-Fus-1237Fusarium solani62.751e-166 476
LLPS-Cogr-0928Colletotrichum graminicola62.681e-164 472
LLPS-Yal-0998Yarrowia lipolytica62.623e-149 431
LLPS-Usm-0567Ustilago maydis62.541e-151 438
LLPS-Dos-0346Dothistroma septosporum62.465e-159 457
LLPS-Gag-0572Gaeumannomyces graminis62.465e-157 452
LLPS-Coo-0444Colletotrichum orbiculare62.397e-165 472
LLPS-Aso-1202Aspergillus oryzae62.394e-161 462
LLPS-Zyt-0632Zymoseptoria tritici61.833e-158 455
LLPS-Ast-1260Aspergillus terreus61.816e-159 457
LLPS-Pytr-0622Pyrenophora triticirepentis61.786e-161 462
LLPS-Pyt-0950Pyrenophora teres61.491e-160 461
LLPS-Mao-0999Magnaporthe oryzae61.453e-161 463
LLPS-Cae-0574Caenorhabditis elegans61.33e-144 419
LLPS-Osl-0265Ostreococcus lucimarinus61.151e-142 414
LLPS-Scj-0817Schizosaccharomyces japonicus61.02e-150 434
LLPS-Spr-1084Sporisorium reilianum60.961e-154 446
LLPS-Sac-1406Saccharomyces cerevisiae60.91e-139 406
LLPS-Tum-1329Tuber melanosporum60.822e-152 441
LLPS-Asfu-0927Aspergillus fumigatus60.04e-152 439
LLPS-Mel-0506Melampsora laricipopulina59.942e-152 440
LLPS-Tru-0814Triticum urartu59.747e-130 383
LLPS-Miv-0384Microbotryum violaceum59.62e-153 442
LLPS-Nef-0206Neosartorya fischeri59.425e-150 434
LLPS-Phn-0553Phaeosphaeria nodorum59.294e-156 450
LLPS-Chc-0033Chondrus crispus58.283e-137 400
LLPS-Gas-1032Galdieria sulphuraria57.882e-133 390
LLPS-Cym-0826Cyanidioschyzon merolae56.291e-127 377
LLPS-Mod-0304Monodelphis domestica37.861e-66 220
LLPS-Tut-1863Tursiops truncatus37.222e-66 219